• 비교문화연구
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• 제33권
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• pp.143-169
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• 2013

Recently, because of the danger and damages that following the steady development of scientific technologies, natural science is faced with many humane and ethical problems. So it is asserted the interdisciplinary with social and human science. However, it comes commonly that the ethical issues such as world view and one's view of life caused the development of sociology, especially development of the market economy. But in many cases, the interdisciplinary can be useful for widen the view of scholars. The interdisciplinary is actually connected with the problems of philosophy, and located in that domain. In this case, this is noticed as a model to the philosophers in 18th century, especially Denis Diderot. Diderot published De $l^{\prime}interpr{\acute{e}}tation$ de la nature during editing the Encyclopedia, from there he picked out the contents from piles of documents of Encyclopedia. Even though the contents or opinions of De $l^{\prime}interpr{\acute{e}}tation$ de la nature are inaccuracy or erroneous, it shows that how human-social science and natural science encountered. Diderot studied mathematics and then Diderot accepted to the natural science proposal, he approaches philosophy with translate English books to the French. Next he understood natural science by reading Buffon and Maupertuis, and during working for Encyclopedia, he possessed his knowledge that he can claim his opinion to other scholars. However in this De $l^{\prime}interpr{\acute{e}}tation$ de la nature, Diderot who sometimes rebutted other scholars' theory and demonstration, tried to build a philosophy on metaphysics in order to it was important for himself that he imposed the methods of science and importance of experience. Anyhow, this De $l^{\prime}interpr{\acute{e}}tation$ de la nature cause consider the recognition of Diderot in the field of natural science, and is suggested as a model about his Nature. This mean that it is an expression of his philosophy, and the content is found from natural philosophy and empirical philosophy. Like giving these attache the importance of method study for science and technique, these are targeted the promotion of popularization of natural-science and scientific-technology. Also it advocates fulfilling from reasonable philosophy to empirical philosophy. Therefore, the philosophy which was speculative and abstracted became his philosophy which was writing the meaning, as waiting the discovery of science. And at that time, the humanities made interdisciplinary with natural science.

• 한국도서관정보학회지
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• 제44권4호
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• pp.277-294
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• 2013

본 연구의 목적은 우리나라 문헌정보학계에 iSchool에 대한 학문적 관심을 환기시키고 이를 통해 iSchool에 대한 연구의 시발점을 마련하고자 하는 것이다. 연구목적 달성을 위해 문헌정보학자들과의 심층인터뷰를 진행하였으며 인터뷰자료는 질적 분석 방법을 활용하여 분석하였다. 분석결과 우리나라에 iSchool을 도입하기위해서는 교과과정의 개편을 통한 교육의 다변화가 필요하며 iSchool 도입을 통해서는 융, 복합 연구 및 교육의 기회, 현 문헌정보학의 위기 돌파를 위한 외연의 확장, 문헌정보학에 대한 새로운 이미지의 구축이 가능할 것이라는 기대가 있는 것으로 나타났다. 하지만 iSchool의 도입은 사서양성 교육기관으로서의 문헌정보학의 정체성마저 위협할 수 있다는 위기의식 또한 존재하는 것으로 나타났다.

• Journal of Construction Engineering and Project Management
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• 제4권3호
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• pp.13-20
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• 2014

Estimating time and cost is an important mission in the early phase of a construction project, especially in feasibility study. It provides a foundation for making decision whether or not the project is performed on schedule and within budget. Thus, reliability of this estimate plays a key role in measuring the success of a project. This study was carried out to investigate the time-cost relationship in building construction projects in Bangladesh. The mathematical equation used in this study is based on Bromilow's equation. The research data were collected from sixty-three completed building projects through questionnaire survey. Type of clients, type of projects, and tender methods are the project characteristics considered in this study. The results of analysis indicated that the Bromilow's time-cost (BTC) models developed for each project characteristic are appropriate due to quite high coefficient of determination and relatively small mean percent errors. Among them, the forecasted model for time and cost according to tender methods is the best fit model. It is concluded that the BTC model could be applied in building construction project to predict its time and cost in Bangladesh. Four different regression models were also developed in this study. The results of BTC model between some selected countries were compared to gain the comprehensive view.

• 디지털융복합연구
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• 제13권12호
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• pp.325-336
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• 2015

본 연구의 목적은 평생교육에 대한 이용자의 공유기대가치 구성 요소를 융복합적 측면에서 접근, 정량적으로 확인하는데 있다. 선행연구 검토와 심층인터뷰 및 설문조사 실시 등, 2차 자료 수집과 1차 자료 수집, 그리고 정량적 정성적 방법론을 동시에 실시한 결과, 평생교육에 대한 이용자의 공유기대가치 구성요소는, 10개 관점, 27개 구성개념, 81개 측정 항목으로 정리되었다. 확인적 요인분석 결과, 잠재적 측정모델은 적합한 것으로 확인되었고, 구성요인에 대한 개념타당성, 수렴타당성, 내적일관성 및 구성 개념 간의 판별타당성 등도 적절한 것으로 나타났다. 연구결과로 정리된, 평생교육에 대한 이용자의 공유기대가치 구성요소는 융복합적 측면을 바탕으로 평생교육에 대한 이용자의 다양한 기대가치를 보여주는 바, 본 연구는 이론의 학제적 구축 측면에서, 다양한 분야로부터 평생교육에 대한 이용자의 공유 기대가치를 체계적으로 파악하는데 기여할 것으로 판단되며, 전략적 측면에서, 평생교육의 기획 관리 운영에서 이용자 욕구의 범주화 된 파악과 이에 상응하는 프로그램의 기획 개발에 기여할 것으로 판단되며, 관리적 측면에서, 평생교육 이용자의 공유기대가치에 대한 효과의 정량적 파악에 현실적인 도움을 줄 것으로 판단된다.

• 정보관리학회지
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• 제28권2호
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• pp.37-51
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• 2011

디지털도서관 분야는 컨텐츠, 운영, 기반 기술 관련하여 다양한 분야를 포함하고 있는 학제적 학문분야 중 하나로 여겨진다. 이 연구의 목적은 기존의 문헌정보학 범주 내에서 파악되었던 디지털도서관의 하위분야 규명을 넘어서 다양한 학문 분야에서 다루고 있는 디지털도서관을 학제적 공동연구의 관점에서 분석하고자 하였다. 1997년부터 2010년까지 게재된 디지털도서관 주제의 논문 1,394편을 대상으로 다양한 분야의 공동저자 분석을 수행하였다. 그 분석결과 문헌정보학, 컴퓨터학, 공학 분야가 공동연구의 중심 역할을 수행하였음을 밝혔다. 또한 디지털도서관의 세부영역은 핵심디지털도서관영역, 자연과학영역, 의학관련 영역, 생물학 및 의학영역으로 파악되었다. 이러한 결과는 디지털도서관은 다양한 학문 분야에서 다루고 있으며, 이론중심의 연구뿐만 아니라 구축과 운영과 관련된 실무 영역이 함께 발전된 특징을 지니고 있기 때문인 것으로 파악되었다.

• 대한한의학회지
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• 제33권1호
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• pp.90-106
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• 2012

Objectives: Eight constitution medicine (ECM), which was first introduced in 1965, has been further developed and refined over the decades, and has consolidated its foundation through many studies on theories, diagnosis and clinical application. However, there have been few reviews on dissertations of ECM. In this study, we reviewed previously published studies related to ECM. Methods: We reviewed a total of 55 ECM-related studies published from 1965 to 2010 found on PubMed and various domestic Oriental medicine journals. Each thesis was classified as a theoretical, diagnostic, or remedy-related study. Results: 1. In the review of theoretical studies, shortly after ECM's introduction in 1965 by Kwon, the authors found studies on constitutional diseases, diets and food table which helped establish the background of ECM. ECM has further developed by comparing its theories with Sasang constitutional medicine, Huang-di-nei-jing, Saam, and Taegeuk acupuncture theories. 2. Research on diagnosis has been focused on its objectivity and accuracy. Constitution could be diagnosed by pulse-taking. To compensate for the lack of accuracy innate in pulse-taking, the Eight Constitution Questionnaire has been invented. 3. Remedies can be largely divided into acupuncture and diet. There were case studies comparing treatment effect of ECM acupuncture to other treatments. Diet related studies were carried out in the fields of immunology and nutrition. Conclusions: The authors reviewed studies that contributed to improved understanding of theories and clinical implications of ECM. Although there were various approaches to its theoretical and clinical grounds, more clinical research is needed. There is also a need to evaluate the accuracy of the experts' diagnoses of the constitution. The relationship between the diet and constitution also needs further research.

• Journal of Applied Biological Chemistry
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• 제59권1호
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• pp.49-56
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• 2016

The current study investigated the anti-obesity effect of Cissus quadrangularsis extracts (CQR-300) and its molecular action mechanism on obese mice induced high-fat diet (HFD). To induce the obesity, mice were fed a HFD for 6 weeks and then fed HFD only or HFD with CQR-300 at 50 and 200 mg/kg. Then, body weight gain and white adipose tissue weights were measured. We investigated the reduction in body fat and the regulation of fatty acid synthesis was measured by dual energy X-ray absorptiometry and real-time PCR with Western blot, respectively. In vitro study, CQR-300 inhibited pancreatic lipase activity. The CQR-300 treatment was significantly decreased the body weight gain and adipocytes size as well as white adipose tissues weights in HFD-induced obese mice. Furthermore, CQR-300 reduced the body fat and fat mass with regulating of adipose tissue hormones as leptin. Treatment with 50 mg/kg CQR-300 showed effectively lower expression levels of adipogenesis/lipogenesis related genes and proteins such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), Sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) in white adipose tissue (WAT) as compared with the HFD fed only mice. These results suggest that the CQR-300 has an anti-obesity effect via inhibition of lipase activity, decrease the body fat mass by regulating the adipogenesis and lipogenesis related genes and proteins in epididymal adipose tissue with evaluate body fat reduce in the HFD-induced obese mice.

• 대한의용생체공학회:의공학회지
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• 제36권5호
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• pp.204-210
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• 2015

Although many studies have analyzed the relationship between electrodermal activity (EDA) and sleep stages, a practical method for detecting sleep stage using EDA has not been suggested. The aim of this study was to develop an algorithm for real-time automatic detection of deep sleep using the EDA signal. Simultaneously with overnight polysomnography (PSG), continuous measurement of skin conductance on the fingers was performed for ten subjects. The morphometric characteristics in the fluctuations of EDA signal were employed to establish the quantitative criteria for determining deep sleep. The 30-sec epoch-by-epoch comparison between the deep sleep detected by our method and that reported from PSG exhibited an average sensitivity of 74.6%, an average specificity of 98.0%, and an average accuracy of 96.1%. This study may address the growing need for a reliable and simple measure for identifying sleep stage without a PSG.

• Genomics & Informatics
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• 제10권4호
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• pp.256-262
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• 2012

Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping technologies has allowed us to perform genome-wide association studies (GWASs). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWASs. Multifactor dimensionality reduction (MDR) is one of the powerful and efficient methods for detecting high-order gene-gene ($G{\times}G$) interactions. However, the biological interpretation of $G{\times}G$ interactions identified by MDR analysis is not easy. In order to aid the interpretation of MDR results, we propose a network graph analysis to elucidate the meaning of identified $G{\times}G$ interactions. The proposed network graph analysis consists of three steps. The first step is for performing $G{\times}G$ interaction analysis using MDR analysis. The second step is to draw the network graph using the MDR result. The third step is to provide biological evidence of the identified $G{\times}G$ interaction using external biological databases. The proposed method was applied to Korean Association Resource (KARE) data, containing 8838 individuals with 327,632 single-nucleotide polymorphisms, in order to perform $G{\times}G$ interaction analysis of body mass index (BMI). Our network graph analysis successfully showed that many identified $G{\times}G$ interactions have known biological evidence related to BMI. We expect that our network graph analysis will be helpful to interpret the biological meaning of $G{\times}G$ interactions.

• 대한한방내과학회지
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• 제33권3호
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• pp.298-305
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• 2012

Objectives : This study was aimed to promote the cooperative system of Korean and Western medicine in the dual health care system through a survey of physicians on recognition, problems and solution of the cooperative system. Methods : The research took place at Dongguk University Hospital from May 25 to 27, 2009 with 44 professors, residents, and interns employed by the hospital. Results : Of total 44 surveyed doctors, positive and moderate responses on the cooperative system between Korean and Western medicines were 40.9% and 43.2%, respectively. They scored it positive (62.5%) and moderate (31.3%) based on their experiences. These results can be supposed to represent the environment for the interdisciplinary medicine. Even in the interdisciplinary hospital of Korean and Western medicine, 68.2% of responders had no experience of the cooperative medical system. Expected interdisciplinary efficient departments were ordered rehabilitation medicine, neurology and orthopedics and associated with musculoskeletal disorders, the most frequent diseases treated by Korean traditional medicine. Conclusions : Korean and Western medical doctors, as medical personnel, intellectual persons as well as specialists, need a recognition and attitude to understand and respect each others' medicine. However, both groups also realize there are many complicated issues in the treatment of patients. It is difficult to require a change of Western doctors' perceptions and attitude toward Korean traditional medicine only with results of a survey. For the efficient cooperative system in the medical field, Korean medical doctors will need to study and consider specific problems mentioned by Western medicine.