• IMMUNE NETWORK
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• v.20 no.1
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• pp.3.1-3.20
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• 2020

Immune checkpoint inhibitors (ICIs), including anti-PD-1 and anti-CTLA-4 therapeutic agents, are now approved by the Food and Drug Administration for treatment of various types of cancer. However, the therapeutic efficacy of ICIs varies among patients and cancer types. Moreover, most patients do not develop durable antitumor responses after ICI therapy due to an ephemeral reversal of T-cell dysfunction. As co-stimulatory receptors play key roles in regulating the effector functions of T cells, activating co-stimulatory pathways may improve checkpoint inhibition efficacy, and lead to durable antitumor responses. Here, we review recent advances in our understating of co-stimulatory receptors in cancers, providing the necessary groundwork for the rational design of cancer immunotherapy.

• Journal of Microbiology and Biotechnology
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• v.19 no.7
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• pp.690-697
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• 2009

In the present study, production of compactin by Penicillium brevicompactum WA 2315 was studied. In the first step, various precultural parameters were studied by substituting one factor at a time. Subsequently, the effect of maltodextrin DE 18 on compactin production was studied. The optimized parameters gave maximum compactin production of 850 ${\mu}g/gds$as compared with 678 ${\mu}g/gds$before optimization. Statistical study was performed to further improve the production and develop a robust model. An improved yield of 950 ${\mu}g/gds$was obtained using the conditions proposed by the experimental model. The present study emphasizes the importauce of precultural and nutritional parameters on the production of compactin, and further confirms the usefulness of solid-state fermentation for the production of industrially important secondary metabolites. It also confirms that complex nitrogen sources such as oil cakes can be used for the production of compactin.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.1
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• pp.73-81
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• 2020

This study analyzed the causes of failure of SCM435 bolts that fix the springs of automobile air brakes that have been fractured during use. The cause of failure was analyzed using SEM, EDS, metallogical microscope and Vickers hardness tester. In the fracture, the ratchet mark began at the outer boundary of crack origin, and the grains at crack origin were found to have clear intergranular corrosion. One SCM435 bolt was subjected to a stress of 398 MPa, it's a stress of about 80% of the fatigue limit. As a result of such a large applied stress, cracks occurred at the corrosion origin and were fractured. In order to prevent the SCM435 bolt from fracture, it is necessary to use the correct composition, the accuracy of heat treatment, preventing damage by external impact, preventing corrosion of the damage part by moisture, and introduction a compressive residual stress by peening.

• Journal of Korean Society of Water and Wastewater
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• v.34 no.1
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• pp.61-73
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• 2020

Tetracycline is one of the most commonly used antibiotics in domestic and foreign livestock industries to suppress the growth of pathogens. Tetracycline has been reported as a non-biodegradable compound. Therefore it has been not completely removed in the sewage treatment process. In this study, tetracycline was degraded using liquid ferrate (VI). Based on these experiments, the optimal water condition (pH and water temperature) were selected, appropriate liquid ferrate (VI) dosage was calculated, and finally the degradation pathway was estimated with the intermediate products detected by LC/MS/MS. All degradation experiments were completed within 30 seconds and the optimal condition was obtained in basic condition (pH 10) at room temperature (20℃). And the appropriate molar ratio between tetracycline and liquid ferrate (VI) was 12.5:1. Finally, 12 intermediate products were detected with LC/MS/MS and the degradation pathways and the degradation pathways and proposed the degradation pathways.

• Computers and Concrete
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• v.30 no.1
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• pp.75-83
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• 2022

This study introduced a post-tensioned precast concrete system that was developed and designed to improve the performance of joints by post-tensioning. Full-scaled specimens were tested to investigate flexural performances at the negative moment region, where the test variables were the presence of slabs, tendon types, and post-tensioned lengths. A specimen with slabs exhibited significantly higher stiffness and strength values than a specimen without slabs. Thus, it would be reasonable to consider the effects of a slab on the flexural strength for an economical design. A specimen with unbonded mono-tendons had slightly lower initial stiffness and flexural strength values than a specimen with bonded multi-tendons but showed greater flexural strength than the value specified in the design codes. The post-tensioned length was found to have no significant impact on the flexural behavior of the proposed post-tensioned precast concrete system. In addition, a finite element analysis was conducted on the proposed post-tensioned precast concrete system, and the tests and analysis results were compared in detail.

• International Journal of Contents
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• v.6 no.1
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• pp.35-40
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• 2010

In recent years, China Digital Media Design related undergraduate education has developed into great dimensions while producing a lot of problems. Now cause of rapid development, Disciplinary Location, Training Objectives and Curriculum require study. Firstly, the paper points out the scope and general process of Digital Media Design through an analysis of properties of digital media industry. Secondly, the paper studies the current status of Digital Media Design-related undergraduate education from the policy of Chinese Ministry of Education and the practice of representative universities. Through questionnaire survey of Digital Media Designers from Beijing, Shanghai and Guangzhou, the paper points out the problems of China Digital Media Design related undergraduate education. Finally, paper brings forward the right direction of new system of China Digital Media Design related undergraduate education.

• International Journal of High-Rise Buildings
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• v.7 no.1
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• pp.47-64
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• 2018

The last decade has seen great design opportunities for tall building construction around the globe. The best designs represent a new generation of skyscrapers that go beyond willful preconceptions of building form and iconography, trying instead to simultaneously address interrelated issues of program space utility, structural efficiency, and environmentally sustainable systems. The resulting identities of these towers are unique because of their search for the intersection of spaces tuned to people's needs, expressive optimized structures, and high performance, site-responsive systems. This paper, through examples of recent SOM towers, both built and unbuilt, will discuss how a design becomes content-driven, how ideas create value, and how the typology of the tall building is advanced through the integration of architecture design and engineering systems.

• Journal of Bio-Environment Control
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• v.30 no.4
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• pp.278-286
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• 2021

In this study, based on the Computational Fluid Dynamics (CFD) simulation model developed through previous study, inner environmenct of the modified glass greenhouse was predicted. Also, suggested the optimal shape of the greenhouse and location of the heat exchangers for heat energy management of the greenhouse using the developed model. For efficient heating energy management, the glass greenhouse was modified by changing the cross-section design and the location of the heat exchanger. The optimal cross-section design was selected based on the cross-section design standard of Republic of Korea's glass greenhouse, and the Fan Coil Unit(FCU) and the radiating pipe were re-positioned based on "Standard of greenhouse environment design" to enhance energy saving efficiency. The simulation analysis was performed to predict the inner temperature distribution and heat transfer with the modified greenhouse structure using the developed inner environment prediction model. As a result of simulation, the mean temperature and uniformity of the modified greenhouse were 0.65℃, 0.75%p higher than those of the control greenhouse, respectively. Also, the maximum deviation decreased by an average of 0.25℃. And the mean age of air was 18 sec. lower than that of the control greenhouse. It was confirmed that efficient heating energy management was possible in the modified greenhouse, when considered the temperature uniformity and the ventilation performance.

• Science of Emotion and Sensibility
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• v.17 no.2
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• pp.45-54
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• 2014

In recent years, advancing technology and growing interest in neuromarketing and neurobranding have led to foundational research that facilitates a better understanding of consumers' affective responses and unconscious information processing. However, the areas of aesthetics and design have remained largely unaffected by such advances and implications. The purpose of this study is to present a systematic review of the neuroscientific evidence aimed at sensible design for design and marketing researchers interested in exploring neuroaesthetics, an interdisciplinary area by nature. Sciencedirect, EBSCO, and the Google Scholar database were searched in February 2014 to select and review previous studies of aesthetics involving neuroscience. Twenty-eight studies were reviewed and divided into two categories: reward system and emotion. In addition to discussions on previous approaches, future research directions focusing on the process of aesthetic judgments (e.g., design elements, marketing stimuli) are proposed.

• Journal of Fashion Business
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• v.25 no.2
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• pp.63-79
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• 2021

In order to expand the overseas market of the Korean fashion industry, it is necessary to investigate the fashion-related purchases and fashion consciousness of Muslim women, who are increasingly attracting attention as global fashion consumers. Therefore a survey was conducted to identify the fashion design preferences and fashion consciousness of Malaysian Muslim women. A total of 245 responses were collected and analyzed. The survey included questions on demographic characteristics, fashion product purchases, design preferences and environmental awareness. The data were analyzed through frequency, average and standard deviation. The analysis showed that the majority of respondents were young Malaysian Muslim women in their 20s and 30s. They preferred a modern, Sophisticated, and sporty image, and their preference for unpatterned fabrics was high. When choosing fashion products, these women seek to both pursue fashion trends and comply with Islamic laws. When the women buy clothes, they consider practicality and design elements. The women also collected fashion trend information through SNS and the Internet, and ues this information to purchase fashion products through the Internet and shopping malls. This study was based on a practical survey of local consumers. Therefore, it is expected that the results can be used as data for fashion-related studies and to expand overseas markets to reach Muslim women in Southeast Asia.