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http://dx.doi.org/10.4014/jmb.0808.466

Effect of Precultural and Nutritional Parameters on Compactin Production by Solid-State Fermentation  

Nikhil S., Shaligram (Food Engineering and Technology Department, Institute of Chemical Technology, University of Mumbai)
Singh, Sudheer Kumar (Biotechnology Division, National Institute for Interdisciplinary Science and Technology (NIIST) (Formerly Regional Research Laboratory))
Singhal, Rekha S. (Food Engineering and Technology Department, Institute of Chemical Technology, University of Mumbai)
Szakacs, George (Department of Applied Biotechnology and Food Sciences, Budapest University of Technology and Economics)
Pandey, Ashok (Biotechnology Division, National Institute for Interdisciplinary Science and Technology (NIIST) (Formerly Regional Research Laboratory))
Publication Information
Journal of Microbiology and Biotechnology / v.19, no.7, 2009 , pp. 690-697 More about this Journal
Abstract
In the present study, production of compactin by Penicillium brevicompactum WA 2315 was studied. In the first step, various precultural parameters were studied by substituting one factor at a time. Subsequently, the effect of maltodextrin DE 18 on compactin production was studied. The optimized parameters gave maximum compactin production of 850 ${\mu}g/gds$as compared with 678 ${\mu}g/gds$before optimization. Statistical study was performed to further improve the production and develop a robust model. An improved yield of 950 ${\mu}g/gds$was obtained using the conditions proposed by the experimental model. The present study emphasizes the importauce of precultural and nutritional parameters on the production of compactin, and further confirms the usefulness of solid-state fermentation for the production of industrially important secondary metabolites. It also confirms that complex nitrogen sources such as oil cakes can be used for the production of compactin.
Keywords
Compactin; Penicillium brevicompactum WA 2315; solid-state fermentation; fractional factorial design; Box-Behnken design;
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1 Box, G. E. P. and D. W. Behnken. 1960. Some new three level designs for the study of quantitative variables. Technometrics 2: 455-475   DOI   ScienceOn
2 Chakravarti, R. and V. Sahai. 2002. Optimization of compactin production in chemically defined production medium by Penicillium citrinum using statistical methods. Process Biochem. 38: 481-486   DOI   ScienceOn
3 Konya, A., A. Jekkel, J. Sutö, and J. Salat. 1998. Optimization of compactin fermentation. J. Ind. Microbiol. Biotechnol. 20: 150-152   DOI   ScienceOn
4 Kumar, M. S., S. K. Jana, V. Senthil, S. Shasshanka, V. Kumar, and A. K. Sadhukhan. 2000. Repeated fed-batch process for improving lovastatin production. Process Biochem. 36: 363-368   DOI   ScienceOn
5 Pandey, A. 2003. Solid-state fermentation. Biochem. Eng. J. 13: 81-84   DOI   ScienceOn
6 L$\acute{o}$pez, J. L. C., J. A. S. P$\acute{e}$rez, J. M. F. Sevilla, F. C. A. Fern$\acute{a}$ndez, E. M. Grima, and Y. Chisti. 2004. Fermentation optimization for the production of lovastatin by Aspergillus terreus: Use of response surface methodology. J. Chem. Technol. Biotechnol. 79: 1119-1126   DOI   ScienceOn
7 Chundakkadu, K. 2005. Solid state fermentation systems - An overview. Crit. Rev. Biotechnol. 25: 1-30   DOI   ScienceOn
8 Endo, A., K. Hasumi, A. Yamada, R. Shimoda, and H. Takeshima. 1986. The synthesis of compactin (ML-236B) and monacolin K in fungi. J. Antibiot. 39: 1609-1610   DOI
9 Hosobuchi, M., T. Shiori, J. Ohyama, M. Arai, S. Iwado, and H. Yoshikawa. 1993. Production of ML-236B, an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, by Penicillium citrinum: Improvement of strain and culture conditions. Biosci. Biotechnol. Biochem. 57: 1414-1419   DOI
10 John, R. P., R. K. Sukumaran, K. M. Nampoothiri, and A. Pandey. 2007. Statistical optimization of simultaneous saccharification and l (+)-lactic acid fermentation from cassava bagasse using mixed culture of lactobacilli by response surface methodology. Biochem. Eng. J. 36: 262-267   DOI   ScienceOn
11 Shaligram, N. S., S. K. Singh, R. S. Singhal, G. Szakacs, and A. Pandey. 2008. Compactin production in solid-state fermentation using orthogonal array method by P. brevicompactum. Biochem. Eng. J. 41: 295-300   DOI   ScienceOn
12 Chakravarti, R. and V. Sahai. 2004. Compactin - a review. Appl. Microbiol. Biotechnol. 64: 618-624   DOI
13 Sayyad, S. A., B. P. Panda, S. Javed, and M. Ali. 2007. Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology. Appl. Microbiol. Biotechnol. 73: 1054-1058   DOI   ScienceOn
14 Tholudur, A., T. Sorensen, X. Zhu, and S. Shepard. 2005. Using design of experiments to assess Escherichia coli fermentation robustness. Bioprocess In. 3: 46-48
15 Endo, A., M. Kuroda, and Y. Tsujita. 1976. ML-236a, ML-236b, and ML-236c, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29: 1346-1348   DOI
16 Gao, H. and W. Y. Gu. 2007. Optimization of polysaccharide and ergosterol production from Agaricus brasiliensis by fermentation process. Biochem. Eng. J. 33: 202-210   DOI   ScienceOn
17 Liu, J., J. Xing, T. Chang, Z. Ma, and H. Liu. 2005. Optimization of nutritional conditions for nattokinase production by Bacillus natto NLSSE using statistical experimental methods. Process Biochem. 40: 2757-2762   DOI   ScienceOn
18 Linde, G. A., G. Magagnin, J. A. V. Costa, T. E. Bertolin, and N. B. Colauto. 2007. Column bioreactor use for optimization of pectinase production in solid substrate cultivation. Braz. J. Microbiol. 38: 557-562   DOI
19 Bazarra, W. A., M. K. Hamdy, and R. Toledo. 1998. Bioreactor for continuous synthesis of compactin by Penicillium cyclopium. J. Ind. Microbiol. Biotechnol. 21: 192-202   DOI   ScienceOn
20 Valera, H. R., J. Gomes, S. Lakshmi, R. Gururaja, S. Suryanarayan, and D. Kumar. 2005. Lovastatin production by solid state fermentation using Aspergillus flavipes. Enz. Microbial Technol. 37: 521-526   DOI   ScienceOn
21 Singh, S. K., G. Szakacs, C. R. Soccol, and A. Pandey. 2007. Production of enzymes by solid-state fermentation, pp. 183-200. In A. Pandey, C. Larroche, and C. R. Soccol (eds.). SSF for Bulk Chemicals and Products Part 2, Asia Tech Publishers, New Delhi, India
22 Manzoni, M., S. Bergomi, M. Rollni, and V. Cavazzoni. 1999. Production of statins by filamentous fungi. Biotechnol. Lett. 21: 253-257   DOI   ScienceOn