• Analytical Science and Technology
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• v.18 no.1
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• pp.27-34
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• 2005

$Li_2B_4O_7$ and $Na_2B_4O_7$ were synthesized with boron isotopic standard material for the measurement of boron isotopes of positive ions (PTIMS) such as $Li_2BO_2{^+}$ (mass 56, 57) and $Na_2BO_2{^+}$ (mass 88, 89) instead of boron mass 10 and 11. The negative ions (NTIMS) such as $^{10}BO_2{^-}$ and $^{11}BO_2{^-}$(mass 42와 43) were also measured with the same boron isotopic standard material. The precision and accuracy were compared between each method, and prescan of isobaric effect was studied. Good result was obtained from NTIMS method which provided the stable and enough peak intensities with good precision and accuracy. The measurement of boron isotopes were performed in ground water sample with about 8 ng-B ($5{\mu}L$ sample solution) obtained from IAEA for international inter-comparison analysis. The standard deviation was found to be 0.03%. Boron content of this ground water was measured using the NTIMS-IDMS. The result was $1.65{\pm}0.003ug-B/mL$ which was better precision compared to the ICP-AES result.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.313-323
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• 2018

This study was conducted to develop an individualized upper extremity exercise program for patients after mastectomy and evaluate its effectiveness. A nonequivalent control-group pretest-posttest design was used for this investigation. Research participants were patients with breast cancer who underwent mastectomy at two university hospitals (experimental group, n=17; control group, n=16). The experimental group received an individualized upper extremity exercise program three times a week for 7 weeks. Data were analyzed by the ${\chi}^2-test$, Fisher's exact test, Mann-Whitney U-test and Wilcoxon Signed Rank test using SPSS WIN 21.0. Inter-group comparison revealed significant differences between pre-test and post-test in hands behind the back, flexion, abduction, external rotation, internal rotation, and grip strength. Moreover, the experimental group showed significant improvements in hands behind the back, flexion, abduction, external rotation, internal rotation, and grip strength relative to the control. In conclusion, the individualized upper extremity exercise program was shown to be an effective intervention to improve physical functions in upper limbs and shoulders. Therefore, this program should be applied to patients after mastectomy in clinics since many patients have suffered from decreased physical functions in upper extremities.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.4
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• pp.273-279
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• 2012

Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h or 3.2 mg/kg daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women. Inter-individual random variabilities of CL and $V_d$ were 16% and 9%. Based on a CL estimate from the final PK model, a simple dosage scheme to achieve the target $AUC_{0-inf}$ (defined as median AUC0-inf with a once-daily dosage) of 26.18 $mg/l{\cdot}hr$, was proposed: $24.79{\cdot}ABW^{0.5}mg$ q24h, where ABW represents the actual body weight in kilograms. The dosing scheme reduced the unexplained interindividual variabilities of CL and Vd of iBu with ABW being a significant covariate affecting clearance of iBU. We propose a new simple dosing scheme for iBu based only on ABW.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.500-504
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• 2008

The objective of this paper is to evaluate the feasibility of using an optimization model as a effective way to search conjunctive operation scheme to meet two conditions; one is to minimize the electric cost for pumping and another is to meet the water demand for satisfying customers. The feasibility is confirmed as comparing the best combinations of pumps between multi-regional water supply networks from multiple sources which are obtained through an optimization modeling and EPAnet modeling. KModsim model, a network optimization model, was used to determine conjunctive operation scheme in the pipe system. KModsim, based on Lagrangian Relaxation algorithm, is useful for modeling network system and obtaining simultaneously pump combination and water allocation with given input option such as energy unit cost supplying from a source into a consumer, operating pumping combination. This study develops the procedure of determining optimal conjunctive operation scheme with using KModsim model. As a study region, the water supplying systems of the Geojae-city in the Geongsang Namdo Province was selected and investigated. The EPAnet hydraulic simulation result(Ryu et al, 2007, KSWW) gave input data for optimization model; energy unit price(won/$m^3$), water service available area etc.. It was assured that the combination of pump operation through optimum conjunctive operation is to be optimum scheme to obtain the best economic water allocation with comparison to the hydraulic simulation result such as electric cost and pump combination cases. The results obtained through the study are as follows. First, It was found that a well-allocated water supply scheme, the best combination of pump operation through optimum joint operation, promises to save the electric cost and satisfy all operational goals such as stability and revenues during the period. Second, an application of KModSim, a network model, gave the amount of water allocation from each source to a consumer with consideration of economic supply. Finally, in a service area available to supply through conjunctive operation of existing inter-regional water supply networks within short distance, a conjunctive operation is useful for determining each transmission pipeline's service area and maximizing the effectiveness of optimizations in pumping operation time.

• Journal of Sericultural and Entomological Science
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• v.51 no.2
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• pp.137-141
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• 2013

In this study, nucleotide sequence structures of intergenic transcribed spacer (ITS) 1, complete 5.8S ribosomal RNA gene and ITS 2 region were analyzed to identify three Peruvian entomopathogenic fungal isolates. The isolates had highly conserved sequence region in 5.8S rRNA gene and unique sequences in ITS 1 and 2 region among them. 5.8S rRNA gene regions were highly conserved and showed high homoloies among tested isolates. In contrast, ITS region showed species-specific sequence region, resulting in inter-genus differencies. Scanning electron microscopic images of these isolates supported the result of ITS-based identification. From these result, Peruvian entomopathogenic fungal isolate J270, J278, were identified as Beauveria bassiana and J271 was identified as Lecanicillium attenuatum.

• The korean journal of orthodontics
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• v.41 no.1
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• pp.6-15
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• 2011

Objective: The aim of this study was to evaluate the biomechanical aspects of peri-implant bone upon root contact of orthodontic microimplant. Methods: Axisymmetric finite element modeling scheme was used to analyze the compressive strength of the orthodontic microimplant (Absoanchor SH1312-7, Dentos Inc., Daegu, Korea) placed into inter-radicular bone covered by 1 mm thick cortical bone, with its apical tip contacting adjacent root surface. A stepwise analysis technique was adopted to simulate the response of peri-implant bone. Areas of the bone that were subject to higher stresses than the maximum compressive strength (in case of cancellous bone) or threshold stress of 54.8MPa, which was assumed to impair the physiological remodeling of cortical bone, were removed from the FE mesh in a stepwise manner. For comparison, a control model was analyzed which simulated normal orthodontic force of 5 N at the head of the microimplant. Results: Stresses in cancellous bone were high enough to cause mechanical failure across its entire thickness. Stresses in cortical bone were more likely to cause resorptive bone remodeling than mechanical failure. The overloaded zone, initially located at the lower part of cortical plate, proliferated upward in a positive feedback mode, unaffected by stress redistribution, until the whole thickness was engaged. Conclusions: Stresses induced around a microimplant by root contact may lead to a irreversible loss of microimplant stability.

• The korean journal of orthodontics
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• v.31 no.3 s.86
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• pp.301-309
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• 2001

Because many of patients seeking orthodontic treatment worry about the facial appearance and their chief motivation for orthodontic treatment is facial esthetics, it is critical to understand the influence of gender or culture on the evaluation of profile esthetics. The purpose of this study was to find out any influence of gender or culture on judging good facial profile. 4 different groups were asked to evaluate 133 facial profiles to test the influence of gender or culture on judging good facial profiles. Those 4 groups consisted of 10 Korean males, 10 Korean females, 10 Korean American males, and 10 Korean American females. 2 evaluation systems were introduced, absolute and relative. Soft tissues of selected good profile group were analyzed and statistic analysis was performed. Conclusions were as follows 1. Inter-evaluator difference for judging good facial profile was statistically significant, even if there was general agreement for the best profile among 40 raters. 2. Gender difference under the same cultural environment was not significant statistically. 3. The same ethnic groups with different cultural background showed statistically different preference on judging good Profile. 4. Good facial profile group had their own characteristics compared to remaining group in several soft tissue measurements which were vertical facial ratio, soft tissue facial convexity, and antero-posterior relative lip position.

• Journal of Korea Spatial Information System Society
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• v.9 no.2
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• pp.55-66
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• 2007

There has been increasing concerns regarding marine mineral resources as the land energy resources has been depleting from worldwide energy crisis. Also, all the coastal countries around the world are getting into the high competition as EEZ implemented to widen each country's marine autonomy. Especially, the adoption of EEZ in UN's marine regulation agreement at the January of 1996 has aggravated conflicts among coastal countries and eventually resulted in critical agenda to determine the boundaries of EEZ among such countries. It is imperative for us to have negotiation with neighboring countries to determine the boundaries of EEZ. For the preparation of such negotiation, it is essential to have data such as mineral distribution, deep-sea geology, related agreement and marine laws, etc. Therefore, this study mainly concentrates on analyzing existing data of resources exploration and establishing standards for each type of data and manipulating data based on such standards, thereby building a database for more efficient management of EEZ data from marine resources survey. MRIS has also been developed to diversely analyze and visualize graphic and attribute data considering data usage and inter-relationship in the database. This system can provide various spatial analysis and spatial searching techniques to enable easier comparison of cost-benefit analysis and data provision of any area in EEZ thereby facilitating major policy making. In addition, the system can support sustainable management of marine resources of EEZ regions and data supply for systematic management of national marine resources. Furthermore, this will be very useful for negotiating with neighboring countries to determine EEZ boundaries to lead more favorable results.

• Korean Journal of Ecology and Environment
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• v.46 no.2
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• pp.310-318
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• 2013

In territorial ecosystem, soil has stored considerable amount of carbon, and it is vulnerable to weakness release much of the carbon to atmosphere. In this study, we have been effort realization and discussion to the error between inter-instruments and measurement methods, time and special variations, gap filling and separation from each source included in soil respiration, used to collect soil respiration data in various ecosystems in Korea. In conclusion, it have to collect calibration data throughout comparison test between methods and instruments because accumulated data from past and accumulating data in present did not calibrated. In predicting change of soil carbon dynamic using the model method, it needs important data such as longterm and short-term data, artificial handling data of major factor, data from various ecosystem, soil texture, soil depth etc. In company with, we should collect highly qualified data through deep consideration of present problems.

• Journal of the Korean Chemical Society
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• v.28 no.4
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• pp.210-216
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• 1984

Solvatochromic comparison methods were applied to determine Taft's solvent parameters, ${\pi}^{\ast}$(solvent polarity-polarizability), ${\alpha}$(solvent hydrogen bond donor acidity) and ${\beta}$ (solvent hydrogen bond acceptor basicity) for MeOH-MeCN solvent mixtures. Swain's solvent parameters A(anion solvation scale) and B(cation solvation scale) were also determined by least square fitting of kinetic data in the same binary solvent mixtures. It was found that: (i)${\beta}$ depends on the basicity of the solvent and increases with the MeOH content owing to the increase in polymeric structure of methanol; (ii) ${\pi}^{\ast}$depends on the dipole moment of the solvent and increases with the MeCN content of the solvent; (iii) ${\alpha}$ increases rapidly with the MeOH content as the hydrogen bond donor acidity of the solvent mixtures increases. Taft's reaction constants a and s and Swain's reaction constants a and b were determined for the reactions reported from our laboratory previously using solvent parameters determined in this work. No meaningful inter-relationship was found between the two set of reaction parameters, but a good linear correlation was found between the ratios a/s and a/b. Solvent effect on the reaction mechanism, substituent effect and leaving group ability were examined in the light of these reaction constants ratios.