• The korean journal of orthodontics
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• v.16 no.1
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• pp.51-70
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• 1986

Parathyroid hormone (PTH) is known to exert its effects on bone cells through the mediation of adenosine 3', 5'-monophosphate (cAMP). Orthodontic forces have also been shown to alter the cAMP content of paradental cells, particularly the alveolar bone osteoblasts. The objective of this experiment was to determine whether a combined orthodontic treatment-PTH administration regimen would have an additive effect on cAMP content in paradental cells in sites of periodontal ligament (PDL) tension. Seven groups of 4 one year old female cats each were treated for 1,3,6,12,24 h, 7 and 14 d by tipping one maxillary canine. PTH was administered twice daily, 30u/kg. Maxillary horizontal sections were stained immunohistochemically for cAMP and the degree of cellular staining intensity was determined microphotometrically as per cent light transmittance at 600nm. Alveolar bone osteoblasts, progenitor cells, PDL fibroblasts and cementoblasts in tenion sites were measured and the data were analyzed statistically by a mixed model analysis of variance. PTH administration increased the cAMP staining of nonorthodontically treated paradental cells in comparison to cells untreated by force or hormone. Cells in PDL tension sites of PTH-treated cats demonstrated significantly darker cAMP staining than cells in non-orthodontically-treated sites. Osteoblasts demonstrated the greatest response in terms of cAMP elevation, while in PDL fibroblasts orthodontic force did not increase cAMP levels above those measured in non-stretched hormonally-treated cells. These results demonstrate that PTH increases cAMP levels in paradental cells, particullarly in osteoblasts, and that the effects of PTH and orthodontic forces on paradental target cells may approach additivity.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.21 no.4
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• pp.473-485
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• 1997

Detailed experimental study has been made of air blast kerosene spray flames with and without swirl in combustion air flow. Phase-Doppler detect technique is used to measure Sauter mean diameter, axial component mean and rms velocity, size-velocity correlation, and number density. These measurements are obtained for both nonreacting and reacting cases under several stable flame conditions. The results show that the introduction of swirl to the combustion air modifies the spatial distribution of droplet size, velocity, and number density, and thus alters the flame structure. However, due to the weak swirl intensity, the overall structure of swirling flames are essentially same as that of nonswirling flames. Physical model of structure of air blast atomized spray flames is projected to show that spray flames are composed of three distinct regions: the two-phase mixture region, the main reaction and the intermittent combustion region. Near the atomizer, two phase mixture of droplet and air is formed in the core region. This dense spray region is characterized by high droplet number density and the strong convective effect. There follows the main combustion region where the main flame penetrates within the spray boundary. Main reaction region of these flames are governed by internal group combustion mode. Finally there exists the intermittent combustion region where local group burning or isolated droplet burning occurs.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1691-1695
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• 2010

본 연구에서 AFDA(Approximate Full Distribution Approach)를 사용하여 하수관의 불능확률을 정량적으로 산정할 수 있는 신뢰성 모형이 개발되었다. 여러 도시의 연 최대강우강도(Yearly Maximum Rainfall Intensity)를 이용하여 그 확률분포함수를 분석하였고 우수관(Storm sewer)의 불능확률 산정을 위한 신뢰성 모형에 적용하였다. 연 최대강우강도 자료의 분석결과 우리나라 중부지방의 여러 중소도시에 대한 연 최대강우강도의 확률분포함수는 Gumbel분포와 일치하는 것으로 나타났다. 신뢰성 모형은 불능확률의 신뢰함수를 구하기 위해 하중(Load)을 규정하는 식은 합리식이 사용되었고 용량(Capacity)를 규정하는 식은 Darcy-Weisbach공식과 Manning의 공식이 사용되었다. 이렇게 개발된 신뢰성 모형을 실제 우수관에 적용하여 불능확률을 산정하는 신뢰성 해석을 수행하였다. Y자형 우수관망에서 2개의 관으로 유입하는 각각의 유량이 그 관의 허용유량을 초과할 경우를 불능확률로 가정하였고, 나머지 관의 경우는 두 개의 관으로부터 유입하는 유량과 그 세 번째 관의 매설지역의 우수유입량의 합이 그 관의 허용유량을 초과할 경우를 불능상태(state of system failure)로 간주하여 불능확률을 정량적으로 산정하였다. Darcy-Weisbach공식과 Manning의 공식을 사용한 신뢰성 해석결과를 비교하였으며 우수관 직경의 변화에 따른 불능확률을 산정하였다. 특정한 수치(설계직경)이하일 경우 불능확률이 급격히 증가하는 것으로 나타났다. 따라서 실제 우수관의 유효직경이 설계직경에 항상 가깝도록 불순물을 제거하는 것이 최선의 관리 방법이며 불능확률을 줄이는 최선의 방법일 것이다. 본 연구에서 개발된 신뢰성 모형은 우수관의 운용, 관리, 감독은 물론 설계에 활용이 가능 할 것이다.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.4
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• pp.84-94
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• 2009

Moisture Index time series derived from NOAA/AVHRR data have showed to be useful for humid and arid states. The humid/arid states of the Geum river basin are classified by means of the moisture index estimated from the climatic water budget model. Validations showed that the moisture index has excellent ability to detect humid/arid conditions and to measure time of its onset, intensity and duration. In this study, a simple method to classify the moisture index is proposed by statistical distribution condition. Also, the moisture index is compared with the regional actual state to detect drought area.

• Tribology and Lubricants
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• v.38 no.3
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• pp.73-83
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• 2022

This paper is concerned with an analysis of a surface edge crack emanated from a sharp contact edge. For a geometrical model, a square wedge is in contact with a half plane whose materials are identical, and a surface perpendicular crack initiated from the contact edge exists in the half plane. To analyze this crack problem, it is necessary to evaluate the stress field on the crack line which are induced by the contact tractions and pseudo-dislocations that simulate the crack, using the Bueckner principle. In this Part I, the stress filed in the half plane due to the contact is re-summarized using an asymptotic analysis method, which has been published before by the author. Further focus is given to the stress field in the half plane due to a pseudo-edge dislocation, which will provide a stress solution due to a crack (i.e. a continuous distribution of edge dislocations) later, using the Burgers vector. Essential result of the present work is the corrective functions which modify the stress field of an infinite domain to apply for the present one which has free surfaces, and thus the infiniteness is no longer preserved. Numerical methods and coordinate normalization are used, which was developed for an edge crack problem, using the Gauss-Jacobi integration formula. The convergence of the corrective functions are investigated here. Features of the corrective functions and their application to a crack problem will be given in Part II.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1153-1164
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• 2024

In recent years, unmanned ground vehicles (UGVs) have been used to search for lost or stolen radioactive sources to avoid radiation exposure for operators. To achieve autonomous localization of radioactive sources, the UGVs must have the ability to automatically determine the next radiation measurement location instead of following a predefined path. Also, the radiation field of radioactive sources has to be reconstructed or inverted utilizing discrete measurements to obtain the radiation intensity distribution in the area of interest. In this study, we propose an effective source localization framework and method, in which UGVs are able to autonomously explore in the radiation area to determine the location of radioactive sources through an iterative process: path planning, radiation field reconstruction and estimation of source location. In the search process, the next radiation measurement point of the UGVs is fully predicted by the design path planning algorithm. After obtaining the measurement points and their radiation measurements, the radiation field of radioactive sources is reconstructed by the Gaussian process regression (GPR) model based on machine learning method. Based on the reconstructed radiation field, the locations of radioactive sources can be determined by the peak analysis method. The proposed method is verified through extensive simulation experiments, and the real source localization experiment on a Cs-137 point source shows that the proposed method can accurately locate the radioactive source with an error of approximately 0.30 m. The experimental results reveal the important practicality of our proposed method for source autonomous localization tasks.

• International conference on construction engineering and project management
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• 2024.07a
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• pp.127-136
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• 2024

Flooding presents a significant threat to infrastructure, and climate change is exacerbating these risks. High-speed rail (HSR) infrastructure, designed based on historical data, may struggle to cope with future extreme flood events. Infrastructure stakeholders require forecasting capabilities to predict the intensity and frequency of future floods so they can develop adaptive strategies to mitigate flood risks and impacts. Floods can cause significant damage to HSR infrastructure networks, disrupting their operations. Traditional network theory-based frameworks are insufficient for analyzing the three-dimensional effects of floods on HSR networks. To address this issue, this study proposes a comprehensive approach to assess flood risk and vulnerability under future climate scenarios for HSR networks. The method consists of three components. (i) Generate flood inundation data by utilizing global climate models, Shared Socioeconomic Pathways(SSPs), and the CaMa-Flood model. (ii) Fit extreme flood depths to the Gumbel distribution to generate flood inundation scenarios. (iii) Overlay flood scenarios on the HSR network and quantitatively assess network vulnerability based on topology network. When applied to the HSR system in mainland China, the results indicate that flood severity does not necessarily increase under higher SSPs, but may worsen over time. The minimum flood return period that causes HSR disruptions is decreasing, with Hubei Province showing a significant increase in HSR segment failure probability. Discontinuous phase transitions in HSR network topology metrics suggest potential nationwide collapses under future infrequent floods. These findings can inform preventive measures for the HSR sector and flood-resistant standards for HSR infrastructure. The method used in this study can be extended to analyze the vulnerability of other transportation systems to natural disasters, serving as a quantitative tool for improving resilience in a changing climate.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.12
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• pp.1305-1310
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• 2005

As a way to the optimum design of the collector well lateral in riverbed filtration, experiments were performed using sand tanks which were connected to form a model lateral system. Measured were the residual hydraulic heads along the laterals, the discharge rates at each sand tank and the production rates at the collector well while the model laterals were operated with various scenarios of changing parameters including water level of the collector well, the lateral diameter and length, and the hydraulic conductivity of the sand. Results showed that riverbed filtration could be more efficient when the resistance in the lateral was weak compared with the resistance in the sand, which was indicated by the more flattened distribution of the residual hydraulic heads along the lateral. Results also showed that the discharge rate increased exponentially with the approach to the collector well, and that the exponent increased as the lateral diameter decreased and/or the hydraulic conductivity of the sand increased. It was also seen that the well production increased with the increase in the lateral length and diameter although the marginal productivity decreased. It could be concluded that the axial flow velocity in the lateral was an important factor governing the efficiency of a lateral in riverbed filtration and that the maximum entrance velocity to the collector well, over which the efficiency decreased drastically, was about 1 m/sec under the conditions of this study.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.19 no.4
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• pp.414-434
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• 1997

Though many genetic and epigenetic alterations have been identified in hamster oral carcinogenesis model, there is no information about the possible role of transforming growth factor related with oral cancer. The purpose of this paper was to find the expression patterns of transforming growth factor alpha and beta during the stages of complete oral carcinogenesis model in hamster. 0.5% 9, 10-dimethyl-1, 2-benzanthracene(DMBA) in mineral oil was topically applied to the buccal pouch of 75 hamster three times a week during the experimental periods. The experimental animals were subdivided into two groups of control and experiment. Only the mineral oil was applied to the control group. 0.5% DMBA in mineral oil was applied to the experimental groups of 6, 8, 10, 12, 14, 16, 18 and 20 weeks. The expression of the $TGF-{\alpha}$ and $TGF-{\beta}$ protein were evaluated by the distribution and intensity of positive cells during the carcinogenesis using the immunohistochemical study. The following results were obtained ; 1. The buccal pouch epithelium of hamster was histologically changed to the dysplasia at 6, 8, 10 weeks, carcinoma in situ at 12 weeks, and squamous cell carcinoma at 14 weeks. 2. The expression of the $TGF-{\alpha}$ was restricted to the parabasal and basal layers of the normal and dysplastic mucosa, but those positive cells were extended to the spinous layers of the epithelium in the carcinoma. 3. The degree of $TGF-{\alpha}$ expression was markedly decreased in the carcinoma at 16, 18, 20. The strong positive staining in the center of cancer islands and weak positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma. 4. The positive index of the $TGF-{\alpha}$ had a tendency to increase with DMBA- applied time. There was a statistically significant difference between 12, 18, 20 experimental group and control group (p<0.05). 5. The expression of the $TGF-{\beta}$ was shown at the cytoplasm of all control and experimental groups, and the parabasal and basal layers of the normal and dyslastic mucosa, but it was shown at the basal layers of the epithelium in the carcinoma. 6. $TGF-{\beta}$ was expressed diffusely at 16, 18, 20 experimental group. The strong positive staining in the center of cancer islands and positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma. From the above findings, the expression of $TGF-{\alpha}$ and ${\beta}$ in oral carcinogenesis model seems to have two formal stages, the first being an overexpression step as reaction to uncontrolled growth and the second being one in which external protein accumulate in the surrounding stroma and intracytoplasm. Overexpression of $TGF-{\alpha}$ and ${\beta}$ may have important cooperative roles for the promotion of cancer and factor of prognosis.

• Journal of Distribution Science
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• v.13 no.9
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• pp.71-79
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• 2015

Purpose - The purpose of this paper is to find out the effect of changes in the differentiated "servicescape" on the business performance in the hair salon industry using a case study. For this, we selected hair salon M located in Suwon. The shop is innovatively different from existing shops in terms of spatial layout and functionality. We conducted in-depth research, beginning with the launch of the shop concept through investment and ongoing stable sales. Research design, data, and methodology - The M hair salon is a start up shop providing a differentiated servicescape (physical environment where the service takes place) located in Suwon, Yeongtong-gu. We conducted research to investigate how spatial layout and functionality of the servicescape impact customers' perceived quality. The interview period and case analysis was May 2014 through March 2015, covering 11 months. To conduct the case analysis, we analyzed the spatial layout and functionality of existing shops and interviewed customers and experts about the difference between hair salon M and existing shops. Results - Our results found clues to the positive effect of spatial layout and functionality among servicescape factors on perceived service quality at the salon. The shop showed a fast payback of the principal investment, growth potential in contrast to competitors near the salon, and 45 percent returning customers. The problem with the spatial layout at existing shops was that customers were aware of the way other people were looking at them, since viewing angles overlapped, therefore there was a limitation to the relationship intensity with an exclusive hair designer. In contrast, the layout of the stands at the M salon kept the number of dressing stands limited to maximize the customer's emotional response. Additionally, because of the new layout of dressing stands hiding other customer voices and appearance in the salon, customers perceived their service space as independent. Therefore, they did not have to focus on their personal emotional response, which was one of the advantages of the new layout. Conclusions - This study conducted case study analysis by offering a new perspective focusing on spatial layout, previously not considered as an independent variable of quality evaluations and customer satisfaction in existing literature on hair salon management. Therefore, this study contributes to the field by offering an opportunity to discover the causal relationships between the overlooked physical environment and a customer's perceived quality. However, a process objectifying the results of the study through empirical analysis and hypotheses is needed to overcome the limitations of the case study approach and generalize the results. Moreover, it would be beneficial to conduct further empirical study of the relationship between the spatial layout provided in the case and a customer's emotional response and change in mood. In addition, an analysis is needed regarding how customers feel about the factors using the Kano Model. These suggestions would be considered in further study.