Maxillofacial Plastic and Reconstructive Surgery
- Volume 19 Issue 4
- /
- Pages.414-434
- /
- 1997
- /
- 2288-8101(pISSN)
- /
- 2288-8586(eISSN)
EXPRESSION OF TGF-α AND TGF-β
구강암 발생 과정에서 TGF-α 및 TGF-β 발현에 관한 연구
- Yang, Hee-Chang (Department of Oral and Maxillofacial Surgery, Wonkwang University) ;
- Lee, Dong-Keun (Department of Oral and Maxillofacial Surgery, Wonkwang University) ;
-
Kim, Eun-Cheol
(Department of Oral Pathology, School of Dentistry, Wonkwang University)
- Published : 1997.12.31
Abstract
Though many genetic and epigenetic alterations have been identified in hamster oral carcinogenesis model, there is no information about the possible role of transforming growth factor related with oral cancer. The purpose of this paper was to find the expression patterns of transforming growth factor alpha and beta during the stages of complete oral carcinogenesis model in hamster. 0.5% 9, 10-dimethyl-1, 2-benzanthracene(DMBA) in mineral oil was topically applied to the buccal pouch of 75 hamster three times a week during the experimental periods. The experimental animals were subdivided into two groups of control and experiment. Only the mineral oil was applied to the control group. 0.5% DMBA in mineral oil was applied to the experimental groups of 6, 8, 10, 12, 14, 16, 18 and 20 weeks. The expression of the