• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.4031-4036
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• 2012

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

• Journal of The Korean Society of Integrative Medicine
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• v.2 no.2
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• pp.79-88
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• 2014

Purpose: This study investigated the relationship between smartphone addiction propensities and compare muscle activity of the forearms and brain wave depend on the type of smartphone when inputting text messages. Method: We used an EMG to measure the change in muscle activity by attaching pads to the four muscles in both forearms of all 16 participants. We simultaneously conducted EEG measurements by observing the changes in alpha and beta waves recorded from electrode attached to both ears and the forehead of the participants. The participants had to input a given text using three different types of smartphones for ten minutes each. Result: The comparison of the EMG when inputting text involved a one way analysis of variance and the results showed that the iPad3 was highest for muscle activity followed by GALAXY Note2 and iPhone4. For EEG measurement, a one way analysis of variance was also used and the results showed iPhone4 was higest followed by GALAXY Note2 and finally iPad3 for EEG stress score. Conclusion: The results are thought to be used as reference data for smart phone users.

• Journal of The Korean Society of Integrative Medicine
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• v.2 no.2
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• pp.67-78
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• 2014

PURPOSE: The purpose of this study was to investigate the effects of 3 dimensional exercises and Klapp's exercise on parameters of scoliosis in subjects with non-structure scoliosis. METHOD: This study was performed on 24 subjects. Twenty-four subjects were divided into two groups; 3 dimensional exercise(n=12), Klapp's exercise(n=12). Both of the group performed the exercise 3 times a week for 5 weeks. The data was analyzed by the Paired t-test for comparing before and after changes of factors in each group and the Independent t-test for comparing the between groups. RESULT: The result are as follows. There was statistically significant difference of before and after arthopometric parameters, trunk flexion, Cobb's angle in 3 dimensional exercise(p<0.05). There was statistically significant difference of before and after acromion high, trunk extension, Cobb's angle in Klapp's exercise(p<0.05). There was no statistically significant difference of between the two group in arthropometric parameters, ROM, Cobb's angle(p>0.05). CONCLUSION: As a result of this study, we found that the 3 dimensional exercise may be effective more than Klapp's exercise.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.1
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• pp.85-97
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• 2016

Purpose : The purpose of this study was to investigate the effects on the muscle thickness and contraction time using sound wave vibrator and swiss ball. Methods : This study was performed on 20 subjects. 20 subjects were divided into two groups; Lumbar stability exercise using sound wave vibrator exercise(n=10)(Group1), Lumbar stability exercise using Swiss ball exercise(n=10)(Group2). Both of the group performed the exercise 3 times a week for 5 weeks. The data was analyzed by the paired t-test to compare before and after difference of factors on each group and the Independent t-test to compare the between groups. Results : Both group were increased muscle contracture time on Straight Leg Rise(SLR) test (p<0.05). It means both group were increased lumbar stability. However, by comparing the between groups, there were no statistically significant difference about muscle thickness of multifidus and transverse abdominal.(p>0.05). Conclusion : As a result of this study, we suggest that the sound wave vibrator may be effective exercise tool for lumbar stability exercise like a swiss ball.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.1
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• pp.31-39
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• 2016

Purpose : The purpose of this study was to investigate the effects of flexibility and foot pressure on stretching exercise of hamstring muscle with and without pelvis neutral position. Methods : This study was performed on 30 subjects. Thirty subjects were divided into two group; hamstring passive stretching exercise with pelvis neutral position(n=15), hamstring passive stretching exercise without pelvis neutral position(n=15). Both of the group performed the exercise 4 times a week for 6 weeks. The data was analyzed by the paired t-test for comparing before and after changes of factors in each group and the independent t-test for comparing the between groups. Results : The results were as follows. There was statistically significant difference of before and after hamstring flexibility, foot pressure in pelvis neutral position(p<0.05). There was statistically significant difference of before and after hamstring flexibility, foot pressure without pelvis neutral position group(p<0.05). There was no statistically significant difference of between the two group in hamstring flexibility, foot pressure(p>0.05). Conclusion : As a result of this study, though no statistically significant difference of the between groups, we suggest that stretching exercise of hamstring muscle with pelvic neutral may be effective more than stretching exercise of hamstring muscle without pelvic neutral in flexibility, foot pressure.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.2
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• pp.37-51
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• 2016

Purpose: This research was to discover the value of ethics of physical therapy students and physical therapists. This study was launched to provide the bedrock for this field of study by means of getting the data about the current address of value of ethics. Methods: This investigation was conducted with 900 students from seven different universities in Republic of Korea (3, 4-year colleges) and with 350 clinical physical therapists who are currently working in the national capital region. The tool for the research was to revamp and supplement ethics codes in Korean Physical Therapy Association and a set of questions of Jeom Hui Youk (1992), Young Ran Choi (2001), etcetera and each question was provided with different points by the set of measurement we created. The collected data were analyzed by using SPSS 21.0 statistical program. Results: Comparing the average ethics score both on the general information of both groups and the value of ethics of both groups, we were sure to say that the average ethics score of ethics value was significantly more meaningful than that of general information. Conclusion: Physical therapy students establish a correct ethics values and physical therapists should have training in ethic values education are combined accordingly to correct the wrong ethically values and clearly established.

• Journal of The Korean Society of Integrative Medicine
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• v.3 no.4
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• pp.29-35
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• 2015

Purpose: The purpose of this study was to effect of application methods of stretching exercise on angular variation and muscle activation changes in the hallux valgus. Method : This study was performed on twenty subjects. Twenty subjects were divided into two groups; Agonist Contraction(AC)(n=10), Hold-relax with Agonist Contraction(HR-AC)(n=10). Both of the group performed the exercise 5 times a week for 6 weeks. The data was analyzed by the paired t-test for comparing before and after changes of factors in each group and the independent t-test for comparing the between groups. Result : In the within group comparisons, HR-AC group abductor hallucis muscle activity showed significant difference between before and after the intervention(p<0.01). And all the two groups, there were significant decreased in hallux valgus angle(p<0.01). In the comparison of the two groups, there were significant difference among the two groups in abductor hallucis muscle activity(p<0.01). Conclusion : The findings of this study, we found that the HR-AC technique were more effective than AC technique in increase in abductor hallucis muscle activity.

• Journal of The Korean Society of Integrative Medicine
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• v.7 no.1
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• pp.89-98
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• 2019

Purpose : The purpose of this study was to understand the correlations between occupational basic competencies, job searching efficacy and career preparation behavior of department on occupational therapy students. Methods : The subjects of this study were 103 occupational therapy students in D college. The data collection period was from July 1, 2018 to July 30, 2018. The collected data was processed using SPSS 21.0 and were analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test and Pearson's correlation coefficient. Results : The mean scores for occupational basic competencies, job searching efficacy and career preparation behavior of the occupational therapy students were 3.61 (${\pm}0.59$), 3.58 (${\pm}0.61$) and 3.31 (${\pm}0.66$) respectively. The occupational basic competencies score of the Occupational Therapy students was significantly differed according to their age (t=-2.13, p=.03) and grade point average (F=15.01, p=.00). The job searching efficacy of the Occupational Therapy students was significantly different by grade point average (F=3.40, p=.02). There were no significant differences in job preparation behaviors among occupational therapy students according to gender, age, grade and grade point average. There was a positive correlation between occupational basic competencies and job searching efficacy (r=.675, p<.01), between occupational basic competencies and career preparation behavior (r=.455, p<.01), between job searching efficacy and career preparation behavior (r=.702, p<.01). Conclusion : The results of this study suggest the following: It is necessary to repeat this study with a greater number and range of subjects. In addition, it suggests that the progress of study should be developed and continued and refined in order to identify factors that affect the career preparation behavior of students of occupational therapy. In addition, the development of a program and the application of a curriculum to promote occupational basic competencies and job searching efficacy should be a priority.

• Journal of People, Plants, and Environment
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• v.24 no.3
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• pp.301-309
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• 2021

Background and objective: The purpose of this study is to analyze the case of healing experience for lifestyle and environmental diseases through life and activities in the forest from the perspecitive of critical realism, and how the causal power and mechanism of the healing experience relate to forest healing factors and programs. Methods: 93 video data of people who started living in the forest for disease treatment were analyzed using a qualitative content analysis method from the perspective of critical realism. Categories for analysis include general categories (age, duration, occupation, disease name), forest therapy categories (climate therapy, plant therapy, water therapy, diet therapy, kinesiotherapy, psychotherapy), and other categories (ecology, learning and management, life tools), etc., and the unit of analysis is the context unit. Results: 1) The diseases that motivated life in the forest were digestive system diseases, lung diseases, cardiovascular diseases, endocrine system diseases, and various lifestyle-related diseases and environmental diseases in similar proportions. This indicates that forest life does not have specificity to respond to specific diseases, but provides treatment and recovery for all lifestyle and environmental diseases. 2) Among the forest therapies, climate therapy and plant therapy are related to the climatic and residential environment in the forest where 'natural persons' live. And others such as water therapy, diet therapy, kinesiotherapy, psychotherapy indicate the change from the lifestyle that caused the disease to the lifestyle for treatment and recovery. Conclusion: Life and activities in the forest provide an environment for treatment and recovery in which the healing principles such as aromatherapy, nutritional and dietary therapy, kinesiotherapy, and emotional psychotherapy are integrated in the 'real world'.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.3
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• pp.257-266
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• 2022

Purpose : This systematic review examined evidence published 2000-2021 for occupational therapy interventions for adult Attention Deficit Hyperactivity Disorder (adult ADHD). Methods : In order to find out the studies on the effect occupational therapy intervention on individuals with adult ADHD, studies published from 2000 to February 2022 were searched on Google Academic Search. The keywords used were "adult ADHD" AND "Occupational therapy". A total of 785 studies were searched, and from these, 3 studies were selected based on the application of the selection and exclusion criteria. The included studies comprised of 1 Quasi-experimental design study(one group pre-post test) and 2 randomized controlled trials design studies. The included studies were analyzed in PICO(patients, intervention, comparison, outcomes). Results : As a result of analysing the subjects of the included studies, subjects diagnosed with adult ADHD or classified as high-risk group in Adult ADHD Self-Report Scale test, the number of subjects was 97, and the average age was about 33 years old. Occupational therapy intervention methods for adult ADHD include Tailored Intervention, Computerized Cognitive Training, and Cognitive-Functional Intervention. The Adult ADHD Self-Report Scale was the most used to check the symptoms of ADHD, and the COPM was used the most to measure the effects of occupational therapy interventions. The dependent variables of occupational therapy intervention were occupational performance, quality of life, executive function (behavioral regulation, metacognition), self-regulation function, stress management, and sustained attention. The effect of the intervention was statistically significant in 78.5% of the total. Conclusion : It is expected that the results of this study can be used as basic data for evidence-based practice for occupational therapists to apply adult ADHD interventions. In the field of occupational therapy in Korea, research on various interventions that can improve the occupational performance of adults ADHD should be conducted.