• Biomolecules & Therapeutics
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• 제30권3호
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• pp.221-231
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• 2022

Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely adiponectin receptor 1(AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin (CDH13). Ad plays several roles, especially as a regulator. It modulates lipid and glucose metabolism and promotes insulin sensitivity. This demonstrates that Ad has a robust correlation with fat metabolism. Furthermore, although Ad is not in direct contact with other tissues, including the skin, it can be delivered to them by diffusion or secretion via the endocrine system. Recently it has been reported that Ad can impact skin cell biology, underscoring its potential as a therapeutic biomarker of skin diseases. In the present review, we have discussed the association between skin cell biology and Ad. To elaborate further, we described the involvement of Ad in the biology of various types of cells in the skin, such as keratinocytes, fibroblasts, melanocytes, and immune cells. Additionally, we postulated that Ad could be employed as a therapeutic target to maintain skin homeostasis.

• 대한통합의학회지
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• 제12권2호
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• pp.197-210
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• 2024

Purpose : This study aimed to analyze research trends in the field of integrative medicine through a bibliometric analysis of articles published in Integrative Medicine Research (IMR) journal from 2017 to 2022. Methods : Articles published in IMR journal between 2017 and 2022 were searched using the Web of Science database on August 22, 2023. The analysis was performed using the Bibliometrix and Biblioshiny tools in R (version 4.3.1) and VOSviewer (version 1.6.19). Results : The key findings were as follows: average citations per article (9.41), total authors (1,142), single-authored articles (12), average articles per author (0.27), average co-authors per article (5.27), and rate of international co-authorships (15.69 %). The most-cited article was on the cryopreservation of cells or tissues and their clinical applications. The top keyword analysis by author keywords showed that "acupuncture" was the most frequently used keyword (33 times). Co-occurrence network analysis showed 85 high-frequency keywords that appeared five or more times, and the top five keywords by total link strength were "acupuncture," "herbal medicine," "prevalence," "alternative medicine," and "complementary." The study found that, contrary to the trend in complementary and alternative medicine research in Korea, the IMR journal actively conducts intervention studies to provide clinical evidence. Conclusion : In the IMR journal, "acupuncture" was the most frequent of author keywords. The analysis of keyword trend topics over time showed that the keyword "systematic review" continued to appear from 2020 to 2022, and the keyword "clinical practice guideline" appeared for the first time in 2021. In particular, the co-occurrence network analysis highlighted keywords related to intervention research, in contrast to domestic research trends. While this study analyzed only one journal, future studies expanding the category of integrative medicine and increasing the number of journals analyzed may provide further insights.

• 대한감각통합치료학회지
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• 제7권2호
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• pp.77-90
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• 2009

목적: 감각통합중재의 효과에 대한 체계적인 고찰을 통하여 감각통합중재의 객관적인 근거기반을 제시하기 위하여 감각통합중재가 어떤 효과가 있는지 알아보고, 중재 결과 측정에 사용된 평가도구에 관하여 알아보고자 한다. 연구방법: 연구방법으로 체계적 고찰을 사용하였다. 사용된 데이터베이스는 MEDLINE/PubMed, PsycINFO, CINAHL, Cochrane Library, OTSeeker이었고, 검색어는 "effects of sensory integration", "sensory integration therapy"와 "sensory integration intervention"이었다. 최종적으로 분석에 사용된 논문은 11개로, 근거의 질적 수준은 수준 I과 수준 II, IV이었다. 분석내용으로는 감각 통합중재의 대상군과 중재방법, 중재결과 측정 영역에 따라 중재결과를 측정하는 도구 및 중재효과를 분석하였다. 결과: 1. 감각통합중재 대상으로는 자폐스펙트럼장애가 30.7%로 가장 많았으며, 전반적발달장애와 조산아가 각각 15.4%이었다. 2. 감각통합중재 방법으로는 J. Ayres에 의해 제시된 전통적인 방법이 36.4%로 가장 많이 사용되었고, 감각통합 중재의 효과를 알아보기 위하여 사용된 결과측정 영역은 행동의 문제를 해결하기 위한 영역이 40.63%로 가장 많았으며, 운동수행결과를 보기 위한 것이 28.13%, 감각기초 결과를 보기 위한 것이 25.0%이었다. 3. 감각통합중재 효과는 운동수행기술의 중재결과(66.7%)가 가장 많았으며, 그 다음으로는 감각기초를 위한 중재결과가 62.5%, 그리고 행동 문제 해결에 효과적인 경우가 61.5% 순으로 분석 되었다. 학습과 관련하여 쓰기기술에는 효과적이지 않은 것으로 나타났다. 결론: 감각통합중재는 운동수행기술과 감각기초능력 향상, 그리고 행동문제의 해결에 도움을 제공할 수 있는 치료적 접근방법이었으나 학습에 관하여는 효과적이지 않았다. 앞으로 감각통합중재의 일차적인 효과가 지속되어학습이나 일상생활에까지 영향을 미칠 수 있는가에 대한 연구문제를 가지고 연구방법 및 평가도구, 중재방법 등에 관한 연구가 필요할 것으로 생각된다.

• Korean Journal of Acupuncture
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• 제37권4호
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• pp.209-230
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• 2020

Objectives : Practice-Based Research Networks (PBRNs), collaborations of practitioners and academic researchers, have provided platforms for conducting research to address clinical questions generated from daily routine care. This review aimed to critically analyse articles from PBRNs that are related to complementary and integrative medicine (CIM) and to suggest future directions for a PBRN which is appropriate for Korean Medicine (KM). Methods : PubMed, PBRN registries in Agency for Healthcare Research and Quality and relevant PBRN websites were searched up to November 2019 for research articles from PBRNs that focused on CIM regardless of study design. Methodological quality of the included studies was assessed. The included studies were read in full, classified and summarised according to their topics. Results : A total of 51 articles published from 1998 through 2020 were included in this review. They were categorised into three principal themes based on research questions and findings: health services research (embracing researches examining characteristics of patients and CIM practitioners/practices, and communication between patients and practitioners); effectiveness and safety of CIM practices/interventions; and feasibility studies of instruments and interventions in PBRN settings. The study designs varied including surveys (n=30), prospective observational studies (n=6), 2ndary analyses of existing studies (n=7), protocols (n=7), retrospective chart review (n=1) and qualitative study (n=1). Quality of the included studies greatly varied. Conclusions : PBRNs can serve as a feasible platform for conducting practice-relevant research on KM and CIM. Considering growing demands on evidence-base for routine practice of KM amid various stakeholders, a PBRN in KM community and further researches nested within PBRN designs are warranted.

• Journal of Ginseng Research
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• 제47권2호
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• pp.169-172
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• 2023

The coronavirus disease 2019 (COVID) pandemic began in December 2019. Many countries have implemented restrictions such as mandatory mask wearing and social distancing. These measures have caused diverse and complex health problems, particularly in women's health, anxiety, and depression. This review examines an alternative approach to the treatment of endometriosis during the COVID pandemic. The efficacy of ginseng with anti-inflammatory activity and ability to relieve or prevent symptoms of endometriosis is discussed and reviewed.

• 한국화예디자인학연구
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• 제40호
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• pp.3-24
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• 2019

본 연구는 통합적 심리치료를 위한 인테리어 테라피에서 에코 테라피의 접목 가능성을 제시하는데 목적이 있다. 연구방법은 질적 연구의 문헌연구로 한다. 연구과정은 통합적 심리치료에 대해 고찰과 인테리어 테라피에서 에코 테라피의 접목가능요소를 파악하고, 통합적 심리치료를 위한 인테리어 테라피와 에코 테라피의 접목가능성을 제시한다. 연구범위는 첫째, 통합적 심리치료에 대한 문헌고찰, 둘째, 인테리어에서 테라피와 에코에 대한 논의, 셋째, 통합심리치료의 정서적, 인지적, 행동적 측면과 내담자의 심리변화에 따른 체계와의 관련성을 통해 활용방안을 제시한다. 연구결과, 첫째, 정서적 측면은 공간의 설치적 측면과 감성적 측면을 활용한다. 둘째, 인지적 측면은 공간의 에너지적 측면과 설치적 측면을 활용한다. 셋째, 행동적 측면은 공간의 구조적 측면, 설치적 측면, 감성적 측면, 용도적 측면을 활용한다. 시사점은 '식물'을 장식소품의 협의적 개념에서 인간-환경의 유기적 관계 속에서 심리치료 요소로 활용될 수 있는 에코테라피로 확장하여, 향후 디자인 테라피 교육프로그램 개발을 위한 기초자료로 활용되는데 있다.

• 공학교육연구
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• 제20권2호
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• pp.19-30
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• 2017

This paper investigated how three representative domestic and international engineering education journals explored societal supports contributing to retention and persistence in engineering, especially among women. An integrative literature review of engineering education journals was carried out to identify the flow of research and practice of engineering education for females. The findings indicate that retention and persistence of women in engineering is closely relevant to issues of diversity management, collaboration competency, and self-leadership.

• 대한통합의학회지
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• 제4권4호
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• pp.7-11
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• 2016

Purpose : This study was to suggest a recommendation of the role and the operating qualification system of health education specialists. Method : This study was conducted by law and descriptive literature review on health education and health promotion. Result : This study was to analysis of the contents of the National Health Promotion Law and the relevant literature. Conclusion : This study was to analyze the suggestions below to research a health education specialists qualifications and duties and role-specific factors based on the content of legislation and review of the literature.

• Genomics & Informatics
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• 제2권1호
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• pp.7-18
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• 2004

Integrated genomics refers to the use of large-scale, systematically collected data from various sources to address biological and biomedical problems. A critical ingredient to a successful research program in integrated genomics is the establishment of an effective computational infrastructure. In this review, we suggest that the computational infrastructure challenges include developing tools for heterogeneous data organization and access, innovating techniques for combining the results of different analyses, and establishing a theoretical framework for integrating biological and quantitative models. For each of the three areas - data integration, analyses integration, and model integration - we review some of the current progress and suggest new topics of research. We argue that the primary computational challenges lie in developing sound theoretical foundations for understanding the genome rather than simply the development of algorithms and programs.

• Journal of Ginseng Research
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• 제46권2호
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• pp.183-187
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• 2022

The current Covid-19 pandemic has changed the entire world and bought so many unprecedented challenges to the scientific community. More than 5 million people died due to the SARS-COV-2 outbreak. For many thousands of years, ginseng, the traditional herb has been used for various infectious diseases by traditional healers. Ginseng showed promising antiviral effects by modulating both natural and acquired immunity. Ginseng might be used as a potential therapeutic agent to prevent SARS-CoV-2 infection along with the vaccine. In this current review, we offer an alternative approach for SARS-COV-2 prevention during this unprecedented pandemic.