• Journal of Acupuncture Research
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• v.36 no.3
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• pp.182-185
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• 2019

Dural ectasia is defined as ballooning or expansion of the dural sac surrounding the spinal cord. This report describes a rare case of low back pain and sciatica, suspected as being dural ectasia. The patient was hospitalized for 45 days, and underwent integrative Korean medical treatment, including pharmacopuncture, acupuncture, herbal medicine, Chuna therapy, cupping therapy, and physiotherapy. The effect of the treatment was evaluated using the numerical rating scale, Oswestry disability index, European quality of life 5 dimensions, and subjective symptoms. After inpatient treatment, the pain the patient experienced was significantly reduced and the evaluation indices improved. This case report suggested that integrative Korean medical treatment could be an effective therapeutic choice for low back pain and sciatica, with dural ectasia. Further clinical studies are needed to support this observation.

• Korean Journal of Acupuncture
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• v.30 no.1
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• pp.9-15
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• 2013

Objectives : Definition of Life has led an identity and advancement in the knowledge system of science including biomedicine. The world welcomes the new paradigm about the integrative medicine throughout Western Medicine and Traditional Medicine co-exists so far. Methods : Thus this study has comprised how Life was interpreted in Korean Medical history. To reach the purpose, various data and documents about Life subjected to the medical field was collected from medical textbooks and chapters presented in ancient Korean Medicine. Results : Most of important issue is Life as the key even though there are many opinions and conflicts in the view of Life between Western and Korean medical culture. As a result it is not different in the concept of Life each other except for speaking differently same as using the different languages. Integrative Medicine has accepted that it emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies. Integrative Medicine declares to be a kind of medicine if vary medical system can focus on human being. Conclusions : Since Korean Medicine was early therapeutic medical categories developed based on Dao, Korean Medicine have to focus on mind and body interactive relationship and attribute to the public health care system in the future.

• Journal of Korean Traditional Oncology
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• v.27 no.1
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• pp.57-66
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• 2022

Objective: To report the improvements with Korean medicine-based integrative cancer therapies on adverse effects of adjuvant chemotherapy in non-small cell lung cancer patients. Method: There were two patients complained cough, rhinorrhea, numbness, general weakness, nausea and dyspepsia after chemotherapy. They got treated centered on Korean medicine including herbal medicine, acupuncture, electro-acupuncture, pharmacopuncture, moxibustion, hand and foot bath. They were also treated Western immunotherapies like Thymosin at regular intervals. The symptoms were measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care(EORTC QLQ C-15 PAL) and their subjective assessments. Results: Their chief complaints were relieved and their quality of life scores was improved even though they have been receiving chemotherapy continuously. Conclusion: These cases revealed a possibility that Korean medicine-based integrative cancer therapies could improve some symptoms after chemotherapy in non-small cell lung cancer.

• Herbal Formula Science
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• v.24 no.3
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• pp.233-242
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• 2016

Objective : Chronic renal failure(CRF) is defined as a permanent reduction in glomerular filtration rate(GFR), resulting in Structural and functional abnormalities. The purpose of this thesis is to report the improvement of a CRF stage4 on stroke patient through integrative medicine therapy.Methods : We treated the patient with herbal medication(Sibjeondaebo-tang gagambang), acupuncture and moxibustion as well as Western medication. We measured the Creatinine, BUN, eGFR in the serum and observed clinical symptoms During 4monthsResult : After treatment, the level of BUN and Creatinine was decreased and eGFR was increased. And the symptoms of CRF(edema, anorexia, general weakness) were improved.Conclusion : This study suggests that Integrative Medicine Therapy is effective in the treatment of CRF symptoms. In the future, for the effective management of CRF, It is considered necessary to build a systematic integrative medicine therapy.

• Journal of Acupuncture Research
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• v.40 no.2
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• pp.167-175
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• 2023

This study aimed to report the effect of moving cupping therapy (MCT) on peripheral facial palsy (PFP). Four patients with PFP treated with MCT combined with integrative Korean medicine treatment (KMT). Patients were hospitalized for < 17 days. House-Brackmann Grading System (HBGS), Yanagihara grading score (Y-score), and Sunnybrook Facial Grading System (SBGS) were used to assess the changes during treatment periods, and facial photos were taken at admission, interim, and discharge. Facial paralysis symptoms and HBGS grades improved in all patients (Patient 1: HBGS of IV to II; Patient 2: HBGS of V to III; Patient 3: HBGS of IV to II; Patient 4: HBGS of IV to II) following an average of 14.5 days of treatment. The mean (± standard deviation) Y-scores and SBGS scores also increased (Δ[Y-score]: 13.75 ± 3.50 and Δ[SBGS]: 40.00 ± 13.11) from baseline to end of treatment. These findings suggest the clinical effectiveness of MCT combined with integrative KMT in treating patients with PFP.

• Journal of Korean Traditional Oncology
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• v.19 no.1
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• pp.1-24
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• 2014

Objectives : The purpose of this study was to present the clinical guidelines for gastric cancer. Methods : The literature on Western and Oriental medical treatment of gastric cancer were collected, analyzed and summarized from the Google Scholar, KIOM OASIS and PUBMED from 1993 to 2014. Results : Gastric cancer is the second most common cancer in Korea. In recent studies, applying integrative oriental and western medicine can suppress the tumor, improve the survival, the immune system, and the quality of life in gastric cancer. But there isn't still a unified protocol for gastric cancer treatment, so we have difficulty in clinical application. This study will be helpful for understanding and building systems for integrative gastric cancer treatment. Conclusion : Further studies on integrative gastric cancer treatment are needed to improve the survival of gastric cancer patients and build the clinical practice guidelines of gastric cancer.

• The Journal of Korean Medicine
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• v.42 no.1
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• pp.119-128
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• 2021

Objectives: This is a five-year survival case report on non-small cell lung cancer (NSCLC) treated with western medicine and traditional Korean medicine. 44-year old man diagnosed NSCLC IIIB in 2015 went through two months' concurrent chemoradiotherapy (CCRT) first, however the cancer did not response. After CCRT he began to take intensive integrative therapy including acupuncture, abdominal moxibustion, wild ginseng pharmacopuncture, herbal medicinal product of ginseng, hyperthermia, Thymosin α1, and mega vitamin C injection for 4 years and 9 months. After three months of intensive treatment, the state of cancer changed first to partial response and then complete response. He finally succeeded in five-year survival without any recurrence or complication in 2020, We suggest that integrative approach including traditional Korean medicine can be a meaningful treatment option for nonoperable NSCLC. Further studies with more cases should be performed to establish proper treatment protocol of integrative medicine for lung cancer.

• Clinical and Experimental Pediatrics
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• v.48 no.9
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• pp.915-919
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• 2005

The increasing use of complementary and alternative medicine(CAM) in Korea as well as in U.S.A. and Europe seems to lead to a growing integration of CAM with conventional medicine. By using conventional mainstream medicine with CAM(integrative medicine) proved in efficacy and safety, integrative medicine seeks to treat the whole person, to assist the innate healing properties of each person and to promote health and wellness as well as the prevention of diseases. Also in pediatric diseases, especially for cancer patients, integrative medicine serves as an interdisciplinary, comprehensive, and children-centered care which results in more effective care by synergistically combining therapies. But the research to prove the efficacy and safety of CAM and the education for CAM in the medical school should proceed before applying them to patients.

• Korean Journal of Veterinary Research
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• v.58 no.1
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• pp.17-25
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• 2018

This study aimed at determining the current knowledge, attitude, and practices (KAP) of layer and pig farmers to antimicrobial usage and its consequences. Description of such KAP could provide insights useful for promoting the rational use of antimicrobials in livestock. From May 2014 to February 2016, a survey involving 251 respondents in Chiang Mai, Lamphun, and Chonburi provinces, Thailand, was conducted by using a validated questionnaire. More than half (51.0%) of the respondents incorrectly believed that antimicrobial drug efficacy could not be reduced by using sub-recommended dosages, 61.2% had misconceptions about non-therapeutic antimicrobial use, and 66.9% inaccurately felt that antimicrobials were also effective for virus and fungi. Over half (50.6-55.2%) did not see the need to follow instructions or advice of veterinarians. Moreover, only 10.4% regularly relied on responses to drugs sensitivity tests when evaluating the effectiveness of antimicrobials. Overall, assessment of KAP regarding antimicrobial usage indicated that the majority of respondents had low levels of knowledge of antimicrobials, neutral rather than positive attitudes, and employed poor practices in the use of antimicrobials. The results indicate improvements in KAP could be helpful in developing more effective interventions by farmers, reduce antibiotic usage, and slow the growth of antimicrobial resistance.

• Journal of Ginseng Research
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• v.45 no.4
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• pp.465-472
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• 2021

Background: Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Ginsenosides are the major effective compounds of Ginseng, but their protein targets in the brain have not been determined. Methods: We screened proteins that interact with the main components of ginseng (ginsenosides) by affinity chromatography and identified the 14-3-3 ζ protein as a potential target of ginsenosides in brain tissues. Results: Biolayer interferometry (BLI) analysis showed that 20(S)-protopanaxadiol (PPD), a ginseng saponin metabolite, exhibited the highest direct interaction to the 14-3-3 ζ protein. Subsequently, BLI kinetics analysis and isothermal titration calorimetry (ITC) assay showed that PPD specifically bound to the 14-3-3 ζ protein. The cocrystal structure of the 14-3-3 ζ protein-PPD complex showed that the main interactions occurred between the residues R56, R127, and Y128 of the 14-3-3 ζ protein and a portion of PPD. Moreover, mutating any of the above residues resulted in a significant decrease of affinity between PPD and the 14-3-3 ζ protein. Conclusion: Our results indicate the 14-3-3 ζ protein is the target of PPD, a ginsenoside metabolite. Crystallographic and mutagenesis studies suggest a direct interaction between PPD and the 14-3-3 ζ protein. This finding can help in the development of small-molecular compounds that bind to the 14-3-3 ζ protein on the basis of the structure of dammarane-type triterpenoid.