• Journal of Ginseng Research
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• v.46 no.5
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• pp.666-674
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• 2022

Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated ginsenoside metabolite. Methods: Corticosterone (CORT) was administered repeatedly to induce the depression model, and PPD was given concurrently. The tail suspension test (TST) and the forced swimming test (FST) were used for behavioral evaluation. All mice were sacrificed. Golgi-cox staining, GSK 3β activity assay, and Western blot analysis were performed. In vitro, the kinetic binding analysis with the Biolayer Interferometry (BLI) was used to determine the molecular interactions. Results: TST and FST both revealed that PPD reversed CORT-induced behavioral deficits. PPD also ameliorated the CORT-induced expression alterations of hippocampal Ser9 phosphorylated glycogen synthase kinase 3β (p-Ser9 GSK 3β), Ser133 phosphorylated cAMP response element-binding protein (p-Ser133 CREB), and brain-derived neurotrophic factor (BDNF). Moreover, PPD attenuated the CORT-induced increase in GSK 3β activity and decrease in dendritic spine density in the hippocampus. In vitro, 14-3-3 ζ protein specifically bound to p-Ser9 GSK 3β polypeptide. PPD promoted the binding and subsequently decreased GSK 3β activity. Conclusion: These findings demonstrated the antidepressant-like effects of PPD on the CORT-induced mouse depression model and indicated a possible target-based mechanism. The combination of PPD with the 14-3-3 ζ protein may promote the binding of 14-3-3 ζ to p-GSK 3β (Ser9) and enhance the inhibition of Ser9 phosphorylation on GSK 3β kinase activity, thereby activating the plasticity-related CREBeBDNF signaling pathway.

• Journal of TMJ Balancing Medicine
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• v.11 no.1
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• pp.1-11
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• 2021

Dystonia is a neurological disorder characterized by involuntary and uncontrollable muscle tonus abnormalities. It is a huge burden not only to the patients and their families, but also to the field of medicine, in that there has hardly been any substantial change in the concept of and approach to this intractable disorder and therefore no breakthrough to its diagnosis, evaluation and treatment. As an effort to solve the current impasse, this review briefly summarizes the current concept, etiology, diagnosis, treatment and management, and then suggests a rather new therapeutic approach to this disorder, based on the concept of neurological balance and TMJ integrative approach. These new approaches will provide a platform for the clinicians and researchers to have a leap in the concept, diagnosis and therapeutics.

• Architectural research
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• v.16 no.3
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• pp.93-100
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• 2014

Existing BIM(Building Information Modeling) based energy evaluation tools cannot be utilized enough for the potential performance of BIM because most of them have not provided the integrated model for energy evaluation, assessment of the material, cost of the construction, and so on. This research aims to propose and develop a new application, EcoBIM, to support an integrated evaluation of the energy and cost efficiencies of the design alternatives within the design process. The proposed application functions as a BIM-based evaluation system that calculates energy-savings performance as well as the construction cost of the alternatives at the design stage. This study mainly focuses on the possibilities of developing the proposed technology. We also suggest an advanced design process using the proposed system, corresponding to changes of national regulations in Korea. This study deduce that EcoBIM can allow architects to make suitable decisions regarding energy- and cost-efficient designs. The proposed design process will allow architects not only to check the eco-friendly performance of design alternatives but also predict the operation cost in a certain period in the future. EcoBIM can prevent large-scale design changes required to obtain environmental certification and enable the owner to make an informed decision about the initial investment of construction according to the result of the analysis of the energy requirement at the design stage.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.4
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• pp.344-359
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• 2016

Due to the increasing occurrence of maritime accidents and high-level requirements and modernization of naval wars, the concept of ship environment adaptability becomes more and more important. Therefore, it is of great importance to carry out an evaluation system for ship environment adaptability, which contributes to both ship design and classification. This paper develops a comprehensive evaluation system for ship environment adaptability based on fuzzy mathematics theory. An evaluation index system for ship environment adaptability is elaborately summarized first. Then the analytic hierarchy process (AHP) and entropy weighting methods are applied to aggregate the evaluations of criteria weights for each criterion and the corresponding subcriteria. Next, the multilevel fuzzy comprehensive evaluation method is applied to assess the ship integrative environment adaptability. Finally, in order to verify the proposed approach, an illustrative example for optimization and evaluation of five ship alternatives is adopted. Moreover, the influence of criteria weights, membership functions and fuzzy operators on the results is also analyzed.

• IMMUNE NETWORK
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• v.9 no.5
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• pp.179-191
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• 2009

Background: The present study examines a hypothesis that short allergen-derived peptides may shift an Aspergillus fumigatus (Afu-) specific TH2 response towards a protective TH1. Five overlapping peptides (P1-P5) derived from Asp f1, a major allergen/antigen of Afu, were evaluated for prophylactic or therapeutic efficacy in BALB/c mice. Methods: To evaluate the prophylactic efficacy, peptides were intranasally administered to naive mice and challenged with Afu-allergens/antigens. For evaluation of therapeutic efficacy, the mice were sensitized with Afu-allergens/antigens followed by intranasal administration of peptides. The groups were compared for the levels of Afu-specific antibodies in sera and splenic cytokines evaluated by ELISA. Eosinophil peroxidase activity was examined in the lung cell suspensions and lung inflammation was assessed by histopathogy. Results: Peptides P1-, P2- and P3 decreased Afu-specific IgE (84.5~98.9%) and IgG antibodies (45.7~71.6%) in comparison with Afu-sensitized mice prophylactically. P1- and P2-treated ABPA mice showed decline in Afu-specific IgE (76.4~88%) and IgG antibodies (15~54%). Increased IgG2a/IgG1 and IFN-${\gamma}$/IL-4 ratios were observed. P1-P3 prophylactically and P1 therapeutically decreased IL-5 levels and eosinophil peroxidase activity. P1 decreased inflammatory cells' infiltration in lung tissue comparable to non-challenged control. Conclusion: Asp f1-derived peptide P1, prophylactically and therapeutically administered to Balb/c mice, is effective in regulating allergic response to allergens/antigens of Afu, and may be explored for immunotherapy of allergic aspergillosis in humans.

• Journal of Korean Traditional Oncology
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• v.27 no.1
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• pp.1-12
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• 2022

Objectives: To report recurrent pancreatic cancer treated by Korean medicine based-integrated oncology treatment, who is improved quality of life without progression of cancer Method: A 63-year-old female patient diagnosed with recurrent pancreatic cancer in April, 2022 received Chemotherapy with Korean medicine based integrative oncology treatment. Radiologic outcome was assessed by Abdomen Computed Tomography (CT) based on Response Evaluation Criteria In Solid Tumors (RECIST). Clinical outcomes were assessed by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Eastern Cooperative Oncology Group (ECOG), Numeric Rating Scale (NRS) Result: During 2months of treatment, Cancer size was stable in Abdominal CT. Chief complaints, Abdominal pain and dyspepsia, were improved and ECOG score was improved from grade 2 to 1. There were no toxicity on laboratory test and no side effects of grade 3 or higher on NCI-CTCAE. Conclusion: This report shows that Korean medicine based integrative oncology treatment might contribute to synergetic effect to Chemotherapy and improvement of quality of life

• Journal of The Korean Society of Integrative Medicine
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• v.1 no.2
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• pp.13-22
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• 2013

Purpose : The purpose of the research is that get a cut above clinical practice effect through satisfaction of clinical training, practical training, content, oversight of training and evaluation system. Clinical training consists of part of university in Gwang Ju and Jeon nam. Method : The target of training student was studying at physiotherapy a tree or four-year-course collage in Gwang ju and Jean nam. Data collection period is from 21 November 2012 to 1 February. We explained how to do a means of collecting data and get students consent fill in questionnaire. Data collection prossed by using spss 10.1 program also independent proofs, descriptive statistics, crosstabulation, regression analysis and frequency analysis. Results : The subjects average age is 24 in general characteristic. A school system of subjects was a tree-year-course students. They were 58people(39.1%). A school system of subjects was a four-year-course students. They were 90people(60.9%).The male was 72(48.6%) and the female was 76(51.4%). We researched to know about satisfaction of clinical training, practical training, content, environment of practical establishment, trainee manage and evaluation method. All-round satisfaction of clinical training average was 1.90 Satisfaction of clinical training period and content average was 1.83Satisfaction of environment of practical establishment average was 1.88 Satisfaction of clinical training establishments' trainee manage and evaluation average was 1.94 Conclusion : It is important that student can get specific their future and can do at clinical throught clinical training after their graduation improving satisfaction of clinical training would give to impact a physical therapist reserve.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.4
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• pp.1-13
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• 2018

Purpose : The purpose of this study has been performed to find the relationship between seafarers' cumulative fatigue and stress by evaluating autonomic nervous functions and the results of surveys conducted using questionnaires. Methods : The subjects were seafarers working on various ships (home trade ships) of South Korea, who were healthy adults without any diseases, as confirmed through preliminary surveys were recruited through simple random sampling. A device that measures autonomic nervous functions by analyzing heart rate variability, which is also used often in clinical diagnoses and studies at universities, university hospitals, and general hospitals was used to measure the seafarers' cumulative fatigue and stress. Pearson's correlation analyses were also conducted to test the relationship between cumulative fatigue and stress measured by evaluating autonomic nervous functions and the results of surveys conducted with questionnaires. Results : There was no correlation between mean cumulative fatigue measured for each ship type and seafarers position through autonomic nervous functions evaluation and fatigue severity scale (FSS). There also was no correlation between the mean levels of stress measured for each ship type and seafarers position through autonomic nervous functions evaluation and survey scores of Korean occupational stress scale (KOSS). Conclusion : Therefore, in order to prevent man-made accidents in the sea among seafarers working with irregular port entry/departure schedules and under environments involving continued vibration, noises, and shaking, it is necessary to analyzed cumulative fatigue and stress scientifically and objectively, such as through autonomic nervous functions evaluation rather than through surveys.

• KIEAE Journal
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• v.12 no.2
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• pp.3-14
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• 2012

A sustainable evaluation and planning method shall have an integrative methodology for analysis of interrelationship among environmental resource uses and natural conditions during the planning process. However, there are few methods for understanding or achieving sustainable planning in residential development projects for most planner/architects. Therefore, the purpose of this research is to investigate theories of the concept of environmental carrying capacity based on the ecological view, to propose a sustainable planning method for evaluation and planning of environmental sustainability in residential development projects, to analyze interrelationship of selected environmental resources to represent an environmental carrying capacity for a residential development project based on the proposed sustainable planning method. Finally, through the case studies of a high-density housing project located near Seoul Metropolitan area, the existing case and a sustainable case were analysed by the proposed method.

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.35-46
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• 2008

Objective : This study verifies the effects of sensory integrative (SI) therapy on vestibular- and proprioceptive sensory (BPS) processing ability of a child with Asperger Syndrome (AS). Method : A boy who is 11 years and 2 months old took the Functional Independence Measure for Children (Wee-FIM), Canadian Occupational Performance Measure (COPM), Short Sensory Profile, Bruininks-Oserestky Test of Motor Proficiency-2 (BOT-2), and Test of Playfulness (ToP) for the baseline. The child participated in 3 evaluation sessions and 8 therapy sessions based on the AB research design. Duration of each session is 50 min and the therapy session is divided into 40 minutes for treatment and 10 minutes for evaluation. Since the vestibular sense and proprioception build up one's ability of postural control, several tests were employed to evaluate the child' postural control as outcome measure; distance from front leg of chair to heel of the child with sitting (C-H distance), angle between trunk and thigh (hip joint angle) with sitting, and the 'prone-extension posture' which is a subtest of Clinical Observation of Motor and Postural Skill (COMPS) to examine postural control embodied with integration of reflex and BPS processing. Result : During the therapy, average data of the C-H distance is decreased from 27.33cm to 11.69cm, average data of the hip joint angle is also decreased from $43.3^{\circ}$ to $20^{\circ}$, and average time for the prone-extension posture is increased from 13.15seconds to 24.84seconds. Conclusion : This result indicates that the ability to postural control in sitting and to maintain the prone-extension posture can be improved by sensory integrative therapy, with enhanced BPS processing.