• KSBB Journal
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• v.16 no.6
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• pp.538-546
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• 2001

An integrated data analysis program for DNA chip containing normalization, FDM analysis, various kinds of clustering methods, PCA, and SVD was applied to analyze combined yeast cell cycle data. This paper includes both comparisons of some clustering algorithms such as K-means, SOM and furry c-means and their results. For further analysis, clustering results from the integrated analysis program was used for function assignments to each cluster and for motif analysis. These results show an integrated analysis view on DNA chip data.

• Journal of Korean Academy of Rural Health Nursing
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• v.10 no.2
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• pp.75-92
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• 2015

Purpose: The purpose of this study was to examine the effects of an integrated health promotion program provided by one community health post by comparing this program with more traditional health promotion programs provided by other institutions. Methods: The participants in this study were 110 selected local residents from I city. Of them, 55 residents participated in the integrated health promotion program in the community health post, and the other 55 participated in a program at another institution. SPSS 21.0 was used for descriptive analysis. Result: Scores for program effects, satisfaction level, quality of life related to health and depression were higher for the integrated health promotion program offered by the community health post compared to health promotion programs of the other institution. The differences were statistically significant. Conclusion: The findings of the study indicate that the integrated health promotion program can be helpful for community health posts in being successful in future plans to meet the needs of residents. Use of this program will also contribute to the development of community health posts but sustained research efforts need to be channeled into these programs.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.21 no.1
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• pp.30-38
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• 2013

This paper describes the design optimization of Unmanned Aerial Vehicles(UAVs). An optimization framework has been developed and implemented for the conceptual design of UAVs. An integrated design analysis program was developed with several analysis modules such as propulsion, performance, mission, weight, and stability and control. A UAV configuration design optimization was performed by implementing the integrated analysis to enhance the endurance of UAVs. A SQP optimizer was utilized to build an optimization module for this program and sensitivity analysis was performed to determine the trends of shape variables for developing optimization objective. In conclusion, the results indicate that the resulting optimized UAVs configurations show performance improvements over the baseline design and reliable analysis results.

• Journal of Microbiology and Biotechnology
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• v.23 no.12
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• pp.1791-1801
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• 2013

Diketopiperazine is produced by various organisms, including bacteria, fungi, and animals, and has been suggested as a novel signal molecule involved in the modulation of genes with various biological functions. Vibrio vulnificus, which causes septicemia in humans, produces cyclo($\small{L}$-phenylalanine-$\small{L}$-proline) (cFP). To understand the biological roles of cFP, the effect of the compound on the expression of the total mRNA in V. vulnificus was assessed by next-generation sequencing. Based on the transcriptomic analysis, we classified the cFP-regulated genes into functional categories and clustered them according to the expression patterns resulted from treatment with cFP. From a total of 4,673 genes, excepting the genes encoding tRNA in V. vulnificus, 356 genes were up-regulated and 602 genes were down-regulated with an RPKM (reads per kilobase per million) value above 3. The genes most highly induced by cFP comprised those associated with the transport and metabolism of inorganic molecules, particularly iron. The genes negatively regulated by cFP included those associated with energy production and conversion, as well as carbohydrate metabolism. Noticeably, numerous genes related with biofilm formation were modulated by cFP. We demonstrated that cFP interferes significantly with the biofilm formation of V. vulnificus.

• KSBB Journal
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• v.16 no.4
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• pp.381-388
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• 2001

A program for integrated gene expression profile analysis such as hierarchical clustering, K-means, fuzzy c-means, self-organizing map(SOM), principal component analysis(PCA), and singular value decomposition(SVD) was made for DNA chip data anlysis by using Matlab. It also contained the normalization method of gene expression input data. The integrated data anlysis program could be effectively used in DNA chip data analysis and help researchers to get more comprehensive analysis view on gene expression data of their own.

• Mass Spectrometry Letters
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• v.6 no.3
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• pp.80-84
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• 2015

Here, we demonstrate the use of MALDI-TOF as a fast and simple analytical approach to evaluate the DNA-binding capability of various peptides. Specifically, by varying the amino acid sequence of the peptides consisting of lysine (K) and tryptophan (W), we identified peptides with strong DNA-binding capabilities using MALDI-TOF. Mass spectrometric analysis reveals an interesting novel finding that lysine residues show sequence selective preference, which used to be considered as mediator of electrostatic interactions with DNA phosphate backbones. Moreover, tryptophan residues show higher affinity to DNA than lysine residues. Since there are numerous possible combinations to make peptide oligomers, it is valuable to introduce a simple and reliable analytical approach in order to quickly identify DNA-binding peptides.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.31 no.1
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• pp.66-76
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• 2024

Purpose: This study aimed to develop and evaluate an integrated management program to enhance self-efficacy, compliance with sick-role behaviors, symptom management, and biomarker indication in hemodialysis patients. Methods: The integrated management program was developed through a systematic review of literature, analysis of relevant online data, and expert validation. It comprised 480 min of video-based education delivered eight times over four weeks, supplemented by weekly phone consultations and text message support from a nurse. To evaluate the program's effectiveness, it was administered to 44 patients with hemodialysis in a single group in a pre-post test experimental study. Changes in self-efficacy, sick-role behavior compliance, dialysis symptom index, and biomarkers were assessed. Results: The program yielded statistically significant improvements in self-efficacy (t=-7.13, p<.001), sick-role behavioral compliance (t=-7.35, p<.001), dialysis symptom index (t=4.32, p<.001), and blood urea nitrogen levels (t=2.55, p=.014) among the participants. Conclusion: The integrated management program is an effective intervention for improving hemodialysis patients' self-efficacy, compliance with sick-role behaviors, and experience of symptoms. Additionally, it is considered an intervention with high clinical applicability and efficiency through video reproducibility.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.766-768
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• 2004

Rubbed films of a series of poly(p-phenylene 3,6-bis(4-(n-alkyloxy)phenyloxy)pyromellitimide)s (Cn-PMDA-PDA PIs), which are well-defined brush PIs composed of two aromatic-aliphatic bristles per repeat unit of a fully rodlike backbone, were investigated in detail using atomic force microscopy (AFM), optical retardation analysis and linearly polarized infrared (IR) spectroscopy in order to elucidate their surface morphology and molecular orientation. The liquid crystal (LC) alignment behavior and the anchoring energy of LC molecules on the rubbed films were also determined.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1994.10a
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• pp.17-24
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• 1994

The pre- and post-processor for finite element structural analysis considering the user-friendly device are developed by using GUI. These can be used on WINDOWS' environment which is realized the multi-tasking and the concurrency by object-oriented paradigm. They are designed to control integratedly the pre-processing, execution and the post-processing of the finite element structural analysis program on multiple windows. These object-oriented modeling approach can be used for complex integrated engineering systems.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1993.10a
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• pp.120-127
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• 1993

This paper is concerned with the integrated computer program system aiming at efficiently performing the structural analysis and design. The developed computer program system is introduced and applied to a simple two-dimensional structure to show the general concept of the integrated system. Some design modifications and re-analyses are illustrated including local mesh refinement, These show the efficiency in doing design modification and analysis.