• Nuclear Engineering and Technology
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• v.53 no.11
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• pp.3597-3611
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• 2021

The present paper studies the thermal-hydraulic behaviour of the rectangular supercritical natural circulation loop (SCNCL) using numerical model of one dimensional. Then the results of this model is confirmed with experimental and benchmark results. Variations with several geometric parameters like loop diameter, riser length, and heater length and operating conditions like heater inlet enthalpy, pressure, friction factor, and inlet and exit loss coefficient on steady-state performance are investigated for various orientations like HHHC, HHVC, VHVC and VHHC of the heater and cooler. The chances of existing static instability (Ledinegg excursion) has been investigated, which reveals that it can arise only in a low inlet enthalpy condition, far from the suggested various orientations of heater and cooler.

• Journal of Digestive Cancer Research
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• v.3 no.1
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• pp.5-10
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• 2015

With advances in the understanding of the biology and genetics of colorectal cancer (CRC), diagnostic biomarkers that may predict the existence or future presence of cancer or a hereditary condition, and prognostic and treatment biomarkers that may direct the approach to therapy have been developed. Biomarkers can be ascertained and assayed from any tissue that may demonstrate the diagnostic or prognostic value, including from blood cells, epithelial cells via buccal swab, fresh or archival cancer tissue, as well as from cells shed into fecal material. For CRC, current examples of biomarkers for screening and surveillance include germline testing for suspected hereditary CRC syndromes, and stool DNA tests for screening average at-risk patients. Molecular biomarkers for CRC that may alter patient care and treatment include the presence or absence of microsatellite instability, the presence or absence of mutant KRAS, BRAF or PIK3CA, and the level of expression of 15-PGDH in the colorectal mucosa. Molecularly targeted therapies and some general therapeutic approaches rely on biomarker information. Additional novel biomarkers are on the horizon that will undoubtedly further the approach to precision or individualized medicine.

• Kyungpook Mathematical Journal
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• v.64 no.2
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• pp.353-369
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• 2024

In this study, we investigate the unknown time-dependent heat source function in inverse problems. We consider three general nonlocal conditions; two classical boundary conditions and one nonlocal over-determination, condition, these genereate six different cases. The finite integration method (FIM), based on numerical integration, has been adapted to solve PDEs, and we use it to discretize the spatial domain; we use backward differences for the time variable. Since the inverse problem is ill-posed with instability, we apply regularization to reduce the instability. We use the first-order Tikhonov's regularization together with the minimization process to solve the inverse source problem. Test examples in all six cases are presented in order to illustrate the accuracy and stability of the numerical solutions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.7 s.262
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• pp.620-627
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• 2007

In this paper, we adapt a modified internal energy non-equilibrium first-order extrapolation thermal boundary condition to the thermal lattice Boltzmann model (TLBM). This model is the double populations approach to simulate hydrodynamic and thermal fields. The bounce-back boundary condition which is a traditional boundary condition of lattice Boltzmann method has only a first order in numerical accuracy at the boundary and numerical instability. A non-equilibrium first-order extrapolation boundary condition has been verified to be of better numerical stability than the bounce-back boundary condition and this boundary condition is proved to be of second-order accuracy for the flat boundaries. The two-dimensional natural convection flow in a square cavity with Pr=0.71 and various Rayleigh numbers are simulated. The results are found to be in good agreement with those of previous studies.

• Journal of Biomedical Engineering Research
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• v.33 no.2
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• pp.78-88
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• 2012

Knee joint instability by anterior cruciate ligament(ACL) rupture is allowing the abnormal loading condition at the tibial epiphysis locally, resulting in producing locally different bone bruise. The study examined difference between local alteration patterns of trabecular bone microarchitecture at medial and lateral parts of the tibial epiphysis by ACL rupture. Fourteen SD rats were divided into Control(CON; n = 7) and Anterior Cruciate Ligament Transection(ACLT; n = 7) groups. The tibial joints were then scanned by in vivo ${\mu}$-CT at 0, 4, and 8 weeks post-surgery. The results showed that alteration pattern on trabecular bone microarchitecture at medial part was significantly higher than that at lateral part of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). Tb.Th and Tb.Sp distributions were well corresponded with differences between aforementioned trabecular bone microarchitectural alteration pattens at medial and lateral parts of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). These findings suggest that the alteration patterns of trabecular bone microarchitecture should be locally and periodically considered, particularly with respect to the prediction of bone fracture risk by ACL rupture. Improved understanding of the alteration patterns at medial and lateral trabecular bone microarchitectures at the tibial epiphysis may assist in developing more targeted treatment interventions for knee joint instability secondary to ACL rupture.

• Journal of the Korean Society of Propulsion Engineers
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• v.16 no.5
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• pp.10-19
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• 2012

To eliminate the onset of combustion instabilities and develop effective approaches for control, flame structure is very important. In this study, we conducted experiments under various operating conditions with a model gas turbine combustor to examine the relation of combustion instability and flame structure by OH chemiluminescence and laser diagnostics of He-Ne laser absorbtion system. The swirling LNG($CH_4$)/air flame was investigated with overall equivalence ratio of 1.2 and dump plane fuel-air mixture velocity 25 ~ 70 m/s. We founded that the combustion instability phenomenon occurs at lower mixing velocity and higher mixing velocity conditions. We also concluded that fluid dynamical vortex frequency has major effects on the combustion instability characteristics at lower mixing velocity condition.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.259-264
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• 2005

Measurements of heat release are very important for controling combustion instabilities, which are closely connected with combustion instabilities. $OH^{\ast}$ images were acquired through a ICCD in this study, which were in use as indicating index of the reacting region, global and local heat release rate in the lean premixed combustion. The objectives of this study are to see the effect of equivalence ratio on global heat release rate and local Rayleigh index distribution. The local Rayleigh index distribution was acquired by information from central section of flame. This information was from the line-of-sight images which were inverted by the Abel de-convolution. In each condition, the mean value of heat release increased exponentially with equivalence for a periodic time. Local Rayleigh index distribution cleary showed the region of amplifying or damping the combustion instability as the equivalence ratio increased. This could provide an insight on the region of combustion instability and the structure of flames on the equivalence ratio.

• Journal of the Korean Geotechnical Society
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• v.18 no.2
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• pp.97-105
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• 2002

Random properties of discontinuities were attributed to the limitation of test methods and lack of obtained data. Therefore, the uncertainties are pervasive and inevitable in rock slope engineering as well as other geotechnical engineering fields. The probabilistic analysis has been proposed to deal properly with the uncertainty. However, previous probabilistic approaches do not take account of the condition of kinematic instability but consider only kinetic instability. In this study, in order to overcome the limitation of the previous studies, the geometric characteristics as well as the shear strength characteristics in discontinuities are taken account into the probabilistic analysis. Then, the new approach to evaluate the probability of failure is suggested. The results of the deterministic analysis which was carried out to compare with the result of the probabilistic analysis, are somewhat different from those of the probabilistic approach. This is because the selected and used data in the deterministic approach do not take account of the random properties of discontinuities.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.8
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• pp.857-864
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• 2012

A linear stability analysis of a diffusion flame with radiation heat loss is performed to identify linearly unstable conditions for the Damk$\ddot{o}$hler number and radiation intensity. We adopt a counterflow diffusion flame with unity Lewis number as a model. Near the kinetic limit extinction regime, the growth rates of disturbances always have real eigenvalues, and a neutral stability condition perfectly falls into the quasi-steady extinction. However, near the radiative limit extinction regime, the eigenvalues are complex, which implies pulsating instability. A stable limit cycle occurs when the temperatures of the pulsating flame exceed the maximum temperature of the steady-state flame with real positive eigenvalues. If the instantaneous temperature of the pulsating flame is below the maximum temperature, the flame cannot recover and goes to extinction. The neutral stability curve of the radiation-induced instability is plotted over a broad range of radiation intensities.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.9
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• pp.1627-1634
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• 2017

In this work, a junctionless transistor with different film thickness of amorphous InGaZnO has been fabricated and it's instability has been analyzed with different film thickness under positive and negative gate stress as well as light illumination. It was found that the threshold voltage shift and the variation of drain current have been increased with decrease of film thickness under the condition of gate stress and light illumination. The reasons for the observed results have been explained by stretched-exponential model and device simulation. Due to the reduced carrier trapping time with decrease of film thickness, electrons and holes can be activated easily. Due to the increase of vertical channel electric field reaching the back interface with decrease of film thickness, more electrons and holes can be accumulated in back interface. When one decides the film thickness for the fabrication of junctionless transistor, the more significant device instability with decrease of film thickness should be consdered.