• 한국응급구조학회지
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• 제17권1호
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• pp.63-78
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• 2013

Purpose : This study aimed to improve quality of prehospital emergency care for the insect bite patients by figuring out its current situations and problems. Methods : This study was conducted to 219 insect bite patients who were transferred to the hospital by 119 ambulance in D-City from July 1, 2009 to June 30, 2011. This study was a descriptive study by 119 run sheets. A total of 171 emergency medical technicians(EMTs) working in D-city and C-province completed the questionnaire. All of data were analyzed by SPSS 18.0. Results : Among the 219 patients, bee sting accounted for 62.6% and wasp sting accounted for 20.1%. Some patients complained of dizziness, headache, dyspnea, and disturbance of consciousness. The 119 EMTs initially treated the patients with oxygen supply to 57 patients (31.1%). Knowledge toward insect bite was statistically significant (p=.000) between advanced EMTs and basic EMTs. The obstacle to the prehospital care, many EMTs answered that the obstacle was due to the lack of 119 EMTs. Conclusion : It is necessary to differentiate the patients' symptoms and provide the better prehospital emergency care to verify the exact symptoms and signs.

• Parasites, Hosts and Diseases
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• 제46권4호
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• pp.269-271
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• 2008

A healthy 30-yr-old woman carrying an insect that had been caught in her living room visited the International Clinic at Severance Hospital, Seoul, in December 2007. The insect she brought was identified to be a nymph of a bedbug, Cimex lectularius, and her skin rashes looked typical bedbug's bites. Her apartment was investigated, and a dead body of a bedbug, cast skins, and hatched eggs were found in her rooms and neighbors' rooms in the same building. She was living in that apartment in Seoul for 9 months since she had moved from New Jersey, USA. We assume that the bedbugs were introduced from abroad, since there had been no report on bedbugs in Seoul for more than 2 decades at least. This is a report of a reemergence of the common bedbug, C. lectularius in Seoul, Korea.

• 대한기관식도과학회지
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• 제3권2호
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• pp.323-326
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• 1997

Kimura's disease is a chronic inflammatory disease which often presents as a tumor like swelling in the head and neck region. This lesion is benign but it may easily be mistaken for a malignant tumor. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia(ALHE). The cause is unknown, but theories include autoimmune, allergic, neoplastic, and infectious cause by insect bites and parasites. The treatment of choice is surgical removal. Recently we experienced a case of Kimura's disease occuring in the both side of posterior neck triangle area of a 37 year old male patient who was treated with surgical excision and systemic corticosteroid administration.

• 한방안이비인후피부과학회지
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• 제15권1호
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• pp.285-290
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• 2002

Urticaria is classified as Eunjin in Oriental Medicine. The intrinsic causes include digestive system disorder, food poison, parasite, female reproductive health problem, nervous breakdown, and disorder of endocrine hormone. The extrinsic sources include all kinds of insect bites or stings, medications, pollen, dirt, and toxic smells. Some unknown sources also produce urticaria. The urticaria that lasts for more than six weeks, is categorized as chronic urticaria which is not very different from acute urticaria that occurs rapid but for a short period. The chronic urticaria may come every day, and its symptoms can even get worse at irregular or regular intervals. The cycle is hard to predict. It could be weeks or years. In clinical treatments, the syndromes of patient's chronic urticaria with cerebral hemorrhage have been analyzed and identified as follows: The diagnosis by asking the patient's case history showed that the root cause was retention of food resulting from dysfunction of the spleen and stomach. First, Pyeongwisan was dosed. From the syndrome differentiation with four diagnostic methods, we diagnosed the symptoms as Poong yoel (wind-heat). Then, Hyeongbangpaedocksangamibang was prescribed to get very effective results.

• 동의생리병리학회지
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• 제31권6호
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• pp.348-355
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• 2017

Aster yomena (AY) have been used as a traditional medicine to treat cough, bronchial asthma, and insect bites in Korea. In this study, we evaluated the inhibition of adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-induced obese mice by AY ethanol extract. Lipid accumulation measurement indicates that AY markedly inhibited adipogenesis in a dose-dependent manner. qRT-PCR results demonstrated that the mRNA expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor-${\gamma}$ ($PPAR-{\gamma}$) in 3T3-L1 cells were significantly down-regulated by AY treatment. And inhibited the expression of FAS, a protein responsible for lipid synthesis, transport and storage. Oral administration of AY (100, 250, and 500 mg/kg, P.O/daily for 4 weeks) was conducted in high-fat diet induced obese mice and C57BL/6 mice. AY was orally administered for 4 weeks to extract liver and epididymal fat, and hematoxylin and eosin staining(H&E staining) was observed. Observation showed that the fat concentration of liver tissue tended to decrease dose-dependently and decreased significantly at 500 mg/kg concentration. The AY-administered group of HFD-induced mice had a lower body weight gain, along with decreased triglycerides and total cholesterol compared with the control mice, however, the HDL-cholesterol/total cholesterol ratio was increased. These results indicate that AY exhibits anti-obesity effects in obese mice by decreasing in serum lipid levels and lipogenesis related gene.

• 한국패션뷰티학회지
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• 제5권3호
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• pp.111-117
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• 2007

Essential oils aims to rejuvenate and beautify medical skin care the body through the use of essential oils, and generally to improve our outward appearance. Much of this section fouses on the different methods by which essential oils can be used to improve the complexion or to treat specific medical care skin conditions. Beauty, however, is not just skin-deep. The condition of the medical care express the overall health of an individual. A relaxed attitude, together with a well-balanced diet, enough exercise, and a daily intake of plenty of spring water or herbal teas, all help to keep the system in top condition. Essential oils is a healing art which has powerful effects on both mind and body. The vital element in essential oils is the pure oils which are extracted from various part of different plants. The key to medical aromatherapy care lies in its dual use of essential oils and medical care massage, thus masking full use of two of our most important senses-smell and touch. Medical aromatherapy care is holistic, working mainly on the nervous system and including the head and body as part of the same treatment. Using pressure points along the spine, Medical aromatherapy care on the autonomic nervous system and has an immediate effect of relexation. In directly it also acts on mood. Many of the medical massage movements help lymphatic drainage. Essential oils have many different qualities; they can be relaxing or invigorating and are generally antisepic and antibacterial. Medical aromatherapy care can have psychological benefits. The power of essences in healing has been recognized in the treatment of insect bites. Clove, thyme, sandalwood, and lavender are a few of the essences that have antiseptic. Essential oils effect the dry skin for small visual pores, dull matte finish, rough sandy feeling, tantskin. Essential oils effect the mature/sun damaged skin for some red or couperose areas, loose saggy skin, exposure to a lot of ultraviolet light. Essential oils effect the medical care nomal skin good elasticity, healthy color(good circulation), smooth terture.

• 대한본초학회지
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• 제23권2호
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• pp.179-192
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• 2008

Objectives : Draconis Resina (DR) has been used as a traditional Korean herbal medicine since ancient times, and today it is used as a medication for wounds, tumors, diarrhea, rheumatism, in the itching of insect bites and with other conditions in the folk medicine. The aim of this study was to determine whether fractionated extracts of DR inhibit free radical generation, intracellular oxidation, production of nitrite, an index of NO, PGE2, iNOS, COX-2 and proinflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, Methods : DR extract prepared with methanol, and then fractionated with hexane, dichloromethane, ethylacetate, n-butanol and water. Inhibitory effect of DR onto free radical generation was determined by measuring DPPH, superoxide anions and nitric oxide scavenging activities in vitro. Cytotoxic activity of extracts on RAW 264.7 cells was measured using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. Intracelluar oxidation was analysed by DCF-DA assay. The nitric oxide (NO) production was measured by Griess reagent system. The levels of iNOS and COX-2 expression were confirmed by western blot. And proinflammatory cytokines were measured by ELISA kit. Results : Our results indicated that fractionated extracts, especially dichloromethane and ethyl acetate extracts, significantly inhibited free radical generation, the LPS-induced H202, NO, PGE2 production and iNOS, COX-2 expression accompanied by an attenuation of TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 formation in macrophages. Conclusions : Our results indicate that dichloromethane and ethyl acetate extracts of DR have potential as an agent of chronic inflammatory diseases.

• 한국식품과학회지
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• 제34권1호
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• pp.123-127
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• 2002

Echinacea angustifolia의 줄기와 뿌리 methanol 추출물과 용매별 분획물의 인간유래 백혈암세포인 HL60과 폐암세포인 3LL 세포를 대상으로 항암 활성을 검색한 결과는 다음과 같다. HL60 세포의 경우에 뿌리 추출물은 저농도(0.125 mg/mL)에서 ethylacetate, acqueous, buthanol 분획물의 순으로 $77%{\sim}72%$의 세포독성효과를 나타내었고, hexane 분획물이 저농도에서는 독성효과가 낮았으나 점진적으로 독성효과가 커짐(1.0 mg/mL, 82%)을 알 수 있었다. 3LL 세포주에 대해서는 뿌리의 경우 저농도(0.25 mg/mL)에서 buthanol, ethylacetate 분획물이 $43.5%{\sim}26.3%$의 낮은 세포독성효과를 나타내었고, 1.0 mg/mL 농도에서는 chloroform, hexane 분획물이 $68.4%{\sim}58.5%$의 세포독성을 나타내었다. 에키네시아의 줄기보다 뿌리의 세포독성이 컸고, HL60이 3LL보다 세포독성이 크게 나타났다.

• Parasites, Hosts and Diseases
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• 제52권1호
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• pp.93-97
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• 2014

Subolesin (4D8), the ortholog of insect akirins, is a highly conserved protective antigen and thus has the potential for development of a broad-spectrum vaccine against ticks and mosquitoes. To date, no protective antigens have been characterized nor tested as candidate vaccines against Dermacentor silvarum bites and transmission of associated pathogens. In this study, we cloned the open reading frame (ORF) of D. silvarum 4D8 cDNA (Ds4D8), which consisted of 498 bp encoding 165 amino acid residues. The results of sequence alignments and phylogenetic analysis demonstrated that D. silvarum 4D8 (Ds4D8) is highly conserved showing more than 81% identity of amino acid sequences with those of other hard ticks. Additionally, Ds4D8 containing restriction sites was ligated into the pET-32(a+) expression vector and the recombinant plasmid was transformed into Escherichia coli rosetta. The recombinant Ds4D8 (rDs4D8) was induced by isopropyl ${\beta}$-D-thiogalactopyranoside (IPTG) and purified using Ni affinity chromatography. The SDS-PAGE results showed that the molecular weight of rDs4D8 was 40 kDa, which was consistent with the expected molecular mass considering 22 kDa histidine-tagged thioredoxin (TRX) protein from the expression vector. Western blot results showed that rabbit anti-D. silvarum serum recognized the expressed rDs4D8, suggesting an immune response against rDs4D8. These results provided the basis for developing a candidate vaccine against D. silvarum ticks and transmission of associated pathogens.