• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.166-171
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• 2018

Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics education. General formulas for time courses of drug concentrations after single and multiple dosing were used to build source code that allows users to simulate situations tailored to their learning objectives. A mathematical relationship for a 1-compartment model was implemented in the form of differential equations. The concept of population pharmacokinetics was also taken into consideration for further applications. The source code was written using R. For the convenience of users, two types of software were developed: a web-based simulator and a standalone-type application. The application was built in the JAVA language. We used the JAVA/R Interface library and the 'eval()' method from JAVA for the R/JAVA interface. The final product has an input window that includes fields for parameter values, dosing regimen, and population pharmacokinetics options. When a simulation is performed, the resulting drug concentration time course is shown in the output window. The simulation results are obtained within 1 minute even if the population pharmacokinetics option is selected and many parameters are considered, and the user can therefore quickly learn a variety of situations. Such software is an excellent candidate for development as an open tool intended for wide use in Korea. Pharmacokinetics experts will be able to use this tool to teach various audiences, including undergraduates.

• Journal of the Microelectronics and Packaging Society
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• v.25 no.1
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• pp.41-45
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• 2018

As the size of semiconductor chip shrinks, the electronic industry has been paying close attention to fan-out wafer level packaging (FO-WLP) as an emerging solution to accommodate high input and output density. FO-WLP also has several advantages, such as thin thickness and good thermal resistance, compared to conventional packaging technologies. However, one major challenge in current FO-WLP manufacturing process is to control wafer warpage, caused by the difference of coefficient of thermal expansion and Young's modulus among the materials. Wafer warpage induces misalignment of chips and interconnects, which eventually reduces product quality and reliability in high volume manufacturing. In order to control wafer warpage, it is necessary to understand the effect of material properties and design parameters, such as chip size, chip to mold ratio, and carrier thickness, during packaging processes. This paper focuses on the effects of thickness of chip and molding compound on 12" wafer warpage after PMC of EMC using finite element analysis. As a result, the largest warpage was observed at specific thickness ratio of chip and EMC.

• Korean Journal of Optics and Photonics
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• v.18 no.4
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• pp.280-285
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• 2007

Based on the multimode fiber taper, a mode size converter for effective optical beam coupling between laser and optical fiber or between the two different optical fibers has been proposed and demonstrated. The device has a multimode input end and a single mode output end. The influence of various parameters, including device structure and launching conditions, on the coupling efficiency has been theoretically analyzed. The theoretical results revealed that the gaussian beam can be coupled into a single mode fiber without considerable insertion loss. The proposed multimode fiber taper has been fabricated using heating and pulling equipment incorporating two micro-torches. Experimental results showed that an optical beam with $50\;{\mu}m$ of large beam size was effectively coupled into single mode fiber through the multimode fiber taper. The insertion loss of the device was 1.3 dB.

• The Transactions of the Korean Institute of Power Electronics
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• v.12 no.3
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• pp.267-275
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• 2007

This paper presents about energy input and output modeling for a flywheel energy storage system that can store and supply mechanical energy, which is emerging as one of clean energy sources, and the analysis and control of a PWM inverter system. Moreover, this paper describes flywheel's characteristics related to variations of mechanical and electrical parameters like as voltage and current versus speed characteristics formed as numerical formula and thus simulate behaviour-status of flywheel energy. Also for comparison and analysis between PI control and PDFF control, the modeling, design and analysis to the single-phase full bridge inverter with double loop feedback control is accomplished through numerical description and simulation. Finally, under load condition 0.1[pu], 1[pu]. it is validated that harmonic characteristics for voltage and current wave is controlled within 5% below even dynamics condition.

• Geomechanics and Engineering
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• v.33 no.3
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• pp.279-289
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• 2023

Brittleness index (BI) is an important property of rocks because it is a good index to predict rockburst. Due to its importance, several empirical and soft computing (SC) models have been proposed in the literature based on the punch penetration test (PPT) results. These models are very important as there is no clear-cut experimental means for measuring BI asides the PPT which is very costly and time consuming to perform. This study used a novel Multivariate Adaptive regression spline (MARS), M5P, and white-box ANN to predict the BI of rocks using the available data in the literature for an improved BI prediction. The rock density, uniaxial compressive strength (σ_c) and tensile strength (σ_t) were used as the input parameters into the models while the BI was the targeted output. The models were implemented in the MATLAB software. The results of the proposed models were compared with those from existing multilinear regression, linear and nonlinear particle swarm optimization (PSO) and genetic algorithm (GA) based models using similar datasets. The coefficient of determination (R²), adjusted R² (Adj R²), root-mean squared error (RMSE) and mean absolute percentage error (MAPE) were the indices used for the comparison. The outcomes of the comparison revealed that the proposed ANN and MARS models performed better than the other models with R² and Adj R² values above 0.9 and least error values while the M5P gave similar performance to those of the existing models. Weight partitioning method was also used to examine the percentage contribution of model predictors to the predicted BI and tensile strength was found to have the highest influence on the predicted BI.

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.78-90
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• 2017

This paper presents the design of closed loop controllers operating a single-phase AC-DC three-level converter for improving power quality at AC mains. Closed loop inhibits outer voltage controller and inner current controller. Simulations of three level converter with three different voltage and current controller combinations such as PI-Hysteresis, Fuzzy-Hysteresis and Fuzzy tuned PI-Hysteresis are carried out in MATLAB/Simulink. Performance parameters such as input power factor and source current total harmonic distortion (THD) are considered for comparison of the three controller combinations. The fuzzy-tuned PI voltage controller with hysteresis current controller combination provides a better result, with a source-current THD of 0.93% and unity power factor without any source side filter for the three level converter. For load variations of 25% to 100%, a THD of less than 5% is obtained with a maximum value of only 1.67%. Finally, the fuzzy-tuned PI voltage with hysteresis controller combination is implemented in a Xilinx Spartan-6 XC6SLX25 FPGA board for experimental validation of power quality enhancement. A prototype 100 W, 0-24-48 V as output converter is considered for the testing of controller performance. A source-current THD of 1.351% is obtained in the experimental study with a power factor near unity. For load variations of 25% to 100%, the THD is found to be less than 5%, with a maximum value of only 2.698% in the experimental setup which matches with the simulation results.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.9
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• pp.907-915
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• 2002

In this paper, a compact digital phase shifter to be used an active phased array antenna system for satellite communications was proposed. The even and odd mode analysis for a given reflection-type phase shifter, which uses a folded hybrid coupler as a base element, was performed and the design parameters were derived. Also, to verify experimentally the electrical performances of the proposed structure, X-band 4-bit digital phase shifter was designed and fabricated using Teflon soft substrate $({\varepsilon}_r; =\;2.17)$. Its circuit size was less than 3.5 cm $\times$ 3.0 cm, and it exhibited at least 50 % size reduction as compared with the conventional unfolded configuration. The experimental results of the fabricated phase shifter showed that the average insertion loss and insertion loss variation were less than 3.5 dB, $\pm$ 0.6 dB within the operating band, 7.9 ~ 8.4 GHz, respectively. And, input and output return loss were more than 10 dB, respectively. Also, the phase response of the phase shifter showed 4-bit operation with $\pm$3$^{\circ}$ rms phase error.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.5
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• pp.463-470
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• 2015

In this paper, a new dual-band bandpass filter(BPF) that has resonators and feed lines with Stepped-Impedance Resonator(SIR) structures is proposed. Feed lines with SIR structure provide maximum magnetic field points which occur at the same locations of the input and output feed lines, so the insertion loss of BPF was reduced. Applying the SIR structure to the BPF for the first passband improves rejection characteristics between the first passband and the second passband. It reduces the coupling between the BPF for the first passband and the BPF for the second passband, so it makes the dual-band BPF more compact. The proposed design method provides independent changes of both the center frequency and the bandwidth for each resonator, and also improves filtering characteristics. The validity of the proposed design method is confirmed by comparisons between the designed parameters and the measured results satisfying WLAN specifications.

• Computers and Concrete
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• v.34 no.3
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• pp.279-296
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• 2024

In this study, ensemble machine learning (ML) models are employed to estimate the hardened properties of Self-Compacting Geopolymer Concrete (SCGC). The input variables affecting model development include the content of the SCGC such as the binder material, the age of the specimen, and the ratio of alkaline solution. On the other hand, the output parameters examined includes compressive strength, flexural strength, and split tensile strength. The ensemble machine learning models are trained and validated using a database comprising 396 records compiled from 132 unique mix trials performed in the laboratory. Diverse machine learning techniques, notably K-nearest neighbours (KNN), Random Forest, and Extreme Gradient Boosting (XGBoost), have been employed to construct the models coupled with Bayesian optimisation (BO) for the purpose of hyperparameter tuning. Furthermore, the application of nested cross-validation has been employed in order to mitigate the risk of overfitting. The findings of this study reveal that the BO-XGBoost hybrid model confirms better predictive accuracy in comparison to other models. The R² values for compressive strength, flexural strength, and split tensile strength are 0.9974, 0.9978, and 0.9937, respectively. Additionally, the BO-XGBoost hybrid model exhibits the lowest RMSE values of 0.8712, 0.0773, and 0.0799 for compressive strength, flexural strength, and split tensile strength, respectively. Furthermore, a SHAP dependency analysis was conducted to ascertain the significance of each parameter. It is observed from this study that GGBS, Flyash, and the age of specimens exhibit a substantial level of influence when predicting the strengths of geopolymers.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.17 no.6
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• pp.105-112
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• 2003

Diode rectifier which can't be controlled output voltage and phase control converter as AC/DC converter have low power factor and harmonics of lower order in the line current. In this paper, three phase PWM(Pulse Width Modulation) AC/DC boost converter is studied to solve these problems. The characteristics of a proposed converter are to control the phase of current without current sensor as a very simple control algorithm using circuit parameters only and to apply sinusoidal PWM method with fixed switching frequency due to a difficult design of input filter and switching device. We simulate for the proposed algorithm that high power factor is achieved and DC link voltage has fast dynamic response without ripple in rectifying and regenerating operation. As a result of experiment with circuit parameter(inductor, capacitor) decided in simulation, the proposed converter had high power factor and reduction of low order harmonics as against diode rectifier.