• Title/Summary/Keyword: Innovator

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Assessment and Interpretation of Bioequivalence for Two Drug Formulations using Crossover Design

  • Ko, Seoung-gon;Oh, Hyun-Sook
    • Communications for Statistical Applications and Methods
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    • v.6 no.2
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    • pp.601-610
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    • 1999
  • Crossover design is officially except for special occasions recommended by KFDA and FDA for assessing Bioequivalence between two drugs one for reference and the other for innovator. Such design is regarded as a special case of latin square split-polt or repeated measurement design and its main difference with other designing methods is that each subject in an experiment is exposed two drugs in sequence. Therefore general statistical analysis is not suitable since the model for this experiment includes carryover effect in addition to period and sequence effect. in this paper analysis for crossover model with two drugs and its interpretation are mainly discussed and an example is given for illustration.

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Fashion Leadership and Expected Values of Appearance Management According to Individualism-collectivism Orientation (개인주의-집단주의 성향에 따른 유행선도력과 외모관리 기대가치)

  • Park, Eun-Hee
    • Korean Journal of Human Ecology
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    • v.23 no.1
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    • pp.85-99
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    • 2014
  • The purpose of this study was to classify individualism-collectivism orientation into groups and analyze the difference of fashion leadership and expected values of appearance management by the groups. Questionnaires were administered to 376 adults in 20's and 30's living in Deagu and Kyungbook area through June 10~June 20, 2013. Frequency, factor analysis, reliability analysis, cluster analysis, correlation analysis, ANOVA, Duncan-test, t-test, and $X^2$-test were used for data analysis. Survey method was used to collect data for this study and the measures such as individualism-collectivism orientation, fashion leadership and expected values of appearance management consisted of 5-point Likerties scale. Individualism-collectivism orientation was categorized into collectivism, competition consciousness, love of family, and individual focus. Fashion leadership were found as opinion leadership, double leader, and innovator. Expected values of appearance management were found as pleasure/individuality, other consciousness, and conformity. This indicates that women showed high opinion leader, double leader, and innovator of fashion leadership and pleasure/individuality, and conformity of expected values of appearance management while men care more about competition consciousness, love of family, and individuality focus of individualism-collectivism orientation. Individualism-collectivism orientation showed significant correlation with the sub-variable of fashion leadership and expected values of appearance management. Individualism-collectivism orientation were classified into three groups such as competition collectivism, individuality, and low individual-collectivism. A test of significance in groups was determined by demographic variables like gender, age, occupancy and monthly income. Groups showed significant difference in fashion leadership and expected values of appearance management.

The Possibility of Social-cultural Creativity Education: A Case Study of "Imaginative Innovator" at H University (사회문화적 창의력 교육의 가능성 제안 : H대학교 '상상력 이노베이터' 교과목 개발 및 운영 사례)

  • Lee, Jee-Young
    • The Journal of the Korea Contents Association
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    • v.21 no.7
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    • pp.448-458
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    • 2021
  • As the fourth industrial revolution accelerates, universities have made great efforts to develop and reform creative convergence courses for improving the students' creative convergence capabilities. Although various subjects such as "Capstone" and "Design Thinking" to the improvement of students' creative convergence competences, many courses focus on creativity education in the direction of creating new products or outputs such as engineering, design, and art, so there is still a lack of systematic education and subjects on creative convergence capabilities from a humanities and sociological perspective. In order to overcome their limitations of creative courses, "H" University developed a 'Imaginative Innovators' class with the purpose of solving creative problems on social issues related to sciences, culture, politics, economics, and so on. In this study, we introduced the purpose, methodology, students' best practices etc. of the "Imaginative innovator" course. In addition, we discussed the limitations and complements as well as the advantages and possibilities of the course. These findings are expected to contribute to the development and expansion of creativity education.

An Empirical Study on The Pattern of Interactive Learning in Strategic Networks (전략네트워크에서 발생하는 학습패턴에 관한 실증연구)

  • Jeong, Jong-Sik;Kim, Hyun-Jee
    • International Commerce and Information Review
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    • v.9 no.4
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    • pp.3-19
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    • 2007
  • The purpose of this paper is to study the pattern of interactive learning in strategic networks. Interactive learning is defined as the exchange and sharing of knowledge resources conducive to innovation between an innovator firm, its suppliers, and/or its customers. The strength of internal knowledge resources can either hamper or facilitate levels of interactive learning. We assume that more complex innovative activities urge firms to co-ordinate and exchange information between users and producers, which implies a higher level of interactive learning. To test our theoretical claims, we estimated the level of interactive learning of firms in strategic networks with: (1) their customers, (2) their suppliers. Theses analyses allow a comparison of the antecedents of interactive learning of firms participating in strategic networks. Our findings suggest that interactive learning with customers is positively affected by company's capabilities and value-created activities, and with supplies is positively affected by value-created activities and technology innovation centers.

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Consumer's Technology Innovation Adoption Type and the Participation Level of Multimedia UCC Services (소비자의 기술혁신 수용유형과 동영상 UCC 서비스 참여수준)

  • Kim, Yeon-Jeong
    • Journal of Families and Better Life
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    • v.27 no.1
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    • pp.209-219
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    • 2009
  • This study identifies the key determinants and technology innovation adoption type of participation in multimedia UCC services. This research examines how the major factors of perceived usability, self-expression, fun & entertainment, arousal, information sharing, other's positive reputation and interface easiness contribute to participation in multimedia UCC services. A sample survey of internet users was conducted, responses were collected from 629 respondents and consumer streaming data were analyzed. Some of the practical implications of the results are follows. This research have categorized that the types of technology adoption for the participation of UCC were innovator consumer, early adaptor consumer, early majority consumer, and late majority consumer. The results of multiple regression analysis indicated that perceived usability, interface easiness, fun & entertainment, self-expression, arousal, other's positive reputation and type of technology adoption posited a significant effect in multimedia UCC Services.

Assessment of Bioequivalence with Dropout Subjects in 3$\times$3 and 3$\times$2 Crossover Design

  • Ko, seoung-gon;Oh, Hyun-Sook
    • Journal of the Korean Statistical Society
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    • v.29 no.2
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    • pp.219-229
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    • 2000
  • Oh et al.(1999) 3$\times$2 crossover design for assessing bioequivalence when two new generic drug formulations and innovator are simultaneously considered. This design is not only more efficient than 3$\times$3 one, proposed by Lee et al.(1998), in practical sense, but also more ethical in medical sense. However, the general statistical methods are not directly applicable to both designs when subjects are dropped out in the experiment, even though it is always possible in bioavailability and bioequivalence studies because of some administrative and economic reasons. In this research we propose an inference to drug effects when subjects are dropped out in the planed-for 3$\times$3 and 3$\times$2 crossover experiments. An example is given for illustration.

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Statistical Consideration of the Development of Biosimilar Products (바이오시밀러 개발에 필요한 통계방법들에 대한 고찰)

  • Kang, Seung-Ho;Nam, Ju-Sun
    • The Korean Journal of Applied Statistics
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    • v.25 no.1
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    • pp.125-138
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    • 2012
  • Recent assessments of the biosimilarity of biologic products have received considerable global attention. A clinical trial should be conducted to assess the biosimilarity of a biosimilar product and a innovator biological product. In this paper we will describe several methods for the implementation of clinical trials and statistical analysis, a real international case and related international guidelines.

Redesign and Evaluation of a Chickpea Harvester

  • Golpira, H.
    • Journal of Biosystems Engineering
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    • v.40 no.2
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    • pp.102-109
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    • 2015
  • Purpose: Slow manual harvesting of rain-fed chickpeas cultivated in fallow fields in developing countries have encouraged the design of a mechanical harvester. Methods: A tractor-pulled harvester was built, in which a modified stripper header detached pods from an anchored plant and a chain conveyor transferred material. The stripper harvester was redesigned to use: 1) the maneuverability of tractor-mounted frames, 2) the adaptability of floating headers, and 3) the flexibility of pneumatic conveyors. Results: A mobile vacuum conveyor, which was an innovator open system, was designed for the dilute phase transferring mode for both grain and material other than grain. A centrifugal fan transferred harvested material to a cyclone separator that settled harvested material in a grain tank 1 m high. The machine at the spot work rate of $0.42ha{\cdot}h^{-1}$ harvested chickpea pods equal to the output of 16.6 farm laborers. Conclusion: The low cost and reasonable projected purchase price are the advantages of the concept. Additionally, the shattering loss reduction confirms the feasibility of the prototype chickpea harvester for commercialization.

ERP-Enterprise Resource Planning: System Selection Process and Implementation Assessment

  • Han, Sung-Wook
    • Industrial Engineering and Management Systems
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    • v.2 no.1
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    • pp.45-54
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    • 2003
  • Enterprise Resource Planning(ERP) systems offer pervasive business functionality the applications encompass virtually all aspects of the business. Understanding and managing this pervasiveness will result in a successful and productive business application platform. Because of this pervasiveness, implementations have ranged from great successes to complete failures. This article has two distinctive parts. The first proposes and discusses a systematic process based on consulting experiences of LG CNS (leading information system company in Korea) for ERP selection. Also, the second provides the key factors that are critical to the successful implementation of ERP. The second part reports the results of a study carried out to assess a number of different ERP implementations in different organizations. A case study method of investigation was used, and the experiences of five Korean manufacturing companies were documented. The critical factors in the adoption of ERP are identified as: learning from the experiences of others, appointment of a process innovator, establishment of committees and project teams, training and technical support for the users, and appropriate changes to the organizational structure and managerial responsibilities.

Securing of Potential Users of Smartphone UI due to the Philosophy of its Design (스마트 폰 UI의 디자인 철학에 따른 잠재적 사용자 확보)

  • Kim, Su-Hee;Oh, Chi-Gyu
    • The Journal of the Korea Contents Association
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    • v.16 no.10
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    • pp.503-513
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    • 2016
  • Innovator and Early Adopter are main clients of smart phone until now, but the silver generation enjoying price stability and the Internet emerges, so a strategy of the importance, systematic classification, and focus of a neglected class is needed. It is necessary to analyze UI that can departmentalize not a neglected class limited to the silver generation but potential users who can be voluntarily users and can secure them. To secure them, the researcher analyzes how Windows, Icons, Mouse Pull-Down-Menus(WIMP) of UI has been applied in the process that skeuomorphism UI of iPhone, Metro UI of MS, and Material UI of Google change. As a result of an analysis, skeuomorphism is not entirely new and has secured potential users slowly with a method to compensate and improve a part that users disregard. As a concept of touch UI, Metro UI considered potential users from the beginning but did not secure them with new and epoch-making UI. However, Material UI of Google compensates the weaknesses of skeuomorphism UI and Metro UI and emphasizes cost-effectiveness, so has developed into UI that can secure final consumers of potential users. Therefore, to secure potential users, it should make users themselves understand why they should use smart phone, and it should approach with more organized studies on UI through feedback of observation and direct talks.