• 노인간호학회지
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• 제20권sup1호
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• pp.160-165
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• 2018

Purpose: There is a need to examine changes in the health care environment and the impact on gerontological nursing care in the era of the Fourth Industrial Revolution. In this article recent healthcare paradigm changes, gerontechnology, high tech and high touch, person-centered approaches are discussed. Methods: A narrative review was used. Results: Cyber physical system, artificial intelligence, advance and convergence of bioengineering, and information communication technology are changing the health care paradigm to "precision", "prediction" and "personalization". Entry into the global aging society and the surge in the elderly population worldwide has led to searches for a new means to prepare for projected demands of this growing population. Thus, efforts such as gerontechnology have been made to apply and utilize recent innovative science and technology in order to promote the health and life of elders. There is a great emphasis on the convergence of high tech and high touch, in which humanistic and artistic approach are critical in order to assure that technology is beneficial to human beings rather than harmful. Conclusion: Positive healthcare experiences among patients and their families are emphasized by utilizing new technology and employing high touch while providing personalized care with a person-centered approach.

• The Journal of Asian Finance, Economics and Business
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• 제8권4호
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• pp.403-412
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• 2021

The COVID-19 pandemic has a great impact in various ways. It changes the normal routine of lives and businesses. Many businesses encounter tremendous financial pressure, some of them lay off workers or choose to close down. According to the statistics, e-commerce experiences a four-fold growth in sales during the pandemic period. There is an urgency for firms to digitalize their businesses to respond to the change in the landscape of purchasing patterns of consumers. The purpose of this study is to understand the success of a few popular apparel brands in digital businesses. This is a qualitative research, and secondary data is collected for the analysis. The findings reveal that all of them engage in omni-channel methods in digitizing their businesses while utilizing other forms of technologies in their product and operational management. All selected firms agree with the importance of digital business, and omni-channel retailing is their choice. In these unprecedented times, the sustainable success of the apparel firms in digital businesses requires a flexible and innovative approach and a commitment to achieving operational excellence. Continuous renewal and digital transformation are needed so that these companies have the capabilities to adapt to changes and reap the benefits of a satisfactory organizational performance.

• 한국임상약학회지
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• 제30권4호
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• pp.217-225
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• 2020

The fourth industrial revolution, with its characteristics of "hyper-connectivity", "hyper-intelligence" and "automation", is a hot topic worldwide. It will fundamentally change industry, economy, and business models through technological innovations, such as big data, cloud computing, Internet of Things (IoT), artificial intelligence (AI), and 3D printing. In particular, the development of highly advanced information technology (IT) and AI is expected to replace human roles, thereby changing employment and occupation prospects in the future. Based on this, some predict that the profession of the pharmacist will soon disappear. To counter this, pharmacists' attention and efforts are required to seek innovative transformations in their functions by responding sensitively and promptly to changes of the fourth industrial revolution. It is also necessary to recognize the new roles of pharmacists and to develop the competencies to perform them. The fourth industrial revolution is an inevitable change of the times. At this time, we should take comprehensive and open perspectives on how the future society will change economically, culturally, and socially, and use it as an opportunity to shape the new future of pharmacists.

• International Journal of Computer Science & Network Security
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• 제21권12spc호
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• pp.513-520
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• 2021

The purpose of the article is to study the impact of digitalization on the transformation of the banking system, taking into account current innovative development trends. The article analyzes the impact of key factors on the development of the digital economy. Ukraine's ranking positions in terms of digital competitiveness are shown. The necessity of using digital technologies in the sphere of banking activity is substantiated. The dynamics of changes in the number of operating banks in Ukraine is analyzed. The directions of introduction of information technologies in the sphere of banking activity are determined. An analysis of changes in the share of the population of individual EU member states that use the Internet for Internet banking. It is noted that modern transformation trends, digitalization of the economy have a significant impact on the landscape of the banking sector, in this context, the rating of Ukrainian banks in the categories of "Internet Banking" and "Mobile Banking". The advantages and disadvantages of using the capabilities of Internet banking are identified. Based on the study, the importance of expanding the boundaries of digitalization of the domestic banking system is substantiated, which will further increase the level of availability of online services in the field of banking. Prospects for further research are identified in the study of the impact of digitalization on the development of the banking system of foreign countries.

• Journal of Information Processing Systems
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• 제19권3호
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• pp.347-354
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• 2023

The rapid development of information technology has accelerated the application of big data and the Internet of Things in various industries. Big data has a great potential in the development of smart tourism. With the help of innovation in emerging technologies such as big data and Internet of Things, smart tourism has a better possibility to surpass traditional tourism. Therefore, this article provides a theoretical support to this process. It has explored the innovative management model of big data and IoT in smart tourism and evaluate their effects on promoting tourism. It offers a reference for the integration and innovation of the tourism theory system. Before big data technology, the development of Internet boosted online tourism. However, tourism marketing is still inefficient due to a lack of understanding about tourists. After many practical explorations of big data technology, tourism websites begin to adopt big data technology in their daily operations. With the changes in tourists' preferences and needs, further innovation and research are needed to help smart tourism keep up with the changes in the market and create more competitive products and services. Innovation serves as the driving force for enterprises to occupy the market and develop.

• Journal of Yeungnam Medical Science
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• 제40권4호
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• pp.328-334
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• 2023

An aging population and changes in dietary habits have increased the incidence of diabetes, resulting in complications such as diabetic foot ulcers (DFUs). DFUs can lead to serious disabilities, substantial reductions in patient quality of life, and high financial costs for society. By understanding the etiology and pathophysiology of DFUs, their occurrence can be prevented and managed more effectively. The pathophysiology of DFUs involves metabolic dysfunction, diabetic immunopathy, diabetic neuropathy, and angiopathy. The processes by which hyperglycemia causes peripheral nerve damage are related to adenosine triphosphate deficiency, the polyol pathway, oxidative stress, protein kinase C activity, and proinflammatory processes. In the context of hyperglycemia, the suppression of endothelial nitric oxide production leads to microcirculation atherosclerosis, heightened inflammation, and abnormal intimal growth. Diabetic neuropathy involves sensory, motor, and autonomic neuropathies. The interaction between these neuropathies forms a callus that leads to subcutaneous hemorrhage and skin ulcers. Hyperglycemia causes peripheral vascular changes that result in endothelial cell dysfunction and decreased vasodilator secretion, leading to ischemia. The interplay among these four preceding pathophysiological factors fosters the development and progression of infections in individuals with diabetes. Charcot neuroarthropathy is a chronic and progressive degenerative arthropathy characterized by heightened blood flow, increased calcium dissolution, and repeated minor trauma to insensate joints. Directly and comprehensively addressing the pathogenesis of DFUs could pave the way for the development of innovative treatment approaches with the potential to avoid the most serious complications, including major amputations.

• 환경정책연구
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• 제10권3호
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• pp.73-91
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• 2011

2000년대 초반의 동아시아 수산활동을 기후변화와 사회경제적 개발과 연관하여 연구하였다. 세계 인구의 약 1/3이 동아시아 지역에 살고 있는데, 이들은 많은 수산물을 생산하고, 소비하며, 국제무역에 기여하고 있다. 지역적으로, 전지구적으로 진행되고 있는 기후변화와 더불어 해수의 온난화 및 산성화는 수산생물과 수산업에 심대한 영향을 미칠 것이다. 동아시아 지역의 잦은 태풍은 연안의 사회집단에 막대한 손실과 희생을 유발할 것이며, 이러한 환경의 변화속도는 우리가 효과적으로 대응하기에 벅찰 정도로 빠르게 진행 중이다. 과학적 활동은 기후변화의 상황에서 발생하는 문제점들을 찾아내고, 더 나아가 효과적인 해결책을 만들기 위한 기본 지침을 제공하여야 한다. 또한 수산관리 계획은 기후변화와 더불어 사회체제의 변화를 고려하여 수립되어야 한다. 그러므로 이 해역에서 공동과학연구를 추진하고, 수산자원을 보존하고 관리하는 국제적 공조체제를 구축하여야 한다는 제안은 매우 논리적이다.

• 패션비즈니스
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• 제24권4호
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• pp.144-160
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• 2020

Today, the development of innovative technologies is accompanied by changes in the industrial structure and the Big Blur phenomenon, where the boundaries in various fields are blurred. The purpose of this study was to view the Big Blur phenomenon as a big paradigm shift in the 21st century and derive environmental changes and characteristics of the Korean fashion market. The research method included an analysis of the fashion brands after 2015. Through this study, we intended to establish a framework for understanding the changes in the fashion market from the perspective of Big Blur and discuss the direction of brand marketing. The research results showed the hyperlinks, connectivity, openness, homeostasis, synchronicity, mobility, interactivity, and brand experience of online and offline spaces beyond the boundaries of virtual space and offline physical spaces such as online physical and spatial viewpoints. It also showed the characteristics. The characteristics from the socio-cultural point of view were characteristic of diversity, mixture, coexistence, composability, and pluralism beyond the traditional socio-cultural and regulatory scopes. Hip hop fashion, street fashion, unisex, genderless, androgynous fashion, and kid fashion are the backbone of the Big Blur and are becoming important factors in fashion. The characteristics of the market and economic viewpoint are prosumers that play roles both as producers and consumers. It shows the extensibility of consumers as producers, the cohesiveness of producers and consumers, the cooperation, and the interconnectivity.

• Nutrition Research and Practice
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• 제15권5호
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• pp.639-654
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• 2021

BACKGROUND/OBJECTIVES: Many adolescents in developing countries skip breakfast. Innovative nutrition education (NE) strategies are needed to enhance knowledge and skills related to the breakfasts of adolescents in a low socioeconomic setting. The objective was to evaluate short- and long-term effects of a multi-strategy, school-based NE intervention on adolescents' breakfast-related personal influences and behaviors. SUBJECTS/METHODS: An intervention study with a cluster randomized controlled trial design was conducted in 4 senior high schools in Makassar, Indonesia. The multi-strategy NE intervention was delivered for 3 months. Data were collected using a self-administered questionnaire and a 3-day breakfast recall (face-to-face interview). Wilcoxon, McNemar, and Mann-Whitney tests were used to determine intra- and intergroup differences. RESULTS: Unlike knowledge, improvement was observed in attitude and self-efficacy scores in the intervention groups (IGs) (P < 0.01); however, no significant changes were observed in the control group (CG). More students showed improved motivation in the IG than in the CG (P > 0.05). Changes in breakfast frequency and macronutrient intake from breakfast were greater in the IG than in the CG (P < 0.05). CONCLUSIONS: A multi-strategy NE intervention is effective in producing positive changes in breakfast-related attitude, self-efficacy, and motivation of adolescents from a low-middle socioeconomic setting. The intervention improved breakfast frequency and nutrient intake. This intervention has promise for sustaining the observed changes over the long-term.

• BMB Reports
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• 제47권8호
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• pp.469-474
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• 2014

Cell therapies utilizing mesenchymal stem cells (MSCs) have a great potential in many research and clinical settings. The mechanisms underlying the therapeutic effects of MSCs have been studied previously and the paracrine effects elicited by their production of various growth factors and cytokines were recognized as being crucial. However, the molecular controls that govern these paracrine effects remain poorly understood. To elucidate the molecular regulators of this process, we performed a global knockdown of microRNAs (miRNAs) in human adipose-derived mesenchymal stem cells (hADSCs) by inhibiting DGCR8, a key protein in miRNA biogenesis. Global disruption of miRNA biogenesis in hADSCs caused dramatic changes in the expression of subsets of growth factors and cytokines. By performing an extensive bioinformatic analysis, we were able to associate numerous putative miRNAs with these genes. Taken together, our results strongly suggest that miRNAs are essential for the production of growth factors and cytokines in hADSCs.