• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.4
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• pp.125-136
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• 2016

The external R&D, which includes the adoption of the external technology and knowledge in addition to the internal R&D, is one of important factors for the innovation. Especially for small and medium-sized enterprises (SMEs), the external R&D has been considered as a key factor to carry out the innovation more efficiently due to the limitations of their resources and capacities. However, most of extant studies related to external R&D have focused on analyzing the influence of external R&D on innovation outputs or outcomes. Only a few studies have explored the impact of external R&D on the innovation efficiency. This study therefore investigates whether the external R&D effects the industry's innovation efficiency and productivity. On this study, we used Korean manufacturing industry data of SMEs from 2012 to 2014 and employed a global Malmquist productivity analysis technique, which is based on the Data Envelopment Analysis (DEA), to assess the innovation efficiency and productivity. Innovation performances of external R&D group and internal R&D group are compared. Then, the sectoral patterns of both innovation efficiency and productivity are analyzed with respect to the technological intensity, which is introduced by OECD. The results show that the gap of innovation efficiency between external and internal R&D groups has gradually decreased because of the continuous improvement of the external R&D group's performance, while the external R&D group lag behind the internal R&D group. In addition, patterns of the innovation efficiency and productivity change were different depending on the technological intensity, which means that the higher the technological intensity, the greater the effect of external R&D.

• Journal of the Economic Geographical Society of Korea
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• v.15 no.2
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• pp.147-165
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• 2012

Recently, the theory of open innovation emerges as a new innovation paradigm. This paper aims to examine open innovation activities of SMEs. Many firms tend to search new knowledge from various external sources and to pursue to achieve innovation resources or knowledge of external innovators. Particularly, this paper focus on the process of external knowledge networking and open innovation occurred in the process of technology innovation. The data used in this study were those that had been collected for total 3,400 sample SMEs that had conducted R&D. and in-depth interviews were conducted with 14 SMEs located at Chungbuk-Technopark. Empirical findings can be summarized as follows; SMEs tend to search new knowledge from various external sources and to pursue to achieve innovation resources or knowledge of external innovators, because they have lack of innovation resources. therefore, the conducting of open innovation affected positively the innovation performance of SMEs. In addition, empirical findings also indicated that expanding flexibility of labor market enhances open innovation activities of SMEs.

• The Journal of Asian Finance, Economics and Business
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• v.4 no.1
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• pp.67-78
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• 2017

The competitive nature of enterprises requires organizations to foster an environment that encourages employee innovation that leads to profitability and customer satisfaction. Organizational innovation is influenced by several factors with employee behaviour being one of the important factors. Employees contribute in the innovation process and thus, it is important for organizations to understand employee expectations to demonstrate innovative work behaviour in order to create and maintain an innovative work culture. In the present study, a conceptual model based on culture, reward and program, training, compensations, leadership and systems was tested to assess that impact on employee expectations leading to innovative work behaviour. The study was conducted in the context of city-state of Singapore due to its significant emphasis on promoting and nurturing employee innovation. The model was tested using empirical data collected through a survey of employees in Singapore. The results indicate that while culture, rewards and training programs have a direct relationship on employee expectations to demonstrate innovative work behaviour, when considered together, leadership and systems are significantly and positively associated with employee expectations. These factors are usually under the control of organizations and can be enhanced through systematic interventions, thereby providing practice managers an avenue to improve employee innovation behaviour. The other implications of the findings and future scope are discussed.

• Journal of Information Technology Applications and Management
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• v.31 no.2
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• pp.15-34
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• 2024

This study aims to analyze the effect of absorptive capacity on technology collaboration performance and the moderating effect of innovation intermediaries. We set absorptive capacity (potential, realized) as independent variables and technology collaboration performance (relative technology level, development period, cost savings, new product development, collaboration satisfaction) as dependent variables, with innovation intermediaries as a moderating variable. We conducted a survey of 145 ICT companies that experienced technology collaboration and analyzed the data using 101 valid responses. The results show that potential absorptive capacity has a significant effect on new product development and collaboration satisfaction, while realized absorptive capacity has a significant effect on relative technology level, cost savings, and new product development. Furthermore, innovation intermediaries have a moderating effect between realized absorptive capacity and new product development. The contribution of this study to academia and industry is that it highlights absorptive capacity as a key factor influencing technology collaboration performance. The limitations of this study include the lack of accurate measurement of absorptive capacity and innovation intermediaries, as well as a lack of control over external factors. These limitations should be addressed through more in-depth research by systematically defining and measuring them in future follow-up studies.

• Biomolecules & Therapeutics
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• v.24 no.1
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• pp.99-107
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• 2016

Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful effects of triclosan in many systemic and cellular processes of the body. In this study, we investigated the effects of triclosan in the survivability of cultured rat neural stem cells (NSCs). Cortical cells from embryonic day 14 rat embryos were isolated and cultured in vitro. After stabilizing the culture, triclosan was introduced to the cells with concentrations ranging from $1{\mu}M$ to $50{\mu}M$ and in varied time periods. Thereafter, cell viability parameters were measured using MTT assay and PI staining. TCS decreased the cell viability of treated NSC in a concentration-dependent manner along with increased expressions of apoptotic markers, cleaved caspase-3 and Bax, while reduced expression of Bcl2. To explore the mechanisms underlying the effects of TCS in NSC, we measured the activation of MAPKs and intracellular ROS. TCS at $50{\mu}M$ induced the activations of both p38 and JNK, which may adversely affect cell survival. In contrast, the activities of ERK, Akt and PI3K, which are positively correlated with cell survival, were inhibited. Moreover, TCS at this concentration augmented the ROS generation in treated NSC and depleted the glutathione activity. Taken together, these results suggest that TCS can induce neurodegenerative effects in developing rat brains through mechanisms involving ROS activation and apoptosis initiation.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.57-67
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• 2015

Recently corporations are faced with the age of convergence technology, so manny corporations recognize the importance of human resources. Therefore, the organization has attracted and remained the necessary human resources to continued growth. Accordingly, This study investigated the impacts of Job embeddedness on Innovation Behavior. In addition, examined the moderating effects of Job Meaning. As a result, Job Embeddedness positively affected to Innovation Behavior, the moderating effect of Job meaning had significant effected. This research provides; 1) When the relationship is maintained stably, the organization's innovation is promoted. 2) Job meaning with individuals can enhance the innovation.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.14-23
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• 2020

Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by ¹³C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.441-456
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• 2021

Enterprise is focused on R&D innovative activities in order to achieve sustainable growth & secure competitive advantage. There are many factors that influence enterprise innovation performance, but enterprise innovation activities do not always have a positive effect. Therefore, this study analyzed the effects of on innovation performance, focusing on innovation acceleration factors and innovation hindrance factors. The research model analyzed 2,081 national manufacturing enterprises that responded to the 2016 Korean Innovation Survey (STEPI). SPSS 25.0 was used to perform reliability, feasibility, and logistic regression analysis. The results are as follows. First, innovation activities have positive effects on enterprise product and process innovation performance. On the other hand, government support had the opposite results. Second, the collaboration of technology showed a positive effect on product innovation performance, independent of innovation acceleration and hindrance factors. Third, innovation activities showed a positive effect on process innovation performance, regardless of the innovation acceleration and hindrance factors. Unlike prior studies limited to technological innovation, this study analyzed the attitudes of enterprises toward innovation acceleration and hindrance factors. This study is expected to contribute to establishing a strategy for reducing the failure and risk of innovation due to its findings on how innovation performance varies by groups.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.4
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• pp.149-161
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• 2012

The current environment of technological and competitive changes influences not only the business R&D environment but also government driven national R&D strategies. Open innovation has now become an important paradigm that is replacing the outdated paradigm of closed innovation. Many companies and nations have been increasing R&D investment because R&D has been considered a driving force for national and corporate competitive advantage. The purpose of this paper is to evaluate and compare the performance of R&D focused on open innovation according to scientific and technological outputs which is based on paper publications, patents and etc. Comparisons should not be only based on the quantity but also on the quality of the output. This paper shows that it is possible to develop DEA models that utilize the Analytical Hierarchical Process in order to transform the qualitative index into a quantitative index. Hence, the relative efficiency for R&D organizations is obtained based on both quantity and quality outputs and subsequently provides comprehensive and realistic methods for decision makers to identify levels of project efficiency.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.5 no.2
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• pp.1-31
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• 2010

Biotechnology has strategic importance related to the development of start-up companies, industries and nations in the near future. Therefore, many countries have promoted and developed biotechnology. The United States has led the world in promoting biotechnology. American biotechnology policies are diverse, and thus no comprehensive systematic studies have been done on it. In our paper, we will discuss American biotechnology policy in detail. For effective analysis, we will rely on the concept of a national innovation system, which emphasizes the institutional settings of innovation actors and their interaction. This paper deals with the American national innovation system for biotechnology. We will analyze the role of major actors, academia, public research institutes, and venture companies and their interactions. The American biotechnological innovation system is composed of diverse actors and numerous start-up companies in the biotechnology industry. In addition, there are many diverse policy programs for promoting biotechnology. Because of country-specific frame conditions, every country has different institutional settings and policies for promoting biotechnology. Our paper will render meaningful implications for various countries. We also think that this paper will be of interest for international readers.