• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

• Journal of Preventive Medicine and Public Health
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• 제23권1호
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• pp.98-105
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• 1990

교통사고와 기상요소와의 관련성을 보기 위하여 대구지방에서 1988년도 1월 1일부터 12월 31일까지 1년간 교통사고를 일으킨 총 운전자중 약 1/10인 2,562명을 대상으로 하여 대구측후소에서 측정한 기상요소를 중심으로 그 관련성을 관찰하였다. 사고양상은 사고당시 인적피해와 물적피해로 구분하고 인적피해와 물적피해가 중복된 경우는 인적피해로 간주하였다. 인적피해는 다시 사망, 중상, 경상 등으로 구분하였으며 두가지 이상에 해당될 때는 피해가 큰 쪽으로 결정하였다. 계절별로 보면 겨울철이 1일평균 사고건수도 적고 인적피해 사고의 비율도 가장 낮았으며 계절에 따른 사고양상은 통계학적으로도 유익한 차이가 있었다. 기온에 다른 시간당 사고건수는 $25.1-30.0^{\circ}C$에서 가장 많았고 인적피해 사고의 비율은 41-50%일 때 가장 높았으나 습도에 따른 사고양상은 통계학적으로 유의하지 않았다. 풍속에 따른 시간당 사고건수는 풍속이 강할수록 많아지는 경향을 보였고 인적피해 사고의 비율은 6.1-7.0m/sec일 때 가장 높은 비율을 보였으나 풍속에 따른 사고양상은 통계학적으로 유의하지 않았다. 강수에 따른 시간당 사고건수는 5.1-10.0mm일 때 5.4건으로 가장 많았고 인적피해 사고이 비율은 강수량이 많을수록 높아지는 경향을 보였으며 강수량과 사고양상 간에는 통계학적으로도 유의한 관련성이 있었다. 시정에 따른 시간당 사고건수는 시정 6 Km미만일 때 가장 많았고 인적피해사고의 비율은 6 Km미만일 때 가장 낮았으며 시정과 사고양상 사이에는 통계학적으로 유의한 관련성이 있었다. 적설이 있을 때 시간당 사고건수는 적설이 없을 때보다 많았고 인적피해사고의 비율은 비교적 적었으나 적설유무와 사고양상과는 통계학적으로 유의하지 않았다. 이상의 결과로 보아 자동차 사고는 기온, 습도, 풍속 등 몇가지 기상조건에 따라 서로 그 발생양상에 크고 작은 차이를 보이고 있는데 계절, 강수량 빛 시정에 따른 사고발생 분포의 차이는 통계적으로도 유의했다.

• Journal of Korean Neurosurgical Society
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• 제50권5호
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• pp.472-474
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• 2011

Cortical laminar necrosis appears as hyperinense lesions with a laminar pattern on T1 weighted magnetic resonance (MR) imaging, without signs of hemorrhage or calcification on T2 weighted MR imaging or computed tomography. It has been reported to be associated with hypoxia, metabolic disturbances, drugs, and infections. We present a 12 month-old male infant who suffered diffuse brain injuries following car accident and showed laminar necrosis of cortex.

• 한국양식학회지
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• 제16권1호
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• pp.37-43
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• 2003

The present study reports morphology and developmental pattern off siliquosa cultured in a laboratory condition. The zygote was spherical with a diameter of 85 ${\mu}{\textrm}{m}$. During development the polarized zygote divided horizontally and the lower daughter cell divided horizontally into 2 cells. The upper cell was divided repeatedly in horizontal and vertical directions to form a cylinder-like structure, which subsequently developed into secondary and tertiary dichotomous branches. Optimum temperature for zygote release and fertilization was 25C. Injury inflicted by slicing was cured by epidermal differentiation, and adventitious branches; the branches emerging from the pith cells, however, developed no rhizoid. Adventitious branch formation rate was over 88% in all plates supplemented with 0.5 mg/L IAA and peaked at 98% under 0.5 mg/L IAA plus 0.5-5.0 mg/L NAA treatment. NAA stimulated the differentiation of adventitious branches at a wide range of concentrations, while IAA, 2,4-D and kinetin exhibited dose-dependent stimulation.

• 대한치과의사협회지
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• 제52권2호
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• pp.85-95
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• 2014

Completely avulsed tooth caused by a traumatic injury needs replantation for treatment choice. But, replantated tooth usually comes with inflammatory root resorption, replacement resorption and ankylosis, moreover ankylosis cause severe functional and esthetic problems. The outcome of replantated tooth depends on the following factors; minimal damage to pulp and periodontal tissue, the length of extraoral time, the medium of the tooth stored, the level of root formation and so on. The purpose of this case report is to describe the variable resorption pattern and to discuss types that influence the occurrence of resorption.

• 한국환경생물학회:학술대회논문집
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• 한국환경생물학회 2003년도 학술대회
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• pp.63-67
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• 2003

Mercury, one of the most diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states. Although the reports indicate that the mercury induces a deleterious damage, little has been known from the investigations of its effects in living organisms. The purpose of this study is to evaluate the effects of mercury chloride and ionizing radiation. Prepubertal male F344 rats were administered mercury chloride in drinking water throughout the experimental period. Two weeks after whole body irradiation, organs were collected to analyze the induced injury. Serum levels of GOT, GPT, ALP, and LDH were checked in the experimental groups and the hematological analysis was accomplished in plasma. In conclusion, the target organ of mercury chloride seems to be urinary organs and the pattern of damage induced by mercury differs from that by irradiation.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.99-102
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• 1996

The ultimate object of FES is on the recovering function of body and shape demaged from desease or injury to original state. On this study, object is recovering of gait function of the disabled who, especially, have gait disturbance. Paralyzed muscle from the central nerve disable, if peripheral nerves which be in the lower part of the harmed are activated, muscle contraction is possible. The traumatic trouble, peripheral nerves aren't connected to a central nerve but origin of peripheral nerve cells which are in the lower part of the harmed are alive, react on stimulation. We design 4-channel stimulator, being based on standard stimuli pattern. stimulator is manufactured with compact size and light weight to portable.

• Mass Spectrometry Letters
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• 제5권3호
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• pp.70-78
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• 2014

Microglia are the confined immune cells of the central nervous system (CNS). In response to injury or infection, microglia readily become activated and release proinflammatory mediators that are believed to contribute to microglia-mediated neurodegeneration. In the present study, inflammation was induced in the immortalized murine microglial cell line BV-2 by lipopolysaccharide (LPS) treatment. We firstly performed phosphoproteomics analysis and phosphoinositide lipidomics analysis with LPS activated microglia in order to compare phosphorylation patterns in active and inactive microglia and to detect the pattern of changes in phosphoinositide regulation upon activation of microglia. Mass spectrometry analysis of the phosphoproteome of the LPS treatment group compared to that of the untreated control group revealed a notable increase in the diversity of cellular phosphorylation upon LPS treatment. Additionally, a lipidomics analysis detected significant increases in the amounts of phosphoinositide species in the LPS treatment. This investigation could provide an insight for understanding molecular mechanisms underlying microglia-mediated neurodegenerative diseases.

• Childhood Kidney Diseases
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• 제23권2호
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• pp.93-99
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• 2019

C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.

• Journal of Trauma and Injury
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• 제34권4호
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• pp.305-308
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• 2021

Comminuted fractures of the patella mostly occur at the inferior pole and require appropriate reduction and fixation to restore the extensor mechanism. Conventional methods such as tension-band wiring are not enough to gain proper fixation strength. Numerous methods have been reported, including circumferential cerclage wiring, osteosynthesis, and suture anchors depending on the fracture pattern. Herein, the author reports a relatively rare case of a comminuted fracture of the upper pole of the patella, for which we used augmented Krackow sutures in the quadriceps and fixation with tying of the suture limbs through patellar bone tunnels. Satisfactory results were obtained in terms of reduction and extensor mechanism recovery.