• 한국운동역학회지
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• 제18권4호
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• pp.1-19
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• 2008

본 연구의 목적은 스노우보더가 플랫폼에서 뛰어내릴 때 경사면에 착지 하는 지면반력 계산을 바탕으로 3가지 종류의 곡선(타원, 원, 브라키스토크론)으로 된 하프파이프의 곡면에 착지할 때의 충격에 대한 역학적 계산의 결과를 해석 하는 것이다. 스노우보더의 착지시 다리의 유연성, 눈이 다져진 정도 경사면의 각도, 초기 속도, 착지 후 동작의 숙련도 등이 충격을 줄여주는 중요한 요소로 작용한다. 그러나 딱딱한 스노우보드용 하프파이프에서는 착지 지점의 곡면에 절대적으로 좌우된다. 이 연구의 역학적 분석 결과 브라키스토크론 곡선이 좀 더 충격 흡수의 효과가 있어 안전한 것으로 판명되었다. 건설의 효율성만을 고려한다면 현재 통용되고 있는 타원형태 이외의 다른 종류의 곡선들은 필요 없다고 생각하기 쉬우나 스노우보더들이 구사하는 기술의 종류와 난이도에 따라서 다양한 기하학적 형태의 시설로 발전되는 것이 바람직하다. 본 연구에서 시행된 연구 방법은 스노우보더 들의 치명적 부강 방지를 위한 하프파이프의 최적 안전 설계 및 사용의 방법과 더불어 스포츠인 들의 사고를 줄일 수 있는 과학적 연구방법에 대한 하나의 모델을 제시 한 것이라고 볼 수 있다.

• 대한본초학회지
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• 제30권4호
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• pp.57-64
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• 2015

Objectives : Oxidative stress is one of the most causes of hepatocyte injury. Gleditsia spina, the thorns ofGleditsia sinensisLam., has been known for its anti-cancer and anti-inflammatory effects in Korean medicine. The present study investigated hepatoprotective effect of Gleditsia spina water extract (GSE) against oxidative stress induced by arachidonic acid (AA) + iron in HepG2 cells.Methods : To investigate cytoprotective effect of GSE, cells were pretreated with GSE and then subsequently exposed to 10 μM AA for 12 h, followed by 5 μM iron. Cell viability was monitored by MTT assay, and expression of apoptosis-related proteins was examined by immunoblot analysis. To identify responsible molecular mechanisms, reactive oxygen species (ROS) production, GSH contents, and mitochondrial membrane potential were measured. In addition, effect of GSE on nuclear factor erythroid 2-related factor 2 (Nrf2) activation was determined by immunoblot and antioxidant response element (ARE)-driven reporter gene assays.Results : GSE pretreatment prevented AA + iron-mediated cytotoxicity in concentration dependent manner. In addition, ROS production, glutathione depletion, and mitochondrial impairment by AA + iron were significantly inhibited by GSE. Furthermore, GSE promoted translocation of Nrf2 to nucleus, which acts as essential transcription factor for induction of antioxidant genes. Increased nuclear Nrf2 that caused by GSE treatment promoted transcriptional activity of ARE. Finally, GSE up-regulated sestrin-2 which was widely recognized as target gene of Nrf2.Conclusions : This study demonstrates that GSE protects hepatocytes from oxidative stress via activation of Nrf2 signaling pathway.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권4호
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• pp.231-239
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• 2012

Objectives: This study sought to provide guidelines in order to decrease the incidence of nerve injury during mandibular ramus bone harvesting, and to improve understanding of the anatomical structure of the inferior alveolar canal (IAC) to include its distance from the exterior buccal cortex. Materials and Methods: In January and February 2009, 20 patients who visited the Wonkwang University Department of Oral and Maxillofacial Surgery reporting various conditions underwent cone beam computed tomography and were included in this study. Patients with missing left or right mandibular first molars or incisors, or who had jaw fracture or bone pathologies, were excluded. The reference point (R point) was defined as the point where the occlusal plane reached the anterior ramus of the mandible. The position of the IAC in relation to the R point, the buccal bone width (BW), the alveolar crest distance (ACD), the distance from the alveolar crest to the occlusal plane (COD), and the distance from the IAC to the sagittal plane (CS) were determined using proprietary image analysis software which produced cross-sectional coronal and axial images. Results: The distance medially from the R point to the IAC along the axial plane was $6.19{\pm}1.21mm$. The HD from the R point, posteriorly to IAC, in the lateral view was $13.07{\pm}2.45mm$, the VD from the R point was $14.24{\pm}2.41mm$, and the ND from the R point was $10.12{\pm}1.76mm$. The pathway of the IAC was positioned almost in a straight line along a sagittal plane within $0.56{\pm}0.70mm$. The distance from the buccal bone surface to the IAC increased anteriorly from the R point. Conclusion: Marking osteotomy lines in the retromolar area in procedures involving bone harvesting should be discouraged due to the risk of damage to IAC structures. Our measurements indicated that the area from the R point in the ramus of the mandible to 10 mm anterior can be safely harvested for bone grafting purposes.

• 한국융합학회논문지
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• 제8권10호
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• pp.105-114
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• 2017

본 연구는 구급대원으로 활동하는 응급구조사의 표준작전절차에 대한 융복합적인 인지도와 수행도를 알고자 하는데 그 목적이 있다. 이러한 목적을 달성하기 위하여 본 연구에서는 구급대원으로 활동하는 응급구조사 400명을 연구대상으로 표집하여 SPSS 20.0 Version을 사용하여 분석하였다. 연구 결과는 다음과 같다. 첫째, 연구대상자의 융복합적인 인지도는 호흡기 감염예방 부분이 가장 높았고, 손위생이 가장 낮았으며, 수행도는 치료장비 및 직원의 안전 부분이 가장 높았고, 손위생이 가장 낮았다. 인지도가 전체적으로 수행도 보다 높았다. 둘째, 일반적 특성에 따라 인지도는 연령, 성별, 상처 경험에 따라 통계적으로 유의한 차이가 있었으며, 수행도는 근무경력만이 유의한 차이를 보였다. 응급구조사의 융복합적인 인지도와 수행도 간에 정적 상관관계를 보이는 것으로 나타났다. 이 같은 결과로 구급대원으로 활동하는 응급구조사의 표준작전절차에 관한 인지도와 수행도를 복합적으로 높이기 위해 인지도를 선행으로 한 프로그램을 지속적으로 반복 교육 시 수행도를 증가시킬 수 있을 것으로 사료된다.

• 한국ITS학회 논문지
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• 제16권1호
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• pp.26-37
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• 2017

본 연구는 random effects Tobit 회귀모형을 이용하여 도심지 교차로에 대한 교통사고모형을 개발하여 교통사고와 요인간의 상관관계를 파악하는 것이 목적이다. Random effects Tobit 회귀모형의 적용성을 비교 분석하기 위하여 fixed effect Tobit 회귀모형을 산정하였다. 산정결과, 교통량, 제한속도, 차로수, 토지이용, 우회전차로, 전방신호등이 유효한 변수로 나타났으며, 총 교통사고율에 대한 random effects 모형의 모형 적합도(결정계수: 0.418, 로그-우도함수값: -3210.103, 우도비: 0.056)와 모형 설명력(MAD: 19.533, MAPE: 75.725, RMSE: 26.886)은 fixed effects 모형의 모형 적합도 (결정계수: 0.298, 로그-우도함수값: -3276.138, 우도비: 0.037)와 모형 설명력(MAD: 20.725, MAPE: 82.473, RMSE: 27.267)보다 우수한 것으로 나타났으며, 부상교통사고율에 대한 교통사고모형에서도 총 교통사고율의 산정결과와 동일하게 나타나 두 모형에서 random effects Tobit 회귀모형이 다소 우수한 것으로 분석되었다.

• 한방재활의학과학회지
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• 제26권4호
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• pp.97-105
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• 2016

Objectives The purpose of this study is to investigate traffic accident patients who were admitted to Korean and Western medicine hospital. Methods According to the medicine record from Dong-eui university, 908 traffic accident patients who were admitted to Korean medicine hospital and Western medicine hospital from 1st January 2011 to 31th July 2016 were analyzed. We classified the patients' sex, age, classification of diseases, hospitalization. Results 1. According to age and sex, the rate of male was 35.4%, and that of female was 64.6% in Korean medicine hospital. However, the rate of male was 46.6%, and that of female was 53.4% in Western medicine hospital. 2. According to admission procedures, the most patients (93.3%) went through out-patient department in Korean medicine hospital and 53.5% of patients went through emergency room in Western medicine hospital. 3. According to principal diagnosis, 'sprain and strain of neck level' was 65.4 percentage Korean medicine hospital and 'intracranial injury' was 63.2 percentage in Western medicine hospital. 4. There was no statistical significant in hospitalization periods between male and female in Korean medicine hospital. However, hospitalization periods of female were longer than that of male in Western medicine hospital. 5. There was no correlation between age and hospitalization period in both Korean and Western medicine hospital. 6. Average hospitalization period of Korean medicine hospital patients were shorter than that of Western medicine hospital patients. 7. According to automobile insurance review organization, hospitalization periods were not significantly different in both Korean and Western medicine hospital. Conclusions It is concluded that there is difference of characteristics between inpatients who were admitted to Korean and Western medicine hospital due to traffic accident.

• Journal of Periodontal and Implant Science
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• 제25권3호
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• pp.635-647
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• 1995

Human polymorphonuclear leukocytes(PMN) constitute a first line of defense against all forms of injury and microbial challenge, which share a common cell lineage with macrophage. Microbial component LPS activates macrophages to produce IL-1, MIP-1${\alpha}$, -1${\beta}$, TNF-${\alpha}$ and IL-6, etc. Those cytokines have autocrine function to the macrophages, and paracrine function to other cell such as PMN and affect them to produce some biological functions. Having a responsive homogeneous cell line, HL-60, offers us the possibility of studying extensively on the function of PMN, which were not possible previously with peripheral PMN, due to the short-lived nature and difficulty of getting a purified PMN. In the present study, I performed MIP-1 receptor binding assay using HL-60 cell and human peripheral PMN. Also, in vitro antimicrobial assay was performed using differentiated or undifferentiated HL-60 cell. Differentiation was induced by treatment with 500 M of $N^6,O^2-dibutyryl$ adenosine 3'5' cyclic monophosphate(dbcAMP) (PMN-like cell), or 20ng/ml of 12-O-tetradecanoylphorbol-13-acetate(TPA) (macrophage/monocyte-like cell). Receptors for MIP-1${\alpha}$ were identified on dbcAMP-treated HL-60 as well as peripheral PMN. However, bound radioactive MIP-1${\alpha}$ on differentiated HL-60 was much higher than that of peripheral PMN, which suggest receptor number of differentiated HL-60 cell is higher than that of peripheral PMN. Although both of TPA and dbcAMP treatment significantly enhanced antimicrobial action of HL-60 cell, dbcAMP-treated cell(PMN-like HL-60) killed S.aureus more effectively in this experiment. TPA or dbcAMP treatment significantly enhanced antimicrobial action of undifferentiated HL-60 cell. MIP-1${\alpha}$ further increased enhancing effect of TPA or dbcAMP. IL-1${\alpha}$, however, increased only dbcAMP-induced enhancing effect of antimicrobial action of HL-60 cell. These results suggest that differentiated HL-60 cell could replace peripheral PMN in analysis of various biological functions of cytokines on PMN cell.

• Tuberculosis and Respiratory Diseases
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• 제74권4호
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• pp.163-168
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• 2013

Background: In uncontrolled hemoptysis patient, bronchial arteriography and bronchial artery embolization (BAE) is a important procedure in diagnosis and treatment. The aim of this study is to assess the incidence of contrast-induced nephropathy and the risk factors of contrast-induced nephropathy (CIN) after bronchial arteriography and BAE. Methods: We retrospectively reviewed the medical records of the patients who underwent bronchial arteriography and BAE in two university hospitals from January 2003 to December 2011. CIN was defined as rise of serum creatinine more than 25% of baseline value or 0.5 mg/dL at between 48 hours and 96 hours after bronchial arteriography and BAE. We excluded patients who already had severe renal insufficiency (serum creatinine${\geq}4.0$) or had been receiving dialysis. Results: Of the total 100 screened patients, 88 patients met the enrollment criteria. CIN developed in 7 patients (8.0%). The mean duration between the exposure and development of CIN was $2.35{\pm}0.81$ days. By using multivariate analysis, serum albumin level was found to be significantly associated with the development of CIN (p=0.0219). Conclusion: These findings suggest that the incidence of CIN was higher than expected and patients with hypoalbuminemia should be monitored more carefully to prevent the development of CIN after bronchial arteriography and BAE.

• 동의신경정신과학회지
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• 제9궈1호
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• pp.1-24
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• 1998

The effects of Hyungbangjiwhangrang on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed.1. As the learning trials of Morris water maze processed repeatedly, sham group achiened 201.64${\pm}$33.13 seconds in 1st trial, 153.14${\pm}$61.80 seconds in 2nd, 106.21${\pm}$46.81 seconds in 3rd, 76.64${\pm}$48.40 seconds in 4th, and 52.29${\pm}$38.25 seconds in 5th. The control group achieved 224.08${\pm}$29.16 in 1st trial, 191.77${\pm}$67.97 seconds in 2nd, 177.77${\pm}$65.44 seconds in 3rd, 140.92${\pm}$68.27 seconds in 4th, and 126.46${\pm}$79.15 seconds in 5th. The sample group achieved 223.36${\pm}$23.33 seconds in 1st trial, 215.86${\pm}$38.93 seconds in 2nd, 190.79${\pm}$51.57 seconds in 3rd, 155.79${\pm}$62.67 seconds in 4th, and 127.93${\pm}$62.11 seconds in 5th. Therefore, these data shows that all three groups were improved in learning capacity as trials were repeated, but the shame group showed prominent improvement in learning compared with the control group(p<0.05).2. In memory retention test of Morris water maze that counts the staying time in the target area, sham group stayed for 15.36${\pm}$5.39 seconds, the control group stayed for 5.54${\pm}$5.64 seconds, and the sample group stayed for 7.43${\pm}$6.09 seconds. The analysis of the memory retention data shows that the sham group marked more significant improvement stati- stically in memory retention compared with the control group(p<0.05).3. In the learning of radial arm maze, the number and rate of animals that arrive the learning criteria amounted 12 out of 14, 85.7% in sham group, 4 out of 13, 30.8% in the control group, and 10 out of 14, 71.4% in the sample group So, the sample group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Hyungbangjiwhangtang can be supposed to have the improving effects on the learning and memory of AD rats induced by eletronical injury of nbM.

• Journal of Trauma and Injury
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• 제30권4호
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• pp.113-119
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• 2017

Purpose: Despite the numerous protocols and evidence-based guidelines that have been published, application of the therapeutics to eligible patients is limited in clinical settings. Therefore, a rounding checklist was developed to reduce errors of omission and the implementation results were evaluated. Methods: A checklist consisting of 12 components (feeding, analgesia, sedation, thromboembolic prophylaxis, head elevation, stress ulcer prevention, glucose control, pressure sore prevention, removal of catheter, endotracheal tube and respiration, delirium monitoring, and infection control) was recorded by assigned nurses and then scored by the staff for traumatized, critically ill patients who were admitted in the trauma intensive care unit (ICU) of Dankook University Hospital for more than 2 days. A total of 170 patients (950 sheets) between April and October 2016 were divided into 3 periods (period 1, April to June; period 2, July to August; and period 3, September to October) for the analysis. Questionnaires regarding the satisfaction of the nurses were conducted twice during this implementation period. Results: Record omission rates decreased across periods 1, 2, and 3 (19.9%, 12.7%, and 4.2%, respectively). The overall clinical application rate of the checklist increased from 90.1% in period 1 to 93.8% in period 3. Among 776 (81.7%) scored sheets, the rates of full compliance were 30.2%, 46.2%, and 45.1% for periods 1, 2, and 3, respectively. The overall mean score of the questionnaire regarding satisfaction also increased from 61.7 to 67.6 points out of 100 points from period 1 to 3. Conclusions: An ICU rounding checklist could be an effective tool for minimizing the omission of preventative measures and evidence-based therapy for traumatized, critically-ill patients without overburdening nurses. The clinical outcomes of the ICU checklist will be evaluated and reported at an early date.