• The Journal of Internal Korean Medicine
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• v.22 no.2
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• pp.251-256
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• 2001

In western medicine, there are some reports about herbal medicine induced hepatitis, but in oriental medicine, there are few reports about that. We experienced one case of drug acute cholestatic-hepatitis in the treatment of oriental medicine for HNP. We treated the patient with acupuncture, physical therapy and herb medicine. The patient's symptoms improved after two weeks of treatment. In the course of treatment, the patient intermittently complained of general weakness, nausea, yellowish urin, dyspepsia, and abdominal discomfort. We recognized that total bilirubin(7.2mg/dl), direct bilirubin(5.5mg/dl), serum transaminase(AST 360U/L, ALT 354U/L), alkaline phosphatase(16.6 K/A), urobilinogen(++) and bilirubin(++) were elevated. We diagnosed drug induced hepatitis. We stopped giving herb medicine and began giving Saeng gan gunbi-tang and Injin-oryung-san. Saeng gan gunbi-tang and Injin-oryung-san have been used to treat hepatic disease and have been known to have beneficial effects. After 3weeks on medication, the clinical symptoms and liver function improved. So, we report this case to bring more attention to the safety and toxicity of herbal medicine.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.3
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• pp.401-407
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• 2019

In this paper, the position estimation considering wheel slip of mecanum wheeled mobile robots is discussed. Since the mecanum wheeled mobile robot does not need a space to rotate, it is very suitable in narrow industrial fields. However, the slip caused by the roller attached to the wheel makes it difficult to estimate the position precisely. Due to these limitations, mecanum wheels are rarely applied to unmanned mobile robots in automation factories. In this paper, a method to compensate the orientation and distance error caused by the slip is proposed. The exact orientation is measured by fusing gyro and magnetometer sensor data with application of Kalman filter. In addition, the kinematic model accounting slip effects will be defined to compensate the distance error.

• Nuclear Engineering and Technology
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• v.55 no.2
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• pp.546-554
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• 2023

The cyclical behavior of Alloy 617 was examined at 25 ℃ and high temperatures of 800, 850, 900, and 950 ℃ in air to obtain its fatigue life curves. The specimens tested at 25, 800, and 850 ℃ cyclically hardened, whereas those tested above 900 ℃ cyclically softened from the first cycle, that is, their fatigue life was reduced at high temperatures owing to loss of strength. Parameters of the typical Coffin-Manson-Basquin relationship were determined for each test temperature. Interestingly, no significant difference in fatigue life was observed for the specimens tested in the range of 800-950 ℃. Owing to the similarity in fatigue life, we determined fatigue strength and fatigue ductility exponents that could be applied for this temperature range. The parameters obtained were close to the universal slopes, although the fatigue ductility exponent was slightly different. The proposed fatigue life curves were compared with those presented in ASME code.

• Journal of Korea Society of Digital Industry and Information Management
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• v.12 no.3
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• pp.181-204
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• 2016

Recently, the exhibition industry based on digital archive has been rapidly growing and the industry sees an innovative change with diverse digital archive exhibition venues emerging. Enabling visitors to enjoy new and varied exhibition provides a turning point to the exhibition environment. In today's world where IT (Information Technology) leads social changes, new framework and contents are required to establish digital culture that connects traditional culture with advanced information telecommunications. The objective of this study is to identify factors that influence the audience in a digital archive exhibition venue and to analyze impacts of these factors on exhibition success based on immersion and satisfaction. The study presents a research model that applies significant variables of emotional response theory in which fundamental psychological desire of humans is emphasized. To empirically verify the research model, the author conducted a survey for students of S university in Seoul and for ordinary people who have been to digital archive exhibition venues.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.1
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• pp.8-14
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• 2018

Printed circuit heat exchangers (PCHEs) are widely used with an increasing demand for industrial applications. PCHEs are capable of operating at high temperatures and pressure. We consider a PCHE as a candidate intermediate heat exchanger type for a high temperature gas-cooled reactor (HTGR). For conventional application using stainless steels, design and manufacturing of PCHEs are well established. For applications to HTGR, knowledge of longitudinal conduction and deformation of channel is required to estimate design margin. This paper analyzes the effects of longitudinal conduction and deformation of channel on thermal performance using a code internally developed for design and analysis of PCHEs. The code has a capability of two dimensional simulations. Longitudinal conduction is estimated using the code. In HTGR operating condition, about ten percent of design margin is required to compensate thermal performance. The cross-sectional images of PCHE channels are obtained using an optical microscope. The images are processed with computer image process technique. We quantify the deformation of channel with dimensional parameters. It is found that the deformation has negative effect on structural integrity. The deformation enhances thermal performance when the shape of channel is straight in laminar flow regime. It reduces thermal performance in cases of a zigzag channel and turbulent flow regime.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.1
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• pp.15-23
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• 2018

A compact heat exchanger is one of critical components in a very high temperature gas-cooled reactor (VHTR). Alloy 617 (Ni-Cr-Co-Mo) is considered as one of leading candidates for this application due to its excellent thermal stability and strengths in anticipated operating conditions. On the basis of current ASME code requirements, sixty sheets of this alloy are prepared for diffusion welding, which is the key technology to have a reliable compact heat exchanger. Optical microscopic analysis show that there are no cracks, incomplete bond, and porosity at/near the interface of diffusion weldment, but Cr-rich carbides and Al-rich oxides are identified through high resolution electron microscopic analysis. In high-temperature tensile testing, superior yield strengths of the diffusion weldment compared to the code requirement are obtained up to 1223 K ($950^{\circ}C$). However, both tensile strength and ductility drop rapidly at higher temperature due to the insufficient grain boundary migration across the interface of diffusion weldment. Best fit curves for minimum yield strength and average tensile strength are drawn from the experimental tensile results of this study.

• Korean Journal of Materials Research
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• v.30 no.10
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• pp.533-541
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• 2020

UO₂ kernels, a key component of fuel elements for high temperature gas cooled reactors, have usually been prepared by sol-gel methods. Sol-gel processes have a number of advantages, such as simple processes and facilities, and higher sphericity and density. In this study, to produce 900 ㎛-sized UO₂ particles using an external gelation process, contact length extension of the NH₃ gas of the broth droplets pass and the improvement of the gelation device capable of spraying 14 M-NH₄OH solution are used to form 3,000 ㎛-sized liquid droplets. To produce high-sphericity and high-density UO₂ particles, HMTA, which promotes the gelation reaction in the uranium broth solution, is added to diffuse ammonium ions from the outside of the gelation solution during the aging process and generate ammonium ions from the inside of the ADU gel particles. Sufficient gelation inside of ADU gel particles is achieved, and the density of the UO₂ spheres that undergo the subsequent treatment is 10.78 g/㎤; the sphericity is analyzed and found to be 0.948, indicating good experimental results.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.11 no.1
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• pp.12-19
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• 2015

As a measure of improving the mechanical properties of a diffusion bonded joint of a ferritic/martensitic steel (FMS), the post-bonding heat treatment (PBHT) is applied. In the temperature range of normalizing condition ($950-1,050^{\circ}C$), diffusion bonding is employed with compressive stress (6 MPa). Due to the martensite structure distributed in the matrix, Vicker's hardness values of the as-bonded are much higher than those of the as-received. Through the PBHT for 1 h at $720^{\circ}C$, hardness values are recovered to as low as those of the as-received condition. Also, tensile properties of PBHT are similar to those of the as-received at up to the test temperature of $550^{\circ}C$, when the diffusion bonding is carried out over $1,000^{\circ}C$. Based on the creep-rupture testing performed at $650^{\circ}C$ in air environment, the joint efficiency of the PBHTed specimens is about 80% in, which is higher than that of the as-bonded specimens.

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.572-582
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• 2021

This study investigated the creep and creep crack growth (CCG) behavior of the base metal (BM), weld metal (WM), and heat affected zone (HAZ) in a Gr. 91 weldment, which was made by a shield metal arc weld process. A series of tensile, creep, and CCG tests were performed for the BM, WM, and HAZ at 550 ℃. Creep behavior of the BM, WM, and HAZ was analyzed in terms of various creep laws; Norton's power-law, Monkman-Grant relation and damage tolerance factor (λ), and their constants were determined. In addition, each CCGR law for the BM, WM, and HAZ was proposed and compared in terms of a C^*-fracture parameter. The WM and HAZ revealed faster creep rate, lower rupture ductility, and faster CCGRs than the BM, but they showed a similar behavior in the creep and CCG. The CCGRs obtained in the present study exhibited a marginal difference when compared with those of RCC-MRx of currently elevated design code in France. A creep crack path in the HAZ plane progressed towards a weak fine-grained HAZ adjacent to the BM.

• Molecules and Cells
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• v.38 no.2
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• pp.105-111
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• 2015

The beta2-adrenergic receptor (${\beta}2AR$) belongs to the G protein coupled receptor (GPCR) family, which is the largest family of cell surface receptors in humans. Extra attention has been focused on the human GPCRs because they have been studied as important protein targets for pharmaceutical drug development. In fact, approximately 40% of marketed drugs directly work on GPCRs. GPCRs respond to various extracellular stimuli, such as sensory signals, neurotransmitters, chemokines, and hormones, to induce structural changes at the cytoplasmic surface, activating downstream signaling pathways, primarily through interactions with heterotrimeric G proteins or through G-protein independent pathways, such as arrestin. Most GPCRs, except for rhodhopsin, which contains covalently linked 11 cis-retinal, bind to diffusible ligands, having various conformational states between inactive and active structures. The first human GPCR structure was determined using an inverse agonist bound ${\beta}2AR$ in 2007 and since then, more than 20 distinct GPCR structures have been solved. However, most GPCR structures were solved as inactive forms, and an agonist bound fully active structure is still hard to obtain. In a structural point of view, ${\beta}2AR$ is relatively well studied since its fully active structure as a complex with G protein as well as several inactive structures are available. The structural comparison of inactive and active states gives an important clue in understanding the activation mechanism of ${\beta}2AR$. In this review, structural features of inactive and active states of ${\beta}2AR$, the interaction of ${\beta}2AR$ with heterotrimeric G protein, and the comparison with ${\beta}1AR$ will be discussed.