• 대한중풍순환신경학회지
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• 제15권1호
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• pp.85-89
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• 2014

■ Objectives The purpose of this clinical study is to evaluate the effect of Traditional Korean Medicine(TKM) on a patient with abnormal eye movement. ■ Methods A patient with abnormal eye movement of limbs diagnosed with midbrain infarction was treated with herbal medication, acupuncture, moxa, and herbal medical injection. Then we evaluated the improvement by measuring range of eye movement. ■ Results Increase of range of eye movement and improvement of symptom of diplopia were observed after the TKM treatment. ■ Conclusion This study proved the effect of TKM treatment on abnormal eye movement due to midbrain infarction.

• 한국임상수의학회지
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• 제24권1호
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• pp.10-14
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• 2007

The present study was performed to elucidate the recovery effect of needle-acupuncture (needle-AP) and moxibustion treatments at Gan Shu (BL18) on $CCl_4$ induced hepatic injury in dogs, Total 9 clinically healthy experimental dogs (1 to 2 years old, 2.3-5.3kg body weight) were divided into control (3 dogs), needle-AP (3 dogs) and moxibustion (3 dogs) groups, respectively. Hepatic iniw was induced by intraperitoneal injection with $CCl_4$ (olive oil : $CCl_4=1:1,\;1ml/kg$, once/day). As far the treatments in each group, control group was not treated at all after induction of the hepatic injury till the end of experiment. Needle-Af group was treated by AP at BL18 (once/day, 20 minutes) from the next day of induction of the hepatic injury for 11 days. Moxibustion group was also treated with commercial moxa at BL18 (once/day, 20minutes) for 11days. The changes of the serum alanine transaminase(ALT), aspartate transaminase(AST) and gamma glutamyl transpeptidase (GGT) activities were investigated on pre, 0, 1, 3, 5, 7 and 11 days after hepatic injury, respectively. Histopathological changes were also investigated in the liver tissues on day 11 in experimental and control groups. The results obtained in the present study were as follows. In needle-AP group, they showed significant lower values on the 1st (p<0.05) and $3^{rd} day (p <0.05)$ in serum ALT activities, and the $11^{th}$ day in serum GGT activities, compared with those of control group, respectively. However, the significances were not detected in serum AST activities of needle-AP group by comparison with those of control group. In moxibustion group, they showed significant low values on the $1^{st}(p<0.05)$, 3rd day (p<0.05) and $5^{th}$ day (p<0.05) in serum ALT activities, compared with those of control group, respectively. However, significances were not detected in serum GGT and AST activities of moxibustion group by comparison with those of control group. Among the experimental groups, the significant low values were found on $1^{st}\;and\;3^{rd}$ day in serum ALT activities (p<0.05), and $3^{rd}\;and\;5^{th}$ day in serum GGT activities (p<0.05) in needle-AP group, compared by those of moxibustion group, respectively. In addition, the marked recovery findings of histopathological changes in experimental groups were found, compared by those of control group: mild vacuolar degeneration and necrosis findings in needle-AP group, and moderate vacuolar degeneration and necrotic findings in moxibustion group were found, in contrast to severe changes such as accumulation of bile juice, vacuolar degeneration and necrotic findings observed in control group. In conclusion, needle-AP and moxibustion treatments at BL-18 were effective for the recovery for $CCl_4$ induced hepatic injury and needle-AP was more effective than that of moxibustion in dogs.

• 한국임상수의학회지
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• 제29권6호
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• pp.470-473
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• 2012

말라세지아성 외이염에 대한 아로마치료법 (아로마오일)과 약침치료법 (아피톡신)을 적용하여 임상증상 개선효과를 알아보기 위해 본 연구를 실시하였다. 실험군 5두는 아로마치료와 약침을 실시하였고 대조군 5두는 케토코나졸을 적용하였다. 임상증상은 대조군과 실험군에서 치료 전에 비해 각각 치료 후 2주 후에 유의성 있는 개선효과를 나타내었다 (p < 0.01, p < 0.05). ALT 수치는 대조군에서 치료 전에 비해 치료 후 1주, 2주 후에 각각 유의성 있는 증가소견을 나타내었다 (p < 0.05, p < 0.01). 실험군의 ALT 수치의 변화는 대조군에 비해 치료 1주 후, 2주 후에 각각 유의성 있는 감소소견을 나타내었다 (p < 0.05, p < 0.01). 결론적으로 말라세지아성 외이염에 대한 아로마치료법(아로마 오일)과 약침치료법은 효과가 있으며 대조군에 비해 간독성은 적은 것으로 나타났다.

• Clinics in Shoulder and Elbow
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• 제23권1호
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• pp.3-10
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• 2020

Background: The aim of this study was to evaluate clinical experience with arthroscopic debridement for septic arthritis of the shoulder joint and to report on our patient outcomes. Methods: The retrospective analysis included 36 shoulders (male:female, 15:21), contributed by 35 patients (mean age, 63.8 years) treated by arthroscopy for septic arthritis of the shoulder between November 2003 and February 2016. The mean follow-up period was 14.3 months (range, 12-33 months). An additional posterolateral portal and a 70° arthroscope was used to access the posteroinferior glenohumeral (GH) joint and posteroinferior subacromial (SA) space, respectively. Irrigation was performed with a large volume of fluid (25.1±8.1 L). Multiple suction drains (average, 3.3 drains) were inserted into the GH joint and SA space and removed 8.9±4.3 days after surgery. Intravenous antibiotics were administered for 3.9±1.8 weeks after surgery, followed by oral antibiotic treatment for another 3.6±1.9 weeks. Results: Among the 36 shoulders, reoperation was required in two cases (5.6%). The average range of motion achieved was 150.0° for forward flexion and T9 for internal rotation. The mean simple shoulder test score was 7.9±3.6 points. Nineteen shoulders (52.8%) had acupuncture or injection history prior to the infection. Pathogens were identified in 15 shoulders, with Staphylococcus aureus being the most commonly identified pathogen (10/15). Both the GH joint and the SA space were involved in 21 shoulders, while 14 cases involved only the GH joint and one case involved only the SA space. Conclusions: Complete debridement using an additional posterolateral portal and 70° arthroscope, a large volume of irrigation with >20 L of saline, and multiple suction drains may reduce the reoperation rate.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.417-421
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• 2018

카르복시테라피(Carboxytherapy)는 메조테라피(mesotherapy)와 방법, 치료 조건 및 결과 면에서 매우 유사하다. 그러나 중요한 차이점은 카르복시테라피는 이산화탄소 가스를 피부 바로 아래의 피하층으로 주입하는 반면 메조테라피는 비타민, 미네랄, 그리고 약물의 혼합물을 주입한다는 것이다. 메조테라피의 합병증으로 혈종, 파누스육아종, 봉와직염, 농양 등 이전에 많은 사례들이 보고되었으나, 카르복시테라피는 피하 및 얕은층에 이산화탄소를 주입하고, 이산화탄소는 주입 1주일 안에 흡수되기 때문에 부작용이 거의 보고 되지 않았다. 3일전과 2주전에 한의원에서 카르복시테라피를 받은 29세 여자 환자가 고열, 근육통, 심한 요통 및 엉덩이 부위부터 아래쪽 흉벽까지 피하 기종을 주소로 응급실에 내원하였다. 진단 및 치료를 위해 컴퓨터 단층 촬영을 시행하였으며, 즉시 영상의학과에 판단을 의뢰하였다. 바늘에 의한 손상으로 인한 급성 복막염을 배제할 수 없어 즉각적인 광범위항생제를 투여하였으며, 판독 결과 근육염과 바늘 손상으로 인한 신우신염이 확진되었다. 신우 신염의 경우 적절한 치료가 이루어지지 않으면 패혈증까지 진행할 수 있어 치명적인 결과를 초래 할 수 있다. 따라서 만일 바늘에 찔리거나 침을 맞은 후에 환자가 늑골척추부위나 허리에 통증이 있는 경우 응급의학과 의사는 진단 및 치료를 위해 신속한 초기 평가가 필요하다.

• 대한관절경학회지
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• 제12권1호
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• pp.53-57
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• 2008

목적: 슬관절에 발생한 급성 화농성 관절염의 관절경적 치료 후 결과에 대하여 분석하였다. 대상 및 방법: 2000년 7월에서 2005년 1월까지 16예(15명)의 관절경적 치료를 시행한 급성 화농성 슬관절염 환자를 대상으로 하였다. 환자의 평균 나이는 61.9세였고 평균 추시 기간은 30.5개월이었다. 당뇨병이나 퇴행성 관절염 등의 기존 질환이 있었던 경우가 8예 였으며 과거력상 슬관절에 침을 맞거나 관절내 주사를 시행 받은 경우가 14예였다. 결과: 원인균의 동정이 가능했던 예는 7예(43.8%)였다. 술 후 정맥 내 항생제를 평균 25.5일 사용하였으며 경구 항생제를 평균 22.5일 사용하였다. 슬관절 강직 5예, 이차성 관절염 2예, 슬관절 주위 만성 골수염 1예, 사망 3예 등 총 11예의 합병증이 발생하였다. 수술 후 3주 이상 부목 고정을 시행한 경우 슬관절 강직이 유의하게 많았으나(p=0.032) 증상 발현 후 1 주일을 기준으로 치료까지의 기간에 따른 합병증의 발생 빈도는 차이를 보이지 않았다(p=0.293). 배양 검사 상 원인균이 동정된 경우 더 많은 합병증이 발생하였다(p=0.034). 결론: 화농성 슬관절염의 관절경적 치료 후 관절 강직의 발생 빈도와 고정 기간과 상관 관계가 있었다. 합병증 발생 빈도는 증상 후 치료까지의 기간과는 연관이 없었으나 원인균의 동정된 여부와는 연관이 있었다.

• 대한의생명과학회지
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• 제11권3호
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• pp.343-347
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• 2005

Bambusae caulis in Liquamen is one of the important herbal medicine produced by heating bamboo indirectly and is used for treatment of stroke, hypertension, and diabetes etc. Recently the mechanism of clinical effects on Bambusae caulis in Liquamen has been studied. This experiment was conducted to confirm the clinical effects of Bambusae caulis in Liquamen on type 1 diabetes and its related mechanism. We divided C57BL/6 mice into 3 groups and induced them to be type 1 diabetes by injection of streptozocin into peritoneum. The dosage of each group was 150 mg/kg once only, 140 mg/kg once only and 40 mg/kg for 5 days respectively. The two groups injected streptozocin for once took orally Bambusae caulis in Liquamen after the induction of diabetes, and the other one group was given Bambusae caulis in Liquamen during the diabetes inducing period. As the result, the two diabetes-induced groups showed blood glucose decreasing effect by Bambusae caulis in Liquamen on an average, but they didn't show the signiftcant differences statistically. But Bambusae caulis in Liquamen showed the anti-diabetic effect suppressing blood sugar rising trend during the diabetes inducing peried (P<0.05). The anti-oxidative effect of Bambusae caulis in Liquamen was measured with the hypoxanthine/xanthine oxidase (HX/XOD) system. The quantity of ROS was measured using DCFDA reagent indirectly. As the result, $10\%$ solution of Bambusae caulis in Liquamen showed anti-oxidative effect by scavenging $93.4\%$ superoxide as compared with control group. It is suspected that the anti-oxidative effect of Bambusae caulis in Liquamen suppressed the increase of blood glucose in the diabetes-inducing group. These results could be useful data to understand the effect of Bambusae caulis in Liquamen on type 1 diabetes and type 1 diabetes developing because ROS were closely connected with the induction and complications of diabetes.

• 재활간호학회지
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• 제1권1호
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• pp.51-60
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• 1998

The result of studying papers about management of lower back pain published in domestic and foreign nursing and medical magazines in these 10 years is as follows ; 1. General characteristic of lower back pain ; 1) In sex distribution, there were more men than women in 5 papers and more women than men in 4 papers among 9 papers surveryed. 2) In age distribution, thirties to forties of patients had more lower back pain as surveyed by general hospitals and fifties to sixties of patients had more lower back pain as surveyed by oriental medical hospitals. 3) In cause factor, there were 50 to 65% of sprain, 32 to 44% of herniated intervertebral disc and 13 to 29% of degenerative changes. 4) In symtom distribution, there were 26 to 57% of lower back pain, 42 to 65% of lower back pain with radiating pain and 34 to 99% of paravertevral muscle spasm. 5) In period of pain management distribution, 18 to 40% of patients experienced pain for less than 6 months and 59 to 82% of them experienced pain for more than 6 months in 3 papers among 4 papers. 6) In surveying the treatment, 66 to 88% of patients had conservative treatment and there were treatments of general hospital, oriental medicine, self remedy and traditional practice in conservative treatment. 7) In job distribution, 12 to 50% of them were housekeepers, 23 to 31% office workers, 4.6 to 36% blue color workers and 11 to 15% students. 2. As psychological character lower back pain paients had anxiety, depression, anger-hostility, phobic anxiety, neurasthenia, hypochondriasis, and interpersonal sensitivity. 3. To distinguish the cause of lower back pain, plain lumbar roentgenogram, straight leg rasing test, eletromyelogic findings, somatosensory evoked potentials CT and MRI were performed. 4. To relieve lower back pain. epidural adhesiolysis, epidulal injection of local anesthetic in mixture with steroid, lumbar spinal root block, low level laser therapy, acupuncture like transcutaneous nerve stimulation(AL TENS), topical capsaicin and lumbar orthotics were used in medical field, and relaxation technique was used in nursing field. 5. Mckenzie's extension exercise and William's flexsion exercise for lower back pain were used in medical field and Yoga exercise was applied in nursing field. 6. The more school education and self efficacy were high, the better they had active coping lower back pain positively and the less self efficacy was the more they had serious pain. As a result of studying the paper there have been very little research for lower back pain in nursing fields of Korea and foreign countries. Because 60 to 80% of population expeience lower back pain at least more than once, it is necessary to develop the study and clinical practice for management of lower back pain.

• The Korean Journal of Physiology and Pharmacology
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• 제21권6호
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• pp.625-632
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• 2017

Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the ${\alpha}$-synuclein (${\alpha}$-syn) gene. Mutant ${\alpha}$-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygous (hemi) or homozygous (homo) A53T ${\alpha}$-synuclein (${\alpha}$-syn Tg) and their wildtype (WT) littermates by treatment with sub-toxic (10 mg/kg, i.p., daily for 5 days) or toxic (30 mg/kg, i.p., daily for 5 days) dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Tyrosine hydroxylase and Bcl-2 levels were reduced in the ${\alpha}$-syn Tg but not WT mice by sub-toxic MPTP injection. In the adhesive removal test, time to remove paper was significantly increased only in the homo ${\alpha}$-syn Tg mice. In the challenging beam test, the hemi and homo ${\alpha}$-syn Tg mice spent significantly longer time to traverse as compared to that of WT group. In order to find out responsible proteins related with vulnerability of mutant ${\alpha}$-syn expressed neurons, DJ-1 and ubiquitin enzyme expressions were examined. In the SN, DJ-1 and ubiquitin conjugating enzyme, UBE2N, levels were significantly decreased in the ${\alpha}$-syn Tg mice. Moreover, A53T ${\alpha}$-syn overexpression decreased DJ-1 expression in SH-SY5Y cells. These findings suggest that the vulnerability to oxidative injury such as MPTP of A53T ${\alpha}$-syn mice can be explained by downregulation of DJ-1.

• Korean Journal of Acupuncture
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• 제40권3호
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• pp.90-98
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• 2023

Objectives : Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized by the loss of the dopaminergic neurons in the substantia nigra (SN). In a previous in vitro study, we demonstrated that Sihogyeji-tang (SG), Sihosogan-tang (SS), and Sihocheonggan-tang (SC) have the potential to be candidate medicines for PD. This study aimed to compare the neuroprotective effect of SG, SS, and SC using 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine (MPTP)-induced PD mouse model. Methods : Eight-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP for 5 days and orally administered SG, SS and SC for 12 days from the first MPTP injection. Motor function was assessed using the pole test and the rotarod test. Dopaminergic neuronal survival in the SN and striatum was evaluated through tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration resulted in behavioral impairment and dopaminergic neuronal death in the SN and striatum. In the pole test, treatment with SG, SS, and SC alleviated the MPTP-induced motor dysfunction on day 5 and 12. In the rotarod test, SS and SG alleviated the MPTP-induced motor dysfunction on day 5, while only SS showed improvement on day 12. SS and SG significantly protected dopaminergic neurons in the SN from MPTP toxicity, and all three compounds (SG, SS, and SC) showed significant protection in the striatum. Notably, SS demonstrated superior efficacy in suppressing MPTP-induced motor dysfunction and dopaminergic neuronal death compared to SG and SC. Conclusions : These findings suggest that SS is the most effective formula among SG, SS, and SC for PD, indicating its potential role in the treatment of PD.