• Korean Journal of Acupuncture
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• v.36 no.1
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• pp.52-62
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• 2019

Objectives : The objective of this study was to investigate the effects of Zingiberis Rhizoma Pharmacopuncture(ZP) at GB30 and ST36 in neuropathic pain induced SD rats by the block of Transient Receptor Potential Vanilloid 1(TRPV1). Methods : Neuropathic pain in rats was induced by tibial and common peroneal nerve transection of right leg. The rat subjects were divided into 6 groups : normal(Nor, n=5), control(Con, n=5), neuropathic pain plus 2 mg/kg ZP injection at GB30 and ST36(ZP-A, n=5), 10 mg/kg ZP(ZP-B, n=5), 20 mg/kg ZP(ZP-C, n=5) and 0.45 mg/kg Tramadol(Tra, n=5). Three days after the surgery, injections were administered once a day for 17 days. Withdrawal response of neuropathic rats' legs were measured by stimulating the paw of Right leg with von frey filament, acetone and radient heat on day 3, 7, 11, 15, 19 after surgery. After all treatments were completed, c-Fos in the midbrain central gray and TRPV1 & TRPA1 of DRG(L5) were analyzed. Results : Groups ZP-B and ZP-C showed a meaningful decrease in the withdrawal response of mechanical allodynia, thermal hyperalgesia and cold allodynia compared to the control group(p<0.05, p<0.01, p<0.001). Groups ZP-B and ZP-C showed a meaningful decrease in the expression of c-fos and TRPV1 protein level compared to the control group(p<0.05, p<0.01, p<0.001). Conclusions : These results suggest that Zingiberis Rhizoma Pharmacopuncture at GB30 and ST36 could decrease mechanical & cold allodynia and thermal hyperalgesia by block the TRPV1 on the model of neuropathic pain.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.1
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• pp.109-118
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• 2021

Objectives The objective of this study was to appraise the effect of electro-acupuncture (EA) for the treatment of cervical vertigo. Methods We performed a literature search using nine electronic databases up to the end of November 2020. We included randomized controlled trials (RCTs) which appraised the effect of EA in the treatment of cervical vertigo. The risk of bias was evaluated from the Cochrane risk of bias tool. Results Thirteen appropriate RCTs were included and analyzed. The efficacy rate of the EA group was statistically higher compared with the control group treated with western medicine (p<0.00001). EA treatment significantly improved efficacy rate when combined with western medicine than western medicine alone (p<0.0001). Also EA used with combined therapy (traction, traditional chinese medicine, injection) significantly improved efficacy rate compared with combined therapy alone (p=0.02). Meta-analysis of thirteen studies demonstrated positive results for using EA for the treatment of cervical vertigo. Conclusions Based on results, EA treatment could be effective in cervical vertigo. However, it should be noted that the studies included in this research are regionally biased and small in number. Further well-designed research should be required.

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.269-276
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• 2023

Objective: This study reported the effectiveness of Korean medicine for a patient with Type-1 diabetes mellitus after pancreatectomy with a compression fracture of the thoracic spine. Methods: A patient diagnosed with Type-1 diabetes mellitus after a pancreatectomy was treated with acupuncture, pharmacopuncture, Gami-hwanggigyejiomul-tang (modified Huangqi Guizhi Wuwu decotion), Jindang-won, etc. The conventional treatment was maintained using an insulin pump and insulin injection. Results: Blood glucose (FBS/PP2hrs), ESR and CRP decreased after one month of treatment. Conclusion: Gami-hwanggigyejiomul-tang and Jindang-won may be effective treatments for Type-1 diabetes mellitus. Further studies are needed to confirm the findings of this case.

• The Journal of the Society of Stroke on Korean Medicine
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• v.16 no.1
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• pp.11-18
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• 2015

■ Objectives The purpose of this clinical study is to evaluate the effect of Traditional Korean Medicine(TKM) on a patient with tremor. ■ Methods A patient with tremor of one side hand diagnosed with Parkinson's disease was treated with herbal medication, acupuncture, electro-acupuncture(EA), and herbal medical injection. Then we evaluated the improvement by Unified Parkinson's Disease Rating Scale(UPDRS), Parkinson's disease Quality of Life(PDQL) and Visual Analog Scale(VAS). ■ Results Decrease of UPDRS, VAS score and improvement of PDQL score were observed after the TKM treatment. ■ Conclusion This study proved the effect of TKM treatment on tremor due to Parkinson's disease.

• The Journal of the Society of Stroke on Korean Medicine
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• v.16 no.1
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• pp.81-88
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• 2015

■ Objectives The purpose of this clinical study is to evaluate the effect of Traditional Korean Medicine(KM) on a patient with Tolosa-Hunt syndrome. ■ Methods We treated a 58 years old male patien t with Tolosa-Hunt syndrome who had several clinical symptoms such as ocular pain, limitaion of ocular movement and unilateral ptosis. We used herbal medication, acupuncture, electro-acupuncture(EA), cupping, moxibustion, bee-venom injection. Then we evaluated the improvement by Numerical Rating scale(NRS), Distance of eye opening and ratio of pupil movement. ■ Results We demonstrated the decrease of pain score and improvement of equal ocular movement(EOM) and ptosis after the KM treatment. ■ Conclusion This study proved the effect of KM treatment on Tolosa-Hunt syndrome. It could cooperative treatment would be more effective than mono treatment of western medicine.

• Korean Journal of Acupuncture
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• v.36 no.4
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• pp.221-229
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• 2019

Objectives : This study investigated the hepatoprotective effect of herbal mixture including Lycii fructus (HML) in thioacetamide (TAA)-induced hepatotoxicity in mice. Methods : To confirm the liver protective effect, induced by TAA for 3 days injection at 100 mg/kg mice, HML were treated for 8 weeks at 300 mg/kg/day, 1000 mg/kg/day. Positive control was treated silymarin 50 mg/kg/day after TAA injection. The changes of mortality rate, clinical signs, organ weight, relative liver, blood chemistry and histopathological findings were analyzed after experiment. Results : Body weight gain was observed in all groups, but TAA treated group at 4th week and all treated groups decreased weight compared to the untreated group. As a result of organ weight measurement, organ weight gain due to hepatic injury was observed statistically significantly in TAA-treated group and TAA+Silymarin treated group, and the herbal mixture-treated group showed a tendency to decrease compared to the TAA treated group. Blood biochemistry showed that total cholesterol and very low density lipoprotein cholesterol decreased statistically in TAA+low-dose and high dose herbal mixture treated group compared to the TAA-treated group. Histopathological examination showed that liver abnormalities were not observed in untreated group, liver fibrosis was observed in liver injury with TAA treated and herbal mixture treated group. And, TAA+high dose herbal mixture group showed relaxation tendency on liver calcification compared to the TAA treated group. Conclusions : According to the above results, HML provided hepatoprotective effects on the hepatic injury by reduction of inflammatory responses.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.4
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• pp.174-185
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• 2022

Objectives: The purpose of this study is to report the improvement of recurrent cervical intraepithelial neoplasia (CIN) and chief complaint including dysmenorrhea, premenstrual syndrome after Korean medicine treatment. Methods: The patient who diagnosed CIN even after undergoing two times of loop electrosurgical excision procedure (LEEP) and complained dysmenorrhea with premenstrual syndrome was treated by acupuncture, moxibustion and herbal medicine as Ojeok-san-gami-bang along with mistletoe extract injection (Abnobaviscum^®). The effect of treatment was evaluated by the results of liquid based cytology and HPV genotyping. Other symptoms were evaluated according to the patient's subjective complaint. Results: Before the treatment, the result of cytology was low grade squamous intraepithelial lesion and a low-risk group for HPV was detected. At the first examination after treatment, cytology showed negative for intraepithelial lesion or malignancy and the HPV genotyping was negative. The result showed negative findings in 3 consecutive follow-up tests. In addition, the chief complaint and general conditions were improved. Conclusion: This study shows that the recurrent cervical intraepithelial neoplasia (CIN) was improved after the Korean traditional treatment and it can be effective medical alternatives or options for patients receiving mistletoe injection during follow-up.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.2
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• pp.58-74
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• 2024

Objectives: This study aims to evaluate the efficacy of urinary incontinence treatment using catgut embedding therapy. Methods: Using electronic databases including Pubmed, EMBASE, and CAJ, we looked for randomized controlled trials that treated urinary incontinence with catgut embedding that were published between January 2000 and December 2023. The chosen clinical studies' interventions and outcomes were examined. Results: Ultimately, eight randomized controlled trials met the inclusion and exclusion criteria. Treatment group was treated with catgut embedding alone in 3 studies, and with Biofeedback Electrical Stimulation Therapy (Biofeedback EST), Kegel exercises, Herbal Medicine and Acupuncture Injection in 5 studies. Control group was treated with Biofeedback EST, Kegel exercises, Herbal Medicine, Vitamin B, Electroacupuncture (EA), Denitine Tolterodine Tartrat with Bladder Drill, Tension-free Vaginal Tape Obturator (TVT-O) and Acupoint Injection Therapy. Outcome measures are total efficacy rate, Urine pad test, Urinary frequency, Maximum bladder capacity, VRP, POP-Q, etc. 關元 (CV4) was the most frequently used acupoint in catgut embedding therapy. In all of 8 studies, treatment group was more effective for urinary incontinence than the control group. Conclusions: According to this study, catgut embedding may be useful in enhancing the therapeutic outcome for urine incontinence, either by itself or in conjunction with standard medical treatment.

• Korean Journal of Acupuncture
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• v.22 no.3
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• pp.83-104
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• 2005

Objectives : DaeBangPungTang(DBPT) is one of the prescriptions used for the treatment of knee arthritis in oriental medicine. The present study aimed to examine the analgesic effect of DBPT on a rat model of carrageenan-induced arthritis, and the relations between DBPT-induced analgesia and endogenous nitric oxide(NO) and inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and c-Fos protein expression in the spinal cord. Methods : Carrageenan-induced arthritis rat model was used to test the effect of DBPT as a chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least tile next 4 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral infection of indomethacin produced temporary improvement of weight bearing. DBPT dissolved in normal saline was minted several acupoints. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 12 hours. Results : DBPT produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 9 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. DBPT produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and iNOS, COX-2 protein expression increased by arthritis were suppressed by DBPT. DBPT on combination with electroacupuncture (EA) produced more powerful and longer lasting improvement of stepping force of the hindlimb affected by the arthritis than either DBPT or EA did. Conclusion : The present study suggest that DBPT produces a potent analgesic effect on the chronic hee arthritis pain model in the rat and that DBPT-induced analgesia modulate endogenous NO through the suppression of iNOS/COX-2 protein expression.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.1
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• pp.163-172
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• 2008

Objectives : This study was performed to evaluate the effects of thoracic vertebral region's Du mai(督脈) and Jia ji xue(夾脊穴) intervention on active range of motion(ROM) restricted shoulder pain. Methods : 1. Measurement : The unpleasantness of pain was measured by visual analogue scale(VAS), and ROM was measured by using Goniometer and scratch test. 2. Intervention : Use Acupuncture and bee venom injection in thoracic vertebral region's Du mai(督脈) and Jia ji xue(夾脊穴) that display main tender points. Results : The pain and ROM were improved after thoracic vertebral region intervention. Conclusion : Thoracic vertebral region intervention was effective to active ROM restricted shoulder pain, to reduce the pain and to improve ROM. And this study shows that active ROM restricted shoulder pain and thoracic vertebral region's tender points are connected to each other. Also, region that suggest main tender points previews region of thoracic vertebrae 5-8.