• Molecules and Cells
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• v.43 no.12
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• pp.1002-1010
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• 2020

Cilia are important eukaryotic cellular compartments required for diverse biological functions. Recent studies have revealed that protein targeting into the proper ciliary subcompartments is essential for ciliary function. In Drosophila chordotonal cilium, where mechano-electric transduction occurs, two transient receptor potential (TRP) superfamily ion channels, TRPV and TRPN, are restricted to the proximal and distal subcompartments, respectively. To understand the mechanisms underlying the sub-ciliary segregation of the two TRPs, we analyzed their localization under various conditions. In developing chordotonal cilia, TRPN was directly targeted to the ciliary tip from the beginning of its appearance and was retained in the distal subcompartment throughout development, whereas the ciliary localization of TRPV was considerably delayed. Lack of intraflagella transport-related proteins affected TRPV from the initial stage of its pre-ciliary trafficking, whereas it affected TRPN from the ciliary entry stage. The ectopic expression of the two TRP channels in both ciliated and non-ciliated cells revealed their intrinsic properties related to their localization. Taken together, our results suggest that sub-ciliary segregation of the two TRP channels relies on their distinct intrinsic properties, and begins at the initial stage of their pre-ciliary trafficking.

• The korean journal of orthodontics
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• v.6 no.1
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• pp.33-38
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• 1976

For the purpose of evaluating the response of the periodontal tissue in relation to the experimental tooth movement, orthodontic force was applied to 15 female rats. The animals were investigated histopathologically and histochemically by several staining methods. Findings were as follows: 1. The application of 60gm on the rat's molar caused mesial tipping movement and undermining resorption. 2. One day after the insertion of the appliance, the osteoblast was increased in activity but not in number. 3. The osteoclastic activity was decreased as soon as removing the appliance. 4. With the P.A.S. staining, osteoclasts Stained mildly in the initial stage and stained more intensely in the last stage. Osteoclasts revealed negative reaction in the initial stage and stained mildly in the last stage. 5. Slides stained with toluidine blue revealed no conclusive variations between osteoblasts and osteoclasts.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.4
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• pp.29-35
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• 2007

The main objective of this paper is to propose the optimal design method of forging process using genetic algorithm. Design optimization of forging process was doing about one stage and multi stage. The objective function is considered the filling of die. The chosen design variables are die geometry in multi stage and initial billet shape in one stage. We performed FE analysis to simulated forging process. The optimized preform and initial billet shape was obtained by genetic algorithm and FE analysis. To show the efficiency of GA method in forging problem are solved and compared with published results.

• Transactions of Materials Processing
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• v.5 no.2
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• pp.97-104
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• 1996

It is very important to obtain the knowledge of loads and flow patterns in most processes because these information are the fundamental data of die design and process design. The objective of present study is to investigate loads and metal flow patterns for various process conditions in flat die extrusion of square-bars from circular billets. For analyzing the metal flow patterns of the billets photo etching is used on sections of split specimen. From this method metal flow patterns are analyzed for various area reductions friction factors and punch stroke through the process from initial-stage to final-stage. Experiments are carried out with hard solder billets at room temperature.

• Korean Journal of Chemical Engineering
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• v.35 no.11
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• pp.2150-2156
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• 2018

We suggest a systematic method for obtaining the optimal compression ratio in the multi-stage closed-loop compression process of carbon dioxide. Instead of adopting the compression ratio of 3 to 4 by convention, we propose a novel approach based on mathematical analysis and simulation. The mathematical analysis prescribes that the geometric mean is a better initial value than the existing empirical value in identifying the optimal compression ratio. In addition, the optimization problem considers the initial installation cost as well as the energy required for the operation. We find that it is best to use the fifth stage in the general closed-loop type carbon dioxide multi-stage compression process.

• Journal of the Korean Operations Research and Management Science Society
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• v.18 no.1
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• pp.1-18
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• 1993

The family disaggregation model of hierarchical production planning (HPP) is the problem of (0 -1) mixed integer programming that minimizes the total sum of setup costs and inventory holding costs over the planning horizon. This problem is hard in a practical sense since optimal solution algorithms have failed to solve it within reasonable computation times. Thus effective familoy disaggregation algorithm should be developed for HPP. The family disaggregation algorithm developed in this paper consists of the first stage of finding initial solutions and the second stage of improving initial solutions. Some experimental results are given to verify the effectiveness of developed disaggregation algorithm.

• Communications for Statistical Applications and Methods
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• v.5 no.1
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• pp.231-238
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• 1998

A two stage shrinkage testimator for the mean of an exponential distribution is considered with the assumption that an initial estimate of the mean is available. Mean squared error(MSE) of testimator and its relative efficiency (to usual single sample mean) are briefly reviewed. It is shown that relative efficiency depends only on the ratio of true mean value and its initial estimate.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.1
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• pp.120-129
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• 2020

This paper aims to benchmark the United States' LRIP, the country's initial production policy, and provide a Korean version of such policy which reflects the circumstances of the country's weapon system research & development(R&D) and acquisition procedures. The research suggests measures to improve the country's initial production policy in a direction that the policy could execute two stage continuously: (1) employment test & evaluation(OT&E), conducted on prototypes during the development stage, and (2) field employment tests(FT), conducted on initial products during the production stage. In addition, the research provides an equation calculating the optimal number of initial test products to be produced, applying statistical theories of t-distribution. The research aims to be used a reference to calculate the optimal number of initial products to be produced for testing in order to improve future national defense acquisition systems and the stable R&D of weapons systems.

• Radiation Oncology Journal
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• v.2 no.1
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• pp.93-100
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• 1984

Among 238 patients with Non-Hodgkin's lymphoma received radiotherapy at Yonsei Cancer center, Yonsei University Medical College, from 1970 to 1981, 30 patients presented with localized(Stage I&II ) gastrointestinal lymphomas. Retrospective analysis of these 30 cases in an attempt to evaluate the influence of various prognostic factors and the effectiveness of therapy is presented. Overall 5 year survival rate of 30 cases of primary gastrointestinal lymphoma was $48\%$. Bulk of residual disease after initial surgery and stage were significant prognostic factors. Stage I with small residual disease treated with post-op irradiation achieved $100\%$ 5 year survival rate. So above group is considered curable with surgery and post-op irradiation. $80\%$ of Stage II with large residual disease were died with intra-abdominal local tumor control failure. Stage II with small residual disease showed $31.5\%$ 5 year survival rate. Non of them died with local failure. So, we suggest that complete surgical resection of tumor mass should be attempted initially in the management of localized gastrointestinal lypmhomas and systemic chemotherapy is needed in addition to post-op irradiation in the cases of Stage II and large residual disease after initial surgery.

• The Research Journal of the Costume Culture
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• v.4 no.2
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• pp.157-171
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• 1996

The purpose of this study was to find out the effect of fashion information source in the stage of purchase decision-making and difference by stage of purchase decision-making and difference by stage of the effect extend, and to analyze the difference by fashion information source. For this study, the data were collected through the questionnaire distributed to 337 female students from five universities. The results are as follows: 1) There was significant difference among the effect to fashion information source according to the purchase decision-making stage. At the adoption stage, fashion information source have the most effect on clothing purchase. 2) The effect of Impersonal Source in the purchase decision-making stage was gradually decreased fro the initial (awareness, interest) sage to the late stage. 3) The effect of Personal Source in the purchase decision-making stage was gradually increased from the initial (awareness, interest) stage to the late stage. 4) Addition stage was highly influenced by friend and family that was Personal Independent Source than other fashion information source. However the final selection on clothing purchase was not influenced by friend and family. 5. There was significant difference among the effect of fashion information source according to the grade. Low garde students were highly influenced by Personal Source on clothing purchase, but high grade students were highly influenced by Impersonal Sources on clothing purchase. 6) There was significant difference among the effect of fashion information source according to the major. The students a majored clothing & textile-design were highly influenced by Impersional Source. These results suggest that fashion information source was significantly different according to purchase decision-making stage and was influenced by grade and major of subjects.