• Tuberculosis and Respiratory Diseases
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• 제71권4호
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• pp.286-290
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• 2011

Although failure of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI) is generally believed to be associated with cross-resistance to other EGFR TKI, the benefit of administering erlotinib as a second EGFR TKI after resistance of gefitinib as the first TKI has been well known. However, good response to gefitinib after an initial response to erlotinib has been rare. We report that a 45-year-old woman (never smoked), with lung adenocarcinoma and EGFR mutation, showed an initial response to erlotinib, and then responded to gefitinib again.

• 한국지진공학회논문집
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• 제26권2호
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• pp.95-103
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• 2022

In order to evaluate the earthquake safety of equipment in structures, it is essential to analyze the In-Structure Response Spectrum (ISRS). The ISRS has a peak value at the frequency corresponding to the structural vibration mode, but the frequency and amplitude at the peak can vary because of many uncertain parameters. There are several seismic design criteria for ISRS peak-broadening for fixed base structures. However, there are no suggested criteria for constructing the design ISRS of seismically isolated structures. The ISRS of isolated structures may change due to the major uncertainty parameter of the isolator, which is the shear stiffness of the isolator and the several uncertainty parameters caused by the nonlinear behavior of isolators. This study evaluated the effects on the ISRS due to the initial stiffness of the bi-linear curve of isolators and the variation of effective stiffness by the input ground motion intensity and intense motion duration. Analyzing a simplified structural model for isolated base structure confirmed that the ISRS at the frequency of structural mode was amplified and shifted. It was found that the uncertainty of the initial stiffness of isolators significantly affects the shape of ISRS. The variation caused by the intensity and duration of input ground motions was also evaluated. These results suggested several considerations for generating ISRS for seismically isolated structures.

• Composites Research
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• 제22권1호
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• pp.1-8
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• 2009

본 논문에서는 면내하중을 받는 복합적층판의 저속충격거동과 손상을 해석하였다. 초기부터 존재하는 면내변형률을 고려하여 판의 변위장을 새롭게 가정하고, 이 가정된 변위장에 따른 적층판의 구조거동에 대한 유한요소방정식을 유도하였으며, 유한요소해석 프로그램을 코딩하였다. 유한요소해석을 수행하여 참고문헌의 수치해석 결과와 비교하였으며, 충격에너지는 동일하나 충격체의 질량과 속도가 다른 조건에 대해서도 해석하여 초기 면내하중의 영향을 분석하였다. 바닥으로부터 첫 번째 층간면에서의 잠재적인 층간분리 파손영역을 추정하여 초기 인내하중 및 충격조건에 따른 크기의 변화를 고찰하였다.

• 한국농공학회논문집
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• 제46권2호
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• pp.67-75
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• 2004

This study aims to investigate the dynamic behaviour of a parabolic arch with initial deflection by using the elasto-plastic finite element model where the von-Mises yield criteria have been adopted. The initial deflection of arch was assumed by the high order polynomial of ${\omega}_i$ = ${\omega}_o$${(1-{(2x/L)}^m)}^n$) and the sinusoidal profile of ${\omega}_i$ = ${\omega}_o$$\sin$(n$\pi$x/L). Several numerical examples were tested considering symmetric initial deflection modes when the maximum initial deflection of an arch is fixed as L/500, L/1000, L/2000 or L/5000. The effects of polynomials order on the dynamic behavior of arch were not conspicuous. The most unfavorite dynamic response occurs when the maximum initial deflection varies from L/1000 to L/4000 if the initial deflection mode is represented by high order polynomials.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 춘계학술대회 논문집
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• pp.225-228
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• 2002

When the fuzzy logic controller (FLC), which is designed based on the plant model, is applied to the real control system, satisfactory control performance may not be attained due to modeling errors from the plant model. In such cases, the control parameters of the controller must be adjusted to enhance control performance. Until now, the trial and error method has been used, consuming much time and effort. To resolve such problem, response surface methodology (RSM), a new method of adjusting the control parameters of the controller, is suggested. This method is more systematic than the previous trial and error method, and thus optimal solutions can be provided with less tuning. First, the initial values of the control parameters were determined through the plant model and the optimization algorithm. Then, designed experiments were performed in the region around the initial values, determining the optimal values of the control parameters which satisfy both the rise time and overshoot simultaneously.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.195-198
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• 1996

The control objective of drum level of boiler in thermal power plant is to maintain drum level at constant setpoint regardless of disturbance such as main steam flow. The initial response of the drum level loop process is in a direction opposite to the final response. The drum level loop shows inverse response when the power is changed abruptly. We adopt fuzzy controller using knowledge base considering system dynamics for controlling drum level. Finally, the simulation result using the digital simulator for boiler system in Seoul Power Plant Unit 4 shows the validity of fuzzy controller.

• 대한소아치과학회지
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• 제6권1호
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• pp.35-41
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• 1979

Of 42 children, 21 in male and 21 in female, whose ages ranged from 2 to 5 years old, the response of young children to their initial series of dental visits was examined. The results were as follows; 1. With continued experience, the child's response improved, indicating desensitization to dental stress. 2. Experience may reduce the general amount of negative response by allowing the child to accurately distinguish between stressful and non-stressful procedures.

• Geomechanics and Engineering
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• 제31권3호
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• pp.329-337
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• 2022

In this paper, the thermal post-buckling characteristics of functionally graded (FG) pipes with initial geometric imperfection are studied. Considering the influence of initial geometric defects, temperature and geometric nonlinearity, Euler-Lagrange principle is used to derive the nonlinear governing equations of the FG pipes. Considering three different boundary conditions, the two-step perturbation method is used to solve the nonlinear governing equations, and the expressions of thermal post-buckling responses are also obtained. Finally, the correctness of this paper is verified by numerical analyses, and the effects of initial geometric defects, functional graded index, elastic foundation, porosity, thickness of pipe and boundary conditions on thermal post-buckling response are analyzed. It is found that, bifurcation buckling exists for the pipes without initial geometric imperfection. In contrast, there is no bifurcation buckling phenomenon for the pipes with initial geometric imperfection. Meanwhile, the elastic stiffness can significantly improve thermal post-buckling load and thermal post-buckling strength. The larger the porosity, the greater the thermal buckling load and the thermal buckling strength.

• Food Science and Biotechnology
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• 제18권4호
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• pp.939-947
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• 2009

In order to produce vinegar using onions, 12 acetic acid bacteria were screened from the juice of fallen peaches, and a strain showing the highest acetic acid productivity among them was selected and identified as Acetobacter tropicalis No. 22. The culture broth containing 2.5%(w/v) of initial sugar concentration showed maximum acetic production after 10 days of cultivation, and the acetic acid was produced at the highest rate and reached the maximum acidity after 2 to 6 days of cultivation when the residual sugar and the ethanol concentration were in the range of 1.6 to 2%(w/v) and 0.6 to 1.8%(v/v), respectively. Also optimum conditions for acetic acid production by response surface method using the fractional factorial design with 3 variables and 5 levels were involved with initial ethanol content of 4.67%(v/v), initial acidity of 0.03%, and initial glucose concentration of 2.35%(w/v) and predicted level of acetic acid production at these conditions was 3.77%.

• Geomechanics and Engineering
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• 제32권6호
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• pp.615-625
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• 2023

Initial geometrical imperfection is an important factor affecting the structural characteristics of plate and shell structures. Studying the effect of geometrical imperfection on the structural characteristics of cylindrical shell is beneficial to explore the thermal post-buckling response characteristics of cylindrical shell. Therefore, we devote to investigating the thermal post-buckling behavior of graphene platelets reinforced mental foam (GPLRMF) cylindrical shells with geometrical imperfection. The properties of GPLRMF material with considering three types of graphene platelets (GPLs) distribution patterns are introduced firstly. Subsequently, based on Donnell nonlinear shell theory, the governing equations of cylindrical shell are derived according to Eulerian-Lagrange equations. Taking into account two different boundary conditions namely simply supported (S-S) and clamped supported (C-S), the Galerkin principle is used to solve the governing equations. Finally, the impact of initial geometrical imperfections, the GPLs distribution types, the porosity distribution types, the porosity coefficient as well as the GPLs mass fraction on the thermal post-buckling response of the cylindrical shells are analyzed.