• 한국전자통신학회논문지
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• 제18권4호
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• pp.649-660
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• 2023

본 연구의 목적은 조직원의 정보보안 준수 활동에 부정적 영향을 주는 조직 환경 조건과 이에 따른 개인의 인식 및 가치 차이의 복합적 영향을 확인하는 것이다. 세부적으로, 연구는 조직 내 성과를 강조하는 경쟁적 심리 분위기가 보안 준수 의도에 부정적 영향을 미치는 과정 중, 정보보안 관련 예측 및 억제 걱정, 그리고 가치차이가 역할을 할 것으로 판단하였으며, 관련 매커니즘을 확인하고자 하였다. 본 연구는 387건의 정보보안 규정을 보유한 조직의 근로자로부터 설문을 확보하였으며, AMOS 22.0과 Process 3.1 패키지를 통해 제기한 연구가설을 검증하였다. 분석 결과, 경쟁적 심리 분위기가 개인의 정보보안에 대한 예측 걱정과 억제 걱정을 높여 보안 준수 의도에 부정적 영향을 주는 것을 확인하였다. 또한, 정보보안 관련 가치 차이가 예측 및 억제 걱정과 상호작용 효과를 가져 준수 의도에 부정적 영향을 주는 것을 확인하였다. 본 연구는 조직 내부의 정보보안 목표 달성을 위해 조직원에게 제공해야 할 정보 및 가치 유형을 제시한 측면에서 실무적 시사점을 가지며, 걱정과 가치 차이의 복합적 영향을 정보보안에 적용한 측면에서 학술적 시사점을 가진다.

• 대한불안의학회지
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• 제2권2호
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• pp.79-85
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• 2006

Anxiety and anxiety disorders are related to many neurotransmitters, such as norepinephrine, serotonine, dopamine, glutamate, and Gamma-aminobutyric acid (GABA). GABA, the main inhibitory neurotransmitter of the CNS, is known to counterbalance the action of the excitatory neurotransmitters and control anxiety. GABA acts on 3 GABA receptor subtypes, $GABA_A$, $GABA_B$, and $GABA_C$. $GABA_A$ and $GABA_c$ receptors are oligomeric transmembrane glycoproteins composed of 5 subunits that are arranged around a central chloride channel. $GABA_B$ receptor comprises two 7-transmembraneis-spanning proteins that are coupled to either calcium or potassium channel via G proteins. This article highlights neurobiological interactions between anxiety and GABA system.

• 대한불안의학회지
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• 제1권1호
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• pp.25-30
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• 2005

In the 40 years since the first benzodiazepine was brought into clinical use there has been a substantial growth in understanding the molecular basis of action of these drugs and the role of their receptors in anxiety disorders. Benzodiazepine receptors are present throughout the brain with the highest concentration in cortex, and it potentiate and prolong the synaptic action of the inhibitory neurotransmitter GABA. Central benzodiazepine receptors and $GABA_A$ receptors are part of the same macromolecular complex. Abnormalities of these $GABA_A$-benzodiazepine receptors as a result of drug challenge tests and neuroimaging studies may underlie some anxiety disorders. The role of $GABA_A$-benzodiazepine receptors in the action of benzodiazepine and as a factor in anxiety disorder, in both animal and humans including knock-out and knock in technique, may lead to new anxiolytics that have potentially significant therapeutic gains without unwanted side effects.

• 한국산학기술학회논문지
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• 제21권9호
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• pp.338-344
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• 2020

불확실성에 대한 인내력 부족은 범불안장애 등 다양한 정신질환과 관련이 있는 것으로 알려져 있다. 하지만 이를 측정하는 척도(IUS: Intolerance of Uncertainty Scale, 이하 IUS)는 여러 연구에서 요인 구조가 다르게 나타나는 바, 본 연구에서는 IUS의 구인 타당도를 검증하고 요인 구조를 명확하게 하고자 하였다. 이를 위해 대학생 533명을 대상으로 자료를 수집하였고, 이 중 임의로 추출한 260명의 자료를 대상으로 탐색적 요인 분석한 결과, 3문항으로 구성된 전향적 요인과 5문항으로 구성된 억제적 요인의 2요인 구조가 적합한 것으로 나타났다. 또한 나머지 273명의 자료를 대상으로 확인적 요인분석과 상관 분석을 한 결과, 8문항 2요인의 구조모형의 적합도가 선행 연구에서 제시한 모형들에 비해 우수하게 나타났다(x²=37.699, TLI=0.951, CFI=0.969, RMSEA=.063, SRMR=.039). 아울러 걱정 및 불안, 우울 관련 측정 도구들과 유의미한 정적 상관을 보였다. 본 연구는 IUS의 구인 타당도를 검증하여 전향적 요인과 억제적 요인으로 구성됨을 확인하고, IUS-08를 제안하여 보다 정확하고 간략한 척도를 개발하였다는 점에서 의의가 있겠다.

• Nutrition Research and Practice
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• 제18권1호
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• pp.110-118
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• 2024

BACKGROUND/OBJECTIVES: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems. SUBJECTS/METHODS: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks. RESULTS: The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all P < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all P < 0.05), but there were no significant differences between the groups (all P > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all P < 0.05). CONCLUSIONS: Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.

• 생약학회지
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• 제34권4호통권135호
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• pp.318-323
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• 2003

Extracts of Black cohosh (Cimicifugae rhizoma) have been used for the treatment of climacteric complaints for decades. A significant number of woman entering menopause exhibit the following symptoms: getting hot flushes, night sweats, irritability, depression, and anxiety, A reduction of the frequency of hot flushes equivalents and hints on the antidepressant activity of Cimcifuga extracts. In the present work, we have screened several 80% ethanol extracts from medicinal plants and found that the extracts from Cimicifugae Rhizoma(Black cohosh:승마) have inhibitory effect on catecholamine secretion in bovine chromaffin cell. Since this extract inhibited 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)-induced catecholamine secretion, but did not inhibit KCl, bradykinin, and veratridine-evoked case, this inhibitory effect is mediated by nicotinic acetylcholine receptors with noncompetitive manner.

• 대한물리치료과학회지
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• 제7권2호
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• pp.567-577
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• 2000

In human body, catecholamines, such as epinephrine and norepinephrine, can be increased anxiety, blood pressure and pain etc. The inhibitory effects of TENS, electroacupuncture and massage on the release of epinephrine, norepinephrine from sympathetic nerve endings has already been known. However, the effects of silver spike point stimulation on the catecholamines was not well understood. Therefore, the purpose of this study was to characterize the SSP-induced inhibitory effects of catecholamines. The following results were obtained. (1) The studies on urinary catecholamines released that the levels of epinephrine and norepinephrine of continue type SSP stimulation group were significantly lower than those in the control group in human in vivo. (2) The dose-response curves of epinephrine and norepinephrine in rat aortic smooth muscle strips were increased dose dependent manner respectively. However, the contractile response of norepinephrine in rat aortic smooth muscle strips were slightly differentiated. It is concluded that the SSP stimulation reflects to the inhibitory effects of epinephrine and norepinephrine in men. Especially, we believe that the amplitude-frequency modulation, such as continue type a)1d frequency modulation type, of SSP stimulation plays a role in regulating catecholamines.

• 생약학회지
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• 제51권4호
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• pp.238-243
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• 2020

Perilla frutescens Britton var. acuta Kudo, an annual plant primarily cultivated in China, Japan, and Korea, has been used as a traditional medicine to treat inflammatory diseases, depression, and many anxiety-related disorders. Previously, we reported the inhibitory effects of n-hexane layer of P. frutescens var. acuta extract against beta-amyloid (Aβ) aggregation, and the isolation of asarone derivatives as active constituents from n-hexane layer. In this study, dichloromethane layer of P. frutescens var. acuta was applied to bioassay-guided isolation methods accompanied with Thioflavin T (Th T) fluorescence assay to investigate the inhibitory effect on Aβ aggregation and disaggregation. As the results, three triterpenoids including ursolic acid (1), tormentic acid (2) and corosolic acid (3) were isolated. All compounds reduced Aβ aggregation and increased disaggregation of preformed Aβ aggregates in a dose-dependent manner. However, the inhibitory effect of three compounds on Aβ aggregation was not correlated with antioxidant activity, which was measured by DPPH assay. Taken together, these results suggest that the triterpenoid derivatives from P. frutescens have the potential to be developed as good therapeutics or preventatives for AD.

• Advances in Traditional Medicine
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• 제7권1호
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• pp.41-45
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• 2007

The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. The effects of chronic administration of Korean ginseng extract (KGE) were investigated on two different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements) and the open field test (OFT). Diazepam (1 mg/kg), KGE (10, 30 and 100 mg/kg) were administered orally for 15 days. On the 14th day, mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On 15th day, mice had two exposures to the enclosed and open arm of the elevated T-maze followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pre-treated in a similar way. Treatment with Diazepam (1 mg/kg) and KGE (10, 30 and 100 mg/kg) significantly (P < 0.05) impaired inhibitory avoidance performance but did not impair escape latency. In OFT, diazepam facilitated locomotion as compared to vehicle and other treatment groups. KGE at any of the selected doses did not impair locomotion. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with KGE. The results suggest that KGE exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.

• Advances in Traditional Medicine
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• 제6권3호
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• pp.179-185
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• 2006

We investigated the effects of chronic administration of different extracts of ginger rhizome [pet ether extract (PE); toluene fraction (TF) of pet ether extract] on anxiety models: the elevated T-maze (ETM) (for inhibitory avoidance and escape measurements) and the open field test. Ondansetron (1 mg/kg), FE (10, 30 &100 mg/kg) and TF (10 & 30 mg/kg) were administered orally for 15 days. On the $14^{th}$ day mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On $15^{th}$ day mice had two exposures to the enclosed and open arm of the ETM followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pretreated in a similar way. Treatment with Ondansetron (1 mg/kg), PE (100 mg/kg), TF (10 mg/kg) and TF (30 mg/kg) significantly (P<0.05) impaired inhibitory avoidance performance but did not impair escape latency. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with PE and TF. The results suggest that PE and TF of Ginger rhizome exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.