• 대한간호학회지
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• 제16권1호
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• pp.81-88
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• 1986

The main purpose of this study was to clarify the validity with patient's general background of Korean Pain Measurement tool. The subjects of this study were 195 patient from the 8 Med-Surgical wards in H. University Hospital in Seoul. The study was conducted over a 40 day period from Oct. 5, 1985 to Nov. 15, 1985. All patients had pain. Korean Pain Measurement tool and simple discriptive pain scale as Graphic Rating Scale were used to measure the pain, The Pearson Correlation Coefficient test was exercised to measure the correlation between the two kinds of pain tools. To clarify the Sensitivity of Korean Pain tool was used frequency with patient's response. To compare the difference in Pain levels with patient's general background, ANOVA and t-test was employed. To compare the difference in pain levels existed due to pain area of the body used mean numbers. The outcome of the study was as follows : 1. A positive correlation did exist between two pain measurement tools. (r=.2028∼.7768, p ＜0.002) 2. The sensitive subclass in Korean Pain Measurement tools was 7 subclass. The 7 subclass are inflammatory repeated pain, simple stimulating, traction pressure, dull pain, cavity pain, digestion related pain, suffering. related pain. 3. The existence of levels of pain in accordance with patient's general background, the department of hospital, pain area of the body and school age was supported. Age, sex, religion, marrital status, economic status, acute or chronic status was not supported. 4. The existence of higher pain levels of the body area was anus, chest, and lower pain levels of the body area was eye, ear, nose and throat. Based on the above results, it was found that sensitive subclasses of the Korean Pain Measurement tool was 7 subclass among all of 20 subclass. Thus it can be concluded that Korean Pain Mea-surement tool when partialy used and supplemented, can be an effective tool of pain measurement for the patient in Korea.

• The Korean Journal of Pain
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• 제27권1호
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• pp.49-53
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• 2014

Background: The carpal tunnel syndrome (CTS) is the most common cause of severe hand pain. In this study we treated acute pain in CTS patients by means of local intradermal injections of anti-inflammatory drugs (mesotherapy). Methods: In twenty-five patients (forty-five hands), CTS diagnosis was confirmed by clinical and neurophysiological examination prior to mesotherapy. A mixture containing lidocaine 10 mg, ketoprophen lysine-acetylsalycilate 80 mg, xantinol nicotinate 100 mg, cyanocobalamine 1,000 mcg plus injectable water was used. Sites of injection were three parallel lines above the transverse carpal ligament and two v-shaped lines, one at the base of the thenar eminence, and the other at the base of the hypothenar eminence. Results: The day after the treatment, all but four patients reported a significant reduction in pain and paresthesias. After 12 months, 17 patients had a complete pain relief, eight patients reported recurrence of pain and sensory symptoms and four out of them underwent surgical treatment. Conclusions: With the obvious limits of a small-size open-label study, our results suggest that mesotherapy can temporary relieve pain and paresthesias in most CTS patients and in some cases its effect seems to be long-lasting. Further controlled studies are needed to confirm our preliminary findings and to compare mesotherapy to conventional approaches for the treatment of CTS.

• The Korean Journal of Pain
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• 제28권1호
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• pp.52-56
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• 2015

Painful periarticular calcification most commonly occurs within the rotator cuff of the shoulder and rarely around the elbow, hip, foot, and neck. As acute inflammatory reaction develops, severe pain, exquisite tenderness, local swelling, and limitation of motion with pain occur. In case of calcific tendinitis of the shoulder, it can be easily diagnosed according to the symptoms and with x-ray. However, in lesions of the hip, as it is a rare location and usually involves pain in the posterolateral aspect of the thigh, which can simulate radicular pain from a lumbar intervertebral disc, it could be difficult to diagnose. Hence, physicians usually focus on lumbar lesions; therefore, misdiagnosis is common and leads to a delayed management. Here, we report the case of a 30-year-old female patient with calcific tendinitis of the rectus femoris that was successfully managed with ultrasound-guided steroid injection. This study offers knowledge about the rectus femoris calcification.

• 치위생과학회지
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• 제17권1호
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• pp.65-72
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• 2017

실험동물의 TMJ 내에 포르말린으로 유도한 염증성 통증 모델에서 홍삼 및 흑삼 추출물이 통증 발생과 조절에 미치는 영향을 평가하고자 하였다. 홍삼 혹은 흑삼 추출물을 TMJ 내에 투여한 후 통증 행위반응의 변화를 관찰하였고, 또한 실험동물의 연수를 적출하여 Nrf2 경로의 활성 변화를 단백정량분석법을 활용해서 분석한 결과 먼저, 포르말린을 TMJ에 주입한 결과 안면부 통증행위반응이 유의하게 증가되었다. 이것을 토대로 홍삼 및 흑삼 추출물의 경구 투여한 결과 포르말린에 의해 유도된 실험동물에서 통증행위 반응이 효과적으로 감소되었고, 단회투여보다 반복투여가 포르말린 2차 통증행위반응 경감에 더 효과적으로 나타났다. 또한 홍삼 및 흑삼 추출물의 반복 투여 시 포르말린에 주입에 의해 증가된 연수에서의 Nrf2 단백 발현량을 감소시켰고, 간과 신장의 독성검사에서도 영향을 미치지 않는 것으로 나타났다. 따라서, 본 연구에서 홍삼 및 흑삼 추출물은 간과 신장을 부작용을 나타내지 않으면서 포르말린으로 유도된 안면부 통증과 Nrf2의 발현의 조절에 효과적인 것으로 나타났다.

• 대한간호학회지
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• 제16권2호
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• pp.13-28
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• 1986

The main purpose of th study was to evaluate he validity of Korean Pain Measurement Tool composed of pain terms. The specific purposes of this study were 1. to examine whether pain intensities of pain terms are congruent with those classified in three previous studies. 2. to evaluate the relative intensity of each term by panel of judges. 3. to explore the difference of ranks of pain terms according to the sex, education, and ages. One hundred and sixty normal individuals were selected by 2$\times$2$\times$4 sampling design. Sex (male, female), education (high school, college), and age (20s, 30s, 40s, 50s) were matched. Each individual was asked to rate the ranks of 3~8 pain terms in each subclass. The data measured by ordinal scale were transformed to the interval scale to compare with the pain intensities gained from the previous study. The pain ranks different from previous results were finally rearranged or cancelled through the consultation of 4 panel of judges and sunmed up to 91 pain terms in the scale. As a result, the ranks of pain terms within each of eleven subclasses among the twenty subclasses completely were congruent with the Previous pain ranks, while the ranks of nine subclasses were different from the previous pain ranks. In addition, there was significant relation between sex and pain ranks in skin punctuate pressure pain and cavity pressure. (sp : $\chi$$^2$=5.18 ø=0.26； cp : $\chi$$^2$=5.83 ø=0.24) In conclusion, seven terms from subclasses of inflammatory repeated pain, traction pressure pain, fatigue-related pain, fear-related pain, dull pain, and pulsation. related pain were cancelled. The ranks of four terms in subclasses of incisive Pressure pain and constrictive pressure pain were tentatively rearranged. Ranks of two terms in the tract pain were left as shown in the third study. As a result, six terms must be studied repeatedly for obtaining exact scores from ratio scale.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.143.2-144
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• 2003

Joins (SKI 306X) is now clinically used for the treatment of osteoarthritis (OA). In previous reports, Joins a natural herbal product extracted from three herbs Clematis Radix. Trichosanthes Radix and Prunella Flos, was shown to have good analgesic and anti-inflammatory effects in several in vivo models. e.g., acetic acid-induced pain, carrageenan-induced paw edema and adjuvant-induced arthritis. (omitted)

• 대한치과의사협회지
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• 제57권11호
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• pp.708-713
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• 2019

Chronic obstructive inflammatory disease of salivary glands is the most frequent disease of the salivary glands and is characterized by recurrent swelling and pain caused by pressure. Sialography is recommended for the diagnosis of obstructive sialadenitis to observe changes in duct morphology, such as stricture and dilatation. Intraductal irrigation using normal saline is a simple treatment for patients with chronic obstructive inflammatory disease by removing the microlith and mucous plugs in the duct. It can be used as a conservative treatment option for resolving the obstructive symptoms.

• Journal of Microbiology and Biotechnology
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• 제18권10호
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• pp.1641-1647
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• 2008

Amygdalin is a cyanogenic glycoside plant compound found in the seeds of rosaceous stone fruits. We evaluated the anti-inflammatory and analgesic activities of amygdalin, using an in vitro lipopolysaccharide (LPS)-induced cell line and a rat model with carrageenan-induced ankle arthritis. One mM amygdalin significantly inhibited the expression of TNF-$\alpha$ and IL-l$\beta$ mRNAs in LPS-treated RAW 264.7 cells. Amygdalin (0.005, 0.05, and 0.1 mg/kg) was intramuscularly injected immediately after the induction of carrageenan-induced arthritic pain in rats, and the anti-arthritic effect of amygdalin was assessed by measuring the weight distribution ratio of the bearing forces of both feet and the ankle circumference, and by analyzing the expression levels of three molecular markers of pain and inflammation (c-Fos, TNF-$\alpha$, and IL-l$\beta$) in the spinal cord. The hyperalgesia of the arthritic ankle was alleviated most significantly by the injection of 0.005 mg/kg amygdalin. At this dosage, the expressions of c-Fos, TNF-$\alpha$, and IL-l$\beta$ in the spinal cord were significantly inhibited. However, at dosage greater than 0.005 mg/kg, the pain-relieving effect of amygdalin was not observed. Thus, amygdalin treatment effectively alleviated responses to LPS-treatment in RAW 264.7 cells and carrageenan-induced arthritis in rats, and may serve as an analgesic for relieving inflammatory pain.

• 한국산학기술학회논문지
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• 제15권9호
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• pp.5708-5715
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• 2014

본 연구는 건강보조제 및 약제로서 전신의 염증반응 및 여러 약리적 효능을 가지고 있는 홍삼이 국소적인 안면 통증의 완화에 영향을 끼치는지에 관해 조사하였다. 실험동물은 4그룹으로 대조군(n=6)과 5% 포르말린 주입군(n=6), 5% 포르말린+D.W. 주입군, 홍삼(4.5 ml)(n=6) 복용군으로 나누어 45분간 안면을 긁거나 문지르는 행위를 계수하여 비교하였다. 홍삼 복용군에서 포르말린 주입군에 비해 유의하게 긁거나 문지르는 행위가 줄어들었으며, 15분부터 통증완화효과가 증가되기 시작되어 30분까지 유의한 효과를 보였다. 홍삼투여군에 대한 단백질정량분석 (western blot)으로 통증유발기전에 연관되는 염증과 항산화, NO생성에 관련된 신호전달 단백질 p38 MAPK와 iNOS, Nrf2를 뇌, 연수에서 활성정도를 비교한 결과 감소하는 경향을 확인할 수 있었다. 이상의 결과들은 홍삼이 전신적 약리효과 뿐만 아니라 국소적인 염증, 통증완화에도 효능이 있음 나타낸다.

• 근관절건강학회지
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• 제17권1호
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• pp.25-34
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• 2010

Purpose: The aim of the present study was to examine the effects of a 4-week aromatherapy on pain and inflammation in patients suffering from rheumatoid arthritis. Methods: A quasi-experimental study using a nonequivalent control group, pretest-posttest non-synchronized design was used. To analyze the data, descriptive statistics, Chi-square test, independent samples t-test, and Fisher's exact test were used. Results: After a 4-week aromatherapy, tender joint count (M=5.67 to 4.17), swollen joint count (M=4.13 to 2.54), and patient's assessment of pain (M=43.33 to 31.08) decreased significantly for the aromatherapy participants compared to the control group. But there was no significant difference between the groups in erythrocyte sedimentation rate. Conclusion: These findings suggest that aromatherapy could decrease joint pain, tenderness, and swelling in patients with rheumatoid arthritis, but some modifications in aromatherapy intervention and research method will be required to examine the effects of aromatherapy on inflammatory level in this population.