• 한국동물위생학회지
• /
• 제25권4호
• /
• pp.333-346
• /
• 2002

We previously reported that the equine herpesvirus type 1(EHV-1) immediate-early protein(IE protein) physically interacts with the general transcription factor human TFIIB(Jang et al, J Virol 75：10219-10230, 2001). The interaction between the IE protein and TFIIB is necessary for the IE protein to efficiently transactivate the early TK and late IR5 EHV-1 promoters. A panel of deletion and truncation mutants of the TFIIB gene was constructed and employed in protein-binding assays to map the IE protein-binding domain within TFIIB. Evidence is presented that the first direct repeat of TFIIB interacts specifically with the EHV-1 IE protein.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권8호
• /
• pp.4509-4513
• /
• 2013

Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These variations include, in particular, mutations in ORF S,C,X gene regions. This mini-review summarizes results of clinical studies and molecular mechanisms on the possible relations of HBV mutations with the development of hepatocellular carcinoma.

• Nuclear Medicine and Molecular Imaging
• /
• 제40권4호
• /
• pp.193-199
• /
• 2006

Infectious and inflammatory bone diseases include a wide range of disease process, depending on the patient's age, location of infection, various causative organisms, duration from symtom onset, accompanied fracture or prior surgery, prosthesis insertion, and underlying systemic disease such as diabetes, etc. Bone infection may induce massive destruction of bones and joints, results in functional reduction and disability. The key to successful management is early diagnosis and proper treatment. Various radionuclide imaging methods including three phase bone scan, Ga-67 scan, WBC scan, and combined imaging techniques such as bone/Ga-67 scan, WBC/bone marrow scan add complementary role to the radiologic imaging modalities including plain radiography, CT and MRI. F-18 FDG PET imaging also has recently been introduced in diagnosis of infected prosthesis and chronic active osteomyelitis. Selection of proper nuclear medicine imaging method will improve the diagnostic accuracy of infections and inflammatory bone diseases, based on understading of pathogenesis and radiologic imaging findings.

• 한국수의병리학회:학술대회논문집
• /
• 한국수의병리학회 2005년도 Proceedings of The 2nd Asian Society of Veterinary Pathology Symposium(Vol.2) and 2005 Annual Meeting of The Korean Society of Veterinary Pathology(Vol.9)
• /
• pp.66-67
• /
• 2005

• Archives of Pharmacal Research
• /
• 제29권6호
• /
• pp.431-458
• /
• 2006

As we approach the completion of the first 25 years of the human immunodeficiency virus(HIV) epidemic, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity. There are twenty currently available antiretrovirals approved in the United States for the treatment of this infection. The medications, including their pharmacokinetic properties, side effects, and dosing are reviewed. In addition, the current approach to the use of these medicines is discussed. We have included a section addressing common comorbid conditions including hepatitis B and C along with tuberculosis.

• 대한수의학회지
• /
• 제59권3호
• /
• pp.157-160
• /
• 2019

The production of rmtB-encoded 16S rRNA methylases has emerged as a novel mechanism promoting high-level resistance toward aminoglycosides in Gram-negative bacteria. Between 2015 and 2017, 636 distinct commensal Escherichia (E.) coli isolates were collected from different farms in South Korea to determine the prevalence and molecular characteristics of rmtB. The positive rates of rmtB between all the isolates and amikacin-resistant isolates were 1.1 and 100%, respectively. High-level aminoglycoside resistance could be transferred by conjugation from rmtB-positive donors to higher amikacin-resistance efficacies. This is the first report of 16S rRNA methylase-encoding genes in E. coli isolated from food-producing animals in Korea.

• Infection and chemotherapy
• /
• 제50권4호
• /
• pp.287-300
• /
• 2018

Pneumonia is the leading cause of morbidity and mortality, particularly in old adults. The incidence and etiologic distribution of community-acquired pneumonia is variable both geographically and temporally, and epidemiology might evolve with the change of population characteristics and vaccine uptake rates. With the increasing prevalence of chronic medical conditions, a wide spectrum of healthcare-associated pneumonia could also affect the epidemiology of community-acquired pneumonia. Here, we provide an overview of the epidemiological changes associated with community-acquired pneumonia over the decades since pneumococcal conjugate vaccine introduction.

• 한국보건간호학회지
• /
• 제35권3호
• /
• pp.343-355
• /
• 2021

Purpose: This study aimed to identify the effects of nursing students' ethical awareness, ethical decision-making and attitude toward performance on intention about performance of infection control guidelines in pandemic infectious diseases. Methods: The survey was performed on 163 nursing students in three universities. Data were collected using a structured questionnaires and analyzed with t-test, analysis of variance (ANOVA), Pearson's correlation and multiple regression analysis. Results: Perceived health status, ethical awareness and attitude toward performance of infection control guidelines about major commitment were significant predictive variables. These variables accounted for 48.1% of the variance in major commitment. Conclusion: The findings indicate the necessity of developing educational programs to enhance nursing students's ethical awareness, and increase performance of control guidelines to prepare for the pandemic infectious diseases.

• Journal of Preventive Medicine and Public Health
• /
• 제51권2호
• /
• pp.109-120
• /
• 2018

Objectives: This study aimed to investigate the current status of infectious disease research in North Korea by analyzing recent trends in medical journals from North Korea in comparison with research from South Korea. Methods: Three medical journals (Preventive Medicine, Basic Medicine, and Chosun Medicine) were analyzed from 2012 to 2016. Articles on tuberculosis (TB), malaria, and parasitic diseases were selected and classified by their subtopics and study areas. Two medical journals published in the South Korea were selected for a comparative analysis of research trends. Results: Of the 2792 articles that were reviewed, 93 were extracted from North Korea journals. TB research in North Korea was largely focused on multi-drug resistant TB and extrapulmonary TB, whereas research in South Korea more frequently investigated non-tuberculous mycobacteria. Research on parasitic diseases in North Korea was focused on protozoan and intestinal nematodes, while the corresponding South Korea research investigated various species of parasites. Additionally, the studies conducted in North Korea were more likely to investigate the application of traditional medicine to diagnosis and treatment than those conducted in South Korea. Conclusions: This study presents an analysis of research trends in preventive medicine in North Korea focusing on infectious diseases, in which clear differences were observed between South and North Korea. Trends in research topics suggest a high prevalence of certain parasitic diseases in North Korea that are no longer widespread in South Korea. The large proportion of studies examining traditional medicine implies a lack of affordable medicine in North Korea.

• 유통과학연구
• /
• 제18권11호
• /
• pp.41-45
• /
• 2020

Purpose: This article aims to explore the new town development paradigm against infectious diseases. The distribution of COVID-19 constricts economic activity. The high frequency of outbreaks of COVID-19 nationwide is due to neither malnutrition nor unhygienic environment. Research design, data and methodology: The research question starts with the idea that understanding the features of the outbreak of pandemic diseases could help public health authorities to better cope with upcoming risks in the future. We have employed a big data-based methodology to explore the outbreak of pandemic diseases. Also, an idiographic approach is used to describe the distribution of new towns against COVID-19. Results: The results demonstrate that the rapid spread of COVID-19 has had a strong impact on regional economies and urban development. It was found that there is a close relationship between infectious diseases outbreaks and new town development. Conclusions: The findings could be used to deal with new town development against infectious diseases better in other cities or countries as well. The distribution of COVID-19 may become an unexpected opportunity for a paradigm shift in the distribution of new town development to prevent not only an excessive concentration in Seoul, but also an imbalance between national and local development.