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http://dx.doi.org/10.7314/APJCP.2013.14.8.4509

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis  

Liang, Tao (Center of Infectious Diseases, West China Hospital of Sichuan University)
Chen, En-Qiang (Center of Infectious Diseases, West China Hospital of Sichuan University)
Tang, Hong (Center of Infectious Diseases, West China Hospital of Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.8, 2013 , pp. 4509-4513 More about this Journal
Abstract
Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These variations include, in particular, mutations in ORF S,C,X gene regions. This mini-review summarizes results of clinical studies and molecular mechanisms on the possible relations of HBV mutations with the development of hepatocellular carcinoma.
Keywords
Hepatocellular carcinoma; hepatitis B virus; gene mutations;
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