Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Mapping of the equine herpesvirus type 1 immediate-early protein interaction domain within the general transcription factor human TFIIB

  • Jang, Hyung-Kwan (Department of Infectious Diseases, College of Veterinary Medicine, and Bio-Safety Research Institute, Chonbuk National University) ;
  • Cho, Jeong-Gon (Department of Infectious Diseases, College of Veterinary Medicine, and Bio-Safety Research Institute, Chonbuk National University) ;
  • Song, Hee-Jong (Department of Infectious Diseases, College of Veterinary Medicine, and Bio-Safety Research Institute, Chonbuk National University)
  • Published : 2002.09.01
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Abstract

We previously reported that the equine herpesvirus type 1(EHV-1) immediate-early protein(IE protein) physically interacts with the general transcription factor human TFIIB(Jang et al, J Virol 75：10219-10230, 2001). The interaction between the IE protein and TFIIB is necessary for the IE protein to efficiently transactivate the early TK and late IR5 EHV-1 promoters. A panel of deletion and truncation mutants of the TFIIB gene was constructed and employed in protein-binding assays to map the IE protein-binding domain within TFIIB. Evidence is presented that the first direct repeat of TFIIB interacts specifically with the EHV-1 IE protein.

Keywords

References

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