• Clinical and Experimental Pediatrics
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• 제53권1호
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• pp.85-88
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• 2010

말라리아는 Plasmodium species의 감염에 의해 생기는 주기적인 발열, 오한, 피로, 빈혈, 비종대를 특징으로 하는 질병이다. 과거 국내에 크게 유행하였던 삼일열 말라리아는 최근 경기도 북부 지역을 중심으로 재유행하고 있고 높은 전염률을 보인다. 저자들은 경기도 포천으로 수학여행을 다녀온 후 고열과 혈소판감소증이 발생한 말라리아 1례를 경험하였다. 환아는 삼일열 말라리아로 진단되어 hydroxychloroquine, primaquine으로 치료받았다. 이에 저자들은 문헌 고찰과 함께 보고하는 바이다.

• Pediatric Infection and Vaccine
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• 제13권2호
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• pp.196-200
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• 2006

선천성 톡소포자충증은 산모로부터 Toxopalsma gondii가 수직 감염되어 유발되는 질환으로, 임상양상은 매우 다양해서 사산 혹은 분만 직후 사망하는 경우부터 중추신경계 손상을 나타내기도 하며 증상이 없기도 하나, 대부분 안 병변을 동반한다. 저자들은 최근까지 아프리카에서 거주하였던 산모로부터 분만된 미숙아에서 미숙아 망막증 추적검사 중 맥락망막염이 발견되고, 톡소포자충 IgM 항체 양성을 보여 선천성 톡소포자충증으로 확진한 환자를 경험하여 보고하는 바이다.

• 한국보육지원학회지
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• 제17권2호
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• pp.1-27
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• 2021

Objective: Covid-19 is changing many aspects of child care programs. The objective of this study was to explore how the pandemic and mitigation efforts affected the experiences and practices at child care centers in the summer of 2020. Methods: Focus group interviews and mobile surveys were conducted with principals and teachers of child care centers in August and September 2020. Descriptive statistics including frequency distributions, means and standard deviations and mean differences were used to analyze the survey data with SPSS 22.0. Results: It was found that each sector of child care settings experienced different difficulties and had various needs. Young children's lack of energy, child care teachers' workload and stress, and principles' efforts to interrupt transmission of the infectious disease based on insufficient government guideline and supports were revealed as the main experiences. Conclusion/Implications: The Covid-19 pandemic has had a tandem of influences on daily life at child care centers. As policy makers consider additional guidelines or supports measures to prevent the infection and spread of Covid-19 at child care centers, long-term as well as short-term plans at various levels should be considered to meet the unique needs of child care programs.

• 한국동물위생학회지
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• 제46권1호
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• pp.93-106
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• 2023

Emerging and re-emerging zoonotic viruses become critical public health, economic, societal, and cultural burdens. The Coronavirus disease-19 (COVID-19) pandemic reveals needs for effective preparedness and responsiveness against the emergence of variants and the next virus outbreak. The targeted next-generation sequencing (NGS) significantly contributes to the acquisition of viral genome sequences directly from clinical specimens. Using this advanced NGS technology, the genomic epidemiology and surveillance play a critical role in identifying of infectious source and origin, tracking of transmission chains and virus evolution, and characterizing the virulence and developing of vaccines during the outbreak. In this review, we highlight the platforms and preparation of targeted NGS for the viral genomics. We also demonstrate the application of this strategy to take advantage of the responsiveness and prevention of emerging zoonotic viruses. This article provides broad and deep insights into the preparedness and responsiveness for the next zoonotic virus outbreak.

• Journal of Information Technology Applications and Management
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• 제31권1호
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• pp.1-9
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• 2024

Predicting the spread of COVID-19 remains a challenge due to the complexity of the disease and its evolving nature. This study presents an integrated approach using the classic SIR model for infectious diseases, enhanced by the chemical master equation (CME). We employ a Monte Carlo method (SSA) to solve the model, revealing unique aspects of the SARS-CoV-2 virus transmission. The study, a first of its kind in Korea, adopts a step-by-step and complementary approach to model prediction. It starts by analyzing the epidemic's trajectory at local government levels using both basic and stochastic SIR models. These models capture the impact of public health policies on the epidemic's dynamics. Further, the study extends its scope from a single-infected individual model to a more comprehensive model that accounts for multiple infections using the jump SIR prediction model. The practical application of this approach involves applying these layered and complementary SIR models to forecast the course of the COVID-19 epidemic in small to medium-sized local governments, particularly in Gangnam-gu, Seoul. The results from these models are then compared and analyzed.

• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.189-196
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• 2005

Objectives: An outbreak of shigellosis occurred among students and staff of S primary and middle school, Seongju-gun, in 2003. This investigation was carried out to institute an effective counterplan, and study the infection source and transmission of the shigellosis. Methods: The authors conducted a questionnaire survey among 235 students and staff from S preschool, primary and middle school relating to the ingestion of school lunch and the manifestation of symptoms. Also, the author investigated the drinking water, feeding facility and reconstructed cooking process of the food presumed to be the cause of the shigellosis. The diarrhea cases were defined as confirmed cases and those cases who had had diarrhea more than one time, accompanied with symptoms such as fever, vomiting and tenesmus. Results: From rectal swabs 20 people, between June 28 and July 4, 2003, were confirmed with shigellosis. The diarrhea attack rate was 40.0%. Those who had ingested tomatoes and cubed radish kimchi had significantly higher diarrhea attack rates (p<0.05), with the relative risk of tomatoes being 2.69 (95% CI: 0.98-7.42). The major cause of shigellosis was presumed to be from contaminated tomatoes due to cooking with rubber gloves containing holes. Conclusion: The cooks in charge of school lunches must make doubly sure to not only attend to their sanitation, but also to manage the table wear and items used in providing school lunches. The health care authority should introduce higher-leveled criteria for health care among cooks, so that they cannot cook when the have a case of any infectious disease.

• Journal of Veterinary Science
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• 제22권3호
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• pp.35.1-35.13
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• 2021

Background: African swine fever (ASF) is an infectious viral disease of domestic pigs that presents as a hemorrhagic fever, and for which no effective vaccine is available. The disease has a serious negative social and economic impact on pig keepers. There is limited information on the potential risk factors responsible for the spread of ASF in South Kivu. Objective: The aim of this study was to determine the potential risk factors associated with ASF infection in suspected ASF virus (ASFV)-infected pigs. Methods: We sampled whole blood from 391 pigs. Additionally, 300 pig farmers were interviewed using a structured questionnaire. Viral DNA was detected by using the real-time polymerase chain reaction technique. Results: The majority of pigs sampled, 78% (95% confidence interval [CI], 74.4-82.6), were of local breeds. Over half, 60.4% (95% CI, 55.5-65.2), were female, and most of them, 90.5% (95% CI, 87.6-93.4), were adult pigs (> 1 year old). Viral DNA was detected in 72 of the 391 sampled pigs, indicating an overall infection rate of 18.4% (95% CI, 14.5-22.4). Multivariable logistic regression analysis revealed several risk factors positively associated with ASFV infection: feeding with swill in pen (odds ratio [OR], 3.8; 95% CI, 2.12-6.77); mixed ages of pigs in the same pen (OR, 3.3; 95% CI, 1.99-5.57); introduction of new animals to the farm (OR, 5.4; 95% CI, 1.91-15.28). The risk factors that were negatively (protective) correlated with ASFV positivity were the presence of male animals and the use of an in-pen breeding system. Conclusion: Local pig farmers should be encouraged to adopt proper husbandry and feeding practices in order to increase the number of ASF-free farms.

• 한국동물위생학회지
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• 제44권4호
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• pp.257-270
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• 2021

Since African swine fever (ASF) spread to East Asia, a fatal crisis has occurred in the global pig industry, because Asia is dominant in pig production. Although some studies conducted bibliometric analysis on ASF, few studies compared research networks, and identified subthemes by major keywords. To fill this gap, this study identified the knowledge structure network of the research, its influence, and core research themes by utilizing the bibliometric analysis of 337 ASF-related journal articles over 50 years from 1970 to 2020 on the Web of Science. The result indicated that papers are mainly published in the fields of veterinary science, virology, microbiology, infectious disease and applied microbiology, and in particular, the fields of veterinary science and virology showed unrivaled weights as they account for 73.40%. With regard to cooperative relationships, European countries such as the UK, Germany, Italy, and Denmark, centered on Spain, are actively contributing to the ASF research. China, France, Thailand, Japan, Vietnam, and South Korea are leading research cooperation, centering on the United States. In the early stage of the studies, major keywords appeared to be related to outbreaks, quarantine and diagnosis, and in the middle stage, the keywords were expanded to a wide range of pig diseases. Recently, the keywords are becoming more diverse towards antibodies, cross-border transmission and disease monitoring. Based on data on major keywords related to ASF, this study proposed discussions and implications for activating ASF research including genotype, protein, vaccine, diagnosis, defense against infection and epidemiological investigation.

• 한국환경농학회지
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• 제42권4호
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• pp.269-278
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• 2023

Antibiotics either kill or inhibit the growth of bacteria. However, antibiotic-resistant bacteria are difficult to treat with antibiotics. Infections caused by such bacteria often lead to severe diseases. Antibiotic resistance genes (ARG) can be horizontally transmitted across different bacterial species, necessitating a comprehensive understanding of how ARGs spread across various environments. In this study, we analyzed the plasmid sequences of 33 extended-spectrum beta-lactamases (ESBL) producing Escherichia coli isolated from pigs, farms, and their owners. We conducted an antibiotic susceptibility test (AST) with aztreonam and seven other antibiotics, as well as whole genome sequencing (WGS) of the strains using MinION. Our results demonstrated that the plasmids that did not harbor ARGs were mostly non-conjugative, whereas the plasmids that harbored ARGs were conjugative. The arrangement of these ARGs exhibited a pattern of organization featuring a series of ARG cassettes, some of which were identical across the isolates collected from different sources. Therefore, this study suggests that the sets of ARG cassettes on plasmids were mostly shared between pigs and their owners. Hence, enhanced surveillance of ARG should be implemented in farm environments to proactively mitigate the risk of antibiotic-resistant bacterial infections.

• 한국응용과학기술학회지
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• 제38권1호
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• pp.48-59
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• 2021

본 연구는 코로나19 유행 시기 간호대학생의 코로나19에 대한 불안, 위험인식, 정보이해력, 감염예방행위 이행 수준을 파악하기 위해 시도되었다. 본 연구는 서술적 조사연구로 2020년 6월 8일부터 6월 14일까지 간호대학생 224명을 대상으로 온라인을 통해 설문조사를 실시하였다. 수집된 자료는 SPSS 26.0을 이용하여 기술통계, t-test, ANOVA, 상관관계 분석을 하였다. 간호대학생의 불안정도는 6.86점(최대10점)으로 보통 수준이었으며, 위험인식은 8.19점(최대10점), 정보이해력은 3.50점(최대4점), 감염예방행위 수행정도는 4.44점(최대5점)으로 높은 수준이었다. 감염예방행위는 불안정도, 위험인식, 정보이해력이 높을수록 수행정도가 높았다. 코로나19와 같은 신종감염병이 유행할 때는 감염에 대한 불안감과 위험인식이 증가할 수 있으므로 감염병에 대한 충분한 정보제공으로 감염병에 대한 정확한 이해가 필요하다. 신종감염병에 대한 정확한 이해는 철저한 감염예방행위를 향상 시키므로 감염병 전파 위험을 감소시킬 수 있을 것이다.