• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.777-780
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• 2015

Currently, our country has promoted sustainable growth in agriculture field by expanding the growth engine which is going to creat new value through agrifood industry & ICT convergence, the deployment of computerization in rural areas and the efficiency increase of agricultural administration system. Since the level of domestic agriculture-ICT convergence technology focusing on production areas is at early stage, it is necessary to deploy the successful models through the systematic development of technology and standardization including production, distribution and consumption phase. In addition, because the management and control systems of large glass greenhouse are mostly foreign products with no standardization and related small domestic companies, there is a limit to agri-food & ICT convergence activation led by the agri-food private sector. Also, it is vital to increase productivity & efficiency and improve quality throughout the entire agricultural process including production, distribution and consumption by the fusion of information technology, automatic control technology and unique ICT on existing agricultural technology, Therefore, in this paper we propose the agricultural-ICT convergence technology fields in which our country can lead technology and the standardization plans through analyzing the development, policy and standardization trends on agricultural-ICT convergence technology.

• Spatial Information Research
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• v.21 no.5
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• pp.43-51
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• 2013

In this study, the concept of spatial big data and effective ways to build a spatial big data system are presented. Big Data is defined as 3V(volume, variety, velocity). Spatial big data is the basis for evolution from 3V's big data to 6V's big data(volume, variety, velocity, value, veracity, visualization). In order to build an effective spatial big data, spatial big data system building should be promoted. In addition, spatial big data system should be performed a national spatial information base, convergence platform, service providers, and providers as a factor of production. The spatial big data system is made up of infrastructure(hardware), technology (software), spatial big data(data), human resources, law etc. The goals for the spatial big data system build are spatial-based policy support, spatial big data platform based industries enable, spatial big data fusion-based composition, spatial active in social issues. Strategies for achieving the objectives are build the government-wide cooperation, new industry creation and activation, and spatial big data platform built, technologies competitiveness of spatial big data.

• The Journal of Internal Korean Medicine
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• v.34 no.2
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• pp.178-191
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• 2013

Objectives : In this study, we made an effort to investigate the protective mechanism of Ukgan-san (UGS) extracts on hypoxia-induced C6 glial cell death. Methods : The cell viability was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MMT) assay and cell morphological changes were analysed with microscope after staining with crystal violet (CV). Reactive oxygen species (ROS) formation was assessed by flow cytometer after staining with 2'7'-dichlorofluorescein diacetate (DCF-DA). We also analyzed expression of hypoxia-inducible factor-1 alpha (HIF-$1{\alpha}$) and p53, processing of procaspase-3 and procyclic acidic repetitive protein (PARP) by western blot method. Results : We estimated the elevated cell viability by UGS extract on $CoCl_2$-induced C6 glial cells. UGS attenuated $CoCl_2$-induced ROS formation in C6 glial cells and also showed a protective activity compared to antioxidants and exhibited abrogation of LDH-released by $CoCl_2$. UGS suppressed the typical apoptotic cell death markers, caspase-3 and PARP activation. UGS inhibited $CoCl_2$-induced HIF-1${\alpha}$ expression which is known as a major regulator for hypoxia-induced cell death, and suppressed p53 expression. Conclusions : These results suggest that UGS extract contains protective constituents for hypoxia-induced C6 glial cell death.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.4
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• pp.487-495
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• 2007

The objectives of the present study were to initiate cloning of Korean native goat by somatic cell nuclear transfer (NT) and to examine whether unovulated (follicular) oocytes can support the same developmental ability of NT embryos as ovulated (oviductal) oocytes after hCG injection in stimulated cycles of the goat. The in vivo-matured and immature oocytes were collected from the oviducts and follicles of superovulated does, respectively, and the immature oocytes were maturated in vitro. Ear skin fibroblasts derived from a 3-yr-old female Korean native goat were used as the donors of nuclei or karyoplasts. Following fusion, activation and in vitro culture to a 2- to 4-cell stage, 49 in vitro-derived and 105 in vivo-derived embryos were transferred to 6 and 17 recipient does, respectively. One doe and three does of the respective groups were identified as pregnant by ultrasonography on day 30 after embryo transfer. However, only one doe, which had received in vivo-derived embryos, delivered a normal female kid of 1.9 kg on d 149. The cloned kid gained more weight than her age-matched females as much as 87% during the first 4 mo after birth (17.7 vs. $9.4{\pm}0.8$ kg) and reached puberty at 6-mo age a few months earlier than normal female does. The telomere length of the kid, which was similar to that of the donor fibroblast at 2-mo age, decreased 8% between 2- and 7-mo ages. Moreover, at 7-mo age, she had 21% shorter telomere than her age-matched goats. To our knowledge, this is the first case in which a cloned animal born with a normal weight exhibited accelerated growth and development. The unusually rapid growth and development of the cloned goat may have resulted from SCNT-associated epigenetic reprogramming involving telomere shortening.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.12 no.6
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• pp.89-98
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• 2017

The dynamic entrepreneurial activities of small businesses or individual entrepreneurs seeking to enter the global market based on innovative ideas and challenging spirit in the modern society, which is trending in entrepreneurial capitalism according to the times, Leading to new growth engines. In order to promote the establishment of universities in Korea, the government has been working on 'Five-Year Plan for University Entrepreneurship Education(2013-2017)', 'Efficiency of Government Start-up Support in 2015', and 'Five-Year Basic Plan for Activation of Industry-University Cooperation(2016-2020)'. However, there are still practical limitations in spite of the efforts made by universities and research institutes to revitalize start-ups. As a way to overcome these limitations, this study aims to systematize the entrepreneurship education of the university, and examines the role of changing universities and theory of clusters and the entrepreneurship education. In addition, we will look at the factors of creative university culture centering on the representative cases of the Innovation University in US, and present a conceptual framework for cluster-based entrepreneurship education for the purpose of 'successful entrepreneurship' which is different from 'start-up success'. The conceptual framework of cluster-based entrepreneurship education is based on the establishment of 'Integrated Entrepreneurship Education Platform' to revitalize start-ups centered on university technology. At the same time, this framework focuses on the three factors of talent, technology, and culture based on the relevant theories and examples, and emphasizes the clustering of entrepreneurial resources, entrepreneurial policies and leadership that should be involved in entrepreneurship education.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.13 no.4
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• pp.183-196
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• 2018

In this study, we conducted in - depth interviews of young entrepreneurs who are currently in the process of establishing new entrepreneurs management diagnosis and consulting for young entrepreneurs, and found the common difficulties experienced in young entrepreneurs' perception of entrepreneurship, In addition, through a case study, we verified product suitability through customer issue / solution suitability, idea marketability verification and MVP (Minimum Viable Product) using Lean Canvas according to the structure of Lean Start-up It is aimed at voluntary management diagnosis and consulting of small business owners, activation of young entrepreneurs' entrepreneurship, and reduction of startup failure rate. The purpose of this study is to examine the items of five young entrepreneurs from the perspective of the customer for about 10 months, focusing on the case of small entrepreneurs in the small entrepreneurs support project. Or we could provide the customer's problem or solution based on Lean Start-up. This study was conducted as a case - based qualitative study due to the limited sample and it is hoped that this study will be used as a basic research to verify the effectiveness of the lean start-up methodology for small business owners through quantitative research.

• Journal of Life Science
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• v.26 no.12
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• pp.1470-1476
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• 2016

The viral hemorrhagic septicemia virus (VHSV), which belongs to the Novirhabdovirus genus of the Rhabdoviridae family, is a viral pathogen that causes severe losses in the olive flounder farming industry. Among six encoding VHSV proteins, the non-virion (NV) protein has been shown to have an impact on virulence. In our previous studies, transcriptomics microarray analysis by using VHSV-infected olive flounder showed that VHSV infection significantly down-regulated the mRNA expression of glycolytic enzymes. In addition, VHSV NV protein variants decreased the intracellular ATP level. Based on these results, we have tried to examine the effect of VHSV NV protein on glycolytic enzyme glucokinase expression, which phosphorylates glucose to glucose 6-phosphate. Our results indicated that the NV protein significantly decreased the mRNA expression of glucokinase in olive flounder HINAE cells. Furthermore, the NV protein played a negative role in the promoter activation of glucokinase. Furthermore, glucose uptake was effectively inhibited by VHSV infection and NV protein expression in olive flounder HINAE cells. These results suggest that the VHSV NV protein negatively regulates glycolytic enzyme expression by a transcription level and eventually leads to gradual morbidity of olive flounder through cellular energy deprivation. The present results may be useful for the prevention and diagnosis of VHSV infection in olive flounder.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.4
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• pp.228-233
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• 2007

Pear psylla, Caccopsylla pyricola (Homoptera: Psyllidae), is a serious insect pest in pear orchards. C. pyricola overwinters as adults under rough bark scales of pear trees. When the weather warms up in the spring, the overwintered adults become active, climb up to the tree branches, and inhabit on fruit twigs to lay eggs. This study was conducted to develop a forecasting model for the onset of upward-movement of overwintered C. pyricola adults to control them by timely spraying of petroleum oil. The adult population densities were observed under rough barks (B) and on fruit twigs (T) of pear trees. Relative upward-movement rates (R) were calculated as T/(B+T). Low threshold temperatures for the activation of overwintered C. pyricola adults were selected arbitrarily from 5 to $9^{\circ}C$ at a $1^{\circ}C$ interval. Then, the days (D) when daily maximum air temperatures were above each low threshold temperature were counted from 1 February until to the dates with R $\geq$ 0.8. The same methods were applied for the prediction of the first observation of eggs. The variation of coefficients (CV) for the mean Des were lowest with the low threshold temperature of $6^{\circ}C$. At this selected threshold temperature, the upward movement of C. pyricola adults occurred with 12 D and they started laying eggs with 25 D. In the field validation, the model outputs with the $6^{\circ}C$ threshold temperature reasonably well explained the observed data in Suwon and Cheonan in 2002. Practical usages of the model were also discussed.

• Journal of Energy Engineering
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• v.26 no.4
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• pp.92-99
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• 2017

In Korea, the zero energy building was designated as the 7 new industries in the Ministry of Land and the 8 new industries in the Ministry of Industry. In order to maximize the insulation performance of the building envelope, improve the efficiency of building equipment, We are aiming. It is necessary to analyze the energy requirements of the buildings (cooling, heating, hot water supply, lighting, ventilation) of buildings with energy efficiency level of 1++ which is equivalent to the zero energy building certification system in Korea, It is aimed to be used as basic data for the advancement of energy building certification system. Zero Energy Building certification is estimated to be 61 buildings by 2017, and the approximate reference value and the first energy requirement for each of the five loads are calculated considering passive and active aspects. It is difficult to say that it is a clear standard because there is a small sample of data for calculating the load standard. However, it is necessary to interpret various methods in order to upgrade the Zero Energy Building certification standard in the future.

• Journal of Life Science
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• v.25 no.6
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• pp.715-723
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• 2015

Insects represent the largest class within the animal kingdom in terms of species number. Humans had been utilized insect in the broad area, including food, agriculture, industry, pharmaceuticals and so on. At present, insects are emerging as a leading group for identifying and extracting novel bioactive substances due to enormous number and a high nutritional value. Insects rely on a suite of systemic response to resist infection such as immune cells, hemocytes, activation of enzymes cascades, and antimicrobial peptide/protein. Among the substances, antimicrobial peptides (AMPs) are main components of potent antimircrobial innate defense system into the insect hemolymph. AMPs raise influential candidate as avenue to resolve the development of antibiotic-resistant microbial organism. Insect AMPs are classified into four main classes: cecropins, insect defensins, glycine/proline-rich peptides. Insect AMPs have been purified, over 150. In this review, AMPs derived from several insects were summarized including honey bee, dung beetle, butterfly and longicorn beetle. These peptides almost exhibited potent antimicrobial activities against human microbial pathogens without causing remarkable hemolysis to erythrocytes excluding melittin, and their mode of action(s) are based on disruption of the plasma membrane or fungal apoptosis. Therefore, study of insect AMPs is expected to be useful for designing novel therapeutic antimicrobial applications.