• Wind and Structures
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• v.9 no.4
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• pp.297-313
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• 2006

The concentration of air pollution along roads is higher than the surrounding area because ventilation efficiency has decreased due to the high-density use of space along roads in recent years. In this study, ventilation efficiency around a heavily traffic road covered by an elevated highway and hemmed in along its side by buildings is evaluated using Visitation Frequency (VF, the frequency for pollutant to return to the objective domain) and Purging Flow Rate (PFR, the air flow rate for defining the local domain-averaged concentration). These are analyzed using Computational Fluid Dynamics (CFD) based on the standard $k-{\varepsilon}$ model. The VF and PFR characteristics of four objective domains are analyzed in terms of the changes in wind direction and arrangements of the fencing dividing up and down direction in the road center under the elevated highway. The resulting VFs are more than 1.0 for all cases, which means that pollutants return to the objective domain restricted by the elevated highway and side buildings. The influence of the arrangement of the buildings around the objective domain and the structure in the domain on the VF is substantial. In cases where there are no obstacles under the elevated highway, the local air exchange rate in the domain tends to be improved. Using these indices, the urban ventilation efficiencies between different urban areas can be compared easily.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.813-819
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• 2019

Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe respiratory impairment with a reported mortality rate of ~36% in humans. The absence of clinically available MERS-CoV vaccines and treatments to date has resulted in uncontrolled incidence and propagation of the virus. In vaccine design, fusion with the IgG Fc domain is reported to increase the immunogenicity of various vaccine antigens. However, limited reports have documented the potential negative effects of Fc fusion on vaccine antigens. To determine whether Fc fusion affects the immunogenicity of MERS-CoV antigen, we constructed a Fcassociated MERS-CoV spike protein (eS770-Fc, 110 kDa), whereby human IgG4 Fc domain was fused to MERS-CoV spike protein (eS770) via a Gly/Pro linker using baculovirus as the expression system. For comparative analyses, two eS770 proteins lacking the IgG4 Fc domain were generated using the IdeS protease ($eS770-{\Delta}Fc$) or His tag attachment (eS770-His) and the immunogenicity of the above constructs were examined following intramuscular immunization in mice. Contrary to expectations, non-Fc spike proteins ($eS770-{\Delta}Fc$, eS770-His; 90 kDa) showed higher immunogenicity than the Fc fusion protein (eS770-Fc). Moreover, unlike non-Fc spike proteins, eS770-Fc immunization did not elicit neutralizing antibodies against MERS-CoV. The lower immunogenicity of Fc-fused eS770 was related to alterations in the structural conformation of the spike protein. Taken together, our results indicate that IgG Fc fusion reduces the immunogenicity of eS770 by interfering with the proper folding structure.

• Journal of the Korean Institute of Landscape Architecture
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• v.15 no.2
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• pp.101-113
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• 1987

The landscape structure of the both pre-industrial and industrial cities should be influenced to the topographical feature , religious thoughts, political ruling system and history. In the major socio-cultural factors in the pre-industrial townscapes in korea, the Feng - Shui(poongsu) which is an acient human settlement organization system based on the “Yin - Yang” principle and “Five Elements” and “Chryaegogong”system were the most important factors to the formation of traditional town scape in Korea. The landscape during the Japanese colonial periods were basically reorganized through change of “Boundary”, “Center” “Direction(path)” and “Domain” which were expressed by distinct traditional townscape in Yi dynasty. The physical shapes, meanings and behaviors of townscape were expressed properly of the intention of the colonization. As changes to the mordern industrial cities, the townscape had been amended landscape elements of the Japanese imperialism to an ideology of rebirth nation. Also as changes to the modern industrial cities, “Boundary”, “Center”, and “Domain” spreaded into the suburbs by funtionalsm and these were expressed an incoherent value system which were the advancement of growth, pursuit policies as well as an advancement of science techniques.

• Wind and Structures
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• v.11 no.6
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• pp.455-478
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• 2008

The present study aims to estimate the wind ventilation performance for pedestrian level domains from the air quality point of view. Three typical models of a dense urban area were considered and numerically simulated in order to examine the effects of the geometry of such models on wind flow characteristics, which in turn affect the air quality, within the pedestrian domain of a street canyon located within this area. The calculated flow fields were employed to estimate the exceedance probabilities within the study domain using a new approach: air exchange rate within the domain. The study has been applied to nine cities in Japan: Tokyo, Osaka, Sapporo, Niigata, Fukuoka, Nagoya, Sendai, Yokohama, and Kyoto, based on their mean wind velocity data. The results demonstrated that the exceedance probability analysis of the pedestrian wind environment could be a valuable tool during the design stage of inhabited areas for the evaluation of pollutant-removal efficiency by the applied wind. Also, the calculated probabilities demonstrated substantial dependence on both the geometry of building arrays and the wind conditions of the nine cities.

• Smart Structures and Systems
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• v.8 no.4
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• pp.343-365
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• 2011

Structural system identification (SSI) is an inverse problem of difficult solution. Currently, difficulties lie in the development of algorithms which can cater to large size problems. In this paper, a parameter estimation technique based on evolutionary strategy is presented to overcome some of the difficulties encountered in using the traditional system identification methods in terms of convergence. In this paper, a non-traditional form of system identification technique employing evolutionary algorithms is proposed. In order to improve the convergence characteristics, it is proposed to employ immune algorithms which are proved to be built with superior diversification mechanism than the conventional evolutionary algorithms and are being used for several practical complex optimisation problems. In order to reduce the number of design variables, domain decomposition methods are used, where the identification process of the entire structure is carried out in multiple stages rather than in single step. The domain decomposition based methods also help in limiting the number of sensors to be employed during dynamic testing of the structure to be identified, as the process of system identification is carried out in multiple stages. A fifteen storey framed structure, truss bridge and 40 m tall microwave tower are considered as a numerical examples to demonstrate the effectiveness of the domain decomposition based structural system identification technique using immune algorithm.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.3 no.1
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• pp.107-114
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• 1999

In many applications (e,g., identification of non-destructive testing signal and biomedical signal and multiscale analysis of image), it is of interest to analyze and identify phenomena occurring at the different scales. The recently introduced wave let transforms provide a time-scale decomposition of signals that offers the possibility of such signals. However, there is no corresponding statistical properties to development of multiscale statistical signal processing. In this paper, we derive such properties of random signals in wavelet domain.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.8 no.1
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• pp.81-92
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• 2004

Muskhelishvili's complex variable method has been applied to derive exact and closed expressions for Gaursat's functions for the first and second fundamental problems of the infinite plate weakened by a curvilinear hole which is conformally mapped on the domain outside the unit circle by means of rational mapping function. The hole having three poles. The previous work of the authers in this domain is considered as special cases of this work.

• Journal of Korean Institute of Industrial Engineers
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• v.11 no.2
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• pp.141-154
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• 1985

The capacity expansion problem has been defined. Existing literatures on capacity expansion problems have been reviewed and unified under a structure of problem domain. The problem domain has been defined by three relavent coordinates; function or objective of the project, consideration of resource allocation, and consideration of project sequencing. Long range planning is of vital importance in setting up ultimately efficient capital investment plans to meet immediate demand increase. Simplified expansion sequencing example problems have been introduced and solved to help understanding of a solution scheme.

• Journal of Korean Institute of Industrial Engineers
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• v.27 no.1
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• pp.37-46
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• 2001

Business process(workflow) analysis has been recognized as a core step to building information systems. However, most analysts have recognized that deriving consistent business process artifacts even in a simple business domain is very difficult, since most analysis methods give the designers narrative and/or diagrammatic tools that do not support rigorous analysis rules. This often generates inconsistent analysis results, leading to create useless information systems and resulting in tremendous budget wastes. To overcome this weakness, this paper presents a declarative business process modeling method called contract-collaboration net(cc-net), which is not only somewhat formal but also useful to the practitioners. A case study on bank domain is presented to illustrate our approach.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1142-1145
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• 2006

The Finite-difference time-domain (FDTD) method is used to directly solve Maxwell's equations, and the techniques required for optical simulation of Bragg reflections of cholesteric liquid crystal (ChLC) displays are introduced in this paper. The simulated results show that the color gamut of a ChLC display can be broadened by using of a circular polarizer on top surface of the ChLC film, and are examined by experiments.