• Proceedings of the Korean Society of Computer Information Conference
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• 2018.07a
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• pp.431-432
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• 2018

본 논문은 라즈베리파이(Raspberry Pi)와 각종 센서 위치 정보를 관련된 정보를 거울에 출력해주는 스마트 미러(Smart Mirror)를 제안한다. 스마트 미러는 온도 습도 등의 다양한 센서를 통해 사용자 주변 환경과 외부 환경을 결합하여 사용자에게 풍부한 정보를 제공할 수 있다. 다양한 센서와 구글 클라우드 스피치 오픈 API를 이용하여 위치 정보를 기반으로 날씨와 일정 및 음성 인식을 통해 인식된 명령에 따라 원하는 정보를 보여주는 스마트 미러를 구현하였다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2018.07a
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• pp.27-28
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• 2018

본 논문에서는 구동 장치의 다양한 상태를 나타내는 소음과 진동으로부터 특징데이터를 추출하여 이를 학습 한 후 실시간으로 장치의 상태를 진단하는 하였다. 실제 현장에서 발생할 수 있는 예측 외 소음환경에 유연하게 대처하기 위해 CNN모델 사용과 소리, 진동 데이터의 Butterworth filter와 Kalman filter를 적용하여 노이즈 배제처리 하였다. 제안된 시스템의 유용성을 확인하기 위해 제안된 시스템과 기존 CNN기반 시스템을 소음환경에서 비교 실험하였다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2018.07a
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• pp.321-322
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• 2018

빅데이터 분석은 스포츠에서 다양한 분야에서 사용되고 있다. 야구산업에서도 세이버 메트릭스를 활용하여 전술 훈련, 개인 훈련 등 다양한 방면으로 활용되고 있다. 본 논문에서는 기존의 연구인 빅데이터 분석과 게임이론을 활용한 축구선수 영입 모델을 야구에 적용킨 시뮬레이션을 진행하고 합리적인 의사결정 모델을 제안한다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2018.07a
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• pp.63-66
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• 2018

스팸 스미싱 SMS의 차단을 위하여 지금까지 다양한 차단기법이 개발되어 사용되고 있다. 그 중에서도 대부분을 차지하는 방법들이 기계학습을 통한 내용 기반의 차단과 사용자의 스팸신고를 통한 송신자 차단 방법이다. 그러나 이러한 방법들은 공통적으로 스팸 스미싱을 식별하기 위해 학습 데이터가 필요하다는 문제점을 갖고 있기 때문에, 신종 스팸 공격들은 차단이 불가능하여 차단율의 한계를 보인다. 본 논문에서는 오늘날 사용되고 있는 스팸 스미싱 차단 기법들의 근본적인 문제점들을 규명하고, 이를 해결할 수 있는 스팸차단 기법 중 하나인 송신자 자가인증 기법을 소개한다. 그리고 송신자 자가인증 기법을 적용한 안드로이드애플리케이션의 구현 및 동작과정을 설명한다.

• IMMUNE NETWORK
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• v.14 no.6
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• pp.328-332
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• 2014

Dexamethasone (Dex) was shown to inhibit the differentiation, maturation, and antigen-presenting function of dendritic cells (DC) when added during DC generation or maturation stages. Here, we examined the direct effects of Dex on MHC-restricted antigen processing. Macrophages were incubated with microencapsulated ovalbumin (OVA) in the presence of different concentrations of Dex for 2 h, and the efficacy of OVA peptide presentation was evaluated using OVA-specific CD8 and CD4 T cells. Dex inhibited both class I- and class II-restricted presentation of OVA to T cells; this inhibitory effect on antigen presentation was much more potent in immature macrophages than in mature macrophages. The presentation of the exogenously added OVA peptide SIINFEKL was not blocked by Dex. In addition, short-term treatment of macrophages with Dex had no discernible effects on the phagocytic activity, total expression levels of MHC molecules or co-stimulatory molecules. These results demonstrate that Dex inhibits intracellular processing events of phagocytosed antigens in macrophages.

• International Journal of Industrial Entomology and Biomaterials
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• v.43 no.2
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• pp.94-98
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• 2021

Reactive oxygen species (ROS) induce a variety of cellular responses, such as proliferation, differentiation, senescence, and apoptosis. Intestinal epithelial cells are continuously exposed to ROS, and excessive generation of ROS severely damages cells via oxidative stress. Pro-inflammatory cytokines may lead to intestinal inflammation and damage by inducing excessive ROS generation. In this study, we showed that papiliocin, an antimicrobial peptide, significantly inhibited ROS production, without affecting cell viability. Moreover, TNF-α and IL-6 expression was decreased in the intestinal epithelial cells. The activity of papiliocin may significantly contribute to preserving the integrity of the intestinal mucosa against oxidative damage and inflammation-related disorders.

• Journal of Korean Academy of Nursing Administration
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• v.19 no.5
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• pp.565-577
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• 2013

Purpose: This study was done to propose an improvement in the Nursing Fee Differentiation Policy to alleviate polarization of nursing staffing level among hospitals and to rectify the confusion of legally mandated standards between the Korean Medical Law and National Health Insurance Act. Methods: The policy regulation was reconstructed related to nurse staffing standards and nurse-to-patients ratios. Data on nurse staffing grades were obtained from database of the Health Insurance Review & Assessment Service (HIRA) for the third quarter of 2010 for 44 tertiary hospitals, 274 general hospitals, and 1,262 hospitals. A break-even analysis was used to estimate financial burden of the revised policy improvement proposal. An industrial engineering method was used to calculate Nurse-to-Patients ratios per shift. Results: Twelve tertiary hospitals were downgraded. 74 general hospitals and 102 hospitals were upgraded after application of the regulation. Finances for total hospitalization expenditures changed from -3.55% to +3.14%. Conclusion: The results indicate that the proposed policy would decrease polarization between tertiary hospitals and small hospitals, and would not put a major strain on the finances of the Korean National Health Insurance. Therefore, it is suggested that government stake-holders and many interest groups consider this policy proposal and build a consensus.

• Development and Reproduction
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• v.6 no.2
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• pp.71-76
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• 2002

Present study was aimed to summary the recent reports of chromosomal technology such like a polyploidv, sex differentiation, gynogenesis, transgenic fish and gene manipulation. Triploid cells for rainbow trout and channel catfish were induced through thermal shocks of varying temperature levels and produced as a industrial use. A monosex fish with homogametic females of 15 species of high valued fish were produced by exposing to irradiation. It seemed that different irradiation was suitable to inactivate the sperm and block the formation in producing the gynogenetic diploids. Since 1985, transgenic fish have been successfully produced by microinjecting or electroporating desired foreign DNA into unfertilized or newly fertilized eggs using about 40 fish species. More recently, transgenic fish have also been produced by infecting newly fertilized eggs with pantropic, defective retroviral vectors carrying desired foreign DNA. These transgenic fish can serve as excellent experimental models for basic scientific investigations as well as in marine biotechnological applications.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.292-292
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• 2017

This study was conducted to evaluate the effect of anti-obesity and antioxidant enzyme activities in vitro by different solvent fractions from the roots of Codonopsis lanceolata. The cytotoxicity of different solvent fractions of C. lanceolata on 3T3-L1 preadipocytes were evaluated using the MTT assay, the rate of cell survival progressively decreased in a dose-dependent manner. Butyl alcohol fraction at $200{\mu}g/mL$ exhibited a pronounced cytotoxic effect (75.73%) on 3T3-L1 cell comparable to that of the hexane fraction (79.82%), methylene chloride fraction (84.02%), ethyl acetate fraction (87.62%) and DW fraction (86.30%) at the same concentration. The Oil Red O solution was used to determine whether different solvent fractions of C. lanceolata induce adipocyte differentiation in 3T3-L1 preadipocytes. Confluent 3T3-L1 cells were treated with $50{\mu}g/mL$ concentration of solvent fraction extracts from C. lanceolata. Inhibitory degree of lipid accumulation against solvent fraction extracts showed a significant level compared with the control. Both lipid accumulation and adipocyte differentiation showed relatively high effect on methyl chloride fraction. The root extract of C. lanceolata had the highest SOD enzyme activity of 84.5% in ethyl acetate partition layer and while water partition layer of diploid showed the lowest SOD enzyme activity of 57.9%. The activity of CAT, APX and POD showed a significantly higher activity in ethyl acetate partition layer compared with the other fraction. These results suggested that the roots of C. lanceolata may assist in the potential biological activity on anti-obesity and antioxidant capacity.

• Animal cells and systems
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• v.2 no.2
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• pp.249-258
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• 1998

Obesity, one of the most common metabolic diseases in industrial countries is characterized by an increase in the number or size of adipocytes. In an effort to create transgenic mouse models for the study of obesity we developed a novel technique in which adipose tissue can be ablated genetically at will, at any specific developmental stage and/or physiological condition, by the treatment of ganciclovir. We made a series of adipocytespecific expression vectors using minimal regulatory regions of brown adipocyte-specific uncoupling protein (UCP-1) gene and adipocyte-specific aP2 gene, and then analyzed their expression characteristics in cultured cell lines. When both constructs pUCP-LacZ and paP2-LacZ were transfected transiently into differentiating 3T3-L1 (pre-while adipocytes) and HIB-1B (pre-brown adipocytes) cell lines in vitro and then monitored by X-gal staining of cells, these regulatory regions were sufficient to show proper differentiation stage-specific expression in adipocvtes. To confirm that adipocytes expressing HSV-TK controlled by these minimal requlatory elements are sufficient to kill themselves with ganciclovir treatment pUCP-TK and paP2-TK expression constructs were transfected stably into HIB-1B and 3T3-L1 cells, respectively, and their ganciclovir sensitivities were tested during in vitro differentiation of cells. As expected more than 80% of cells were dead by the 7th day of treatment with ganciclovir while negative control cells were not affected at all. The data suqqest that the constructed vectors are suitable for obtaining novel obese transqenic models based on a conditional genetic tissue ablation method.