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http://dx.doi.org/10.7852/ijie.2021.43.2.94

Papiliocin, an antimicrobial peptide, rescues hyperoxia-induced intestinal injury  

Kim, Seong Ryul (Sericultural and Apicultural Materials Division, National Institute of Agricultural Sciences, RDA)
Park, Seung-Won (Department of Biomedical Science, Daegu Catholic University)
Publication Information
International Journal of Industrial Entomology and Biomaterials / v.43, no.2, 2021 , pp. 94-98 More about this Journal
Abstract
Reactive oxygen species (ROS) induce a variety of cellular responses, such as proliferation, differentiation, senescence, and apoptosis. Intestinal epithelial cells are continuously exposed to ROS, and excessive generation of ROS severely damages cells via oxidative stress. Pro-inflammatory cytokines may lead to intestinal inflammation and damage by inducing excessive ROS generation. In this study, we showed that papiliocin, an antimicrobial peptide, significantly inhibited ROS production, without affecting cell viability. Moreover, TNF-α and IL-6 expression was decreased in the intestinal epithelial cells. The activity of papiliocin may significantly contribute to preserving the integrity of the intestinal mucosa against oxidative damage and inflammation-related disorders.
Keywords
papiliocin; pro-inflammatory cytokines; reactive oxygen species; intestinal injury;
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