• Journal of Preventive Medicine and Public Health
• /
• 제38권1호
• /
• pp.82-92
• /
• 2005

Objective : To evaluate the relationships among sociodemographic characteristics, health behaviors, levels of pros and cons and stages of change in Pap testing for uterine cervical cancer. Methods : A questionnaire survey was performed on 560 randomly sampled people who were assigned to participate in a Pap testing program by the National Cancer Screening Project in 2003' between 25 September and 10 October in Gyeonggi, Korea. Data about the behaviors and intentions of Pap testing, sociodemographic characteristics, health behaviors, and levels of acknowledged benefit (pros) and barrier (cons) for Pap testing was collected. The stages of change were grouped according to behaviors and intentions of Pap testing as passive, active, and relapse. Results : Logistic analysis between the passive and active groups showed that city dwellers, 'high' and 'middle' groups in terms of the individual s health belief, those who had undergone a health examination within the past 2 years, and those who had undergone hormone replacement therapy had a higher odds ratios to be in the active group. As the 'benefit' scores increased and the 'Unnecessity' scores decreased, the probabilities to be in the active group increased. According to the logistic analysis results between the active and relapse groups, those who were 60 years or older, members of the National Heath Insurance, and those who had not undergone a health examination within the past 2 years had a higher odds ratio to be in the relapse group. The 'Benefit' scores were not significant in this relationship. The probabilities of being in the relapse group increased as the Unnecessity and 'Shamefulness' scores increased. Conclusions : In conclusion, health planners should inform women in the passive group of the benefits and necessity of Pap testing. It would be better to reduce the barriers to the active group of undergoing Pap smear. This study might be a useful guide for future planning of Pap testing program.

• Journal of Preventive Medicine and Public Health
• /
• 제6권1호
• /
• pp.101-117
• /
• 1973

Socio-medical survey was carried out on six hundred and thirty Korean households in the cities of Tokyo, Osaka, Kyoto, and Nagoya in Japan from Nov. 1972 to Dec. 1972, and following results were obtained. 1. Age distribution of households showed the highest occurence in the group of 40 to 49 years of age in the both sexes. Families with five members showed highest occurence, and the average number of familial members was 5.7 persons per one household. 2. More than half of the householders were some independent enterprisers rather than to be the employees and most of the household had one familial member engaged in more or less liberal profession. 3. 19.4% of households moved into these cities from 1941 to 1945. 4. 40.5% of all the households had their own houses. The possession rate of one's own house was higher in the households which had long period of residence in Japan. 5. 83.5% of all households had various medical insurances. And the 6.2% of the household which had no insurance stated that the reason for not being affiliated was 'because to be the foreigner'. Household of shorter dwelling period had less tendency to be affiliated to the various insurances. 6. In 41.3% of all the households, average medical expenditure amounted to 1000-5000 Yen per month. And only 25.6% of household stated that they do not worry about the medical expenditure for the futures. 7. 66.3% of households were consulting to medical doctors for their sickness, such as toothache, severe coughing, profuse sputum, children's fever and stomach pain etc. 8. 59.4% of households were using the facilities of health center services. The health center service was used mainly for individual health service rather than the environmental aspect. And 19.8% of households were not aware of health center activities. 9. It was found that 23.5% of households received the screening test of the tuberculosis and adult diseases. Especially, the rate of screening test of the adult diseases showed as following ; stomach cancer, 8.9% ; hypertension, 7.9% ; diabetes mellitus, 2.1% ; and uterus cancer, 1.6%. 10. Birth control was carried out in 17.3% of households but not in 52.5%. The chief reason of birth control was 'because of poor maternal health' (40.0%) or 'should not be done' (5.4%). 11. Most of them are obtaining the knowledges and informations on family plannings. public nuisance problems and nutritions etc. by means of the mass communications, while those no preventing diseases and the environmental hygiene through the administrative organizations.

• 대한임상검사과학회지
• /
• 제52권1호
• /
• pp.53-61
• /
• 2020

Cell migration은 embryogenesis 혹은 cancer metastasis 이외에, 물리적 손상에 의한 상처의 수복을 위해서 손상된 부위로 세포가 이동하는 매우 흔하게 관찰되는 현상 중 하나 이다. Wound healing assay는 in vitro의 이차원 평면상에서 세포의 이동을 관찰할 수 있는 기본적인 연구 기법이다. In vitro상에서 물리적 손상을 재현하는 가장 손쉬운 접근법으로서, 세포의 confluent monolayer 표면에 날카로운 도구를 이용하여 기계적인 스크레치를 내는 방법이 사용되고 있다. 완충 스프링이 탑재된 금속 핀을 96-well plate를 기반으로 하는 wound maker에 장착하여 multi-well plate 바닥 표면의 고르지 못한 굴곡과 스크레칭 팁 사이에 직각을 이루는 접촉면에서의 미세한 조절이 가능하도록 하였다. 실험용 팁으로 confluent monolayer위에 스크래치를 내었을 때에는 다양한 지그재그 패턴이 그려진 반면에, 직접 제작한 wound maker에서는 동일한 형태의 선형 wounds가 fibroblast가 seeding된 96-well plate의 각 well의 중심부에 그려짐을 확인하였다. 상용화 되어있는 몇몇 multi-well plate가 본 실험에서 제작된 wound maker와 호환되는 것을 고려하여 보았을 때에, 실시간 wound healing을 관찰하는 high content screening (HCS)실험에 있어서의 활용적인 측면에서 기존의 전형적인 polypropylene 파이펫 팁을 이용한 스크래칭 방법보다 더욱 용이한 방법임을 알 수 있다.

• Journal of the Korean Data and Information Science Society
• /
• 제26권6호
• /
• pp.1397-1407
• /
• 2015

개체의 표현형은 대부분 유전적인 요인의 영향과 환경적인 요인의 영향을 모두 받는다. 따라서 한우의 경제적인 특성과 연관이 있는 유전자 마커 선별 연구에서도 관심이 있는 유전적인 요인의 효과를 좀 더 정확히 보기 위해서는 환경적인 요인의 보정이 필요하다. 본 연구의 목적은 고품질 한우 생산을 위한 우수 유전자 마커 선별 연구에서 환경적인 요인이 보정된 새로운 통계 모형을 제안하고 그 효과를 규명하는 데 있다. 먼저 환경적인 요인과 유전적인 요인을 모두 포함한 통계모형을 구축한 뒤, 환경적인 요인인 도축일령과 사육농가의 효과를 제거하여 보정된 경제형질의 값을 구한다. 그리고 다중인자차원축소 방법을 보정 전 후 데이터에 각각 적용하여 우수 유전자 마커 조합을 선별하고 정확도를 비교한다. 사용된 경제형질은 C18:1, SFA, MUFA, MS, CWT, BFT이며 사용된 유전자 마커는 49개 LPL 유전자 마커 중 지방산 조성 및 경제 형질 능력 검정을 통해 나머지에 비해 더 뛰어난 유전자 마커로 선별된 6개 (g.6960 A>T, g.6974 G>A, g.21604 G>A, g.22488 G>T, g.22649 G>A, g.25670 C>T)이다.

• 과학기술학연구
• /
• 제1권2호
• /
• pp.343-369
• /
• 2001

생명공학의 사회적 함의에 대한 논의를 위해서는 일반 시민의 인식과 형성과정에 대해 파악할 필요가 있다. 이에 따라 생명공학에 대한 ELSI (Ethical, Legal and Social Implications) 연구의 일환으로 필자는 생명공학에 대한 사회적 인식의 지형을 정기적으로 조사하는 프로젝트를 시작하였다. 본 논문은 이 조사 프로젝트의 한 부분으로 생명공학에 대한 인지도 수준과 태도를 파악하고 관련 요인을 찾아보았다. 인식조사는 전국 성인남녀 500명을 대상으로 전화면접방법을 이용하여 이루어졌으며, 표본은 유층표집방법을 이용하여 추출하였다. 조사결과 의료 관련 생명공학에 대해서는 긍정적인 태도가 많았지만, 유전정보의 사회적 관리 및 유전자 변형식품에 대해서는 부정적 태도가 긍정적 태도와 비슷한 수준이거나 아니면 더 많았다. 그리고 인지도 수준이 높을수록 태도가 더 명확하였다. 또한 이러한 시민들의 태도는 아직 잠정적인 느낌 수준인 경우가 많으며, 매스미디어의 영향을 많이 받은 것으로 나타났다. 이러한 연구결과는 생명공학에 대한 사회적 함의에 대한 논의가 보다 건설적이기 위해서는 우선 생명공학에 대한 정보의 생산과 유통이 보다 활성화될 필요가 있다는 것을 보여준다.

• 한국환경보건학회지
• /
• 제48권1호
• /
• pp.1-8
• /
• 2022

Objectives: The purpose of this study is to reveal the circumstances under which the cases of harm to health caused by humidifier disinfectant were neglected and show the points where the number of victims and the degree of damage could have been reduced. In addition, it attempts to describe how damage management proceeded immediately after the incident and actually exacerbated the damage. Finally, it explores the unfortunate aspects of the recent trial. By doing so, it attempts to take this as an opportunity to consider whether a tragic event such as the humidifier disinfectant incident could occur in the future. Methods: This study collected and analyzed data on chemical material characteristics related to humidifier disinfectants, data on health effect characteristics, data on related laws and regulations from the Ministry of Environment, data related to the damage investigation by the Korea Environmental Industry and Technology Institute, and current contents. Results: The lack of related systems and laws is the area where the greatest responsibility for the cause of the humidifier disinfectant disaster falls, so it is difficult for the government to escape this responsibility. Establishing a dedicated department to identify the prevalence of certain diseases within the functions of the Health Insurance Review and Assessment Service to monitor health can greatly contribute to the prevention and management of diseases through early detection and management of group outbreaks caused by harmful factors. Humidifier disinfectant damage relief should have been expanded earlier beyond HDLI (humidifier disinfectant lung injury) to include non-specific diseases such as asthma, pneumonia, and interstitial pneumonia. The scope of relief benefits should have also been expanded earlier to include the payment of disability benefits. Fortunately, with the 2020 revision of the Special Act, the conditions for estimating causal relations were eased and individual screening systems such as health impact assessment were reorganized along with the introduction of a rapid screening system. Conclusions: The management system for chemical substances in a country is clearly of paramount importance, and the ministry in charge must have a response system in case of damage to health effects. Administration that looks at the victims' situation from their point of view is needed, and technical countermeasures are required to quickly recognize the prevalence of certain diseases.

• Journal of Microbiology and Biotechnology
• /
• 제33권4호
• /
• pp.552-558
• /
• 2023

Levulinic acid (LA) is a valuable chemical used in fuel additives, fragrances, and polymers. In this study, we proposed possible biosynthetic pathways for LA production from lignin and poly(ethylene terephthalate). We also created a genetically encoded biosensor responsive to LA, which can be used for screening and evolving the LA biosynthesis pathway genes, by employing an LvaR transcriptional regulator of Pseudomonas putida KT2440 to express a fluorescent reporter gene. The LvaR regulator senses LA as a cognate ligand. The LA biosensor was first examined in an Escherichia coli strain and was found to be non-functional. When the host of the LA biosensor was switched from E. coli to P. putida KT2440, the LA biosensor showed a linear correlation between fluorescence intensity and LA concentration in the range of 0.156-10 mM LA. In addition, we determined that 0.156 mM LA was the limit of LA detection in P. putida KT2440 harboring an LA-responsive biosensor. The maximal fluorescence increase was 12.3-fold in the presence of 10 mM LA compared to that in the absence of LA. The individual cell responses to LA concentrations reflected the population-averaged responses, which enabled high-throughput screening of enzymes and metabolic pathways involved in LA biosynthesis and sustainable production of LA in engineered microbes.

• 대한원격탐사학회지
• /
• 제32권2호
• /
• pp.73-86
• /
• 2016

이 연구에서는 Suomi-National Polar Partnership(Suomi-NPP) 위성에 탑재된 Visible Infrared Imaging Radiometer Suite(VIIRS) 센서의 Day/Night Band(DNB)로부터 측정된 인공광원 복사휘도 정보를 이용하여 우리나라 소도시들에서 야간 에어로졸 광학두께를 추정하는 방법을 개발하였다. 개발된 알고리즘에서는 야간에 도시의 인공광원들로부터 방출되는 빛을 광원으로하여 Beer의 복사 감쇠법칙이 이용되었으며, VIIRS의 적외선 영역 M밴드 관측자료를 사용하여 구름화소를 제거함으로써 청천화소에 대하여 에어로졸 광학두께를 산출하였다. 본 연구에서 산출된 야간 에어로졸 광학두께 결과는 주간 MODerate resolution Imaging Spectroradiometer(MODIS) 센서로부터 산출된 자료와 비교 검증하였다. 검증 결과, 도시에 따라 0.6~0.7이상의 상관계수와 0.14~0.18 범위의 제곱근-평균-제곱 차이(Root-Mean-Square Difference; RMSD)를 보였다. 추가적으로 야간 에어로졸 광학두께에 영향을 미치는 인자들에 대한 민감도 실험을 수행하여 개발된 알고리즘의 산출 오차의 범위를 추정하였다. 본 연구를 통하여 우리나라에서 야간에 DNB채널 관측자료를 이용하여 에어로졸 광학두께를 추정할 수 있는 가능성을 확인 하였으며, 개발된 알고리즘의 지속적인 개발 및 개선이 이루어진다면 향후 국내에서 기존에 부족했던 야간 에어로졸 정보의 산출에 기여할 것으로 기대된다.

• 한국산학기술학회논문지
• /
• 제18권5호
• /
• pp.382-390
• /
• 2017

본 연구는 제6기 2차년도 국민건강영양조사 결과를 토대로 인구사회학적특성, 건강상태, 정신건강 측면에서 암환자의 삶의 질에 영향을 미치는 요인을 확인하기 위해 시도되었다. 연구도구는 국민건강영양조사의 인구사회학적 특성, 건강상태, 정신건강, 삶의 질을 이용하였으며 SAS 9.3 version으로 분석하였다. 연구결과 연령, 성별, 경제활동 여부, 소득사분위수(개인), 주관적 건강상태, 본인인지 구강건강상태, 활동제한 여부, 스트레스 인지율, 우울증상 경험률에서 삶의 질이 유의한 차이가 있었다. 암환자의 삶의 질에 영향을 미치는 요인은 연령, 성별, 소득사분위수(개인), 주관적 건강상태, 활동제한 여부, 우울증상 경험률로 이들 변인은 삶의 질을 39.1% 설명하였다. 본 연구의 의의는 암환자 삶의 질 영향요인을 인구사회학적 특성, 건강상태, 정신건강의 다차원적 측면에서 확인하였다는 점과 본인인지 구강건강상태가 삶의 질에서 유의한 차이가 있음을 밝혀내었다는데 있다. 이와 같은 결과를 바탕으로 암환자의 삶의 질을 향상시키기 위해서는 암 진단부터 치료, 회복 후 사회로 복귀까지를 포함하는 포괄적인 관리가 요구된다. 또한 삶의 질에 대한 다차원적 접근 및 안위 증진, 암의 조기검진과 암예방 교육, 우울증상 관리, 사회적지지를 포함한 장기적인 프로그램 개발 및 적용이 필요하다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제27권3호
• /
• pp.164-172
• /
• 2016

Objectives: This study attempted to evaluate the usefulness and direction of development of post-traumatic assessment and interventions based on the opinions of psychiatrics and disaster and trauma-related experts using the Delphi survey technique. Methods: In-depth individual interviews served as the pre-survey and were followed by Delphi primary and secondary surveys. Specialists in child and adolescent mental health, psychological support professionals specialized in disasters and related practitioners with experience of disasters in Korea completed a set of questionnaires and participated in focus group interviews and in-depth individual interviews on post-traumatic assessment and intervention. Results: We found that the following issues have a significant impact on the interventions after disasters: the proper time of the initial interview in the event of a disaster, assessment notices, aged assessment services, mandatory enforcement measures, scale screening and treatment intervention elements, symptoms degree classification, intervention standardization, the use of a levelled program, care unit environment, and operation plan. Conclusion: This study proposed effective mental health intervention measures and has implications for the development of evaluation treatment protocols after disasters.