Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Proposal of statistical model adjusted environmental factor in genetic research for high quality Hanwoo production

고품질 한우 생산 유전자 연구에서 환경 요인을 보정한 통계적 모형 제안

  • Received : 2015.10.05
  • Accepted : 2015.11.28
  • Published : 2015.11.30
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Abstract

Individual phenotype is mostly influenced by genetic factors as well as the effects of environmental factors. Therefore, adjustment of environmental factors are needed in order to see more clearly the effects of genetic factors that we are interested in gene screening study related to Hanwoo's economic trait. The purpose of this study is to propose new statistical model that was adjusted environmental factor and identify adjustment effect in a superior gene marker screening study for producing high quality Hanwoo. First, statistical model including both genetic factor and environmental factor establishes and adjusted value of economic trait find by removing effect of environmental factor such as age, breeding farm. Finally, we identify superior gene marker combination and compare accuracy by applying MDR to data of before and after adjustment. Economic trait is used C18:1, SFA, MUFA, MS, CWT, BFT and SNP marker is used 6 markers of LPL that were identified as more excellent SNP marker than the others among 49 markers through fatty acid composition and economic trait performance test.

개체의 표현형은 대부분 유전적인 요인의 영향과 환경적인 요인의 영향을 모두 받는다. 따라서 한우의 경제적인 특성과 연관이 있는 유전자 마커 선별 연구에서도 관심이 있는 유전적인 요인의 효과를 좀 더 정확히 보기 위해서는 환경적인 요인의 보정이 필요하다. 본 연구의 목적은 고품질 한우 생산을 위한 우수 유전자 마커 선별 연구에서 환경적인 요인이 보정된 새로운 통계 모형을 제안하고 그 효과를 규명하는 데 있다. 먼저 환경적인 요인과 유전적인 요인을 모두 포함한 통계모형을 구축한 뒤, 환경적인 요인인 도축일령과 사육농가의 효과를 제거하여 보정된 경제형질의 값을 구한다. 그리고 다중인자차원축소 방법을 보정 전 후 데이터에 각각 적용하여 우수 유전자 마커 조합을 선별하고 정확도를 비교한다. 사용된 경제형질은 C18:1, SFA, MUFA, MS, CWT, BFT이며 사용된 유전자 마커는 49개 LPL 유전자 마커 중 지방산 조성 및 경제 형질 능력 검정을 통해 나머지에 비해 더 뛰어난 유전자 마커로 선별된 6개 (g.6960 A>T, g.6974 G>A, g.21604 G>A, g.22488 G>T, g.22649 G>A, g.25670 C>T)이다.

Keywords

References

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