• 제목/요약/키워드: Individual Variation

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Personal Genomics, Bioinformatics, and Variomics

  • Bhak, Jong;Ghang, Ho;Reja, Rohit;Kim, Sang-Soo
    • Genomics & Informatics
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    • 제6권4호
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    • pp.161-165
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    • 2008
  • In 2008 at least five complete genome sequences are available. It is known that there are over 15,000,000 genetic variants, called SNPs, in the dbSNP database. The cost of full genome sequencing in 2009 is claimed to be less than $5000 USD. The genomics era has arrived in 2008. This review introduces technologies, bioinformatics, genomics visions, and variomics projects. Variomics is the study of the total genetic variation in an individual and populations. Research on genetic variation is the most valuable among many genomics research branches. Genomics and variomics projects will change biology and the society so dramatically that biology will become an everyday technology like personal computers and the internet. 'BioRevolution' is the term that can adequately describe this change.

Copy Number Variations in the Human Genome: Potential Source for Individual Diversity and Disease Association Studies

  • Kim, Tae-Min;Yim, Seon-Hee;Chung, Yeun-Jun
    • Genomics & Informatics
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    • 제6권1호
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    • pp.1-7
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    • 2008
  • The widespread presence of large-scale genomic variations, termed copy number variation (CNVs), has been recently recognized in phenotypically normal individuals. Judging by the growing number of reports on CNVs, it is now evident that these variants contribute significantly to genetic diversity in the human genome. Like single nucleotide polymorphisms (SNPs), CNVs are expected to serve as potential biomarkers for disease susceptibility or drug responses. However, the technical and practical concerns still remain to be tackled. In this review, we examine the current status of CNV DBs and research, including the ongoing efforts of CNV screening in the human genome. We also discuss the characteristics of platforms that are available at the moment and suggest the potential of CNVs in clinical research and application.

Variation of Glucosinolate Composition during Seedling and Growth Stages of Brassica rapa L. ssp. pekinensis

  • Hong, Eunyoung;Kim, Gun-Hee
    • 원예과학기술지
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    • 제32권5호
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    • pp.730-738
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    • 2014
  • The objective of this study was to evaluate glucosinolate (GSL) profiles and variation of total and individual GSLs concentrations within seedling (0-14 days) and growth stages (0-15 weeks) of Korean Chinese cabbage (Brassica rapa L. ssp. pekinensis). Ten GSLs (progoitrin, glucoraphanin, glucoalyssin, gluconapin, glucobrassicanapin, 4-hydroxyglucobrassin, glucobrassicin, 4-methoxyglucobrassicin, neoglucobrassicin and gluconasturtiin) were identified from Korean Chinese cabbage. In general, total GSL content significantly decreased during seedling (from 92.89 to $35.26{\mu}mol{\cdot}g^{-1}$ DW) and g rowth stages ( from 74.11 to $1.97{\mu}mol{\cdot}g^{-1}$ DW). Gluconapin was the highest in seeds and in the germination period ($73.1{\mu}mol{\cdot}g^{-1}$ DW) and declined gradually from 73 to 15% during seedling stages. The level of the major aliphatic GSLs, gluconapin and progoitrin, tended to decrease sharply, whereas levels of indolic GSLs (4-methoxyglucobrassicin, glucobrassicin) and aromatic GSLs (gluconasturtiin) were found to increase generally at the beginning of growth stages.

PERIOD VARIATION STUDY OF THE A-TYPE W UMA ECLIPSING BINARY V839 OPH

  • Hanna, Magdy A.
    • 천문학회지
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    • 제43권6호
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    • pp.201-211
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    • 2010
  • We present an analysis of the measurements of mid-eclipse times of V839 Oph, collected from literature sources. Our analysis indicates a period increase of $3.2{\times}10^{-7}$ day/yr. This period increase of V839 Oph can be interpreted in terms of mass transfer of rate $1.76{\times}10^{-7}M_{\odot}/yr$, from the less to the more massive component. The O - C diagram shows a damping sine wave covering two different complete cycles of 36.73 yr and 19.93 yr with amplitudes approximately equal to 0.0080 and 0.0043 day, respectively. The third cycle has to be expected to cover about 13.5 years with lower amplitude than those of the former two cycles. These unequal duration cycles show a non periodicity which may be explained as resulting from either the presence of a tertiary component to the system or cyclic magnetic activity variations due to star spots. For the later mechanism, the obtained characteristics are consistent when applying Applegate (1992) mechanism.

Improvement of an Early Failure Rate By Using Neural Control Chart

  • Jang, K.Y.;Sung, C.J.;Lim, I.S.
    • International Journal of Reliability and Applications
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    • 제10권1호
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    • pp.1-15
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    • 2009
  • Even though the impact of manufacturing quality to reliability is not considered much as well as that of design area, a major cause of an early failure of the product is known as manufacturing problem. This research applies two different types of neural network algorithms, the Back propagation (BP) algorithm and Learning Vector Quantization (LVQ) algorithm, to identify and classify the nonrandom variation pattern on the control chart based on knowledge-based diagnosis of dimensional variation. The performance and efficiency of both algorithms are evaluated to choose the better pattern recognition system for auto body assembly process. To analyze hundred percent of the data obtained by Optical Coordinate Measurement Machine (OCMM), this research considers an application in which individual observations rather than subsample means are used. A case study for analysis of OCMM data in underbody assembly process is presented to demonstrate the proposed knowledge-based pattern recognition system.

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다목적 셀 형성을 위한 유전알고리즘 (A Genetic Algorithm for A Cell Formation with Multiple Objectives)

  • 이준수;정병호
    • 산업경영시스템학회지
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    • 제26권4호
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    • pp.31-41
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    • 2003
  • This paper deals with a cell formation problem for a set of m-machines and n-processing parts. Generally, a cell formation problem is known as NP-completeness. Hence the cell formation problem with multiple objectives is more difficult than single objective problem. The paper considers multiple objectives; minimize number of intercell movements, minimize intracell workload variation and minimize intercell workload variation. We propose a multiple objective genetic algorithms(MOGA) resolving the mentioned three objectives. The MOGA procedure adopted Pareto optimal solution for selection method for next generation and the concept of Euclidean distance from the ideal and negative ideal solution for fitness test of a individual. As we consider several weights, decision maker will be reflected his consideration by adjusting high weights for important objective. A numerical example is given for a comparative analysis with the results of other research.

시뮬레이션을 활용한 교과교실형 운영 중학교 학생 이동행태 분석 (An Analysis about the Moving Behavior of Students by Simulation on Variation Type in Middle School)

  • 정주성
    • 교육시설 논문지
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    • 제21권3호
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    • pp.11-18
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    • 2014
  • This study was carried out to observe movement behavior of students about a change of physical condition in moving space of variation type using simulation technique. The moving pattern of students was checked by SIMULEX program. The width of corridor was adjusted to 2.4m, 3.0m and 3.9m and a flow coefficient of simulation was estimated with the change of width. The wider the width of corridor was, the lower a flow coefficient was, and the difference was large when the width of corridor was narrow. It was also observed that the flow coefficient was relatively high in all types of corridor setup individual locker. Unit occupation area with the change of width was additionally measured, as shown in the results, the occupation density was low when the width of corridor was wide and a stationary time was short.

파라메트릭 표피 재 조직화 (Re-organization of Parametric epidermis)

  • 박정주
    • 한국실내디자인학회:학술대회논문집
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    • 한국실내디자인학회 2008년도 춘계학술발표대회 논문집
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    • pp.46-49
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    • 2008
  • This research does Complexity form, Interior epidermis cell re-organization, Object discovery that have correct numerical value concept by purpose. Research applied by Grid re-organization in form generation, Parameter variation of cell unit (morphor, tweener), Symbol, pattern of variation, self-organization cell substitution order. Representation through 3d digital modeler of polygon, Nurbs and street-sheet program(x,y,z coordinates & Network way of points) etc. of main work. Investigator specified numbers of U profiles*30, V point-20 that is 600 Paramaters individual in volume, and define circle radius of lighting in object, Projection size variously and tried difference. Transposition cell to point and Heightened brightness of color using pointillism of painting. Led lighting cell object is expressed being decoded by digital code.

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A Research on Forage Yield and Its Components In Response to Different Sowing Rate and Row Distance of Sorghum (Sorghum bicolor Moench.) in Turkey

  • Altin, Murat;Tekeli, A.-Servet;Orak, Adnan
    • 한국초지조사료학회지
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    • 제18권2호
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    • pp.163-170
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    • 1998
  • This research was carried out to determine the sowing rate and row distance in Edirne province of Thrace Region in 1993 season. According to the results of some important characteristics of sorghum and their interactions were statistically significant. In Havsa and Uzunk'opr& the plant height were 70.36 and 95.28cm respectively, within each sowing rate were not significant. Number of tiller were not significant in distance and individual location Increasing the sowing rate kom I to 3 kg/da and the location Havsa and Umnkoprii resulted in significant stem diameter variation. Variation in 6-esh fodder yield has been found significant in row distance sowing rate and location 1 kglda seed rate with 30 cm row distance together are recommended to the farmer community to obtain the optimum profit.

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Effect of cooking methods on the phytosterol content in nine selected vegetables

  • Shin, Jung-Ah;Park, Jong-Min;Lee, Ki-Teak
    • 농업과학연구
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    • 제43권1호
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    • pp.87-99
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    • 2016
  • Phytosterol contents in nine vegetables such as paprika (red, yellow, and orange), kohlrabi, bamboo shoot, cherry tomato, cucumber, Chinese chive, and corn were analyzed by gas chromatography. Individual contents of ${\beta}$-sitosterol, campesterol, and stigmasterol in fresh and cooked vegetables (boiling, grilling, stir-frying, deep-frying, steaming, roasting, and microwaving) were determined and compared. Total phytosterol content of paprika, cucumber, Chinese chive and cherry tomato ranged from 23.19 to 46.51 mg/kg (0.002-0.005%) of fresh weight of raw vegetables. Total phytosterol content variation (%) was obtained as follows: [(the content of phytosterol after cooking) - (the content of phytosterol before cooking)] / (the content of phytosterol before cooking) ${\times}100$. Total phytosterol content was found to be high in raw kohlrabi at 138.99 mg/kg fw (0.01%), in corn at 302.86 mg/kg fw (0.03%), and in bamboo shoot at 443.15 mg/kg fw (0.04 %). Total phytosterol content variation (%) in orange paprika ranged from 27.5 to 267.3 while that in cherry tomato ranged from -11.0 to 337.5. Generally, high content variation of total phytosterol was found in stir-fried and deep-fried vegetables. Therefore, higher phytosterol levels were obtained from cooked vegetables than raw vegetables. We suggest that these data will be useful to investigate cooking methods for increased intake of phytosterols.