• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.504-511
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• 2010

Diabetes is a disease that contains a high concentration of glucose in blood and due to defects in either insulin secretion or insulin action. Although the distinctive causes and factors of diabetes have not been clarified, the genetic factors are suggested as a main susceptibility until now. SNP (Single Nucleotide Polymorphism), as the most common genetic variation, has an influence on personal susceptibility for diseases. A nonsynonymous SNP, which changes the amino acid of the protein and its function, is especially important. Therefore, this study hypothesized that there are associations between specific SNPs of the targeted genes. Transcription factor 7-like 2 (TCF7L2) and fat mass and obesity associated (FTO) genes were selected as target genes from the results of genome-wide association and other related research studies. Second, four nonsynonymous SNPs (three in TCF7L2 and one in FTO gene) were selected as target SNPs by using public database of NCBI (National Center for Biotechnology Information). The recruited personnel was classified into three subgroups of diabetes, impaired fasting glucose (IFG) and normal groups. The individual genotypes of each group were analyzed by resequencing. None of genetic variations at four targeted SNP sites was revealed in all samples of this study. However, this study found two new SNPs that were not reported in TCF7L2 gene. One is synonymous SNP, which is heterozygous of C/T and no amino acid change of asparagine/asparagines, was located at c1641 and found in one normal person. Another is nonsynonymous SNP, which is heterozygous of G/A, was located at c1501 and found in two samples. This new discovered nonsynonymous SNP induce the amino acid change from alanine to threonine. Moreover, this new nonsynonymous SNP was found among two persons, one of whom was a diabetes patient and the other one was a person at boundary between IFG and normal, suggesting that this variant might be associated with IFG or diabetes. Even if there is a limitation of sample number for statistical power, this study has an importance due to the discovery of new SNPs. In the future study, a large sample number of diabetes cohort will be needed to investigate the frequency and association with new discovered SNP.

• Korean Journal of Community Nutrition
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• v.12 no.3
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• pp.272-283
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• 2007

This study was performed to delineate the relationship between lifestyle and nutritional risk factors associated with hypertension in representative middle-aged Korean population. Hypertension in this study is defined as hypertensive ($SBP{\geq}140mmHg\;or\;DBP{\geq}90mmHg$) adults without recognition of a disease state before a health exam. With data from the 1998 and 2001 National Health and Nutritional Survey, nutrient intakes of 6,112 adults, 40-64 years of age were calculated using food composition database and matched with health examination records by individual ID. After excluding those with extreme intake values, the number of final subjects included in the analysis was 5,200 (male 2,458, female 2,742). Using logistic regression method, socio-demographic data, lifestyle factors, and nutrient intakes were analyzed. Risky factors for hypertension revealed in this study were age, sex, BMI over 23, waist circumference, alcohol intake of more than 16g (male) or 8g (female). Regarding nutrient intakes, the intakes of highest quartile for energy (${\geq}2363.0kcal$) and protein (${\geq}90.2g$) were significantly associated with higher risk of hypertension after adjusting for age, sex, and other socio-demographic factors (OR=1.312(1.046-1.711), OR=1.488(1.194-1.854), respectively)). Although high intakes of sodium (${\geq}6604.0mg$) and phosphorus seemed to be risk factors of hypertension also before energy adjustment (OR=1.278(1.034-1.581), OR=1.280(1.024-1.600), respectively), only high intakes of energy and protein remained significant after adjustment. This study revealed that modifying risky lifestyles and dietary patterns, especially high energy intake, high protein intake, and high alcohol drinking, in middle-aged Korean adults could result in a prevalence decrease and/or prevention of hypertension.

• Economic and Environmental Geology
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• v.26 no.1
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• pp.67-81
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• 1993

This dissertation is a basic research on the degradation of rocks and aims at clarifying the relations between the progression of degree of weathering and the variation of chemical composition. The author wants to make clear the degradation of rocks and the process of formation of sedimentary rocks from a standpoint of elucidation of migration of elements. This study is considered to be significant not only as a part of research on the distribution of earth crust materials but as the petrogenesis of rocks. The chemical studies on the weathered rocks have been started relatively early and there are not a few researches on them: Goldich, 1938; Harris, et al., 1966; Ruxton, 1968; Berner, et al., 1982; Kanuss, 1983; Lasaga, 1984; Siagel, 1984. The degree of migration of elements in weathering is the composite result of various factors. Because, at the present time, it is difficult to clarify the individual and composite effects of each factor theoretically and quanititatively, we must accumulate empirical data and use them relatively. In such consideration the author acquired some data of chemical weathering from the chemical analysis of granitic and basaltic rocks in and around Fukuoka city, Japan and granitic rocks in and around Chonju and Iri cities, Korea. Because both rock types studied can be considered as representative materials of acidic and basic rocks compsing the earth crust, it is significant to examine the phenomena of weathering of both rock types. The following results are obtained from the analysis and examinations of chemical compositions of the original and weathered rocks. The loss rate of major elements has no uniformity, but the following relation holds in general; Ca, Na> K, Si> Mg> Fe, Al. As weathering proceeds, the ratio of $Al_2O_3/CaO$ shows increasing phenomena, and that of $Na_2O/CaO$ decreasing. The range of migration of composition is broad in basaltic rocks but narrow in granitic rocks. The reason is that the chemical weathering of basaltic rocks progresses more easily than that of granitic rocks. The chemical weathering potenitial index of basaltic rocks in larger than that of granitic rocks. The reason is that the chemical weathering of basaltic rocks proceeds more easily than that of granitic rocks. In weathering, the decrease of mobile cations such as $Ca^{2+}$, $Na^{2+}$, $Mg^{2+}$ and the increase of $H_2O$ in basaltic rocks are more obvious than in granitic rocks.

• Journal of the Society of Disaster Information
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• v.7 no.4
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• pp.273-285
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• 2011

This research present actual conditions on realization about safety of observable individual and country, terror countermeasure from danger of terrorism which special guards have. To achieve these purposes, 400 special guards were sampled using the convenience sampling method and collected data through questionnaire from self-administration method. the collected data are in statistics of p<.05 levels. As the result, we drew following conclusions. Special guards thought that terror might occur most in 'aircraft, rapid-transit railway, subway, and bus'. It was no difference in society demography(p>.05). In type of terror, 'bomb terror' seemed to happen most, and they recognized that biochemistry terror and factor terror, and hostage terror may happen in society demography. Purpose of terror was thought that 'political purpose' may be the biggest, and 'ideological purpose' and 'social purpose' joined the remainder. According to society demography, woman's realization about terror was higher than man in two low variables. According to age, image of terror was high in 40 more than 20. According to educational background, university graduate were higher than a high-school diploma in two low variables. According to place of work, metropolis was higher than small and medium-sized city.

• Archives of design research
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• v.14 no.3
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• pp.177-186
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• 2001

Modern times is called the age of image. It means that our society's importance is transferring from the commodity-centered industrial society to intangible culture-oriented society Therefore, it is becoming very important that what kind of image, concept and psychological factor act upon the space, things, incident and time (event) which is constituted around our environment. As regards this standpoint, from the early period, that advanced countries have been taking advantage of the national symbol image very positive way and function for domestic things and place and event and so on which make a standout for the nation's positive image and taken an effort for promoting a pride of their fellow countrymen through this. This study approaches the basic images of national symbol which includes the country's name, national anthem, national flag through the design principle which could express some certain above level of pattern and composition. I suggested various applicative motif based on basic expressions of each individual image and the applied sample goods of this idea, and through the introduction of the process of image development, and I tried to offer a moment of more prosperity and development at a later time. This is for encouraging fellow citizens to use national symbol in the free and positive way which make them to increase a national pride, and give a familiar image in the citizens'daily life. I intended to offer basic materials for promoting ourselves whenever we need it. And also by the offering information on our nation for foreigners which make them to have a favorable impression of our nation. I tried to promote a positive national image.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.1
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• pp.176-182
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• 2018

The purpose of this study was to investigate the safety and rationality of buckling strength and length coefficient by comparing with the design standards of domestic and foreign compression materials based on the buckling test results of circular steel pipe with ball joints. The types of round steel pipes selected for buckling performance evaluation were ø$48.6{\times}2.8t$, ø$60.5{\times}3.2t$ and ø$76.3{\times}3.2t$. For the design of domestic and foreign compression materials, Korea 's Load Resistance and Factor Design, Japan' s Limit State Design, and British Standard BS5950 standard were applied. In this study, we compared and analyzed the buckling performance between the experimental results of the previous research and the domestic and foreign design standards. The results were summarized as follows. As a result of applying the full length of the member to the buckling length in the compression materials design standards of each country, it was 64-89% of the buckling strength by the experiment. Therefore, it is deemed desirable to perform the member design according to the current design standard formula for safety. Experimental results show that the measured buckling strength was 1.02-1.43 times higher than the buckling strength of pure cylindrical steel tubes in the design standards of Korea, Japan and the United Kingdom compression materials. Consequently, it seemed that the buckling strength of individual member in the design of space frame structure should be considered buckling coefficient as the length of pure round steel pipe rather than the length of inter-node.

• Nutrition Research and Practice
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• v.11 no.2
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• pp.105-113
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• 2017

BACKGROUND/OBJECTIVES: A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk of these diseases. It is known that health effects of diet are partially conveyed through epigenetic mechanism including DNA methylation. In this study, we investigated the genome-wide hepatic DNA methylation to identify the epigenetic effects of HFD-induced obesity. MATERIALS AND METHODS: Seven-week-old male C57BL/6 mice were fed control diet (CD), calorie-restricted control diet (CRCD), or HFD for 16 weeks (after one week of acclimation to the control diet). Food intake, body weight, and liver weight were measured. Hepatic triacylglycerol and cholesterol levels were determined using enzymatic colorimetric methods. Changes in genome-wide DNA methylation were determined by a DNA methylation microarray method combined with methylated DNA immunoprecipitation. The level of transcription of individual genes was measured by real-time PCR. RESULTS: The DNA methylation statuses of genes in biological networks related to lipid metabolism and hepatic steatosis were influenced by HFD-induced obesity. In HFD group, a proinflammatory Casp1 (Caspase 1) gene had hypomethylated CpG sites at the 1.5-kb upstream region of its transcription start site (TSS), and its mRNA level was higher compared with that in CD group. Additionally, an energy metabolism-associated gene Ndufb9 (NADH dehydrogenase 1 beta subcomplex 9) in HFD group had hypermethylated CpG sites at the 2.6-kb downstream region of its TSS, and its mRNA level was lower compared with that in CRCD group. CONCLUSIONS: HFD alters DNA methylation profiles in genes associated with liver lipid metabolism and hepatic steatosis. The methylation statuses of Casp1 and Ndufb9 were particularly influenced by the HFD. The expression of these genes in HFD differed significantly compared with CD and CRCD, respectively, suggesting that the expressions of Casp1 and Ndufb9 in liver were regulated by their methylation statuses.

• Journal of Energy Engineering
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• v.24 no.4
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• pp.183-191
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• 2015

Studies on the environment-friendly and permanent low energy saving measure are and will continue to be an eternal challenge. However, the demand is high for the technologies that can save energy significantly in everyday life that produce tangible benefits for the users by applying saving factors and that anyone can access easily when it comes the related procedure. Government policies related to the improvement of energy effect in the existing building structure are characterized by complex procedure. Moreover, cost required and reliability issue emerge when request is made to an expert. Accordingly, this study seeks to present energy improvement plan that can be utilized simply and conveniently at any place, any time by enabling customized design according to individual taste by enabling energy change amount and grade prediction when the users select only the part that they want to replace by using a simple program.

• Journal of Engineering Education Research
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• v.11 no.4
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• pp.64-75
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• 2008

The purpose of the study was to verify reliability and validity of SDLRS instrument and to prove up possibility of usage as an evaluation method for evaluating life-long learning. Literature review and survey were used to accomplish objectives of the study. 218 students in department of mechanical engineering of A university at Gyunggi province were responded for SDLRS(Guglielmino, 1977) instrument. Data were analyzed using descriptive statistics, factor analysis, t-test, and ANOVA test. 58 items in original version instrument were converted to 23 items. There were 7 factors for assessing the self-directed learning readiness according to this measurement scale with a total variance of about 58%. The total reliability of the final 23 items was $\alpha$. The final 7 factors consisted of love for learning, openness for learning, self-perception, basic learning function and independence, acceptance of responsibility for learning, leadership and future directivity, and creativity and exploration. The result of SDLRS analysis according to individual background, there were significant statistically in the grade, period of employment in industry, entering graduate school or not, and GPA, but no significant statistically in sexual difference, employment in industry or not, final academic level of parent, and income level of the family. In the future, final instrument will be needed to check in the respect of correlation with another ability and skill influencing on life-long learning, and more study will be done for developing life-long learning.

• Science of Emotion and Sensibility
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• v.22 no.4
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• pp.45-56
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• 2019

The regulation of emotion is known to mediate the relationship between emotion-relevant differences in individuals and their life outcomes. This study attempted to include a situational factor in addition to the mediation model and investigated whether this conditional component changed the patterns of indirect effects. The researchers recruited 180 emotional laborers working in diverse domains and used a questionnaire to ascertain their negative affectivity, cognitive reappraisal, emotional exhaustion, and the intensity of negative comments they usually received from customers. The results of the conditional indirect effect analysis revealed the positive indirect influence of negative affectivity on emotional exhaustion through cognitive reappraisal when emotional labors receive highly negative comments from customers (high intensity of the situation). Similarly, negative indirect effects were found when emotional labors receive slightly negative comments from customers (low intensity of the situation). The outcomes of this study suggest that cognitive reappraisal can mediate to decrease emotional exhaustion in contexts that arouse more intensive negative emotions; it can also mediate to increase emotional exhaustion in contexts that arouse less intensive negative emotions. The implications of this study include the importance of integrating individual differences with situational factors. The study also provides information about the distinctiveness of groups of emotional laborers.