• Genomics & Informatics
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• v.16 no.1
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• pp.14-20
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• 2018

Despite the importance of mutation rate, some difficulties exist in estimating it. Next-generation sequencing (NGS) data yields large numbers of single-nucleotide polymorphisms, which can make it feasible to estimate substitution rates. The genetic substitution rates of Hanwoo and Holstein cattle were estimated using NGS data. Our main findings was to calculate the gene's substitution rates. Through estimation of genetic substitution rates, we found: diving region of altered substitution density exists. This region may indicate a boundary between protected and unprotected genes. The protected region is mainly associated with the gene ontology terms of regulatory genes. The genes that distinguish Hanwoo from Holstein in terms of substitution rate predominantly have gene ontology terms related to blood and circulatory system. This might imply that Hanwoo and Holstein evolved with dissimilar mutation rates and processes after domestication. The difference in meat quality between Hanwoo and Holstein could originate from differential evolution of the genes related to these blood and circulatory system ontology terms.

• Journal of electromagnetic engineering and science
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• v.3 no.1
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• pp.50-56
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• 2003

This paper proposes a coding scheme of control channel for mobile packet communication to maximize the minimum Hamming distance, which is based on shifting of basis vectors of Reed Muller code with optimized dynamic puncturing and/or(partial) sequence repetition. Since the maximum likelihood decoding can be performed using the extremely simple FHT(Fast Hadamard Transformation), it is suitable for real time optimum decoding of control channel information with very little complexity. We show applications of the proposed coding method to TFCI(Transport Format Combination Indicator) code in split and normal modes of 3GPP W-CDMA system. We also discuss how this method can reduce rate indication error over AWGN(Additive White Gaussian Noise) as well as fading channels when the proposed coding scheme is applied to 1xEV-DV system of $3^{rd}$TEX> generation partnership project 2(3GPP2) to indicate the data rate transmitted on the reverse traffic channel by a Mobile Station(MS).

• BMB Reports
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• v.30 no.3
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• pp.182-187
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• 1997

The NADPH oxidase of phagocytes catalyzes the reduction of oxygen to $O_2^-$ at the expense of NADPH. The enzyme is dormant in resting neutrophils and becomes activated on stimulation. During activation, $p47^{phox}\;(\underline{ph}agocyte\;\underline{ox}idase\;factor)$, a cytosolic oxidase subunit, becomes extensively phosphorylated at a number of serines located between S303-S379. Oxidase activation can also be achieved by the addition of phosphorylated recombinant $p47^{phox}$ by protein kinase C in the cell-free system in the presence of $GTP{\gamma}S$. The cell-free activation is inhibited by wortmannin and LY294002. specific inhibitors of phosphatidylinositol 3kinase (PI 3-kinasel) These results indicate that PI 3-kinase may playa pivotal role in the activation of NADPH oxidase.

• Journal of computational fluids engineering
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• v.10 no.3 s.30
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• pp.19-26
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• 2005

The purpose of this paper is the study on the characteristics of an inlet system with shock/boundary layer interactions by using various types of bumps which are substituted for the conventional bleeding system in supersonic inlet. in this study a comprehensive numerical analysis has been performed to understand the three-dimensional flow field including shock/boundary layer interaction and growth of turbulent boundary layer that might occur around a three-dimensional bump in a supersonic inlet. The characteristics of boundary layer seen in the current numerical simulations indicate the potential capability of a three-dimensional bump to control shock/boundary layer interaction in supersonic inlets.

• Korean System Dynamics Review
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• v.15 no.2
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• pp.75-96
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• 2014

The purpose of this paper is to analyze the functional changes of local educational authority policy based on the systems thinking perspective using causal loop diagrams. In the past, the main function of the local educational authority was to manage and supervise schools. Through this policy, local educational authority would be transformed into a support agency. However, this policy did not achieve the goal, was to cause confusion and require improvement. This study shows structured causes of the problem based on systems thinking. These diagrams make it possible for educational policy makers to provide ideas, although they have some complicated environment. The findings indicate that based on systems thinking in this policy can help those who related to policy decision than existing diagnosis method.

• Journal of Korea Spatial Information System Society
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• v.11 no.2
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• pp.19-26
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• 2009

Ubiquitous service based on Spatio-temporal dataspaces requires not only the moving objects data but also the spatial objects. However, existing methods can not handle the moving objects and spatial objects together. To overcome the limitation of existing methods, we propose a new index structure called UIL (Union Indexing Lists) which contains two parts: MOL (Moving Object List) and SOL (Spatial Object List) to index the moving objects and spatial objects together. In addition, it can suppose the flexible queries on these data. We present the results of a series of tests which indicate that the structure perform well.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.5
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• pp.138-145
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• 1998

Recently, TCS(Traction Control System) is attracting attention, because it maintains traction ability and steerability of vehicles on low-$\mu$ surface roads by controlling the slip rate between tire and road surface. The development of TCS control law is difficult due to the highly nonlinearity and uncertainty involved in TCS. A fuzzy logic approach is appealing for TCS. In this paper, fuzzy logic controller for TCS is introduced and evaluated by the computer simulation with 8 DOF vehicle model. The result indicate that the fuzzy logic TCS improves vehicle's stability and steerability.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.6
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• pp.1035-1046
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• 2002

Time Delay Control(TDC) is a robust nonlinear control scheme using Time Delay Estimation(TDE) and also has a simple structure. To apply TDC to a real system, we must design Time Delay Controller to guarantee stability. The earlier research stated sufficient stability condition of TDC for general plants. In that research, it was assumed that time delay is infinitely small. But, it is impossible to implement infinitely small time delay in a real system. So, in this research we propose a new sufficient stability condition of TDC for general plants with finite time delay. And the simulation results indicate that the previous sufficient stability condition does not work even for small time delay, while our proposed condition works well.

• Biomolecules & Therapeutics
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• v.3 no.1
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• pp.58-62
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• 1995

We investigated whether nitric oxide (NO) may serve a role in bladder function by immunohistochemical analysis of the distribution of intrinsic NADPH-diaphorase and functional study of isometric tension recordings via a photo-induced adequate nitric oxide (PIANO) generating system using rat bladder. Results suggest that a small number of NADPH-diaphorase-positive perikarya are present within the bladder wall and within adjacent small ganglia. Furthermore, NADPH-diaphorase-positive nerve fibers were observed in the adventitial and muscular layers, subjacent to the urothelium and perivascular fibers. Rat bladder strips precontracted with 3$\mu$M carbachol were reversibly relaxed upon NO generation by UV irradiation. PIANO-mediated relaxation was sensitive to oxygen free radicals. In addition, tissue cGMP levels were increased by the PIANO generating system and elevated cGMP levels were decreased by pretreatment of guanylate cyclase inhibitor, methylene blue. These results indicate that NO may serve a role in modulating bladder tone in the rat.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.1
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• pp.32-39
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• 2004

This research is to investigate the performance of a flexible matrix composite driveshaft with respect to shaft design parameters such as the number of layers, ply orientations, and material properties. A finite element formulation is utilized to estimate the allowable misalignment under given driving torque, the maximum temperature at steady states, and external damping for ensuring whirling stability under supercritical speed. Results indicate that the system performance can be greatly affected by the shaft laminate parameters, especially the ply orientations. Several sets of shaft parameters that will provide satisfactory overall system performance are derived.