• 제목/요약/키워드: Indicate System

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Antioxidant Activity in Water and Methanol Extracts from Korean Edible Wild Plants (국내산 산채류의 물 및 메탄올 추출물에 대한 항산화 활성)

  • Lee, Young-Min;Bae, Ji-Hyun;Jung, Ho-Young;Kim, Jae-Hyun;Park, Dong-Sik
    • Journal of the Korean Society of Food Science and Nutrition
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    • 제40권1호
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    • pp.29-36
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    • 2011
  • The present study was performed to investigate antioxidant activities of Korean edible wild extracts. In water and methanol extracts of edible wild plants, total polyphenol content of water and methanol extracts ranged 4.6~183.8 and 8.2~270.1 mg/g, respectively. Radical scavenging activity against DPPH and ABTS radicals was observed to be high in Lysimachia barystachys, Aceriphyllum rossii, Securinega suffruticosa, Sedum kamtschaticum, and Pedicularis resupinata. Pedicularis resupinata, Securinega suffruticosa, Patrinia villosa, and Solidago virga-aurea var. asiatica showed effective SOD-like activity. There was significant correlation between polyphenol content and DPPH and ABTS radical scavenging activities, and SOD-like activity. Plant extracts such as Pedicularis resupinata, Securinega suffruticosa, Rhapontica uniflora, Lysimachia barystachys, and Aceriphyllum rossii had higher polyphenol content, radical scavenging, and SOD-like activity. These results indicate that Korean edible wild plants may be useful as potential antioxidant sources for improving human antioxidant defense system.

Effect of TSHAC on Human Cytochrome P450 Activity, and Transport Mediated by P-Glycoprotein

  • Im, Yelim;Kim, Yang-Weon;Song, Im-Sook;Joo, Jeongmin;Shin, Jung-Hoon;Wu, Zhexue;Lee, Hye Suk;Park, Ki Hun;Liu, Kwang-Hyeon
    • Journal of Microbiology and Biotechnology
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    • 제22권12호
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    • pp.1659-1664
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    • 2012
  • TSAHC [4'-(p-toluenesulfonylamido)-4-hydroxychalcone] is a promising antitumorigenic chalcone compound, especially against TM4SF5 (four-transmembrane L6 family member 5)-mediated hepatocarcinoma. We evaluated the potential of TSAHC to inhibit the catalytic activities of nine cytochrome P450 isoforms and of P-glycoprotein (P-gp). The abilities of TSAHC to inhibit phenacetin O-deethylation (CYP1A2), coumarin 6-hydroxylation (CYP2A6), bupropion hydroxylation (CYP2B6), amodiaquine N-deethylation (CYP2C8), diclofenac 4-hydroxylation (CYP2C9), omeprazole 5-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), chlorzoxazone 6-hydroxylation (CYP2E1), and midazolam 1'-hydroxylation (CYP3A) were tested using human liver microsomes. The P-gp inhibitory effect of TSAHC was assessed by [$^3H$]digoxin accumulation in the LLCPK1-MDR1 cell system. TSAHC strongly inhibited CYP2C8, CYP2C9, and CYP2C19 isoform activities with $K_i$ values of 0.81, 0.076, and $3.45{\mu}M$, respectively. It also enhanced digoxin accumulation in a dose-dependent manner in the LLCPK1-MDR1 cells. These findings indicate that TSAHC has the potential to inhibit CYP2C isoforms and P-gp activities in vitro. TSAHC might be used as a nonspecific inhibitor of CYP2C isoforms based on its negligible inhibitory effect on other P450 isoforms such as CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, and CYP3A.

A study of distribution characteristics of unidentified particulate components in an urban area (도시환경의 총부유먼지 중 미지성분의 분포 특성에 대한 연구)

  • Kim, Yong-Hyun;Kim, Ki-Hyun;Park, Chan-Koo;Shon, Zang-Ho;Song, Sang-Keun
    • Analytical Science and Technology
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    • 제25권2호
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    • pp.133-145
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    • 2012
  • The quantitative composition of total suspended particulates (TSP) in the atmosphere is identified to consist mainly of ions, organic carbon (OC), element carbon (EC), and metals. In terms of environmental analysis, the rest of the TSP composition may be defined as unknown fraction (${\Sigma}X$) which is yet difficult to analyze both quantitatively and qualitatively. In this study, the major components of TSP were measured at an urban residential area (Gang Seo) in Seoul, Korea from February to December 2009. These TSP data were analyzed in various respects to explain the relationship between known and unknown constituents. During this study period, TSP was comprised mainly of unknown compounds (48.6%) followed by ions, OC, EC, and metals. The results of this study indicate that the distribution of ${\Sigma}X$ exhibits a strong similarity with ${\Sigma}Anions$, as they both increase with increasing TSP levels. However, if the concentrations of ${\Sigma}X$ and ${\Sigma}Anion$ are normalized against TSP, they exhibit a strong inverse correlation with each other due probably to larges differences in solubility. To establish a better strategy for air quality control in urban atmosphere, more efforts are needed to characterize unidentified proportion of particulate matters.

A Study on the Time-lag Effects of Financial & Non-financial Performances of Balanced Scorecard (균형성과표의 재무적 및 비재무적 성과의 시차적 효과 특성에 관한 연구)

  • Jeong, Ki-Man
    • Journal of the Korea Academia-Industrial cooperation Society
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    • 제10권8호
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    • pp.2103-2109
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    • 2009
  • Balanced Scorecard(BSC) is one of the ways to estimate the achievement results of enterprises which, beyond the simple financial index traditionally used for enterprise achievement result management system, aims to estimate and manage the key perspectives for the future and goal achievement of enterprises as financial perspectives, customer perspectives, internal business perspectives, learning and growth perspectives with a fully consistent and balanced measure, and moreover manage their relationships regarding cause and effect on its basis. Introduction of BSC can be a profound implication for management strategies not only in that its introduction itself has numerous direct effects but also in the way of understanding whether or not its sequential relations exist. Thus this study focused on if the introduction of BSC is effectual, and if there exist any time-lag sequential relations between the effects. The results of the this study indicate that the introduction of BSC has positive effects on the internal business perspectives, learning and growth perspectives, financial perspectives, with the last aspect lasting longer. After dividing perspectives of BSC into leading indicator and lagging indicator, the analysis on if there was some relationships between two indicators was done. As a result, the introduction makes internal process improve first, which has positive effects on financial performance next.

Performance Analysis of the Channel Equalizers for Partial Response Channels (부분 응답 채널을 위한 채널 등화기들의 성능 분석에 관한 연구)

  • Lee, Sang-Kyung;Lee, Jae-Chon
    • The Journal of Korean Institute of Communications and Information Sciences
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    • 제27권8A호
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    • pp.739-752
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    • 2002
  • Recently, to utilize the limited bandwidth effectively, the concept of partial response (PR) signaling has widely been adopted in both the high-speed data transmission and high-density digital recording/playback systems such as digital microwave, digital subscriber loops, hard disk drives, digital VCR's and digital versatile recordable disks and so on. This paper is concerned with adaptive equalization of partial response channels particularly for the magnetic recording channels. Specifically we study how the PR channel equalizers work for different choices of desired or reference signals used for adjusting the equalizer weights. In doing so, we consider three different configurations that are actually implemented in the commercial products mentioned above. First of all, we show how to compute the theoretical values of the optimum Wiener solutions derived by minimizing the mean-squared error (MSE) at the equalizer output. Noting that this equalizer MSE measure cannot be used to fairly compare the three configurations, we propose to use the data MSE that is computer just before the final detector for the underlying PR system. We also express the data MSE in terms of the channel impulse response values, source data power and additive noise power, thereby making it possible to compare the performance of the configurations under study. The results of extensive computer simulation indicate that our theoretical derivation is correct with high precision. Comparing the three configurations, it also turns out that one of the three configurations needs to be further improved in performance although it has an apparent advantage over the others in terms of memory size when implemented using RAM's for the decision feedback part.

Photoluminescence Properties of CaNb2O6:RE3+ (RE = Dy, Eu, Dy/Eu) Phosphors (CaNb2O6:RE3+ (RE = Dy, Eu, Dy/Eu) 형광체의 발광 특성)

  • Cho, Hyungchel;Cho, Shinho
    • Korean Journal of Materials Research
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    • 제27권6호
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    • pp.339-344
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    • 2017
  • A series of $CaNb_2O_6:Dy^{3+}$, $CaNb_2O_6$:$Eu^{3+}$ and $CaNb_2O_6:Dy^{3+}$, $Eu^{3+}$ phosphors were prepared by solid-state reaction process. The effects of activator ions on the structural, morphological and optical properties of the phosphor particles were investigated. XRD patterns showed that all the phosphors had an orthorhombic system with a main (131) diffraction peak. For the $Dy^{3+}$-doped $CaNb_2O_6$ phosphor powders, the excitation spectra consisted of one broad band centered at 267 nm in the range of 210-310 nm and three weak peaks; the main emission band showed an intense yellow band at 575 nm that corresponded to the $^4F_{9/2}{\rightarrow}^6H_{13/2}$ transition of $Dy^{3+}$ ions. For the $Eu^{3+}$-doped $CaNb_2O_6$ phosphor, the emission spectra under ultraviolet excitation at 263 nm exhibited one strong reddish-orange band centered at 612 nm and four weak bands at 536, 593, 650, and 705 nm. For the $Dy^{3+}$ and $Eu^{3+}$-codoped $CaNb_2O_6$ phosphor powders, blue and yellow emission bands due to the $^4F_{9/2}{\rightarrow}^6H_{15/2}$ and $^4F_{9/2}{\rightarrow}^6H_{13/2}$ transitions of $Dy^{3+}$ ions and a main reddish-orange emission line at 612 nm resulting from the $^5D_0{\rightarrow}^7F_2$ transition of $Eu^{3+}$ ions were observed. As the concentration of $Eu^{3+}$ ions increased from 1 mol% to 10 mol%, the intensities of the emissions due to $Dy^{3+}$ ions rapidly decreased, while those of the emission bands originating from the $Eu^{3+}$ ions gradually increased, reached maxima at 10 mol%, and then slightly decreased at 15 mol% of $Eu^{3+}$. These results indicate that white light emission can be achieved by modulating the concentrations of the $Eu^{3+}$ ions incorporated into the $Dy^{3+}$-doped $CaNb_2O_6$ host lattice.

True Triaxial Physical Model Experiment on Brittle Failure Grade and Failure Initiation Stress (취성파괴수준과 파괴개시시점에 관한 진삼축 모형실험연구)

  • Cheon, Dae-Sung;Park, Chan;Park, Chul-Whan;Jeon, Seok-Won
    • Tunnel and Underground Space
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    • 제17권2호
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    • pp.128-138
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    • 2007
  • At low in-situ stress, the continuity and distribution of natural fractures in rock mass predominantly control the failure processes. However at high in-situ stress, the failure process are affected and eventually dominated by stress-induced fractures preferentially growing parallel to the excavation boundary. This fracturing is often observed in brittle type of failure such as slabbing or spatting. Recent studies on the stress- or excavation-induced damage of rock revealed its importance especially in a highly stressed regime. In order to evaluate the brittle failure around a deep underground opening, physical model experiments were carried out. For the experiments a new tue triaxial testing system was made. According to visual observation and acoustic emission detection, brittle failure grades were classified under three categories. The test results indicate that where higher horizontal stress, acting perpendicular $(S_{H2})$ and parallel $(S_{H1})$ to the axis of the tunnel respectively, were applied, the failure grade at a constant vertical stress level (Sy) was lowered. The failure initiation stress was also increased with the increasing $S_{H1}\;and\;S_{H2}$. From the multi-variable regression on failure initiation stress and true triaxial stress conditions, $f(S_v,\;S_{H1},\;S_{H2})$ was proposed.

The Applicability Assesment of the Short-term Rainfall Forecasting Using Translation Model (이류모델을 활용한 초단시간 강우예측의 적용성 평가)

  • Yoon, Seong-Sim;Bae, Deg-Hyo
    • Journal of Korea Water Resources Association
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    • 제43권8호
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    • pp.695-707
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    • 2010
  • The frequency and size of typhoon and local severe rainfall are increasing due to the climate change and the damage also increasing from typhoon and severe rainfall. The flood forecasting and warning system to reduce the damage from typhoon and severe rainfall needs forecasted rainfall using radar data and short-term rainfall forecasting model. For this reason, this study examined the applicability of short-term rainfall forecast using translation model with weather radar data to point out that the utilization of flood forecasting in Korea. This study estimated the radar rainfall using Least-square fitting method and estimated rainfall was used as initial field of translation model. The translation model have verified accuracy of forecasted radar rainfall through the comparison of forecasted radar rainfall and observed rainfall quantitatively and qualitatively. Almost case studies showed that accuracy is over 0.6 within 4 hours leading time and mean of correlation coefficient is over 0.5 within 1 hours leading time in Kwanak and Jindo radar site. And, as the increasing the leading time, the forecast accuracy of precipitation decreased. The results of the calculated Mean Area Precipitation (MAP) showed forecast rainfall tend to be underestimated than observed rainfall but the correlation coefficient more than 0.5. Therefore it showed that translation model could be accurately predicted the rainfall relatively. The present results indicate that possibility of translation model application of Korea just within 2 hours leading forecasted rainfall.

Analysis of runoff aggregation structure and energy expenditure pattern for Choyang creek basin on the basis of power law distribution (멱함수 법칙분포를 기반으로 한 조양하 유역의 유출응집구조와 에너지소비 양상에 대한 해석)

  • Kim, Joo-Cheol;Cui, Feng Xue;Jung, Kwan Sue
    • Journal of Korea Water Resources Association
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    • 제50권11호
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    • pp.725-734
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    • 2017
  • The main purpose of this study is to analyze runoff aggregation structure and energy expenditure pattern of Choyang creek basin within the framework of power law distribution. To this end geomorphologic factors of every point in the basin of interest, which define tractive force and stream power as well as drainage area, are extracted based on GIS, and their complementary cumulative distributions are graphically analyzed through fitting them to power law distribution. The results indicate that three distinct behavioral regimes are observed from the complementary cumulative distributions of three geomorphogic factors. Based on the parameter estimation of power law distribution by maximum likelihood drainage area and stream power can be judged as scale invariance factor without finite scale while tractive force as scale dependence factor with finite scale. Furthermore, it is judged that tractive force would not follow power law distribution because it shows limited complex system behaviors only within the small extent of scale. The exponent of power law distribution for drainage area obtained in this study by maximum likelihood is larger than the previous researches due to the difference of parameter estimation methodologies. And the exponent for stream power is smaller than the previous researches due to the scaling property of channel slope for the basin of interest.

Economies of Scale and Scope In Seoul's Urban Bus Industry (서울 시내버스운송업의 규모 및 범위의 경제성 분석)

  • 김성수;김민정
    • Journal of Korean Society of Transportation
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    • 제19권6호
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    • pp.89-102
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    • 2001
  • Using a multiproduct translog cost function model, this paper examines the existence or absence of scale and scope economies in Seoul's urban bus industry. The Paper then conceptualizes that the bus firm produces three outputs (city, seat and local bus-kilometers) using low input factors(labor, capital, fuel and maintenance). Using 1996 annual observations for 81 Seoul's bus firms, the equation system consisting of a cost function and three input share equations is estimated with the nonlinear iterative Zellner method. The findings show that the cost function corresponding to a non-homothetic production technology with separability between local bus outputs and inputs adequately represents the structure of cost for Seoul's bus firms, and that the demand lot all input factors is quite inelastic with respect to their own price. On the other hand, nearly all firms experience mild overall economies or scale, but rather marked product-specific economies of scale with respect to all the three outputs. In addition, there appear to be substantial economies or scope associated with the joint production of city and seat bus services, while considerable diseconomies of scope associated with that of city and local bus services. These results indicate that the merger of smaller firms into larger firms with a fleet of approximately 200 buses would result in more cost-efficient bus services.

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