• Title/Summary/Keyword: Indicate System

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Immunomodulatory Activities of Ethanol Extract of Cordyceps militaris in Immunocompromised Mice (밀리타리스 동충하초(Cordyceps militaris) 에탄올 추출물의 면역억제 마우스 면역활성에 미치는 영향)

  • Kim, Hye-Ju;Lee, Tae-Ho;Kwon, Yong-Sam;Son, Mi-Won;Kim, Chae-Kyun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.4
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    • pp.494-500
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    • 2012
  • In order to determine the functional benefits of $Cordyceps$ $militaris$ in the immune system, we examined the immunomodulatory activities of $Cordyceps$ $militaris$ in an immunocompromised C57BL/6 mice model. Mice were injected intraperitoneally with an immunosuppressive drug, cyclophosphamide, and then administered orally with 3% hydroxypropylmethylcellulose or 30, 100, and 300 mg/kg of 50% ethanol extract of $Cordyceps$ $militaris$ (CM 30, CM 100, and CM 300, respectively) for 12 days. Mice treated with CM displayed significantly increased splenocyte proliferation and natural killer cell activity compared to immunosuppressed control mice (p<0.05). The spleen cells isolated from mice treated with CM also displayed increased production of Th1 cytokines, including IL-2, IL-12, IFN-${\gamma}$ and TNF-${\alpha}$, suggesting enhanced cellular immunity in response to CM. However, CM had no significant effect on the production of IL-4 and IL-10. These results indicate that $Cordyceps$ $militaris$ enhances immune function by promoting immune cell proliferation and Th1 cytokine production.

Analysis of China's Aid to North Korea: Focusing on The Two-level game theory (중국의 대북지원 결정요인에 관한 연구: 양면게임이론을 중심으로)

  • Kim, Hyun-Jung;Park, Sunhwa
    • Korea and Global Affairs
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    • v.2 no.1
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    • pp.113-136
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    • 2018
  • The purpose of this study is to start from the recognition of the problem of why the sanctions of the international community could not indicate a great effect. In order to find answers to this question, this study focuses on China's aid to North Korea and analyzes the determinants of support for North Korea. Despite a tough international community's sanctions against North Korea, China has taken a dual stance on sanctions and support for North Korea. As for this dual attitude of China, this study approaches the internal and external situation of the support to the North with the rationale for the Two-level game theory. China's sanction against North Korea could be divided into two categories: external factors and domestic factors. These factors include strengthening supremacy in China, checking the US, playing a responsible role in China, securing resources in North Korea, sustaining stable growth in China, maintaining the legitimacy of China's socialist political system, and spreading the Beijing consensus. Based on the analysis of these factors, it could be expected that China's aid for North Korea will be official, informal, or continuous, and it will be difficult for the North to stop supporting North Korea or deteriorating North Korea- China relations.

Phase transition of (Bi, Pb)-2223 superconductor induced by Fe3O4 addition

  • Ko, Y.J.;Oh, J.Y.;Song, C.Y.;Yang, D.S.;Tran, D.H.;Kang, B.
    • Progress in Superconductivity and Cryogenics
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    • v.21 no.4
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    • pp.1-5
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    • 2019
  • We investigated the effect of Fe3O4 addition on the critical temperature of (Bi, Pb)-2223 polycrystalline samples. Bi1.6Pb0.4Sr2Ca2Cu3O10+δ + x wt. % Fe3O4 (x = 0.0, 0.2, 0.4, 0.6, and 0.8) samples were prepared by using a solid-state reaction method. The analysis of X-ray diffraction data indicates that as Fe3O4 is added, dominant phase of the sample changes from Bi-2223 to Bi-2212 with an increasing Bi-2201 phase. The transition temperature of the samples drastically decreased with the Fe3O4 addition. The resistance data of samples with x = 0.2 and 0.4 showed a double transition indicating a coexistence of Bi-2223 and Bi-2212 phase while the samples with x = 0.6 and 0.8 showed a single transition with a semiconducting behavior. This phase transition may originate from changes in local structure of the Bi-2223 system by Fe3O4 addition. Analysis of the pair distribution function of the Cu-O pair in the CuO2 plane calculated from extended X-ray absorption fine structure data revealed that the oxygen coordination of copper ion changes from CuO4 planar type (x = 0.0 - 0.4) to CuO5 pyramidal type (x = 0.6, 0.8). The correlated Debye-Waller factor, providing information on the atomic disorder within the CuO2 plane, shows an inverse relation to the coordination number. These results indicate that addition of Fe3O4 changes the oxygen distribution around Cu in the CuO2 plane, causing a phase transition from Bi-2223 to more stable Bi-2212/Bi-2201 phases.

Ammonia Conversion in the Presence of Precious Metal Catalysts (귀금속촉매하에서 암모니아의 전환반응)

  • Jang, Hyun Tae;Park, YoonKook;Ko, Yong Sig
    • Korean Chemical Engineering Research
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    • v.46 no.4
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    • pp.806-812
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    • 2008
  • The ammonia decomposition reaction has been of increasing interest as a means of treating ammonia in flue gas in the presence of precious metal catalyst. Various catalysts, $Pt-Rh/Al_2O_3$, $Pt-Rh/TiO_2$, $Pt-Rh/ZrO_2$, $Pt-Pd/Al_2O_3$, $Pd-Rh/Al_2O_3$, $Pd-Rh/TiO_2$, $Pd-Rh/ZrO_2$, $Pt-Pd-Rh/Al_2O_3$, $Pd/Ga-Al_2O_3$, $Rh/Ga-Al_2O_3$, and Ru/Ga-$Al_2O_3$, were synthesized by using excess wet impregnation method. Using a homemade 1/4" reactor at $10,000{\sim}50,000hr^{-1}$ of space velocity in the presence of precious metal catalyst ammonia decomposition reactions were carried out to investigate the catalyst activity. The inlet ammonia concentration was maintained at 2,000 ppm, with an air balance. Both $T_{50}$ and $T_{90}$, defined as the temperatures where 50% and 90% of ammonia, respectively, are converted, decreased significantly when alumina-supported catalysts were applied. In terms of catalytic performance on the ammonia conversion in the presence of hydrogen sulfide, $Pt-Rh/Al_2O_3$ catalyst showed no effect on the poisoning caused by hydrogen sulfide. These results indicate that platinum-rhodium bimetallic catalyst is a useful catalyst for ammonia decomposition.

Spatial dispersion of aggregate in concrete a computer simulation study

  • Hu, Jing;Chen, Huisu;Stroeven, Piet
    • Computers and Concrete
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    • v.3 no.5
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    • pp.301-312
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    • 2006
  • Experimental research revealed that the spatial dispersion of aggregate grains exerts pronounced influences on the mechanical and durability properties of concrete. Therefore, insight into this phenomenon is of paramount importance. Experimental approaches do not provide direct access to three-dimensional spacing information in concrete, however. Contrarily, simulation approaches are mostly deficient in generating packing systems of aggregate grains with sufficient density. This paper therefore employs a dynamic simulation system (with the acronym SPACE), allowing the generation of dense random packing of grains, representative for concrete aggregates. This paper studies by means of SPACE packing structures of aggregates with a Fuller type of size distribution, generally accepted as a suitable approximation for actual aggregate systems. Mean free spacing $\bar{\lambda}$, mean nearest neighbour distance (NND) between grain centres $\bar{\Delta}_3$, and the probability density function of ${\Delta}_3$ are used to characterize the spatial dispersion of aggregate grains in model concretes. Influences on these spacing parameters are studied of volume fraction and the size range of aggregate grains. The values of these descriptors are estimated by means of stereological tools, whereupon the calculation results are compared with measurements. The simulation results indicate that the size range of aggregate grains has a more pronounced influence on the spacing parameters than exerted by the volume fraction of aggregate. At relatively high volume density of aggregates, as met in the present cases, theoretical and experimental values are found quite similar. The mean free spacing is known to be independent of the actual dispersion characteristics (Underwood 1968); it is a structural parameter governed by material composition. Moreover, scatter of the mean free spacing among the serial sections of the model concrete in the simulation study is relatively small, demonstrating the sample size to be representative for composition homogeneity of aggregate grains. The distribution of ${\Delta}_3$ observed in this study is markedly skew, indicating a concentration of relatively small values of ${\Delta}_3$. The estimate of the size of the representative volume element (RVE) for configuration homogeneity based on NND exceeds by one order of magnitude the estimate for structure-insensitive properties. This is in accordance with predictions of Brown (1965) for composition and configuration homogeneity (corresponding to structure-insensitive and structure-sensitive properties) of conglomerates.

Crustal Structure of the Korean Peninsula by Inverting the Rravel Times of First-arrivals from Large Explosions (대규모 발파자료 초동주시 역산을 통한 한반도 지각 속도구조 연구)

  • Kim, Ki-Young;Hong, Myong-Ho;Lee, Jung-Mo;Moon, Woo-Il;Baag, Chang-Eob;Jung, Hee-Ok
    • Journal of the Korean Geophysical Society
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    • v.8 no.1
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    • pp.45-48
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    • 2005
  • In order to investigate the velocity structure of the southern part of the Korean peninsula, exploded seismic signals were recorded for 120 s along a 294-km WNW-ESE line and 150 s along a 335-km NNW-SSE line in 2002 and 2004, respectively. Velocity tomograms were derived from inverting first arrival times. One-dimensional velocity models derived by joint analyses of teleseismic receiver functions and surface wave dispersion at several stations near the profiles were uesd to build initial models. The raypaths indicate several midcrust interfaces including ones at approximate depths of 2.0 and 14.9 km with refraction velocities of approximately 6.0 and 7.1 km/s, respectively. The deepest significant interface varies in depth from 30.8 km to 36.1 km. The critically refracting velocity varies from 7.8 to 8.1 km/s along this interface which may correspond to the Moho discontinuity. The velocity tomograms show (1) existence of a low-velocity zone centered at 6-7 km depth under the Okchon fold belt, (2) extension of the Yeongdon fault down to greater than 10 km, and (3) existence of high-velocity materials under the Gyeongsan basin whose thickness is less than 4.2 km.

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Design Space Exploration of Embedded Many-Core Processors for Real-Time Fire Feature Extraction (실시간 화재 특징 추출을 위한 임베디드 매니코어 프로세서의 디자인 공간 탐색)

  • Suh, Jun-Sang;Kang, Myeongsu;Kim, Cheol-Hong;Kim, Jong-Myon
    • Journal of the Korea Society of Computer and Information
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    • v.18 no.10
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    • pp.1-12
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    • 2013
  • This paper explores design space of many-core processors for a fire feature extraction algorithm. This paper evaluates the impact of varying the number of cores and memory sizes for the many-core processor and identifies an optimal many-core processor in terms of performance, energy efficiency, and area efficiency. In this study, we utilized 90 samples with dimensions of $256{\times}256$ (60 samples containing fire and 30 samples containing non-fire) for experiments. Experimental results using six different many-core architectures (PEs=16, 64, 256, 1,024, 4,096, and 16,384) and the feature extraction algorithm of fire indicate that the highest area efficiency and energy efficiency are achieved at PEs=1,024 and 4,096, respectively, for all fire/non-fire containing movies. In addition, all the six many-core processors satisfy the real-time requirement of 30 frames-per-second (30 fps) for the algorithm.

Specific Effects on Monocular OKN Directional Asymmetry of Unilateral Microinjections of GABA Antagonist into the Mesencephalic Structures in the Chicken (OKN을 유발하는 단축 Mesencephalic 구조에 GABA Antagonist를 미량 주입할 때의 닭의 OKN 방향적 불균형성에 관한 특수효과)

  • 김명순
    • The Korean Journal of Zoology
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    • v.39 no.1
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    • pp.1-11
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    • 1996
  • The SR 95531, a GABA antagonist was microinjected into either the pretectum nuclei (nucleus Superficialis Synencephali nSS) or the nBOR (nucleus Ectomammilaris nEM) of chickens. Monocular optokinetic nystagmus (01(N) was reorded by the search coil technique before and after unilateral intracerebral drug administration. Unilateral microinjections of SR 95531 into either the nSS or nEM induce a reversible increase of gain in OKN directed by contralateral eye for both directions of stimulation. The administration into the nSS increased directional asymmetry by increasing the T~ component velocity gain more strongly than the N-T component velocity gain. On the other hand, the unilateral administration of the drug into the nEM suppressed the diretional O1(N asymmetry by increasing the N-T component velocity gain more strongly than the T-N component velocity gain. The nSS seems especially involved in monocular OKN in response to a T-N stimulation, while the nEM seems more involved in the OKN response to N-T stimulation. These results indicate that the drug suppresses GABAergic inhibition at the mesencephalic level. The increase in gain of OKN directed by the ipsilateral eye to microinjeded nuclei could account for the strong interactions existing between these two mesencephalic structures responsible for horizontal OKN.

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A Review of Research on Social Network Services Using the New Media Evolutionary Model (뉴미디어 발전단계모델을 적용한 소셜네트워크 서비스 분야의 연구동향분석)

  • Kwak, Hyun;Lee, Ho Geun
    • Informatization Policy
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    • v.18 no.3
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    • pp.3-24
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    • 2011
  • The purpose of this paper is to indicate possible future research directions for social network services(SNS) by reviewing past and recent trends in SNS studies. The framework used for the analysis is the New Media Evolutionary Model(NMEM) proposed by Wimmer and Dominick, a four-phase system for research on new media development. Although early forms of SNS emerged in the late 1990s, most research in this field has been published in the past five years. We searched for SNS-related articles published from 2006 to August 2011 from academic journal archives in information systems, communication, marketing, and other fields, and classified them according to the NMEM to analyze the current state of SNS research. Researchers in this field have so far focused on the first two phases of the model(the media itself and use of the media), but little research has been conducted on the third(effects of the media) and fourth phases(improvements in the media). Although SNS research is still in its early stages, we suggest the need for more studies on the effects of SNS and how it can be improved. Very few studies test existing theories or build new theories related to SNS. Thus, a more rigorous approach towards SNS research is warranted, and future research should focus on theory building and testing.

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Synergistic Effects of N-methyl-2-pyrrolidone on Skin Permeation of a Hydrophobic Active Ingredient (N-methyl-2-pyrrolidone 제제의 경피흡수촉진효과)

  • Lee, Geun-Soo;Lee, Dong-Hwan;Kim, Kyoung-Bum;Ko, Hyun-Joo;Pyo, Hyeong-Bae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.2
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    • pp.115-120
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    • 2010
  • The formidable barrier property of the stratum cornemum and the high hydrophilicity of active ingredient make it difficult to permeate through the skin and reach to its site of action. The aim of this study was to investigate the effect of chemical penetration enhancers on the skin permeation of a hydrophilic cosmetic active ingredient, such as arbutin. The enhancing effects of N-methyl-2-pyrrolidone (NMP) on the permeation of a hydrophilic cosmetic active ingredient were evaluated by using Franz diffusion cell. The study indicated that NMP has considerable influence on the skin permeability. NMP was not only the most effective enhancer but also increased the skin permeability of arbutin approximately 1.3~1.5 fold compared with control without penetration enhancer. The lag time did not change with NMP, which suggested no effect of NMP on skin lipid fluidity. This suggest that arbutin co-permeated with NMP. The results indicate NMP is effective enhancer of a hydrophilic cosmetic active ingredient in penetration, with potential applications for drug delivery system.