• Journal of Society of Preventive Korean Medicine
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• v.20 no.3
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• pp.83-91
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• 2016

Objectives : The Levator Ani Muscles Training(LAMT) is one of the well known very effective prevention and treatment method of some specific diseases in the anal organs, digestion system, urinary organs and genital organs, which means LAMT could be considered as an independent exercise. Methods : Chinese databases were searched and found one good source named CNKI(China National Knowledge Infrastructure) where there were downloaded 154 articles, out of which were finally selected 82 used for the introduction of the historical background, health-effectiveness, working mechanism, training methods, etc. Results : LAMT as an independent exercise, is considered very effective for the prevention of diseases in the anal organs, e.g. hemorrhoids, anal fissure, rectal prolapse; urinary organs, e.g. urinary incontinence, frequent micturition; digestion system, e.g. visceroptosis, diarrhea, chronic enteritis; genital organs, e.g. prostatitis, impotence, premature ejaculation, feminine vaginal relaxation, sexual indifference, etc. It is also told LAMT is effective for coronary heart disease, hyperyension and varicose veins of lower extremity to a certain degree. LAMT is also very similar to the Kegel exercise in couple of aspects. They are equally effective for the urinary incontinence and impotence. Conclusions : LAMT as an independent exercise has developed and become more and more health-effective, especially through the combination with the Qigong exercise, and thus many training methods have been introduced. There are not many scientific research and development with very limited accomplishments even in China. It is strongly required to strengthen the research and development activities so that LAMT will become one of the very effective natural healing soonest possible.

• International Journal of Industrial Entomology and Biomaterials
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• v.2 no.1
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• pp.19-26
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• 2001

Transformed Spodoptera frugiperda (Sf9) cells expressing baculovirus very late factor (VLF-1) were constructed by using Autograha nuclear polyhedrosis virus (AcNPV) immediate earthy gene (ie1). Neomycin-resistance gene as a selectable marker was introduced under the control of AcNPV ie1 promoter, and Bombyx mori nuclear polyhedrosis (BmNPV-K1) vlf-1 gene was introduced under the control of the Drosophila heat shock protein gene (hspr70) promoter to yield dual expression plasmid with two independent transcription units. It was transfected into Sf9 cells and cell clones expressing vlf-1 were selected by G4l8 treatment. Genomic DNA from transformed cells was isolated and integration of AcNPV iel harboring vlf-1 was confirmed by PCR using AcNPV iel-specific primers and Southern blot analysis. The transformed cells expressing VLF-1 in an infection-independent manner expressed foreign gene product of recombinant baculovirus in the earlier stage of infection compared with control Sf9 cells. These results suggest the possible to develop highly efficient transformed insect cells for baculovirus expression vector system.

• International Journal of Contents
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• v.14 no.3
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• pp.7-16
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• 2018

The extent and depth of the event plan determines the scope of pedagogical experience in situations and consequently the quality of immersive learning based on our simulated world. In contrast to planning in conventional narrative-based systems mainly pursuing dramatic interests, planning in virtual world-based pedagogical systems strive to provide realistic experiences in immersed situations. Instead of story plot comprising predetermined situations, our inter-event planning method aims at simulating diverse situations that each involve multiple events coupled via their associated agents' conditions and meaningful associations between events occurring in a background world. The specific techniques to realize our planning method include, two-phase planning based on inter-event search and intra-event decomposition (down to the animated action level); autonomous and independent agents to behave proactively with their own belief and planning capability; full-blown background world to be used as the comprehensive stage for all events to occur in; coupling events via realistic association types including deontic associations as well as conventional causality; separation of agents from event roles; temporal scheduling; and parallel and concurrent event progression mechanism. Combining all these techniques, diverse exogenous events can be derived and seamlessly (i.e., semantically meaningfully) integrated with the original event to form a wide scope of situations providing chances of abundant pedagogical experiences. For effective implementation of plan execution, we devise an execution scheme based on multiple priority queues, particularly to realize concurrent progression of many simultaneous events to simulate its corresponding reality. Specific execution mechanisms include modeling an action in terms of its component motions, adjustability of priority for agent across different events, and concurrent and parallel execution method for multiple actions and its expansion for multiple events.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.2
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• pp.176-184
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• 2011

As modern megalopolises become more complex and huge, convenience and safety of citizens are main components for a welfare state. In order to make safe society, telemetrics technology, which remotely measures the information of target system using electronic devices, is an essential component. In general, telemetrics technology consists of USN (ubiquitous sensor network) based on a wireless network, smart sensor, and SoC (system on chip). In the smart sensor technology, the following two problems should be overcome. Firstly, because it is very difficult for transducer manufacturers to develop smart sensors that support all the existing network protocols, the smart sensor must be independent of the type of networking protocols. Secondly, smart sensors should be modular so that a faulty sensor element can be replaced without replacing healthy communication element. To solve these problems, this paper investigates the feasibility of an IEEE 1451 based ZigBee smart sensor system. More specifically, a smart sensor for large network coverage has been developed using ZigBee for active telemetrics.

• The Korean Journal of Applied Statistics
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• v.30 no.6
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• pp.889-899
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• 2017

Independent component analysis is a multivariate approach to separate mixed signals into original signals. It is the most widely used method of blind source separation technique. ICA uses linear transformations such as principal component analysis and factor analysis, but differs in that ICA requires statistical independence and non-Gaussian assumptions of original signals. PCA have a natural ordering based on cumulative proportion of explained variance; howerver, ICA algorithms cannot identify the unique optimal ordering of the components. It is meaningful to set order because major components can be used for further analysis such as clustering and low-dimensional graphs. In this paper, we compare the performance of several criteria to determine the order of the components. Kurtosis, absolute value of kurtosis, negentropy, Kolmogorov-Smirnov statistic and sum of squared coefficients are considered. The criteria are evaluated by their ability to classify known groups. Two types of data are analyzed for illustration.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.3
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• pp.294-299
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• 2005

This paper presents the separation performance of the linearly mixed image signals with additive noises by using an independent component analyses(ICAs) of the fixed-point(FP) algorithm based on Newton and secant method, respectively. The Newton's FP-ICA uses the slope of objective function, and the secant's FP-ICA also uses the tangent line of objective function. The 2 kinds of ICA have been applied to the 2 dimensional 2-image with $512\times512$ pixels. Then Gaussian noise and Laplacian noise are added to the mixed images, respectively. The experimental results show that the Newton's FP-ICA has better the separation speed than secant FP-ICA and the secant's FP-ICA has also the better separation rate than Newton's FP-ICA. Especially, the Newton and secant method gives relatively larger improvement degree in separation speed and rate as the noise increases.

• Korean Journal of Optics and Photonics
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• v.16 no.3
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• pp.261-265
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• 2005

The large and polarization-independent photonic bandgap (PBG) is very useful to the application to various optical devices. Until present, it has been known that the PBG for a triangular lattice remains the largest both in the E- and H-polarized modes. However, we proposed a new structure with a larger polarization-independent PBG, by analyzing and systemizing the PBG opening trends as the structural changes. This optimal structure for maximum bandgap has more increased gap-midgap ratio $(\Delta\omega/\omega)$ of about $30\%$ than the triangular lattice.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.96-104
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• 2020

Objectives: Oleanolic acid, a minor element of ginsenosides, and its derivatives have been shown to have cytotoxicity against some tumor cells. The impact of cytotoxic effect of oleanolic acid 3-acetate on ovarian cancer SKOV3 cells and endometrial cancer HEC-1A cells were examined both in vivo and in vitro to explore the underlying mechanisms. Methods: Cytotoxic effects of oleanolic acid 3-acetate were assessed by cell viability, phosphatidylserine exposure on the cell surface, mitochondrial release of cytochrome C, nuclear translocation of apoptosis-inducing factor, depolarization of mitochondrial transmembrane potential (∆Ψ_m), and generation of reactive oxygen species (ROS). In vivo inhibition of tumor growth was also assessed with xenografts in immunocompromised mice. Results: Oleanolic acid 3-acetate exhibited potent cytotoxicity toward SKOV3 and HEC-1A cells by decreasing cell viability in a concentration-dependent manner. Importantly, oleanolic acid 3-acetate effectively suppressed the growth of SKOV3 cell tumor xenografts in immunocompromised mice. Furthermore, oleanolic acid 3-acetate induced apoptotic cell death as revealed by loss of ∆Ψ_m, release of cytochrome c, and nuclear translocation of apoptosis-inducing factor with a concomitant activation of many proapoptotic cellular components including poly(ADP-ribose) polymerase, Bcl-2, and caspases-8, caspase-3, and caspase-7. Oleanolic acid 3-acetate, however, caused a decrease in ROS production, suggesting the involvement of an ROS-independent pathway in oleanolic acid 3-acetate-induced apoptosis in SKOV3 and HEC-1A cells. Conclusion: These findings support the notion that oleanolic acid 3-acetate could be used as a potent anticancer supplementary agent against ovarian and endometrial cancer. Oleanolic acid 3-acetate exerts its proapoptotic effects through a rather unique molecular mechanism that involves an unconventional ROS-independent but mitochondria-mediated pathway.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.861-865
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• 2006

Takrisodokyeum (TRSDY) has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that TRSDY induced apoptosis in androgen-independent prostate cancer DU145 cells as evidenced by DNA fragmentation and chromatine condensation in hoechst 33342 dye staining. Our data demonstrated that TRSDY-induced apoptotic cell death was accompanied by increases of PTEN and Par-4 in a time-dependent manner Taken together, these results suggest that TRSDY induce PTEN and Par-4 expression, and eventually lead to apoptotic cell death in androgen independent prostate cancer DU145 cells.

• Journal of Digital Convergence
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• v.19 no.10
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• pp.427-434
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• 2021

This paper aimed to reveal the needs and intentions of the people with developmental disabilities through AAC for supporting their independent living in the community and furthermore to contribute to realizing an inclusive community. From August 7 to September 11, 2020, trained researchers conducted 1to1 interviews(AAC) with 74 people recommended by specialized institutions. Data were analyzed by frequency-analysis, Chi-square-analysis and T-test using SPSS 25.0. As a result, the creation of community-level conditions(ex. housing and employment) and job aptitudes and preferences are important for the independent living and expectations and desires for social participation were high. It is different from the previous survey results through agents. It means the policy for the developmentally disabled should be based on their needs and aim for 'living in the community as a community member'. Based on these results, the implications of supporting decision-making for the ordinary lives of people with developmental disabilities were suggested.