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Antidiabetic Activity of Opuntia ficus-indica var. sabotan on db/db Mice (db/db 당뇨모델 생쥐에서 손바닥 선인장의 항당뇨 효과)

  • Shin, Ji-Eun;Han, Myung-Joo;Lee, Young-Churl;Moon, Young-In;Kim, Dong-Hyun
    • Korean Journal of Pharmacognosy
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    • v.33 no.4 s.131
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    • pp.332-336
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    • 2002
  • Opuntia ficus-indica var. sabotan was administered with diet for 5 weeks on db/db diabetic mice and its antidiabetic activity was investigated. Leaves of Opuntia ficus-indica var. sabotan inhibited the increase of body weight, glucose elevation in blood and urine, and protein excretion in urine, and protein excretion in urine. Opuntia ficus-indica var. sabotan also inhibited the intestinal maltase and sucrase activity on db/db Mice loaded with maltose and sucrose. However, it did not significantly lower HbAlc in blood of db/db mice. These results suggest that leaves of Opuntia ficus-indica var. sabotan could be effective on insulin-independent diabetic mellitus type 2.

The Effect of Decline in Functional Ability on Relocation among the American Elderly aged 70 or older (노년기 생활기능 감소와 주거이동에 관한 연구 -미국의 70세 이상 노인들을 대상으로-)

  • 전경숙
    • Journal of the Korean housing association
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    • v.14 no.5
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    • pp.117-128
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    • 2003
  • The purpose of this study is to investigate the effect of functional ability on relocation among the elderly. Longitudinal data from the Asset and Health Dynamics among the Oldest Old (1993, 1995) were analyzed for 6,225 respondents aged 70 or older. Among functional ability measures, difficulties in advanced activities of daily living (i. e., making telephone calls, taking medications, and managing money), lower body activities (i. e., walking several blocks, climbing one flight of stairs, pulling or pushing large objects, and carrying over 10 pounds), and household activities of daily living (i. e., preparing hot meals and shopping for groceries) were the predictors of increased residential move. Difficulties in basic activities of daily living (i. e., bathing, dressing, getting in and out, and using the toilet) were strongly related to increased entrance into an institutional care facility. Efforts to enhance the independent living of the elderly in the community setting should target the compensation of these functional difficulties.

A STUDY OF INCOMPRESSIBLE VISCOUS FLOW ANALYSIS BY VORTEX-IN-CELL METHOD (보오텍스 인 셀 방법을 이용한 점성유동해석 연구)

  • Lee, J.H.;Kim, Y.C.;Lee, K.J.;Suh, J.C.
    • 한국전산유체공학회:학술대회논문집
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    • 2011.05a
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    • pp.78-85
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    • 2011
  • The Vortex-In-Cell(VIC) method combined with panel method is applied to the analysis of incompressible unsteady viscous flow. The dynamics of resulting flow is governed by the vorticity transport equation in Lagrangian form with vortex particle representation of the flow field. A regular grid which is independent to the shape of a body is used for numerical evaluation based on immersed boundary technique. With an introduction of this approach, the development and validation of the VIC method is presented with some computational results for incompressible viscous flow around two or three dimensional bodies such as wing section, sphere, finite wing and marine propeller.

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A Study for Tonal Signal Automatic Classification of Ship-Radiated Noise (선박 방사소음의 Tonal 신호 자동분류에 관한 연구)

  • Lee, Phil-Ho;Park, Kyu-Chil;Yoon, Jong-Rak
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.3
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    • pp.599-607
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    • 2006
  • The ship radiated noise appear the various characteristic signals due to the mechanic system in the ship, the propeller and the interaction between ship body and sea water. Generally, it is classified two main components: the speed dependent signal and the speed independent signal. It is required that very complex procedure to classify the signal origin from the ship-radiated noise. This paper presents techniques to automatically detect and classify the tonal signals ken the ship-radiated noise, using the Q factor and the neural network.

Synthesis of Dopamine by Plasma (플라즈마를 이용한 도파민 합성)

  • Kim, Seong-In;Lee, Deok-Yeon;Lee, Hae-Sin
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.121.2-121.2
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    • 2014
  • Synthesis of catecholamine from aniline is achieved by plasma enhanced CVD process. Catecholamine has a variety of functions in body such as brain and bloodstream controls. Catecholamine also has an interesting property of a material independent ability of functionalizing surface, which is found at mussels' adhesive nature. Synthesis of catecholamine has only been available from DOPA by chemical reduction and oxidation. This study presents the direct synthesis of catecholamine from further elemental source, aniline, which has not been achieved by a conventional chemical method. The process also indicates that a variety of catecholamine can be formed by controlling reactant gases. In additional to PECVD's very useful properties such as conformal, ultrathin and uniform coatings, a direct synthesis from aniline and a capability of controlling formation of a variety catecholamine is believed to open up a numerous applications.

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Combined Two-Back Stress Models with Damage Mechanics Incorporated (파손역학이 조합된 이중 후방응력 이동경화 구성방정식 모델)

  • Yun, Su-Jin
    • Transactions of Materials Processing
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    • v.17 no.3
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    • pp.161-169
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    • 2008
  • In the present work, the two-back stress model is proposed and continuum damage mechanics (CDM) is incorporated into the plastic constitutive relation in order to describe the plastic deformation localization and the damage evolution in a deforming continuum body. Coupling between damage mechanics and isothermal rate independent plasticity is performed using the kinematic hardening rule, which in turn is formulated by combining the nonlinear Armstrong-Frederick rule and the Phillips rule. The numerical analyses are carried out within h deformation theory. It is noted that the damage evolution within a work piece accelerates the plastic deformation localization such that the material with lower hardening exponent results in a rapid shear band formation. Moreover, the results from the numerical analysis reflected closely with the micro-structures around the fractured regime. The effects of the various hardening parameters on deformation localization are also investigated. As the nonlinear strain rate description in the back stress evolution becomes dominant, the strain localization becomes intensified as well as the damage evolution.

An Analysis of Information Security Management Strategies in the Presence of Interdependent Security Risk

  • Shim, Woo-Hyun
    • Asia pacific journal of information systems
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    • v.22 no.1
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    • pp.79-101
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    • 2012
  • This study expands the current body of research by exploring multiple scenarios of insufficient and excessive IT security investments caused by interdependent risks and the interplay between IT security investments and cyber insurance. A key finding is that organizations experiencing interdependent risks with different types of cyber attacks (i.e., targeted and untargeted attacks) use different strategies in making IT security investment decisions and in purchasing cyber insurance policies for their information security risk management than firms that are facing independent risks. The study further provides an economic rationale for employing insurance mechanisms as a risk management solution for information security.

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Cancer Metabolism: Fueling More than Just Growth

  • Lee, Namgyu;Kim, Dohoon
    • Molecules and Cells
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    • v.39 no.12
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    • pp.847-854
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    • 2016
  • The early landmark discoveries in cancer metabolism research have uncovered metabolic processes that support rapid proliferation, such as aerobic glycolysis (Warburg effect), glutaminolysis, and increased nucleotide biosynthesis. However, there are limitations to the effectiveness of specifically targeting the metabolic processes which support rapid proliferation. First, as other normal proliferative tissues also share similar metabolic features, they may also be affected by such treatments. Secondly, targeting proliferative metabolism may only target the highly proliferating "bulk tumor" cells and not the slowergrowing, clinically relevant cancer stem cell subpopulations which may be required for an effective cure. An emerging body of research indicates that altered metabolism plays key roles in supporting proliferation-independent functions of cancer such as cell survival within the ischemic and acidic tumor microenvironment, immune system evasion, and maintenance of the cancer stem cell state. As these aspects of cancer cell metabolism are critical for tumor maintenance yet are less likely to be relevant in normal cells, they represent attractive targets for cancer therapy.

Correlation between Dietary Sodium and Electroecardiographic Left Ventricular Hypertrophy Among Hypertensives

  • Jones, Daniel W.
    • Journal of Preventive Medicine and Public Health
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    • v.27 no.2 s.46
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    • pp.226-229
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    • 1994
  • In hypertensives, electrocardiographic left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease. Animal and human studies suggest an association between left ventricular mass and dietary sodium (Na) intake. This study determined if dietary Na intake in a homogenous ethnic population is associated with electrocardiographic LVH (S in Vl + R in $V5{\geq}5.5 mV$). Blood pressure (BP), body mass index, EKG, and 24 hour urine Na and potassium (K) excretion were determined in 40 otherwise healthy Korean patients with untreated essential hypertension on the standard Korean diet. Among these variables, only Na excretion (mmol/day) was significantly different between those with and without LVH $[LVH+:357{\pm}50,\;LVH-;\;268{\pm}25(p=0.04]$. Thus, dietary sodium intake may be predictive of electrocardiographic LVH.

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COMPLEX STOCHASTIC WHEELBASE PREVIEW CONTROL AND SIMULATION OF A SEMI-ACTIVE MOTORCYCLE SUSPENSION BASED ON HIERARCHICAL MODELING METHOD

  • Wu, L.;Chen, H.L.
    • International Journal of Automotive Technology
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    • v.7 no.6
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    • pp.749-756
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    • 2006
  • This paper presents a complex stochastic wheelbase preview control method of a motorcycle suspension based on hierarchical modeling method. As usual, a vehicle suspension system is controlled as a whole body. In this method, a motorcycle suspension with five Degrees of Freedom(DOF) is dealt with two local independent 2-DOF suspensions according to the hierarchical modeling method. The central dynamic equations that harmonize local relations are deduced. The vertical and pitch accelerations of the suspension center are treated as center control objects, and two local semi-active control forces can be obtained. In example, a real time Linear Quadratic Gaussian(LQG) algorithm is adopted for the front suspension and the combination of the wheelbase preview and LQG control method is designed for the rear suspension. The results of simulation show that the control strategy has less calculating time and is convenient to adopt different control strategies for front and rear suspensions. The method proposed in this paper provides a new way for the vibration control of multi-wheel vehicles.