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Antidiabetic Activity of Opuntia ficus-indica var. sabotan on db/db Mice  

Shin, Ji-Eun (Department of Food and Nutrition, Kyung Hee University)
Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University)
Lee, Young-Churl (Korea Food Research Institute)
Moon, Young-In (Bukjeju County Rural Community Guidance Center)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.4, 2002 , pp. 332-336 More about this Journal
Abstract
Opuntia ficus-indica var. sabotan was administered with diet for 5 weeks on db/db diabetic mice and its antidiabetic activity was investigated. Leaves of Opuntia ficus-indica var. sabotan inhibited the increase of body weight, glucose elevation in blood and urine, and protein excretion in urine, and protein excretion in urine. Opuntia ficus-indica var. sabotan also inhibited the intestinal maltase and sucrase activity on db/db Mice loaded with maltose and sucrose. However, it did not significantly lower HbAlc in blood of db/db mice. These results suggest that leaves of Opuntia ficus-indica var. sabotan could be effective on insulin-independent diabetic mellitus type 2.
Keywords
Opuntia ficus-indica var. sabotan; hypoglycemic activity; db/db mice; antidiabetic activity;
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