• 대한수학회보
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• 제55권6호
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• pp.1869-1889
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• 2018

We are concerned with the following fractional p-Laplacian inclusion: $$(-{\Delta})^s_pu+V(x){\mid}u{\mid}^{p-2}u{\in}{\lambda}[{\underline{f}}(x,u(x)),\;{\bar{f}}(s,u(x))]$$ in ${\mathbb{R}}^N$, where $(-{\Delta})^s_p$ is the fractional p-Laplacian operator, 0 < s < 1 < p < $+{\infty}$, sp < N, and $f:{\mathbb{R}}^N{\times}{\mathbb{R}}{\rightarrow}{\mathbb{R}}$ is measurable with respect to each variable separately. We show that our problem with the discontinuous nonlinearity f admits at least one or two nontrivial weak solutions. In order to do this, the main tool is the Berkovits-Tienari degree theory for weakly upper semicontinuous set-valued operators. In addition, our main assertions continue to hold when $(-{\Delta})^s_pu$ is replaced by any non-local integro-differential operator.

• The Journal of Korean Physical Therapy
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• 제2권1호
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• pp.65-74
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• 1990

This study was carried out to measure the degree of work-related stress and to identify factors influencing the excessive stress among clinical physical therapists. One thousand and five physical therapists surveyed nationwide met the established criteria for inclusion in the study. The respondents were an average age of 27.1 years, $34.5\%$ were married, and $61.2\%$ were female. Most of the respondent $(48.1\%)$ worked in local clinics. The average stress score was 50.9. Analysis-of-variance test demonstrated significant difference in the degree of stress among treatment facilities. There was a significant relationship between treatment facilities (general hospital, local hospital, clinic), number of patients treated per day, job satisfaction, low back pain and work-related stress, respectively. Work-related stress was unrelated to matters of sex, marital status, education. Hospital administrators, physical therapydirectors, directors, and individual therapists should work within their organizations to reduce work stress and its detrimental effects. Further research is necessary to investigate preventive measures to decrease the work-related stress.

• Journal of Preventive Medicine and Public Health
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• 제34권4호
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• pp.363-371
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• 2001

Objectives : To assess the degree of quality improvement (QI) implementation and to identify its associated factors. Methods : A mailed questionnaire survey of the QI staffs at hospitals with 400 beds or more was conducted between September 15 and October 30, 2000. Of the 108 hospitals eligible for inclusion in our study, 79 participated, yielding a response rate of 73.1%. After excluding 12 hospitals that did not perform any QI activities, 117 responses from 67 hospitals were used in our analysis. The degree of QI implementation was measured using the Malcolm Baldrige National Quality Award Criteria (MBNQAC). Factors evaluated for association with the degree of QI implementation were cultural, technical, strategic, and structural factors of the hospitals. Results : The average 01 implementation score across the 7 dimensions of MBNQAC was 3.34 on a 5-point scale, with the highest score for the area of customer satisfaction (3.88) followed by information and analysis (3.59) and quality management (3.35). The results of regression analysis showed that hospitals with a ofter information system (p<0.05) and using scientific and systematic problem solving approach (p<0.01) tended to perform a higher degree of QI implementation. While statistically insignificant, positive associations were observed for the factors of group or developmental culture, the degree of employee empowerment, and the use of prospective strategy. Conclusions : It appears that the most important factors contributing to active implementation of QI in Korean hospitals were the use of scientific skills in decision making, and having a quality information system to produce precise and valid information.

• Asian-Australasian Journal of Animal Sciences
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• 제33권7호
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• pp.1113-1125
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• 2020

Objective: This study was investigated the effects of dietary supplementation of Antrodia cinnamomea fermented product on modulation of antioxidation, anti-inflammation, and lipid metabolism in broilers. Methods: Functional compounds and in vitro antioxidant capacity were detected in wheat bran (WB) solid-state fermented by Antrodia cinnamomea for 16 days (FAC). In animal experiment, 400 d-old broiler chickens were allotted into 5 groups fed control diet, and control diet replaced with 5% WB, 10% WB, 5% FAC, and 10% FAC respectively. Growth performance, intestinal microflora, serum antioxidant enzymes and fatty acid profiles in pectoral superficial muscle were measured. Results: Pretreatment with hot water extracted fermented product significantly reduced chicken peripheral blood mononuclear cells death induced by lipopolysaccharide and 2,2'-Azobis(2-amidinopropane) dihydrochloride. Birds received 5% and 10% FAC had higher weight gain than WB groups. Cecal coliform and lactic acid bacteria were diminished and increased respectively while diet replaced with FAC. For FAC supplemented groups, superoxide dismutase (SOD) activity increased at 35 days only, with catalase elevated at 21 and 35 day. Regarding serum lipid parameters, 10% FAC replacement significantly reduced triglyceride and low-density lipoprotein level in chickens. For fatty acid composition in pectoral superficial muscle of 35-d-old chickens, 5% and 10% FAC inclusion had birds with significantly lower saturated fatty acids as compared with 10% WB group. Birds on the 5% FAC diet had a higher degree of unsaturation, followed by 10% FAC, control, 5% WB, and 10% WB. Conclusion: In conclusion, desirable intestinal microflora in chickens obtaining FAC may be attributed to the functional metabolites detected in final fermented product. Moreover, antioxidant effects observed in FAC were plausibly exerted in terms of improved antioxidant enzymes activities, increased unsaturated degree of fatty acids in chicken muscle and better weight gain in FAC inclusion groups, indicating that FAC possesses promising favorable mechanisms worthy to be developed.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.590-600
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• 2003

The matrix metalloproteinases (MMPs) are a family of enzymes responsible for degrading connective tissue. MMPs catalyze the breakdown of collagen from the extracellular matrix, leading to wrinkle formation and accelerated skin aging. Furthermore, ultraviolet irradiation causes increased expression of certain MMPs. In the extracellular matrix turnover, MMPs are interacting with endogenous regulators named tissue inhibitors of metalloproteinases (TIMPs). Using peptide substrate assays, it has been demonstrated that TIMP-MMP complexes interact highly specifically with $K_{i}$ values of 10$^{-9}$ -10$^{-16}$ M. Therefore applications for TIMP as inhibitor of collagen degradation are suggested for cosmetic anti-aging products to prevent wrinkle formation and loss of elasticity. To date four TIMP proteins (TIMP-1, TIMP-2, TIMP-3 and TIMP-4) have been identified which show a high degree in sequence similarity. The production of human TIMP-2, a 194-residue nonglycosylated protein, was performed by fed-batch culture of Escherichia coli. TIMP-2 accumulated in the bacterial cells in an insoluble form as inclusion bodies. The inclusion bodies were solubilized and the protein refolded to yield the native TIMP-2 in the active form. The integrity of the protein was confirmed by mass analysis, Edman sequencing and gel shift experiments with authentic samples. The inhibitory activity of the refolded and purified TIMP-2 was demonstrated with MMP-1 and MMP-2 assays using synthetic fluorogenic peptide substrates.s.

• 자원환경지질
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• 제25권3호
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• pp.297-316
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• 1992

The Daebong gold-silver deposits is located in 8 km southwest of Cheongyang, Chungcheongnam-Do, Republic of Korea. The gold-silver-bearing hydrothermal quartz veins was formed within the Precambrian metasediments of Gyeonggi massif. Ore minerals occur as mainly of pyrite, sphalerite (0.78~6.19 wt.% Cd), galena, pyrrhotite and minor amounts of chalcopyrite, arsenopyrite, magnetite, ilmenite, chalcocite, electrum (55.00~89.55 wt.% Au) and argentite. The gangue minerals are quartz, calcite, chlorite, K-feldspar, biotite. Wall-rock alterations such as chloritization, silicification, pyritization, carbonatization and sericitization can be observed near the quartz veins. According to the mineral paragenetic sequence based on vein structure and mineral assemblages, three stage mineralizations can be recognized. Fluid inclusion, sulfur isotope and thermodynamic data show that the ore minerals were dominantly deposited at the between 388 and $204^{\circ}C$ from fluids with salinities of 8.1~0.3 wt.% equivalent NaCl, and sulfur isotope value 4.84 to 6.40 per mil of sulfides indicates igneous sources of sulfur in the hydrothermal system and fluid inclusion salinity data suggest that thermal fluids may have magmatic origin with some degree mixing of meteoric water.

• Korean Chemical Engineering Research
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• 제43권1호
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• pp.110-117
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• 2005

초임계유체를 이용한 공정을 통하여 물에 대해 난용성 성질을 지니는 약물인 itraconazole과 $2-hydroxypropyl-{\beta}-cyclodextrin(HP-{\beta}-CD)$의 포접복합체를 제조하였다. 제조된 포접복합체는 SEM, DSC, XRD 등을 이용하여 고체상태의 특성 분석을 수행하여 itraconazole의 결정성적 특성이 $HP-{\beta}-CD$와의 포접체를 형성하며 무정질적으로 변화된 것을 확인할 수 있었다. pH 1.2의 인공위액을 이용하여 수행된 수용액 내에서의 포접복합체의 용해도 및 용출시험 결과 itraconazole 원재료에 비하여 20-200배 정도의 증가된 용해도 결과를 얻을 수 있었다. 초임계유체 공정을 통하여 얻어진 포접복합체의 용해도는 압력증가에 의한 이산화탄소 밀도 증가에 따라 증가하였으며 동일 조건에서 용액 중의 $HP-{\beta}-CD$의 함량이 높아질수록 증가하였다. $35^{\circ}C$, 140 bar의 공정 조건에서 itraconazole과 $HP-{\beta}-CD$의 구성 몰비가 1:3인 용액을 사용하였을 경우 itraconazole 원재료에 비하여 약 200배 이상의 용해도인 $758.6{\mu}g/mL$의 용해도를 지니는 포접복합체를 얻을 수 있었다. 용출시험 결과 투입 약물의 90% 이상이 용출 개시 5-10분 내에 용출되어 대조제로 사용한 시판제제 및 원재료에 비하여 매우 빠른 초기 방출률과 우수한 용출 특성을 확인할 수 있었다. 본 연구를 통하여 기존의 시간소비성 및 다단계의 포접체 제조공정을 개선할 수 있는 한 방법으로 초임계유체 공정이 적용될 가능성을 확인할 수 있었다.

• 가정과삶의질연구
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• 제23권6호
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• pp.79-93
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• 2005

The study investigated whether the characteristics of human figures in Kinetic Family Drawing showed significant differences according to the drawer's personality (neurosis, intellectual openness, friendliness, extroversion, sincerity). The participants of this study were 340 high-school girls. The Five Factors Personality Test was conducted to assess personality factors and the Kinetic Family Drawing Test was used to obtain data on drawing characteristics. The data were analyzed using Chi-square. The results of this study are as follows: First, there were significant differences in ten subcategories such as face, countenance, eyes, mouth, inclusion of body. hands, posture, erasure, exertion of pressure on the paper, and lines, according to the degree of neurosis. Second, there were significant differences in countenance, eyes, posture, exertion of pressure on the paper, and lines according to the degree of extroversion. Third, there were significant differences in face, countenance, eyes, and posture, according to the degree of openness. Fourth, there were significant differences in erasure and lines according to the degree of friendliness Fifth, there were significant differences in countenance and posture according to the degree of sincerity. This study proved that among the personality factors, neurosis is most highly related with characteristics of persons drawn in the Kinetic Family I)lawing, whereas countenance and posture in the drawing were highly indicative of personality factors.

• 보건행정학회지
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• 제11권4호
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• pp.54-69
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• 2001

This study was conducted to assess factors associated with the degree of performance of qualify improvement(QI) activities. A mailed questionnaire survey was conducted between September 15 and October 30, 2000, with the staffs being charge of QI at each of the hospitals with 400 beds or greater. Of the 108 hospitals eligible for inclusion in our study, 79 participated, yielding a response rate of 73.1%. After excluding 12 hospitals that did not perform any QI activities, 117 responses from 67 hospitals were used for the analysis. Using the Malcolm Baldrige National Quality Award Criteria(MBNQAC), perceived performance of QI was measured in terms of the improvement of the quality of clinical practice, clinical supporting department, administrative procedure of receiving care, customer satisfaction, efficiency and standardization of work process. Factors evaluated for the association were the extent of QI implementation, compliance to 5 QI principles, participation of hospital CEOs, budget allocation, history of QI, and bed size. Path analysis was performed to assess the relationship between QI performance and these factors. Major findings of this study are as follows. Hospitals showing higher degree of QI implementation (path coefficient=0.5967, p<0.001)) and better compliance with the basic principes of QI(0.5736, p<0.05) tended to achieve better performance. Path analysis results showed that interest and participation of hospital CEOs(0.1954, p<0.05) and compliance with the basic principes of QI(0.4028, p<0.0001) indirectly affected the outcomes of QI by influencing the intermediate variable of the level of QI implementation. This study results suggest that having employees have a good orientation of the basic concept and principes of QI through relevant training be the most important requirement to achieve better outcomes from QI activities. In addition, to educate leaders of hospitals the need of active implementation of QI is important to encourage their participation and draw strong support for QI programs.

• 한국식품과학회지
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• 제29권2호
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• pp.302-308
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• 1997

Epichlorohydrin을 이용하여 ${\beta}-CD$ 중합체를 제조한 후 차단분자량 10,000인 막(YM 10)을 이용하여 수용성 ${\beta}-CD$ 중합체와 불용성 ${\beta}-CD$ 중합체를 분리하였다. 최적분리 조건은 막횡단압력 51.7 kPa, 운용온도 $35^{\circ}C$, 용적농축비 10이었으며, 이때의 flux는 $0.025\;mL/cm^{2}/min$ 이었다. 겔 투과 크로마토그래피 결과 수용성 중합체의 중합도는 $2{\sim}8$, 불용성 중합체는 10 이상으로 나타났으며, 이들 ${\beta}-CD$ 중합체의 소수성 물질들과의 포접 형성능을 비교하였다. 색소물질인 4-dimethylaminoazobenzene과 methyl red를 이용하여 ${\beta}-CD$와 ${\beta}-CD$ 중합체와의 포접 능력을 측정하였다. 포접 복합체 형성 여부를 간접적으로 알 수 있는 분광학적 변화를 측정한 결과 두 색소물질 흡광도의 강도가 증가하였으며 최대 흡광도 위치가 변하였다. 감귤류의 주된 flavonoid이며 쓴맛물질인 naringin은 물에 대한 용해도가 낮으나 ${\beta}-CD$ 중합체과 포접복합체를 형성함으로써 수용성이 증가하였다. ${\beta}-CD$ 단위체보다는 ${\beta}-CD$ 중합체의 포접능력이 훨씬 강하였으며, 중합도별 포접능력에 있어 불용성 ${\beta}-CD$ 중합체와 수용성 ${\beta}-CD$ 중합체간에 큰 차이는 나타나지 않았다. ${\beta}-CD$ 단위체는 용해도가 극히 낮아 쓴맛 물질 제거 이용에 있어 제한이 있는 반면, 수용성 ${\beta}-CD$ 중합체는 용해도가 높아 감귤류 등으로부터 쓴맛 성분을 감소시키는 공정에의 이용 가능성이 높은 것으로 나타났다.