Browse > Article
http://dx.doi.org/10.5713/ajas.19.0392

Effects of dietary Antrodia cinnamomea fermented product supplementation on antioxidation, anti-inflammation, and lipid metabolism in broiler chickens  

Lee, M.T. (Department of Animal Science, National Chung Hsing University)
Lin, W.C. (Department of Animal Science, National Chung Hsing University)
Lin, L.J. (School of Chinese Medicine, College of Chinese Medicine, China Medical University)
Wang, S.Y. (Department of Forestry, National Chung Hsing University)
Chang, S.C. (Kaohsiung Animal Propagation Station, Livestock Research Institute, Council of Agriculture)
Lee, T.T. (Department of Animal Science, National Chung Hsing University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.33, no.7, 2020 , pp. 1113-1125 More about this Journal
Abstract
Objective: This study was investigated the effects of dietary supplementation of Antrodia cinnamomea fermented product on modulation of antioxidation, anti-inflammation, and lipid metabolism in broilers. Methods: Functional compounds and in vitro antioxidant capacity were detected in wheat bran (WB) solid-state fermented by Antrodia cinnamomea for 16 days (FAC). In animal experiment, 400 d-old broiler chickens were allotted into 5 groups fed control diet, and control diet replaced with 5% WB, 10% WB, 5% FAC, and 10% FAC respectively. Growth performance, intestinal microflora, serum antioxidant enzymes and fatty acid profiles in pectoral superficial muscle were measured. Results: Pretreatment with hot water extracted fermented product significantly reduced chicken peripheral blood mononuclear cells death induced by lipopolysaccharide and 2,2'-Azobis(2-amidinopropane) dihydrochloride. Birds received 5% and 10% FAC had higher weight gain than WB groups. Cecal coliform and lactic acid bacteria were diminished and increased respectively while diet replaced with FAC. For FAC supplemented groups, superoxide dismutase (SOD) activity increased at 35 days only, with catalase elevated at 21 and 35 day. Regarding serum lipid parameters, 10% FAC replacement significantly reduced triglyceride and low-density lipoprotein level in chickens. For fatty acid composition in pectoral superficial muscle of 35-d-old chickens, 5% and 10% FAC inclusion had birds with significantly lower saturated fatty acids as compared with 10% WB group. Birds on the 5% FAC diet had a higher degree of unsaturation, followed by 10% FAC, control, 5% WB, and 10% WB. Conclusion: In conclusion, desirable intestinal microflora in chickens obtaining FAC may be attributed to the functional metabolites detected in final fermented product. Moreover, antioxidant effects observed in FAC were plausibly exerted in terms of improved antioxidant enzymes activities, increased unsaturated degree of fatty acids in chicken muscle and better weight gain in FAC inclusion groups, indicating that FAC possesses promising favorable mechanisms worthy to be developed.
Keywords
Antrodia cinnamomea; Broiler Chickens; Antioxidant; Microflora; Fatty Acids;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tirpanalan O, Reisinger M, Huber F, Kneifel W, Novalin S. Wheat bran biorefinery: an investigation on the starch derived glucose extraction accompanied by pre- and post-treatment steps. Bioresour Technol 2014;163:295-9. https://doi.org/10.1016/j.biortech.2014.04.058   DOI
2 Sahin K, Orhan C, Smith MO, Sahin N. Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry. World's Poult Sci J 2013;69:113-24. https://doi.org/10.1017/S004393391300010X   DOI
3 Zhang Y, Guo F, Ni Y, Zhao R. LPS-induced inflammation in the chicken is associated with CCAAT/enhancer binding protein beta-mediated fat mass and obesity associated gene down-regulation in the liver but not hypothalamus. BMC Vet Res 2013;9:257. https://doi.org/10.1186/1746-6148-9-257   DOI
4 Arantes V, Goodell B. Current understanding of brown-rot fungal biodegradation mechanisms: a review. In: Schultz TP, Goodell B, Nicholas DD, editors. Deterioration and protection of sustainable biomaterials. Washington, DC, USA: American Chemical Society; 2014. p. 3-21. https://doi.org/10.1021/bk- 2014-1158.ch001
5 Wang HC, Chu FH, Chien SC, et al. Establishment of the metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity. J Agric Food Chem 2013;61:8556-64. https://doi.org/10.1021/jf402849b   DOI
6 Chang ST. Overview of mushroom cultivation and utilization as functional foods. In: Cheung PCK, editor. Mushrooms as functional foods. Hoboken, NJ, USA: John Wiley and Sons; 2008. p. 1-34. https://doi.org/10.1002/9780470367285.ch1
7 Chen J, Tellez G, Richards JD, Escobar J. Identification of potential biomarkers for gut barrier failure in broiler chickens. Front Vet Sci 2015;2:14. https://doi.org/10.3389/fvets.2015. 00014
8 El-Lethey H, Huber-Eicher B, Jung TW. Exploration of stress-induced immunosuppression in chickens reveals both stress-resistant and stress-susceptible antigen responses. Vet Immunol Immunopathol 2003;95:91-101. https://doi.org/10.1016/S0 165-2427(02)00308-2   DOI
9 Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem 1956;28:350-6. https://doi.org/10.1021/ac60111a017   DOI
10 Gomes AVS, Quinteiro-Filho WM, Ribeiro A, et al. Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens. Avian Pathol 2014;43:82-90. https://doi.org/10.1080/03079457.2013. 874006   DOI
11 Aviagen Limited. ROSS Broiler Management Manual. Scotland, UK: Aviagen Limited; 2014.
12 Committee on Nutrient Requirements of Poultry, National Research Council. Nutrient requirements of poultry. 9th rev. ed. Washington, DC, USA: National Academy Press; 1994.
13 Peisker K. A rapid semi-micro method for preparation of methyl esters from triglycerides using chloroform, methanol, sulphuric acid. J Am Oil Chem Soc 1964;41:87-88. https://doi.org/10.1007/BF02661915   DOI
14 Yang FC, Yang YH, Lu HC. Enhanced antioxidant and antitumor activities of Antrodia cinnamomea cultured with cereal substrates in solid state fermentation. Biochem Eng J 2013; 78:108-13. https://doi.org/10.1016/j.bej.2013.04.020   DOI
15 Wan X, Luo MX, Jie C, et al. Edaravone protects against vascular oxidative damage induced by AAPH in chick embryo. Int J Pharm Sci Dev Res 2016;2:19-22. http://dx.doi.org/10.17352/ijpsdr.000007   DOI
16 Lu MY, Fan WL, Wang WF, et al. Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development. Proc Natl Acad Sci USA 2014;111:E4743-52. https://doi.org/10.1073/pnas.1417570111   DOI
17 Brisbin JT, Gong J, Sharif S. Interactions between commensal bacteria and the gut-associated immune system of the chicken. Anim Health Res Rev 2008;9:101-10. https://doi.org/10.1017/S146625230800145X   DOI
18 Guo FC, Williams BA, Kwakkel RP, Verstegen MW. In vitro fermentation characteristics of two mushroom species, an herb, and their polysaccharide fractions, using chicken cecal contents as inoculum. Poult Sci 2003;82:1608-15. https://doi.org/10.1093/ps/82.10.1608   DOI
19 Guo FC, Williams BA, Kwakkel RP, et al. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci 2004;83:175-82. https://doi.org/10.1093/ps/83.2.175   DOI
20 do Nascimento PGG, Lemos TLG, Bizerra AMC, et al. Antibacterial and antioxidant activities of ursolic acid and derivatives. Molecules 2014;19:1317-27. https://doi.org/10.3390/molecules19011317   DOI
21 Senthilkumar RP, Balakrishnan V. Effect of graded levels of dietary non-starch polysaccharide on the performance of broilers. Int J Sci Environ Technol 2014;3:1826-34.
22 Delles RM, Xiong YL, True AD, Ao T, Dawson KA. Dietary antioxidant supplementation enhances lipid and protein oxidative stability of chicken broiler meat through promotion of antioxidant enzyme activity. Poult Sci 2014;93:1561-70. https://doi.org/10.3382/ps.2013-03682   DOI
23 Lukaszewicz E, Kowalczyk A, Jerysz A. Effect of dietary selenium and vitamin E on chemical and fatty acid composition of goose meat and liver. Anim Sci Pap Rep 2016;34:181-94.
24 Missotten J, De Smet S, Reas K, Doran O. Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of ${\Delta}5$- and ${\Delta}6$-desaturase in tissues of female piglets. Animal 2009;3:1196-204. https://doi.org/10.1017/S1751731109004455   DOI
25 Sanz M, Lopez-Bote CJ, Menoyo D, Bautista JM. Abdominal fat deposition and fatty acid synthesis are lower and beta-oxidation is higher in broiler chickens fed diets containing unsaturated rather than saturated fat. J Nutr 2000;130:3034-7. https://doi.org/10.1093/jn/130.12.3034   DOI
26 Feingold KR, Grunfeld C. Introduction to lipids and lipoproteins. In: De Groot LJ, Chrousos G, Dungan K, editors. Endotext [Internet]. Dartmouth, MA, USA: MDText.com, Inc.; 2000.
27 Daghir NJ. Nutritional strategies to reduce heat stress in broilers and broiler breeders. Lohmann Info 2009;44:6-15.
28 Oguri M, Okano K, Ieki H, et al. Feed intake, digestibility, nitrogen utilization, ruminal condition and blood metabolites in wethers fed ground bamboo pellets cultured with white-rot fungus (Ceriporiopsis subvermispora) and mixed with soybean curd residue and soy sauce cake. Anim Sci J 2013;84:650-5. https://doi.org/10.1111/asj.12054   DOI
29 Grashorn MA. Functionality of poultry meat. J Appl Poult Res 2007;16:99-106. https://doi.org/10.1093/japr/16.1.99   DOI
30 Zanini SF, Torre CAA, Bragagnolo N, Turatti JM, Silva MG, Zanini MS. Effect of oil sources and vitamin E levels in the diet on the composition of fatty acids in rooster thigh and chest meat. J Sci Food Agric 2004;84:672-82. https://doi.org/10.1002/jsfa.1654   DOI