• Current Research on Agriculture and Life Sciences
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• 제4권
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• pp.22-26
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• 1986

과수원(果樹園)에 발생(發生)되는 잡초(雜草)의 발생동태(發生動態)를 조사(調査)하고 효과적(效果的)인 방제시기(防除時期)를 확립(確立)코져 시험(試驗)하여 얻어진 약간의 결과(結果)를 요약(要約)하면 다음과 같다. 1. 본(本) 조사지(調査地)에서 여뀌외(外) 27종(種)의 잡초(雜草)가 발생검정(發生檢定)되었다. 2. 시기별(時期別) 발생량(發生量)을 종합(綜合)해 보면 8월(月) 10일(日)의 여뀌 발생량(發生量)이 60.79%로 가장 우점(優占)하였으며 그밖에도 애기매꽃, 둑새풀, 냉이, 속속이풀, 피, 쇠비름, 왕바랭이 등(等)이 그 다음으로 많이 발생(發生)하였다. 3. Simpson's index는 5월(月) 1일(日)에 0.11에서 8월(月) 10일(日)에 0.40으로 크게 증가(增加)하여 여러 종(種)의 잡초종(雜草種)이 비교적(比較的) 고르게 발생(發生)해 있다가 특정잡초(特定雜草)가 크게 우점화(優占化)하는 현상을 보였다. 4. Oxyfluorfen을 3월(月) 25일(日)에 1ha당(當) 5kg(상품량(商品量)) 처리(處理)는 처리후(處理後) 120일(日)까지 93.3%의 높은 방제율(防除率)을 나타내어 적합한 처리시기(處理時期) 및 엽량(葉量)으로 사료(思料)되며 1ha당(當) 3kg을 3월(月) 25일(日)에 처리시(處理時)는 6월말(月末)경에 비선택성(非選擇性) 제초제(除草劑) paraquat을 처리(處理)하면 효과적(效果的)으로 방제(防除)가 가능(可能)한 것으로 나타났다.

• 한국응급구조학회지
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• 제12권1호
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• pp.17-26
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• 2008

Purpose : With a view to providing basic data to develop basic cardiopulmonary resuscitation education suitable for female college students, the basic cardiopulmonary resuscitation education was conducted to grasp students' knowledge, skill accuracy and the attitude change before and after the education. Methods : Convenience sampling was made on first graders(total-38 students) of K college located in K city, Chungcheongnam-do, and this was a preliminary research designed before and after choosing a single group. In terms of methods, the researchers as specified ; 1) Handed out questionnaires to students directly to make them fill in firsthand and collected the questionnaires. 2) Utilized Power Point materials based on 2005 AHA guideline and used Anne/Skill Reporter$^{(R)}$ torso produced by Leardal Inc, and Little Anne$^{(R)}$ to conduct practical education individually. 3) Asked students to give Anne/Skill Reporter$^{(R)}$ torso basic cardiopulmonary resuscitation five times with the ratio of 30:2, and then one of researchers filled in the evaluation sheet individually. 4) Evaluated the accuracy of students' ability to perform the resuscitation based on the record of Anne/Skill Reporter$^{(R)}$ integrated printer(which was the objective tool to grasp students' skills accuracy). 5) Gave out questionnaires to make students fill them in and then collected them, after completing the practical evaluation. Results : 1) In case of the attitude(confidence) about basic cardiopulmonary resuscitation, students' confidency rose from 14%(before the education) to 55.5%(after the education)- which was a positive change. 2) In case of the attitude(educational necessity) about basic cardiopulmonary resuscitation, students' confidency rose from 94.7%(before the education) to 100%(after the education)- which was a positive change. 3) As a result of the education, some female college students' scored knowledge about basic cardiopulmonary resuscitation. The average point also reached 88.95%(after the education), jump from 63.51%(before the education), which was the rise of 25.44%. 4) Regarding skill accuracy, pressure accuracy(%)($M{\pm}SD=91.37{\pm}14.16$) was higher than respiration accuracy(%)($M{\pm}SD=61.55{\pm}26.13$). Conclusion : The result showed that students' attitude(confidence, on basic cardiopulmonary resuscitation changed positively, and meaningful difference(p= .000) existed in the change of students' knowledge. Anne/Skill Reporter$^{(R)}$ performance showed that the accuracy of mouth-to-mouth resuscitation was lower than that of chest compression.

• 약학회지
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• 제52권3호
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• pp.195-200
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• 2008

Gabapentin, [1-(aminomethyl) cyclohexaneacetic acid], a structural analog of $\gamma$-aminobutyric acid (GABA), is being developed for the treatment of epilepsy. Unlike GABA, gabapentin crosses the blood-brain barrier after systemic administration. Gabapentin is an effective antiepileptic drug in patients with partial and secondarily generalized seizures who are uncontrolled with use of existing anticonvulsant drug therapy. The purpose of the present study was to evaluate the bioequivalence of two gabapentin 400 mg capsules, $Neurontin^{(R)}$ capsule 400 mg (Pfizer Inc.) and Gabatin capsule 400 mg (Korean Drug Co. Ltd), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of gabapentin from the two gabapentin formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty six healthy male subjects, 23.58$\pm$1.50 years in age and 66.74$\pm$8.31 kg in body weight, were divided into two groups and a randomized 2$\times$2 cross-over study was employed. After one capsule containing 400 mg as gabapentin were orally administered, blood was taken at predetermined time intervals and the concentrations of gabapentin in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition, the pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Neurontin^{(R)}$ capsule 400 mg, were 2.04, -3.68 and 16.79% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91$\sim$log 1.16 and log 0.87$\sim$log 1.11 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Gabatin capsule 400 mg was bioequivalent to $Neurontin^{(R)}$ capsule 400 mg.

• 대한방사선기술학회지:방사선기술과학
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• 제44권5호
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• pp.513-523
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• 2021

The purpose of this study was to discuss the required items and feasibility of medical records of radiological examinations performed by radiological technologists at medical institutions. An online survey was conducted to a total of 10,000 radiation-related workers, of which 1,026 (10.3%) responded. As a research method, self-made questionnaires were used. The online survey was conducted from September 10 to September 20, 2021 for the survey period. For response data, a Chi-square test was performed according to demographic characteristics using SPSS 27.0 version (IBM Inc., Chicago, Ill, USA), and it was judged to be significant when the P value was less than 0.05. The reliability of the questionnaire response was found to be Chronbach α=0.933. More than 90% of the medical records related to radiological examinations are necessary, and they answered that a curriculum, remuneration curriculum, and legal system for medical records should be prepared. More than 90% of the respondents agreed with the proposal of the Radiological Technologist Independent Act for legal preparation, and most of the information required for medical records is currently recorded in DICOM images. According to the demographic characteristics, the medical record requirement for radiological examination, curriculum, continuing education, and legislation were found to be higher with higher education and higher with longer working experience. In addition, most of the radiology departments showed a high demand for medical records, so most of them responded positively to the medical records requirements for radiological examinations. This study analyzed the medical record requirements for radiological examinations, and as shown in the results, medical record requirements for radiological examinations was found that most radiological technologists felt need for the new law and supported it. In addition, if the information recorded in the DICOM image is used, it is considered that medical records could be easily prepared without additional work by the radiological technologists.

• Nutrition Research and Practice
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• 제12권6호
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• pp.494-502
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• 2018

BACKGROUND/OBJECTIVES: Reducing the number of adipocytes by inducing apoptosis of mature adipocytes as well as suppressing differentiation of preadipocytes plays an important role in preventing obesity. This study examines the anti-adipogenic and pro-apoptotic effect of red pepper seed water extract (RPS) prepared at $4^{\circ}C$ (RPS4) in 3T3-L1 cells. MATERIALS/METHODS: Effect of RPS4 or its fractions on lipid accumulation was determined in 3T3-L1 cells using oil red O (ORO) staining. The expressions of AMP-activated protein kinase (AMPK) and adipogenic associated proteins [peroxisome proliferator-activated receptor-${\gamma}$ ($PPAR-{\gamma}$), CCAAT/enhancer-binding proteins ${\alpha}$ (C/EBP ${\alpha}$), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)] were measured in 3T3-L1 cells treated with RPS4. Apoptosis and the expression of Akt and Bcl-2 family proteins [B-cell lymphoma 2 (Bcl-2), Bcl-2-associated death promoter (Bad), Bcl-2 like protein 4 (Bax), Bal-2 homologous antagonist/killer (Bak)] were measured in mature 3T3-L1 cells treated with RPS4. RESULTS: Treatment of RPS4 ($0-75{\mu}g/mL$) or its fractions ($0-50{\mu}g/mL$) for 24 h did not have an apparent cytotoxicity on pre and mature 3T3-L1 cells. RPS4 significantly suppressed differentiation and cellular lipid accumulation by increasing the phosphorylation of AMPK and reducing the expression of $PPAR-{\gamma}$, C/EBP ${\alpha}$, SREBP-1c, FAS, and ACC. In addition, all fractions except ethyl acetate fraction significantly suppressed cellular lipid accumulation. RPS4 induced the apoptosis of mature adipocytes by hypophosphorylating Akt, increasing the expression of the pro-apoptotic proteins, Bak, Bax, and Bad, and reducing the expression of the anti-apoptotic proteins, Bcl-2 and p-Bad. CONCLUSIONS: These finding suggest that RPS4 can reduce the numbers as well as the size of adipocytes and might useful for preventing and treating obesity.

• 한방안이비인후피부과학회지
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• 제32권3호
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• pp.23-36
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• 2019

Objectives : The purpose of this study is to confirm the efficacy and safety of "Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans" on dry skin due to mild atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from November 1st, 2018 to December 20th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans. For 4 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase in treatment group in baseline, 2 weeks and 4 weeks. 2. In the primary endpoint, Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 4 weeks. 3. In the secondary endpoint, Skin pH showed a statistically significant decrease in treatment group between baseline and 4 weeks. 4. To evaluate the safety of the products for the human body, Adverse events, SCORAD Index Assessment were conducted; There were no severe adverse events during this study. And SCORAD Index showed a statistically significant decrease in treatment group in baseline, 2 weeks and 4 weeks. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that "Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans" should be effective for dry skin due to mild atopic dermatitis.

• Asian-Australasian Journal of Animal Sciences
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• 제32권7호
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• pp.913-921
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• 2019

Objective: The objectives of this study were to compare identified informative regions through two genome-wide association study (GWAS) approaches and determine the accuracy and bias of the direct genomic value (DGV) for milk production traits in Korean Holstein cattle, using two genomic prediction approaches: single-step genomic best linear unbiased prediction (ss-GBLUP) and Bayesian Bayes-B. Methods: Records on production traits such as adjusted 305-day milk (MY305), fat (FY305), and protein (PY305) yields were collected from 265,271 first parity cows. After quality control, 50,765 single-nucleotide polymorphic genotypes were available for analysis. In GWAS for ss-GBLUP (ssGWAS) and Bayes-B (BayesGWAS), the proportion of genetic variance for each 1-Mb genomic window was calculated and used to identify informative genomic regions. Accuracy of the DGV was estimated by a five-fold cross-validation with random clustering. As a measure of accuracy for DGV, we also assessed the correlation between DGV and deregressed-estimated breeding value (DEBV). The bias of DGV for each method was obtained by determining regression coefficients. Results: A total of nine and five significant windows (1 Mb) were identified for MY305 using ssGWAS and BayesGWAS, respectively. Using ssGWAS and BayesGWAS, we also detected multiple significant regions for FY305 (12 and 7) and PY305 (14 and 2), respectively. Both single-step DGV and Bayes DGV also showed somewhat moderate accuracy ranges for MY305 (0.32 to 0.34), FY305 (0.37 to 0.39), and PY305 (0.35 to 0.36) traits, respectively. The mean biases of DGVs determined using the single-step and Bayesian methods were $1.50{\pm}0.21$ and $1.18{\pm}0.26$ for MY305, $1.75{\pm}0.33$ and $1.14{\pm}0.20$ for FY305, and $1.59{\pm}0.20$ and $1.14{\pm}0.15$ for PY305, respectively. Conclusion: From the bias perspective, we believe that genomic selection based on the application of Bayesian approaches would be more suitable than application of ss-GBLUP in Korean Holstein populations.

• 한국환경생태학회지
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• 제35권2호
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• pp.126-134
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• 2021

식재된 수목이 활착되기 위해 소요되는 시간은 수종별로 차이가 있기 때문에 개별 수종에 대한 생장량 변동 추이 분석을 통해 관리 기간을 설정할 필요가 있다. 이에 본 연구는 수변생태벨트 조성 지역에 식재된 소나무의 연간 생장량 변화 분석 자료를 바탕으로 관리 기간을 제안하고자 하였다. 생장량을 분석한 결과, 식재 전에는 평균 0.6cm, 식재 후 1~2년차 0.3cm, 3~4년차 0.5cm, 5년차 이후에는 약 0.7cm 내외였다. 식재된 소나무의 생장량은 1~2년차 생장 불량, 3~4년차 회복 단계를 거쳐, 5년차부터 정상 생장 단계가 확인되었기 때문에 활엽수와는 달리 최소 4년은 집중관리가 필요한 기간으로 판단되었다. 수목별 활착에 필요한 기간은 차이가 있을 수 있기 때문에 생장량 연구를 통해 수종별 관리 기간을 설정해야 할 것이다.

• 한국수산과학회지
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• 제54권6호
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• pp.869-879
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• 2021

Methods for the development of home meal replacement seafood tailored to consumer needs for the advanced use of Broughton's ribbed ark Scapharca broughtonii (BRA) in Korea are required. In this study, we developed a cheese-topped, semi-dried, and seasoned Broughton's ribbed ark (S-BRA) tailored for the younger generation with an improved texture and fish odor. The optimization of conditions to improve the texture and fish odor was performed using RSM. The design of the model was appropriate because there was no significant difference (P>0.05) between the predicted and actual values of moisture content, hardness, and overall acceptance, and the optimal preparation conditions were a vinegar content of 2.68%, a soaking time of 62 min, a drying temperature of 60℃, and a time of 162 min. The S-BRA manufactured under these optimal conditions exhibited a lower odor intensity compared to the unsoaked and undried control, suggesting that the fish odor of S-BRA has been improved. The moisture content related to the texture of the S-BRA was lower than that of the control, and the hardness was higher. Therefore, the S-BRA developed in this study will appeal to people of all ages, especially the younger generation; their consumption is expected to increase.

• 대한물리의학회지
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• 제18권1호
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• pp.67-76
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• 2023

PURPOSE: The study compared the satisfaction of the exercise program in a face-to-face and non-face-to-face manner with the same exercise program. METHODS: This study was conducted through convenience sampling for 57 seniors over 65 years of age. After conducting 30 minutes of the same exercise program face-to-face on the first visit and non-face-to-face on the second visit, a satisfaction survey was conducted. The survey data were processed statistically using SPSS 26.0 (SPSS Inc, IBM, USA). An independent t-test was used to compare the type of exercise program. The Spearman's Rank Correlation was conducted to correlate the satisfaction between cognitive function and education level. RESULTS: The overall satisfaction with the face-to-face program was higher than the non-face-to-face exercise programs. All three satisfaction items in face-to-face exercise programs were higher than in non-face-to-face exercise programs (p < .05). The main source of dissatisfaction in the case of face-to-face exercise programs was having a good relationship with people for face-to-face and a 'lack of communication' in the case of non-face-to-face. CONCLUSION: The elderly showed higher satisfaction in face-to-face exercise than in non-face-to-face exercise. This study is significant in that accurate satisfaction comparison was possible by conducting the same exercise program on the same subject for a relatively short time, and through this, the development of an exercise program was suggested.