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The Effect of N-Alkyloxycarbonyl Group on the Anticonvulsant Activities of N-Alkyloxycarbonyl-alpha-amino-N-methylsuccinimides

  • Jung, Kyung-Im;Son, Ki-Chun;Kim, Min-Jeong;Lee, Jae-Won;Choi, Jong-Won;Lee, Eung-Seok;Park, Min-Soo
    • Archives of Pharmacal Research
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    • v.21 no.6
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    • pp.759-763
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    • 1998
  • In connection with the development of new anticonvulsant agents with a broad spectrum, we found that N-Cbz-alpha-amino-alkylsuccinimides showed significant anticonvulsant activities, and the pharmacological activities of these compounds were dependent on their stereochemistry and N-substituted alkyl group. These results prompted us to define the effects of other functional group on the anticonvulsant activities of these compounds. Therefore a series of N-alkoxycarbonyl-alpha-amino-N-methylsuccinimide were prepared from N-Cbz-aspartic acid and were evaluated with their anticonvulsant activities againt the MES and PTZ tests, in order to define the effect of N-substituted alkoxy carbonyl group with the anticonvulsant activities. From these studies, it was found that all the tested N-alkoxycarbonyl-alpha-amino-N-methylsuccinimides exhibited significant anticonvulsant activities in the PTZ test and were not active in the MES test. The most active compound in the PTZ test was (S) N-ethoxycarbonyl-alpha-amino-N-methyl-succinimide. We found that the pharmacological activities in the PTZ test were dependent on their N-alkoxycarbonyl groups. They follow as such: The order of anticonvulsant activities for (R) series as evaluated by $ED_{50}$ was N-phenoxycarbonyl=N-4-nitrobenzyloxycarbonyl > N-ethoxycarbonyl > N-allyloxycarbonyl > N-tert. butoxycarbonyl compound: For the (S) series N-ethoxycarbonyl > N-phenoxycarbonyl > N-allyloxycarbonyl compound. From the above results, it was conceivable that N-substituted alkoxycarbonyl group had certain effects on the anticonvulsant activities of N-alkoxycarbonyl-${\alpha}$-amino-N-methylsuccinimides.

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Nitrogen Dynamics in Soil Amended with Different Rate of Nitrogen Fertilizer

  • Kim, Sung Un;Choi, Eun-Jung;Jeong, Hyun-Cheol;Lee, Jong-Sik;Lee, Hyun Ho;Park, Hye Jin;Hong, Chang Oh
    • Korean Journal of Soil Science and Fertilizer
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    • v.50 no.6
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    • pp.574-587
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    • 2017
  • Excessive application of nitrogen (N) fertilizer to support switchgrass growth for bioenergy production may cause adverse environmental effects. The objective of this study was to determine optimum N application rate to increase biomass yield of switchgrass and to reduce adverse environmental effects related to N. Switchgrass was planted in May 2008 and biomass yield, N uses of switchgrass, nitrate ($NO_3$) leaching, and nitrous oxide ($N_2O$) emission were evaluated from 2010 through 2011. Total N removal significantly increased with N rate despite the fact that yield did not increased with above $56kg\;N\;ha^{-1}$ of N rate. Apparent nitrogen recoveries were 4.81 and 5.48% at 56 and $112kg\;N\;ha^{-1}$ of N rate, respectively. Nitrogen use efficiency decreased into half with increasing N rate from 56 to $112kg\;N\;ha^{-1}$. Nitrate leaching and $N_2O$ emission were related to N use of switchgrass. There was no significant difference of cumulative $NO_3$ leaching between 0 and $56kg\;N\;ha^{-1}$ but, it significantly increased at $112kg\;N\;ha^{-1}$. There was no significant difference of cumulative $N_2O$ emission among N rates in crest, but it significantly increased at $112kg\;N\;ha^{-1}$ in toe. Excessive N application rate (above $56kg\;N\;ha^{-1}$) beyond plant requirement could accelerate $NO_3$ leaching and $N_2O$ emission in switchgrass field. Overall, $56kg\;N\;ha^{-1}$ might be optimum N application rate in reducing economic waste on N fertilizer and adverse environmental impacts.

CONVERGENCE THEOREMS OF THE ITERATIVE SEQUENCES FOR NONEXPANSIVE MAPPINGS

  • Kang, Jung-Im;Cho, Yeol-Je;Zhou, Hai-Yun
    • Communications of the Korean Mathematical Society
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    • v.19 no.2
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    • pp.321-328
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    • 2004
  • In this paper, we will prove the following: Let D be a nonempty of a normed linear space X and T : D -> X be a nonexpansive mapping. Let ${x_n}$ be a sequence in D and ${t_n}$, ${s_n}$ be real sequences such that (i) $0\;{\leq}\;t_n\;{\leq}\;t\;<\;1\;and\;{\sum_{n=1}}^{\infty}\;t_n\;=\;{\infty},\;(ii)\;(a)\;0\;{\leq}\;s_n\;{\leq}\;1,\;s_n\;->\;0\;as\;n\;->\;{\infty}\;and\;{\sum_{n=1}}^{\infty}\;t_ns_n\;<\;{\infty}\;or\;(b)\;s_n\;=\;s\;for\;all\;n\;{\geq}\;1\;and\;s\;{\in}\;[0,1),\;(iii)\;x_{n+1}\;=\;(1-t_n)x_n+t_nT(s_nTx_n+(1-s_n)x_n)\;for\;all\;n\;{\geq}\;1.$ Then, if the sequence {x_n} is bounded, then $lim_{n->\infty}\;$\mid$$\mid$x_n-Tx_n$\mid$$\mid$\;=\;0$. This result improves and complements a result of Deng [2]. Furthermore, we will show that certain conditions on D, X and T guarantee the weak and strong convergence of the Ishikawa iterative sequence to a fixed point of T.

On Comaximal Graphs of Near-rings

Development of Selective GaN etching Process for p-GaN/AlGaN/GaN E-mode FET Fabrication (p-GaN/AlGaN/GaN E-mode FET 제작을 위한 선택적 GaN 식각 공정 개발)

  • Jang, Won-Ho;Cha, Ho-Young
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.24 no.2
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    • pp.321-324
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    • 2020
  • In this work, we developed a selective etching process for GaN that is a key process in p-GaN/AlGaN/GaN enhancement-mode (E-mode) power switching field-effect transistor (FET) fabrication. In order to achieve a high current density of p-GaN/AlGaN/GaN E-mode FET, the p-GaN layer beside the gate region must be selectively etched whereas the underneath AlGaN layer should be maintained. A selective etching process was implemented by oxidizing the surface of the AlGaN layer and the GaN layer by adding O2 gas to Cl2/N2 gas which is generally used for GaN etching. A selective etching process was optimized using Cl2/N2/O2 gas mixture and a high selectivity of 53:1 (= GaN/AlGaN) was achieved.

The Effect of $\textrm{NO}_3$-N and $\textrm{NH}_4$-N Ratio on the Growth of Perilla frutescens in Hydroponics (수경재배시 $\textrm{NO}_3$-N과 $\textrm{NH}_4$-N의 비율이 잎들깨의 생육에 미치는 영향)

  • 김영식
    • Journal of Bio-Environment Control
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    • v.2 no.2
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    • pp.119-125
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    • 1993
  • The effect of NO$_3$-N and NH$_4$-N ratio on the growth of Perilla frutescens in deep flow culture was studied in winter season. NO$_3$-N and NH$_4$-N were treated in the ratios of 12 : 0, 9 : 3, 6 : 6(me/ $\ell$ ). The pH of the nutrient solution was increased an NO$_3$-N:NH$_4$-N=12 : 0 treatment, and decreased in the treatments containing NH$_4$-N, greatly in NO$_3$-N : NH$_4$-N = 6 : 6 treatment. The EC was increased regardless of treatments, but more increased in the treatments containing NH$_4$-N. The stem-base circumference, plant height, root weight, shoot weight, and yields of leaves were by far the highest in NO$_3$-N:NH$_4$-N=6 : 6 treatment and the lowest in NO$_3$-N:NH$_4$-N= 12 : 0 treatment. Among the mineral contents of leaves, N, K, Fe and P were higher in the treatments containing NH$_4$-N. Ca, Mg and Mn were higher in NO$_3$-N :NH$_4$-N= 12 : 0 treatment.

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Quality Factors and Functional Components in the Edible Seaweeds I. Distribution of n-3 Fatty Acids in 10 Species of Seaweeds by Their Habitats (식용 해조류의 품질구성요인과 그 기능성 성분 I. 서식지에 따른 10종 해조류의 n-3 지방산의 분포)

  • 정보영;조득문;문수경;변재형
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.22 no.5
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    • pp.621-628
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    • 1993
  • Total lipid contents from 10 species of marine algae(2 green, 5 brown, and 3 red algae) collected from different places in Korea were examined and their fatty acid compositions were compared among species and habitats. Total lipid(TL) was prominent in green laver(about 7.3~10.1%) of the green algae, in sea mustard and seaweed fusiforme(about 3.1~4.8%) of the brown algae and purple laver(about 4.9~6.4%) of the red algae. Sea mustard and seaweed fusiforme collected at Chungmu contained a relatively high level of TL than that at Yosu and Kijang. The TL content of purple laver showed the highest portion in that collected at Nakdong. Green algae comprised the majority of n-3 fatty acids(29.0~66.3%), which mainly consisted of 16 : 4(n-3) (or 16 : 3 (n-3)), 18 : 3(n-3) and 18 : 4(n-3). Brown algae accounted for a low level of n-3 fatty acids(17.9~36.5%) mainly 18 : 4(n-3), 18 : 3(n-3) and 20 : 5(n-3), whereas the brown algae contained a significant level of n-6 fatty acids(7.23~26.5%) such as 20 : 4(n-6) and 18 : 2(n-6). In the case of red algae, the n-3 fatty acids consisted mostly of 20 : 5(n-3) which scored 53% of polyenoic acids in purple laver collected at Nakdong. The proportion of n-3 fatty acids in algae belonging to the same species was higher in algae of high TL contents. Consequently, TL and n-3 fatty acid levels from the seaweeds studied in this paper were different from their habitats.

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COUNTING FORMULA FOR SOLUTIONS OF DIAGONAL EQUATIONS

  • Moon, Young-Gu;Lee, June-Bok;Park, Young-Ho
    • Bulletin of the Korean Mathematical Society
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    • v.37 no.4
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    • pp.803-810
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    • 2000
  • Let N($d_1,...,{\;}d_n;c_1,...,{\;}c_n$) be the number of solutions $(x_1,...,{\;}x_n){\in}F^{n}_p$ of the diagonal equation $c_lx_1^{d_1}+c_2x_2^{d_2}+{\cdots}+c_nx_n^{d_n}{\;}={\;}0{\;}n{\geq},{\;}c_j{\;}{\in}{\;}F^{*}_q,{\;}j=1,2,...,{\;}n$ where $d_j{\;}>{\;}1{\;}and{\;}d_j{\;}$\mid${\;}q{\;}-{\;}1$ for all j = 1,2,..., n. In this paper, we find all n-tuples ($d_1,...,{\;}d_n$) such that the reduced form of ($d_1,...,{\;}d_n$) and N($d_1,...,{\;}d_n;c_1,...,{\;}c_n$) are the same as in the theorem obtained by Sun Qi [3]. Improving this, we also get an explicit formula for the number of solutions of the diagonal equation, unver a certain natural restriction on the exponents.

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CHARACTERIZATIONS OF THE POWER FUNCTION DISTRIBUTION BY THE INDEPENDENCE OF RECORD VALUES

  • Chang, Se-Kyung
    • Journal of the Chungcheong Mathematical Society
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    • v.20 no.2
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    • pp.139-146
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    • 2007
  • In this paper, we present characterizations of the power function distribution by the independence of record values. We establish that $X{\in}$ POW(1, ${\nu}$) for ${\nu}$ > 0, if and only if $\frac{X_{L(n)}}{X_{L(n)}-X_{L(n+1)}}$ and $X_{L(n)}$ are independent for $n{\geq}1$. And we prove that $X{\in}$ POW(1, ${\nu}$) for ${\nu}$ > 0; if and only if $\frac{X_{L(n+1)}}{X_{L(n)}-X_{L(n+1)}}$ and $X_{L(n)}$ are independent for $n{\geq}1$. Also we characterize that $X{\in}$ POW(1, ${\nu}$) for ${\nu}$ > 0, if and only if $\frac{X_{L(n)}+X_{L(n+1)}}{X_{L(n)}-X_{L(n+1)}}$ and $X_{L(n)}$ are independent for $n{\geq}1$.

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Intersexuality of Five Bivalves Species in Korea (한국에서 이매패류 5종의 이성생식세포 발현)

  • Kim, Hyejin;Jeon, Mi Ae;Ju, Sun Mi;Kang, Seung Wan;Kim, Jae Won;Lee, Yeon Gyu;Lee, Jung Sick
    • The Korean Journal of Malacology
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    • v.32 no.3
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    • pp.197-202
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    • 2016
  • This research reports the intersexuality of bivalves, such as Crassostrea gigas, Mytilus galloprovincialis, Rupiditapes philippinarum, Gomphina veneriformis and Barnea davidi discovered during the process of investigating the ecological health status of coastal waters of Korea. In intersex ovaries, the opposite germ cells were observed either individually or in groups in the interfollicular space and inside the oogenic follicle. Oocytes in the intersex testis were at the previtellogenic or initial vitellogenic stage. They were either scattered individually or in groups in the interfollicular space and inside the spermatogenic follicle. The intersexuality in C. gigas was 10.4% (n = 19/183), while female (12.2%, n = 6/49) exhibited a higher proportion than male (9.7%, n = 13/134). The intersexuality in M. galloprovincialis was 31.7% (n = 19/60), while female (36.4%, n = 12/33) exhibited a higher proportion than male (25.9%, n = 7/27). The intersexuality in R. philippinarum was 11.2% (n = 11/98), while male (16.7%, n = 7/42) exhibited a higher proportion than female (7.1%, n = 4/56). The intersexuality in G. veneriformis was 28% (n=30/107), while male (31.5%, n=17/54) exhibited a higher proportion than female (24.5%, n=13/53). The intersexuality in B. davidi was 18.4% (n = 7/38), while female (35.7%, n =5 /14) exhibited a higher proportion than male (8.3%, n = 2/24).