• 한국약용작물학회지
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• 제24권5호
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• pp.375-385
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• 2016

Background: The study was conducted to elucidate the extraction conditions under which white ginseng has cognition-improving efficacy. Methods and Results: Extracts from white ginseng under different solvent and temperature conditions were analyzed for ginsenoside content and inhibitory effect on N-methyl-D-aspartate (NMDA) receptor and acetylcholinesterase. The total ginsenoside contents and amounts of ginsenoside Rb1 plus ginsenoside Rg1 from the 1st extracts (prepared with EtOH/$H_2O$ as solvent) were higher than those from the 2nd extracts (extracted with $H_2O$ after the 1st EtOH/$H_2O$ extraction). The contents in the 1st and 2nd extracts produced at $80^{\circ}C$ were also higher than those obtained at $50^{\circ}C$. Samples from the 1st extraction at $80^{\circ}C$ indicated higher inhibitory activities on NMDA receptors-whose excessive activation is thought to mediate the calcium-dependent neurotoxicity associated with several neurodegenerative diseases-than those from the 2nd extraction. Among the samples prepared at varying temperatures, the extract prepared at $50^{\circ}C$ showed the highest suppression activity on NMDA receptors. Note, however, that the extracts from the 2nd extraction at $50^{\circ}C$ inhibited acetylcholinesterase-whose inhibition could be a therapeutic strategy for neurodegenerative diseases with cognitive deficits and memory malfunction-more effectively than those from the 1st extraction. Conclusions: To enhance the cognition-improving activity of white ginseng extract, it is suggested that the extracts be utilized after being combined the 1st extracts (made with EtOH/$H_2O$ solvent) and the 2nd extracts (prepared with $H_2O$) at low temperature.

• 디지털콘텐츠학회 논문지
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• 제12권1호
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• pp.33-48
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• 2011

본 연구에서는 발달장애 아동의 사회적 기술 향상을 위하여 지역사회 기반의 현장체험학습을 지원하는 시스템을 설계하고 구현하였다. 본 시스템의 특징은 다음과 같다. 첫째, 구체적이고 실제적인 사전 학습을 통해 발달 장애 아동의 현장 적응력을 높이고 현장체험학습의 효과성 및 효율성을 향상시킬 수 있다. 둘째, 현장학습이 단순한 체험 및 지식의 습득 차원에서 머무르는 것이 아니라 실제적인 문제 상황에서 지식을 적용하고 활용할 수 있는 능력을 키울 수 있다. 셋째, 시스템 설계시 지역사회 활용성 및 관리의 용이성을 고려하여 설계함으로써 학습자의 실생활에 맞게 컨텐츠를 변형하여 사용할 수 있다. 넷째, 학교에서의 현장체험학습 뿐 아니라 가정에서의 생활 교육 등에 시스템을 활용함으로써 발달장애 아동의 사회적 기술 및 기초학습 능력 향상에도 긍정적인 영향을 제공한다. 본 시스템을 구현하여 적용한 결과, 발달장애 아동의 현장체험 학습시 현장 적응력을 높이고 학습 결과에 긍정적인 영향을 끼치는 것으로 나타났다. 첫째, 본 시스템을 이용하여 사전학습을 실시한 결과 학습이나 사물에 대한 집중도가 낮은 발달장애 아동들에게 매우 높은 관심과 흥미를 유발하였다. 둘째, 발달장애 아동들이 실제 현장학습장소에서도 현장 적응력이 높았으며, 관심 및 주의집중이 유지되었다. 셋째, 현장체험학습 후 실시한 사후지도 및 평가에서도 많은 학습 내용을 기억하고 있는 것으로 나타났다.

• Design & Manufacturing
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• 제11권2호
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• pp.51-56
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• 2017

Nitinol, a shape memory alloy (SMA), is manufactured from titanium and nickel and it used in various fields such as electrical applications, micro sensors. It is also recommended as a material in medical for implant because it has excellent organic compatibility. Nitinol is intended to be inserted into the human body, products require a high-quality surface and low residual stress. To overcome this problems, explore electrolyte polishing (EP) is being explored that may be appropriate for use with nitinol. EP is a particularly useful machining method because, as a non contact machining method, it produces neither machining heat nor internal stress in the machined materials. Sandpaper polishing is also useful machining method because, as a contact machining method, it can easily good surface roughness in the machined materials. The electrolyte polishing (EP) process has an effect of improving the surface roughness as well as the film polishing process, but has a characteristic that the residual stress is hardly generated because the work hardened layer is not formed on the processed surface. The sandpaper polishing process has the effect of improving the surface roughness but the residual stress remains in the surface. We experimented with three conditions of polishing process. First condition is the conventional polishing. Second condition is the electrochemical polishing(EP). And Last condition is a mixing process with the conventional polishing and the EP. Surface roughness and residual stress of the nitinol before a polishing process were $0.474{\mu}mRa$, -45.38MPa. Surface roughness and residual stress of the nitinol after mixing process of the conventional polishing and the EP were $1.071{\mu}mRa$, -143.157MPa. Surface roughness and residual stress of the nitinol after conventional polishing were $0.385{\mu}mRa$ and -205.15MPa. Surface roughness and residual stress of sandpaper and EP nitinol were $1.071{\mu}mRa$, -143.157MPa. The result shows that the EP process is a residual stress free process that eliminates the residual stress on the surface while eliminating the deformed layer remaining on the surface through composite surface machining rather than single surface machining. The EP process can be used for biomaterials such as nitinol and be applied to polishing of wafers and various fields.

• Journal of Korean Dental Science
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• 제16권2호
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• pp.128-148
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• 2023

Dementia is an umbrella term that describes the loss of thinking, memory, attention, logical reasoning, and other mental abilities to the extent that it interferes with the activities of daily living. More than 50 million individuals worldwide live with dementia, which is expected to increase to 131 million by 2050. Recent research has shown that poor oral health increases the risk of dementia, while oral health declines with cognitive decline. In this narrative review, the literature was based on the "hypothesis" that dementia and oral health have a close relationship, and appropriate oral health and occlusal rehabilitation treatment can improve the quality of life of patients with dementia and prevent progression. We conducted a literature search in PubMed and Google Scholar databases, using the search terms "dementia," "major neurocognitive disorder," "dentition," "occlusion," "tooth loss," "dental prosthesis," "dental implant," and "occlusal rehabilitation" in the title field over the past 30 years. A total of 131 studies that scientifically addressed dementia, oral health, and/or oral rehabilitation were included. In a meta-analysis, the random effect model demonstrated significant tooth loss increasing the dementia risk 3.64-fold (pooled odds ratio=3.64, 95% confidence interval [2.50~5.32], P-value=0.0348). Tooth loss can be an important indicator of cognitive function decline. As the number of missing teeth increases, the risk of dementia increases. Loss of teeth can lead to a decrease in the ascending information to the brain and reduced masticatory ability, cerebral blood flow, and psychological atrophy. Oral microbiome dysbiosis and migration of key bacterial species to the brain can also cause dementia. Additionally, inflammation in the oral cavity affects the inflammatory response of the brain and the complete body. Conversely, proper oral hygiene management, the placement of dental implants or prostheses to replace lost teeth, and the restoration of masticatory function can inhibit symptom progression in patients with dementia. Therefore, improving oral health can prevent dementia progression and improve the quality of life of patients.

• 대한인간공학회지
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• 제31권5호
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• pp.629-636
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• 2012

Objective: The purpose of this study is to compare the characteristics of single and double finger gestures related on the web browser and to extract the appropriate finger gestures. Background: As electronic equipment emphasizes miniaturization for improving portability various interfaces are being developed as input devices. Electronic devices are made smaller, the gesture recognition technology using the touch-based interface is favored for easy editing. In addition, user focus primarily on the simplicity of intuitive interfaces which propels further research of gesture based interfaces. In particular, the fingers in these intuitive interfaces are simple and fast which are users friendly. Recently, the single and double finger gestures are becoming more popular so more applications for these gestures are being developed. However, systems and software that employ such finger gesture lack consistency in addition to having unclear standard and guideline development. Method: In order to learn the application of these gestures, we performed the sketch map method which happens to be a method for memory elicitation. In addition, we used the MIMA(Meaning in Mediated Action) method to evaluate gesture interface. Results: This study created appropriate gestures for intuitive judgment. We conducted a usability test which consisted of single and double finger gestures. The results showed that double finger gestures had less performance time faster than single finger gestures. Single finger gestures are a wide satisfaction difference between similar type and difference type. That is, single finger gestures can judge intuitively in a similar type but it is difficult to associate functions in difference type. Conclusion: This study was found that double finger gesture was effective to associate functions for web navigations. Especially, this double finger gesture could be effective on associating complex forms such as curve shaped gestures. Application: This study aimed to facilitate the design products which utilized finger and hand gestures.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제9권10호
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• pp.213-220
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• 2020

높은 사양이 필요한 하드웨어 기반의 모바일 및 IoT 임베디드 시스템은 저전력과 성능에 중요한 이슈를 갖고 있다. 이는 전력 소비로 발열량 증가 및 기기의 수명 단축 문제가 발생된다. 이러한 환경에서 소프트웨어도 제한된 전력, 메모리 등에서 안정적인 동작을 수행해야하므로 디바이스의 소비전력이 증가한다. 이를 해결하고자, 코드 관점에서 성능을 저하시키는 모듈을 식별하고, 그 모듈의 전력 최소화를 통한 성능 개선 가시화 방법을 제안한다. 이는 코드 가시화를 통해 복잡한 모듈(특히 Cyclomatic complexity, Coupling & Cohesion)을 식별하고, 저전력 코드 패턴화와 성능 코드를 간결화 한다. 이런 코드로 소비전력을 감소 및 성능 개선 함으로써 코드의 품질을 최적화 할 수 있다.

• 대한한의학방제학회지
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• 제26권1호
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• pp.1-12
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• 2018

Objectives : Cheongnoimyungshin-hwan (CNMSH) is a Herbal compound prescription that is composed mainly of herbal medicines such as Ginseng Radix Alba, Angelicae Gigantis Radix, Dioscoreae Rhizoma, Longan Arillus and cornus cervi parvum, and for the purpose of improving memory and preventing dementia. Methods : In this study, it was investigated whether CNMSH could suppress inflammatory response and oxidative stress in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. As a result, CNMSH decreased expression of inducible nitric oxide (NO) synthase and cyclooxygenase-2, and also inhibited production of NO, prostaglandin E2. Results : This effect was associated with the suppression of the expression of p65, one of the nuclear factor-kappaB ($NF-{\kappa}B$) subunits, and increased expression of $I{\kappa}B-{\alpha}$, inhibit the $NF-{\kappa}B$ transcription factor. In addition, CNMSH significantly blocked intracellular reactive oxygen species accumulation in response to LPS stimulation. Furthermore, CNMSH increased expression of nuclear factor erythroid 2-related factor (Nrf)-2 activation and heme oxygenase (HO)-1. Conclusions : Therefore, it has been shown anti-inflammatory and antioxidant effects by inhibiting the expression and production of inflammatory mediators in LPS-stimulated macrophages, and is associated with ROS generation and is activated by Nrf2/HO-1 signaling pathway.

• 대한간호학회지
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• 제48권4호
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• pp.407-418
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• 2018

Purpose: The purpose of this study was to develop an eye-health program based on social learning theory (EPST) of preschoolers and evaluate its effectiveness. Methods: A nonequivalent control group pre-post test design was utilized and 141 six-year-old preschoolers and their parents participated (experimental group=69, control group=72) in the study. The EPST in this study included eye-health education and eye exercises. Attention, memory, replay, motivation, reinforcement, and self-efficacy were used as interventional strategies. To examine the effectiveness of EPST, proficiency in eye-health activities, refractive power, and visual acuity were measured before and after the intervention. Data were analyzed with SPSS WIN 21.0 using the Shapiro-Wilk test, ${\chi}^2$-test, Mann-Whitney U test and Wilcoxon signed rank test. Results: Following the intervention, eye-health activities, refractive power, and visual acuity significantly improved in the experimental group compared to the control group. Conclusion: The results of this study suggest that EPST is effective in improving eye-health activities, refractive power, and visual acuity in preschoolers, and its wider implementation in educational institutions will promise improved eye-health among preschoolers.

• 한국정보과학회논문지:시스템및이론
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• 제33권6호
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• pp.326-336
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• 2006

유무선 통신 기술 및 인터넷의 발전으로 인터넷 방송, VOD 등과 같은 멀티미디어 서비스가 일반화되고 있다. RTP는 인터넷상에서 실시간 멀티미디어 데이타를 전송하는데 적합하도록 IETF에서 제정한 프로토콜이다. RTP는 주로 라이브러리 형태로 구현되어 다양한 애플리케이견에 사용되나, 라이브러리 형태로 사용되는 RTP는 성능 측면에서 문제가 있어 이를 개선한 프로토콜이 embeddedRTP이다. 본 논문에서는 기존의 커널 레벨 RTP인 embeddedRTP를 기반으로 그 문제점을 보완하며, API를 네트워크 애플리케이션에서 널리 사용되는 BSD 소켓 API와 통합하고 그 성능을 개선한 ExtendedERTP를 제안한다. embeddedRTP의 API가 BSD 소켓 API에 통합되어 기존의 네트워크 스택이 RTP를 내장하게 되면, 사용자들은 별도의 RTP 라이브러리를 사용할 필요 없이 익숙한 BSD 소켓 API 형태의 인터페이스를 통해 실시간 데이타를 송수신할 수 있다. 본 논문은 또한 embeddedRTP에 비해 패킷 처리 속도를 15$\sim$20% 가량 향상시키는 방안과 패킷 처리에 필요한 메모리 요구량을 기존의 3.5% 수준으로 줄일 수 있는 방안을 제시한다.

• 한국지리정보학회지
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• 제12권1호
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• pp.26-35
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• 2009

본 논문은 LBS기반 모바일 시스템 구현을 위하여 GoF의 디자인 패턴을 활용한 효율적인 설계방법을 제안하고자 한다. 본 논문에서 제안된 설계기법은 사용자와 모바일 시스템 관점에서 디자인 패턴의 생성패턴, 구조패턴, 행위패턴을 이용하여 모바일 시스템 인터페이스를 설계하고 구현한다. 디자인 패턴을 활용한 설계 방법은 소프트웨어 개발에 있어서 모듈 및 소프트웨어 재사용성 증가, 개발시간을 단축, 유지보수 최소화, 시스템의 메모리 절감 효율성을 보여준다. 따라서 본 논문은 모바일 환경에서 지리정보시스템을 접목한 미들웨어를 개선하기 위해 디자인 패턴을 활용하였다. 본 논문은 모바일 시스템에 디자인 패턴을 적용하여 높은 안정성과 신뢰성을 보여주고, 모듈 및 소프트웨어의 재사용과 확장성을 높이며 효율적인 시스템을 개발하는데 기여할 것이다.