• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.64-71
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• 2022

Norovirus (NV) is the most common cause of viral gastroenteritis, with the potential to develop into a fatal disease in those who are immuno-compromised, and effective vaccines and treatments are still non-existent. In this study, we aimed to elucidate the molecular mechanism of the previously identified NV replication inhibitor utilizing a vinyl-stilbene backbone, AC-1858. First, we confirmed the inhibition of the NV RNA replication by a structural analog of AC-1858, AC-2288 with its exclusive cytoplasmic sub-cellular localization. We further validated the induction of one specific host factor, the phosphorylated form of heat shock factor (HSF)-1, and its increased nuclear localization by AC-1858 treatment. Finally, we verified the positive and negative impact of the siRNA-mediated downregulation and lentivirus-mediated overexpression of HSF-1 on NV RNA replication. In conclusion, these data suggest the restrictive role of the host factor HSF-1 in overall viral RNA genome replication during the NV life cycle.

• The Journal of Korea Robotics Society
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• v.17 no.1
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• pp.48-57
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• 2022

In this paper, we propose a legged landing platform for the quadcopter taking off and landing in the ship environment. In the ship environment with waves and winds, the aircraft has risks being overturned by contact impact and excessive inclination during landing on the ship. This landing platform has four landing legs under the quadcopter for balancing and shock relief. In order to make the quadcopter balanced on ships, the position of each end effector was controlled by PID control. And shocks have mainly happened when quadcopter contacts the ship's surface as well as legs move fast. Hence, impedance control was used to cope with the shocks. The performance of the landing platform was demonstrated by a simulation and a prototype in three sea states based on a specific size of a ship. During landing and tracking the slope of the ship's surface, oscillations of rotation and translation from the shock were mitigated by the controller. As a result, it was verified that transient response and stability got better by adding impedance control in simulation models and prototype experiments.

• Journal of the Mineralogical Society of Korea
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• v.29 no.3
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• pp.131-139
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• 2016

Detailed knowledge on maskelynite, a glassy phase of plagioclase found in shocked meteorites and impact craters, is essential to understand a shock metamorphism. Here, we explore an inhomogeneous shock metamorphism in the lunar meteorite Mount DeWitt (DEW) 12007 with an aim to understand the formation mechanism of maskelynite. Most plagioclase grains in the DEW 12007 partially amorphized into maskelynite with a unidirectional orientation. Back-scattered electron (BSE) images of maskelynite show a remnant of planar deformation fracture possibly indicating that the maskelynite would be formed by solid-state transformation(i.e., diaplectic glass). Plagioclase with flow texture is also observed along the rim of maskelynite, which would be a result of recrystallization of melted plagioclase. Results of Raman experiments suggest that shock pressure for plagioclase and maskelynite in the DEW 12007 is approximately 5-32 GPa and 26-45 GPa, respectively. The difference in shock pressures between plagioclase and maskelynite can be originated from 1) external factors such as inhomogeneous shock pressure and/or 2) internal factors such as chemical composition and porosity of rock. Unfortunately, Raman spectroscopy has a limitation in revealing the detailed atomic structure of maskelynite such as development of six- or five-coordinated aluminum atom upon various shock pressure. Further studies using nuclear magnetic resonance spectroscopy are necessary to understand the formation mechanism of maskelynite under high pressure.

• Journal of Distribution Science
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• v.11 no.10
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• pp.63-72
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• 2013

Purpose - This study analyzes the relationship and dynamic interactions between stock price index, interest rate, price index, and housing price indices using Korean monthly data from 2000 to 2013, based on a VAR model. This study also examines Granger causal relationships among these variables in order to determine whether the time series of one is useful in forecasting another, or to infer certain types of causal dependency between stochastic variables. Research design, data, and methodology - We used Korean monthly data for all variables from 2000: M1 to 2013: M3. First, we checked the correlations among different variables. Second, we conducted the Augmented Dickey-Fuller (ADF) test and the co-integration test using the VAR model. Third, we employed Granger Causality tests to quantify the causal effect from time series observations. Fourth, we used the impulse response function and variance decomposition based on the VAR model to examine the dynamic relationships among the variables. Results - First, stock price Granger affects interest rate and all housing price indices. Price index Granger, in turn, affects the stock price and six metropolitan housing price indices. However, none of the Granger variables affect the price index. Therefore, it is the stock markets (and not the housing market) that affects the housing prices. Second, the impulse response tests show that maximum influence on stock price is its own, and though it is influenced a little by interest rate, price index affects it negatively. One standard deviation (S.D.) shock to stock price increases the housing price by 0.08 units after two months, whereas an impulse shock to the interest rate negatively impacts the housing price. Third, the variance decomposition results report that the shock to the stock price accounts for 96% of the variation in the stock price, and the shock to the price index accounts for 2.8% after two periods. In contrast, the shock to the interest rate accounts for 80% of the variation in the interest rate after ten periods; the shock to the stock price accounts for 19% of the variation; however, shock to the price index does not affect the interest rate. The housing price index in 10 periods is explained up to 96.7% by itself, 2.62% by stock price, 0.68% by price index, and 0.04% by interest rate. Therefore, the housing market is explained most by its own variation, whereas the interest rate has little impact on housing price. Conclusions - The results of the study elucidate the relationship and dynamic interactions among stock price index, interest rate, price index, and housing price indices using VAR model. This study could help form the basis for more appropriate economic policies in the future. As the housing market is very important in Korean economy, any changes in house price affect the other markets, thereby resulting in a shock to the entire economy. Therefore, the analysis on the dynamic relationships between the housing market and economic variables will help with the decision making regarding the housing market policy.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.5
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• pp.128-134
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• 2009

This paper aims to design a variable-stiffness type economical safety joint for service robots. The safety joint was designed to have a passive shock absorbing mechanism for protecting human from a catastrophic collision under service condition of robots. A simple mechanism composed of two action disks for switching the load transfer, a spring and a screw for pre-load was proposed. In order to evaluate the performance of the safety joint a testing platform which can carry out the static and impact tests was also designed and fabricated. From the test results, the designed safety joint was proved to have a variable load-carrying capacity and about 42% impact absorption capacity with simple manipulation of the control screw.

• Computers and Concrete
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• v.6 no.5
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• pp.377-390
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• 2009

In this paper an improved one-dimensional frame element for modelling of reinforced concrete beams and columns subjected to impact is presented. The model is developed in the framework of a flexibility fibre element formulation that ignores the shear effect at material level. However, a simple shear cap is introduced at section level to take account of possible shear failure. The effect of strain rate at the fibre level is taken into account by using the dynamic increase factor (DIF) concept for steel and concrete. The capability of the formulation for estimating the element response history is demonstrated by some numerical examples and it is shown that the developed 1D element has the potential to be used for dynamic analysis of large framed structures subjected to impact of air blast and rigid objects.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.3
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• pp.409-415
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• 2003

The purpose of this paper is to develop the 2-Dim Lagrangian Hydrocode for the analysis of large deformations of solids with implementation of the contact algorithm. First, th e governing equations are discretized into a system of algebraic equations. For more accurate and robust contact force computation. the defense node contact algorithm was adopted and implemented. For the verification of the code developed, two cases are carried out; the Taylor-Impact test and two bodies impact. The von -Mises criterion is implemented into the code with the Shock equation of state. The simulation results show a good agreement compared with the published experimental data and results from the commercial code. It is necessary to implement several material models and failure models for applications to different impact and penetration problems.

• Journal of the Korea Institute of Military Science and Technology
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• v.7 no.3 s.18
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• pp.11-20
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• 2004

In this paper, the acceptance criteria(Striking Velocities) for the A12519 weldments have been developed. Dynamic impact simulation of A12519 plate was achieved by using LS-DYNA, and predict the projectile velocity and the crack length. Also, Ballistic impact tests of A12519 plate have been performed, and compared with analysis results. Critical velocities of A12519 plate were acquired respectively, and striking velocities of A12519 weldments were calculated. Present work data will be used by basic data in ballistic impact test for A12519 weldments.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.3
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• pp.532-537
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• 2011

This paper describes the development of SPH(Smooth Particle Hydrodynamics) scheme and integration into the multi-material shock physics code(ExLO) for the purpose of the application to the extreme large deformation problems. SPH numerical scheme has been extended into the fluid dynamics and the high-speed impact events, such as space structure protection against space debris and meteorite catering. Like other hydrocodes, SPH scheme also solves the conservation equations with the constitutive equation including equation of state. The benchmark problem, Taylor-Impact test, was simulated and the predictions show good agreements with both the published numerical data and experimental data. Currently, the contact treatment between materials is under development.

• Journal of the Korea Institute of Building Construction
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• v.14 no.4
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• pp.350-358
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• 2014

The demand for the lightweight wall has increased as the structure of the multi-unit dwelling has shift to the rahmen structure. The lightweight wall is required to secure certain degree of shock resistance for the structural safety. The study performed the load analysis test for 7 small hard bodies with different masses and shapes and 5 hard materials which applied the impact load on the wall. It was found out from the experiment that different pendulum weight doubled the load maximum even though the shock energy was the same. In addition, the study compared and analyzed the weight of materials and the load of small hard bodies to propose fundamental data for the material design of the lightweight wall.